Important #LongCovid finding of auto-antibodies in patients directed to neural tissue, and then, by transferring the antibodies, recapitulated the disease symptoms in mice @cellcellpress.bsky.social @virusesimmunity.bsky.social cell.com/cell/abstrac...

#Macrophages have already been crowned as the best cell, and as amazing as they are, they only get better. Pigeon macrophages are literally magnetic, and enable the pigeon equivalent to GPS! www.science.org/doi/10.1126/...

Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures" but their own internal data.

LIMmunity 2nd brew: Motherhood comes with superpower: pathogen protection! 🤰🤱 www.nature.com/articles/s41... We often think moms are immunologically vulnerable during reproduction to tolerate the baby. But I always wondered: why would evolution make such a critical period of life so dangerous?

Love this! #philsky #academicsky

Also very useful for Germans in the US!

I'm officially an expert in failing! I was asked to give the opening keynote today for a @cruk-ci.bsky.social conference, speaking on the topic "Failing in Science" youtu.be/BdrTzYcT7MY?...

An interesting new study, by Clare Smith’s lab and me, here at Duke. We found that during Mtb infection, CCR6 knockout mice (on a B6 background) form necrotic pulmonary granulomas, have increased IL17 production and have sex specific differences in susceptibility. journals.asm.org/doi/10.1128/...

Fascinating! Sampling of living cells rather than utilization of apoptotic bodies as a way to maintain tolerance to self! @nature.com @amycfanphd.bsky.social Krummel Thota Serwas &co 👇👉 www.nature.com/articles/s41...

So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. rdcu.be/ff9GB #tuberculosis #immunology

Wan’t to be faculty at a collegial host-pathogen focused department in a beautiful bikable city with amazing food? This link is for you: facultycareers-ohsu.icims.com/jobs/39006/a...

An adaptive source of IL-17A/F is indispensable for EAE induction! And B cell-derived IL-17 induces IL-23 signaling required to convert stem-like Th17 cells to encephalitogenic Th17 cells. www.science.org/doi/10.1126/...

There needs to be a giant billboard in every major American city that touts this. In any other era except this suicidal science administration, this would be a miraculous, wondrous thing.

There are Science papers and then there are *I just dropped and shattered my mug of coffee Usual Suspects style* Science papers www.science.org/doi/10.1126/...

For those interested in T cell trafficking to the gut - maybe LPAM is not so dominant during enteric infection... www.biorxiv.org/content/10.6...

We’re unwrapping a new method today at @mskcancercenter.bsky.social. Led by Sydney Blattman, Nabih Maslah, and @austinv11.com with @danapeer.bsky.social, @ronanchaligne.bsky.social and @10xgenomics.bsky.social, we present GIFT: Genotyping In Fixed Transcriptomes www.biorxiv.org/content/10.6... 1/n

Key takeaways: • P-values shrink with large sample sizes • Log2FC tells you about effect size • QC cutoffs vary by tissue • Know your biology

ICYMI: Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers

Eric Idle is 83 today. Happy Birthday Mr. Idle! Thank you for the laughter! 🎉 youtube.com/watch?v=uAzw...

This is a great paper - even down to the honest way the authors critique their own findings in the final sentence of the results www.nature.com/articles/s41...

Chronic inflammation has long been linked to cancer, but how is that history retained in the tissue? In a new #Nature study, Nagaraja et al show that colitis leaves a lasting epigenetic memory in colonic stem cells, which persists after inflammation resolves & primes for subsequent tumor growth 🧪🔬

Macrophage lineage and spatial compartmentalization govern tumor immunity @natimmunol.nature.com @claudjak.bsky.social @xinli0419.bsky.social www.nature.com/articles/s41...

The reductions in the number of new and competing renewal R01s by topic (based on simple searches in NIH Reporter). The cuts are across the board: Cancer down 24%, Alzheimer down 45%, Obesity down 29%, Child by 21%. Transgender was down by 84% but represents only a small number of grants.

Our work with Lena Takayasu and @dwmckellar.bsky.social in Iwijn De Vlaminck's lab is now out in @natmicrobiol.nature.com ! 🎉 Spatial transcriptomics maps host–gut microbiome biogeography at high resolution rdcu.be/e7i7o

#SpatialTranscriptomics Optimizing Xenium In Situ data utility by quality assessment & best-practice analysis workflows Must-read for Xenium user🔥 👉Segmentation 👉Spatially variable feature selection 👉Imputation 👉Spatial domain identification #NatMethods 2025 www.nature.com/articles/s41...

The rules of immunity are different in early life! Lead author Dr. Yue Xing finds that early life DCs sense allergens and trigger inflammation directly in skin. This in-situ activation state emerges from a developing HPA and low glucocorticoids. #Naiklab @nature.com www.nature.com/articles/s41...

New work from our lab, hot off the press in Nature Immunology (@natureportfolio.nature.com)! How do human T cell responses diversify — and how does this lead to durable protection after vaccination? Paper: www.nature.com/articles/s41... Press release: www.fau.eu/2026/02/news... 1/6

NEW YORK CITY! Join your local March 7th rally to take back our science! Learn more at standupforscience.net/march7 #rally #March7 #ImpeachRFKJr #science #standupforscience

I accept you with minor revisions.

Ulcerative colitis induces stem- and effector-like γδ T cell subsets influencing therapeutic response @sciimmunology.bsky.social www.science.org/doi/10.1126/...

2/ Bioinformatics isn't just data processing. It’s not: “Load → Analyze → Publish.” It’s exploration, interpretation, ITERATION. It’s art.

This #MucosalMonday @bainlab.bsky.social and @lizihegarty.bsky.social are in the Authors Corner discussing their recent #macrophage work from MI. Then @kknoop.bsky.social brings you more allergy and anaphylaxis with Caroline Sokol and @stephanieeisen.bsky.social: www.iheart.com/podcast/269-...

Tools 'To address this knowledge gap, we developed “cytokine cellular locating platforms” (CyCLoPs), a reporter system that translates cytokine receptor engagement into a genetically traceable signal.' #Immunology www.cell.com/cell/abstrac...

279 postdoctoral fellowships! Download freely our database of postdoctoral fellowships and grants. For each entry, we provide eligibility criteria, $ amount, deadline, etc. Good luck! Here: research.jhu.edu/rdt/funding-...

2026 is here! We’re excited to share Global Immunotalks first semester poster, featuring an outstanding lineup! Please share and help us spread the word!

Here's a summary of all the data that supports adding more red meat to your diet

Nature research paper: Neuro-epithelial circuits promote sensory convergence and intestinal immunity go.nature.com/4qeRjlt

Colonic macrophage heterogeneity revealed by CD11c and CD163 www.mucosalimmunology.org/article/S193...

Re-submitting the paper to other journals

💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...

@drjonlim.bsky.social & @reisesousalab.bsky.social show cDC1s & DNGR1 favor "tethered" neoantigens from F-actin proteins, trapping them in necrotic debris for better cross-presentation! Calls for prioritizing these neoantigens for cancer vaccine design #Immunotherapy www.nature.com/articles/s41...

On the use of murine models: Results should be interpreted with caution. Batf3-deficient mice have been traditionally used as a model to study the function of cDC1; however, this transcription factor seems to play other essential roles in other immune populations👇

Blog post: Just quit Quitting projects in science is hard, but we should be doing a lot more of it. open.substack.com/pub/arjunraj...

Now online! Gut microbiota promotes immune tolerance at the maternal-fetal interface

We wrote two reviews on cell migration, published today in Nature Methods. They provides practical guidelines how to select a cell-migration assay and how to analyze cell-migration data Review 1: nature.com/articles/s41... Review 2: nature.com/articles/s41...

The issue features The neutrophil collective, a Review focusing on both traditional properties of neutrophils and those that challenge existing dogmas. www.cell.com/cell/fulltex...

Urs Mörbe, William Agace et al. characterize and spatially map the fibroblast landscape within human large and small intestinal gut-associated lymphoid tissues, including Peyer’s patches and isolated lymphoid follicles, during homeostasis and #Crohns disease. rupress.org/jem/article/... #IBD

Have you heard about the Night Science Podcast, where we talk about the creative process of doing science? We explore this with discussions with brilliant scientists & philosophers and artists, to figure out the tricks of the creative scientific trade. podcasts.apple.com/us/podcast/n...