Preprint: Type I IFN activates border-associated macrophages to drive MHC-I–dependent immune surveillance after stroke www.researchsquare.com/article/rs-8...

@salva-iborra.bsky.social and Co in @jem.org elegantly sow that plasmacytoid DCs expand tissue-resident memory CD8+ T cell responses during viral reinfection rupress.org/jem/article/...

My main PhD paper is finally out! 🎉 After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺. @natimmunol.nature.com It all started with an unexpected observation 🔍: 👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice. 1/11 🧵

On the use of murine models: Results should be interpreted with caution. Batf3-deficient mice have been traditionally used as a model to study the function of cDC1; however, this transcription factor seems to play other essential roles in other immune populations👇

Isn't this the coolest Christmas present (or miracle) for a #gdTcell aficionado?! Our latest preprint showing the role of BATF3 on gd T cells is ou on bioRxiv: www.biorxiv.org/content/10.6...

Qian Zhang et al. @casanovalab.bsky.social @rockefeller.edu report a fatal case of avian #influenza #H5N1 infection caused by autoantibodies neutralizing type I IFNs. These rogue autoantibodies are common, especially in elderly people. rupress.org/jem/article/... (1/2) 🧵 👇

Feel better during the day than at night during #influenza? Find out the “Role of IL-10 signaling in the #circadian control of host response to influenza infection” www.mucosalimmunology.org/article/S193...

mRNA vaccines 💉don't cause death but prevent it Massive study from France showed that mRNA vaccines reduced deaths and saved lives @mahmoudzureik.bsky.social @jama.com jamanetwork.com/journals/jam...

Fascinating study revealing how NK cells can eliminate intracellular E. coli infecting the urothelium. -Just a comment on the NK depletion experiment, NK1.1 is also expressed by ILC1s, NKT and most γδ T1 cells (IFN-γ producers).

👇No os lo perdáis! Hoy, a las 19:00 h, Oscar Palomares hablará en Allergotrends (Inmunotek) sobre los"Avances en inmunidad innata entrenada en inmunoterapia específica de alérgeno: Vacunas bacterianas para la prevención y tratamiento del asma alérgica". eventos.quodem.com/allergotrend...

Gracias @larazonlr.bsky.social ! Por hacerse eco de nuestra investigación. www.larazon.es/salud/que-ma...

..cross your 't's folks.. here's how! www.nature.com/articles/s41...

Delighted to have written this Insight article together with @victor-bosteels.bsky.social and Will Stainier about a cool new story by Tam et al. And with a title to honour Jason Cyster’s heritage.

In @jem.org, Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/... #MucosalImmunology

pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection @jem.org rupress.org/jem/article-...

Excited to share our new paper in @jem.org! 🎉 We reveal a key mechanism showing how tissue-resident memory CD8⁺ T cells (#Trm) amplify antiviral protection during reinfection. #immuno 🧵👇1/6

@biorxivpreprint.bsky.social TGF-β triggers IFN-λ from intestine plasmacytoid DCs at homeostasis, contributing to tonic localized innate immune responses www.biorxiv.org/content/10.1...

Aemet confirma que la ola de calor de agosto ha sido la más intensa desde que hay registros

Our latest review: Inborn errors of immunity affecting the MHC class I pathway for antigen presentation url: rupress.org/jhi/article/...

🧬 A new study by David Sancho at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) links the gut-derived metabolite imidazole propionate (ImP) to #atherosclerosis. The research explores ImP as a potential marker & contributor to early disease development. 👉 europa.eu/!wBktrm

Are you interested in antifungal immunity in the skin? Then, this postdoc position may be of interest to you 👇 #Immunology #immunosky

Wild mice reveal surprising immune system differences! 🐭🔬 Discover how wild mouse bone marrow composition contrasts with lab mice, unlocking new immunology insights. Read here: https://bit.ly/4jtlZeC #Immunology #InnateImmunity

I’m pleased to share my latest work, published in Science Advances. In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections. #immunology #immunosky www.science.org/doi/10.1126/...

As the USA shuts down programs to develop HIV vaccines, we have exiting news from Australia of new work delivering RNA encoding bits of HIV to T cells #Immunosky 🧪🧵

More evidence of the link between microbiome and immune function as excess antibiotics impair response to vaccines in infants and those with Bifodibacterium in the gut did better with vaccine responses🧪

Interesting link between microbial metabolism and disease in IBD which is linked with high levels of succinate. Turns out this affects Treg stability and function. #Immunosky 🧪

The scientific community must take a strong and active stand against vaccine revisionism — the false narrative that there is insufficient evidence to support the safety and efficacy of vaccines www.nature.com/articles/s41... #vaccines #immunology #virology

#Medsky🧪 #IDsky #pedsky #immunosky #publichealth Combining multiple vaccines may trigger stronger immune responses in fewer shots, potentially improving the efficacy of immunization programs. www.the-scientist.com/why-are-some...

A tour de force by the team of Marco Colonna describing in @cp-cell.bsky.social the role of "lymphoid RORγt+ Dendritic Cells in maintaining intestinal immune balance and preventing conditions like food allergies". www.cell.com/cell/fulltex...

I'm excited to share my first-author PhD paper, now out in Science Immunology! @science.org We show that S.aureus skin infection leaves a lasting imprint on bone marrow eosinophils, fueling allergic responses in the lungs. 📄 Read the full study: www.science.org/doi/10.1126/... Let’s dive in 🧵 1/9

Patients being admitted to hospital in Texas with symptoms indicative of vitamin A toxicity- RFK jr has been promoting vitamin a and nutrition over and above vaccines to manage the measles outbreak in USA 🧪

New publication!!! Together Carlos Del Fresno Lab, we discussed how mucosal hashtag#vaccines based on trained immunity (TIbVs) work to prevent respiratory infections — including MV130, developed by Inmunotek #AMR #TrainedImmunity #immunosky www.cell.com/trends/immun...

Its a tragedy that an unvaccinated child died of measles but disgusting this being used for anti-vaccination propaganda. Vax is safe- measles is not & far from measles boosting your immune system it can wipe your immune memory making you more vulnerable to infxns

New publication!!! Together Carlos Del Fresno Lab, we discussed how mucosal hashtag#vaccines based on trained immunity (TIbVs) work to prevent respiratory infections — including MV130, developed by Inmunotek #AMR #TrainedImmunity #immunosky www.cell.com/trends/immun...

💯 RFK Jr. approved!

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

Pues que se la devuelva. #microbiota www.elespanol.com/ciencia/salu...

This is utterly irresponsible- RFK is not qualified- MMR is a safe vaccine which is well validated. Measles is a deadly disease. His words MATTER

📢 Nuevo estudio: La alimentación parcial con leche de fórumula se asocia con un 2.48x mayor riesgo de alergias alimentarias a los 12 meses (IC 95% 1.05-5.85), incluyendo alergia al cacahuete 🥜 🔬📊 www.medpagetoday.com/meetingcover...

🚨 New study reveals a bladder-blood immune barrier! 🦠🔬 Suburothelial perivascular macrophages (suPVMs) prevent UPEC from spreading into the bloodstream during UTIs. Loss of suPVMs increases the risk of bacteremia, but monocytes can replenish them! 🛡️💪 #UTI #Immunology www.cell.com/immunity/ful...

'In rewilded mice, we observed B cells in circulation with increased signs of maturation, alongside heightened germinal center responses within secondary lymphoid organs. Rewilding also expanded B cells in the gut, which was accompanied by elevated systemic levels of IgG & IgM'

The perils of RFK Junior's anti-vaccine leadership for public health www.thelancet.com/journals/lan...

Primero se creía que las DCs inducían linfocitos Th2 mediante la secreción de IL-4. Después, por ausencia de una señal tipo 3. Un nuevo estudio sugiere que la clave está en la IL-2, presentada por DCs, a través de su propio receptor (CD25) a células T. #immunosky www.nature.com/articles/s41...

And... More evidence that polymerization can reduce proteolytic activity & stabilize grass pollen mixtures. 🌿 New study with Polymerized Alternaria alternata extracts Safer, more effective AIT is possible: @inmunotek #Allergy #AIT #Immunotherapy mdpi.com/2309-608X/11...

Can we make multi-allergen immunotherapy more stable and effective? 🤔 Our new paper shows how polymerized mite allergoids (PMAs) reduce proteolytic activity & enhance allergen mixture stability! #immunosky #immunology Here’s a breakdown! 🧵👇🔗 Full paper: www.frontiersin.org/journals/all...

I’m excited to share our new study of the off-target effects of #BCGVaccine on response to #SARSCoV2 & #COVID-19 vaccines. We analysed immune responses before & after COVID-19 vaccination in healthcare workers in the #BRACE RCT. 💉🦠 #Immunology #IDsky #Immunosky doi.org/10.1002/cti2...

We offer 2 PhD positions! Expertise in immunology and bioinformatics required!

Read the paper here: www.nature.com/articles/s41... #microsky 🧪🦠☕

Intriguing BCG discovery! BCG induces a new antigen-presenting cell: ILC1-MHCII+, critical to promoting anti-viral immunity 🤯 But why do we need this extra APC? And why does subcutaneous BCG drive their migration from skin to lung? #ImmunoSky #Immunology www.nature.com/articles/s41...