Type 2 Immunity & Allergy Lab
@jimenez-saiz-lab.bsky.social
š¤ 422
š„ 142
š 12
https://www.jimenezsaizlab.com/
reposted by
Type 2 Immunity & Allergy Lab
Waggoner Lab
2 days ago
@biorxivpreprint.bsky.social
A single-cell atlas of intestinal immune cells across the day-night cycle reveals dynamic populations
www.biorxiv.org/content/10.6...
@jkpfeiff.bsky.social
@utswim.bsky.social
@lhooperlab.bsky.social
0
10
2
reposted by
Type 2 Immunity & Allergy Lab
Waggoner Lab
10 days ago
Review
@natrevimmunol.nature.com
How crosstalk at the immune synapse shapes T cell and dendritic cell biologys
www.nature.com/articles/s41...
0
6
3
reposted by
Type 2 Immunity & Allergy Lab
Angel GoƱi-Moreno
13 days ago
New tech adventure: co-founded Newton Biotwins together with
@mirobueno.bsky.social
. We're building
#DigitalTwins
for the lab ā starting with a flow cytometry twin. Turning
#biology
into an information science!
newtonbiotwins.com/en/home_en/
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5
4
reposted by
Type 2 Immunity & Allergy Lab
Angel GoƱi-Moreno
about 1 month ago
Preprint out! By controlling growth, via RNAP, we control the entire cellular machinery, and tune the cellular context into distinct, stable states. See how NOT gates behave! Kudos to
@angeles-hg.bsky.social
and
@mirobueno.bsky.social
šhttps://www.biorxiv.org/content/10.64898/2025.12.19.695408v1
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Growth control as a central regulator for tuning the cellular context
The cellular context interacts with genetic circuits, decisively defining their performance. However, contextual dependencies (the interplay between the host and the circuit) are often difficult to en...
https://www.biorxiv.org/content/10.64898/2025.12.19.695408v1
0
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11
Grateful for the invitation to present at the 3rd Research Day of the METRI²A Group at
@idibaps.bsky.social
. A pleasure to discuss how
#microbial
metabolism of allergens impacts
#allergicinflammation
and
#anaphylaxis
.
about 1 month ago
0
1
0
reposted by
Type 2 Immunity & Allergy Lab
Science Magazine
about 2 months ago
Researchers in
#ScienceTranslationalMedicine
find a distinct
#Bcell
and antibody profile in infants and mothers in an Older Order Mennonite farming community, associated with lower incidence of egg
#allergy
.
https://scim.ag/48rPBGS
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Farm exposure in infancy is associated with elevated systemic IgG4, mucosal IgA responses, and lower incidence of food allergy
Infants from a traditional farming community exhibited antibody profiles that were found to be associated with lower incidence of egg allergy.
https://scim.ag/48rPBGS
0
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We enjoyed discussing in
@allergy-eaaci.bsky.social
the findings by Cembellin-Prieto et al. (
@johnshopkinsmmi.bsky.social
) published in
@natimmunol.nature.com
, who identified a regulatory
#mechanism
mediated by
#Bcell-derived
#acetylcholine
during
#influenza
#infection
.
doi.org/10.1111/all....
about 2 months ago
0
3
1
reposted by
Type 2 Immunity & Allergy Lab
Clinical and Experimetal Allergy - Prof Shamji and Dr Boyle
3 months ago
CompITO study compares rush vs. conventional oral immunotherapy for milk and egg allergy managementāfind out more!
#FoodAllergy
#Immunotherapy
#CompITO
doi.org/10.1111/cea....
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Comparison Between a Rush and a Conventional Oral Immunotherapy Protocol to Treat Cow's Milk and Hen's Egg Allergy. CompITO Study Methodology
Click on the article title to read more.
https://doi.org/10.1111/cea.70168
0
1
1
reposted by
Type 2 Immunity & Allergy Lab
Oded Rechavi
3 months ago
āThe bad review will come from your list of suggested reviewersā
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227
40
reposted by
Type 2 Immunity & Allergy Lab
Waggoner Lab
3 months ago
Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
0
12
4
reposted by
Type 2 Immunity & Allergy Lab
Nature
3 months ago
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research
go.nature.com/4hriohE
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What makes PhD students happy? Good supervision
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.
https://go.nature.com/4hriohE
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We
#run
for
#science
& type 2
#immunity
in
#Madrid
!
#YoCorroPorLaCiencia
@csic.es
3 months ago
0
1
0
reposted by
Type 2 Immunity & Allergy Lab
Waggoner Lab
4 months ago
Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
0
1
2
reposted by
Type 2 Immunity & Allergy Lab
Society for Mucosal Immunology
4 months ago
SMI Member Eduardo Villablanca and colleagues review B cells in inflammatory bowel disease at Immunology Letters:
www.sciencedirect.com/science/arti...
#SMIMemberPaper
#MucosalImmunology
#Immunology
0
6
4
reposted by
Type 2 Immunity & Allergy Lab
4 months ago
Iām excited to share a perspective that an incredible group of experts in the B cell field worked on over the past 2 years. The thoughtful conversations resulted in what we hope will be a helpful framework moving forward. An open access link is available below:
urldefense.com/v3/__https:/...
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https://urldefense.com/v3/__https://kwnsfk27.r.eu-west-1.awstrack.me/L0/https:*2F*2Fauthors.elsevier.com*2Fa*2F1lpaC_OR*257EyinEI/1/0102019971f12645-140befdf-ab0c-4f3e-9774-977e6c5649b6-000000/zcNfHqjLgNK41hUhOoV_RyDY-vk=444__;JSUlJSU!!Dq0X2DkFhyF93HkjWTBQKhk!SRgv0ALewYENetxcj_xGSMPdOswQjD7dwvYDX-grgZuQOgarf6Q_h26DTDRlVqVOuEWqKnhLER-eq_nmfc34Bi8Fs_-QV7cUkX0$
0
1
1
Celia & Elisa participated at
#SICAM
at
isciiisalud.bsky.social
. Contrats to Elisa for winning the Best Oral Talk Award (sponsored by Inmunotek) on
#Microbial
#metabolism
of food
#allergens
drives
#IgE-mediated
#anaphylaxis
. A collaboration with the Caminero Lab at
@mcmasteruniversity.bsky.social
4 months ago
1
3
0
reposted by
Type 2 Immunity & Allergy Lab
Science Magazine
5 months ago
"The day the paper was published should have been a moment of pride. Instead, it felt like a quiet erasure."
#ScienceWorkingLife
https://scim.ag/4p3eH5g
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24
reposted by
Type 2 Immunity & Allergy Lab
Center for Immunology-UMN
5 months ago
With deep gratitude, we thank Dr. Marc Jenkins for his decades of leadership, mentorship, and dedication to the Center for Immunology. The foundation he built will guide and inspire us for years to come.
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16
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reposted by
Type 2 Immunity & Allergy Lab
EFIS_Immunology
5 months ago
šCongratulations to Prof. Klaus Rajewsky on receiving the first ever
#EFIS
Lifetime Achievement Award which recognizes not only his groundbreaking science but also his mentorship of countless young researchers worldwide. We honor his vision, brilliance + generosity.Thank you for inspiring us all.
1
6
3
In Seminars in
#Immunology
, we comment how
#microbes
may be central to the developmemt and progression of
#food
#allergy
and
#celiac
disease, and their therapeutic implications.
doi.org/10.1016/j.sm...
6 months ago
1
3
1
reposted by
Type 2 Immunity & Allergy Lab
Waggoner Lab
6 months ago
Cysteinyl leukotrienes are important drivers of the anaphylactic response to ingested food antigens
@science.org
Comment:
www.science.org/doi/10.1126/...
on
@rmedzhitov.bsky.social
@stephanieeisen.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
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Opening the gateway to food-induced anaphylaxis
Cysteinyl leukotrienes are important drivers of the anaphylactic response to ingested food antigens
https://www.science.org/doi/10.1126/science.adz6439
0
10
4
reposted by
Type 2 Immunity & Allergy Lab
King Lab at McGill University
7 months ago
Thanks to Pāng Loke and Oyebola Oyesola for highlighting our recent article on immune-stromal interactions in
@cp-trendsparasitol.bsky.social
!! IFNg does it all!!
www.cell.com/trends/paras...
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Is IFN-γ good or bad for the host during helminth infections?
IFN-γ function during a type-2 helminth infection remains enigmatic. Westfall et al. found an unexpected role for IFN-γ in limiting tissue damage during intestinal infection by Heligmosomoides polygyr...
https://www.cell.com/trends/parasitology/abstract/S1471-4922(25)00140-0?dgcid=raven_jbs_etoc_email
0
10
1
reposted by
Type 2 Immunity & Allergy Lab
Preprint Club - Immunology
7 months ago
Take a look at our feedback šš
www.preprintclub.com/preprint-rev...
add a skeleton here at some point
0
2
1
reposted by
Type 2 Immunity & Allergy Lab
Victor de Lorenzo (CNB, Madrid)
8 months ago
Predatory practicesājournals, meetings etcāare spoiling the research landscape and erasing trust in science. But what can be done? Here Timmis et al inspect the phenomenon & propose a few measures to contain and even revert the damage
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
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Journals Operating Predatory Practices Are Systematically Eroding the Science Ethos: A Gate and Code Strategy to Minimise Their Operating Space and Restore Research Best Practice
Scientific research seeks to extend knowledge and understanding, an activity that perhaps more than any other advances society and humanity. In essence, it is the search for truth. But, because it se....
https://enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/1751-7915.70180
1
5
5
reposted by
Type 2 Immunity & Allergy Lab
Immunity
10 months ago
Online now: Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract
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Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract
IgE-expressing B cells fail to form memory B cells (MBCs). Nelson etĀ al. show that inhaled allergen induces the formation of lung-resident MBCs with IgG1+ MBCs class switching to IgE driven by interleukin-4 from lung Th2 cells. Upon rechallenge, these lung-resident lymphocytes generate IgE in the airway independent of IgE in the circulation.
http://dlvr.it/TJlWyX
0
5
2
reposted by
Type 2 Immunity & Allergy Lab
Preprint Club - Immunology
10 months ago
Today
#preprinthub2ās
@alisaiakupova.bsky.social
will lead a discussion of this
#preprint
š„šš¦
add a skeleton here at some point
0
5
2
reposted by
Type 2 Immunity & Allergy Lab
Sarah Ross
11 months ago
ICYMI by First release - now in print
@science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By
@cicacanesso.bsky.social
@danmucida.bsky.social
@victora.bsky.social
et al
2
59
18
Our article "Allergic
#inflammation
triggers
#dyslipidemia
via IgG signalling" published in Allergy received the award for "Best Scientific Publication of Young Researchers 2024" at the Princess Hospital Excellent Awards".
doi.org/10.1111/all....
11 months ago
0
2
0
In this
@biorxivpreprint.bsky.social
@biorxiv-immuno.bsky.social
, we show that
#oral
#bacteria
can break down
#food
#allergens
, potentially affecting their systemic absorption,
#IgE
recognition, and allergic reactionsāincluding
#anaphylaxis
.
www.biorxiv.org/content/10.1...
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https://www.biorxiv.org/content/10.1101/2025.02.17.638013v1
12 months ago
0
1
2
reposted by
Type 2 Immunity & Allergy Lab
bioRxivpreprint
12 months ago
Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis
https://www.biorxiv.org/content/10.1101/2025.02.17.638013v1
0
2
1
reposted by
Type 2 Immunity & Allergy Lab
bioRxiv Immunology
12 months ago
Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis
https://www.biorxiv.org/content/10.1101/2025.02.17.638013v1
0
8
4
reposted by
Type 2 Immunity & Allergy Lab
Clinical and Experimetal Allergy - Prof Shamji and Dr Boyle
about 1 year ago
Anaphylaxis: Spotlight on Inflammation - Editorial in Clinical & Experimental Allergy (Jan 2025 Issue) ā By Emilio NuƱez, Mattia Giovannini
et.al
.
doi.org/10.1111/cea....
0
2
1
reposted by
Type 2 Immunity & Allergy Lab
Waggoner Lab
about 1 year ago
Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow
@cp-immunity.bsky.social
@sancholab.bsky.social
www.cell.com/immunity/ful...
0
6
2
reposted by
Type 2 Immunity & Allergy Lab
bioRxiv Immunology
about 1 year ago
Diacylglycerol kinase zeta dictates CD40-mediated immune synapse formation, mTORC1 signaling and plasma cell fate in B lymphocytes
https://www.biorxiv.org/content/10.1101/2025.01.11.632541v1
0
2
2
In this new study, published in Allergy, we show that
#IgE
can form without first switching through
#IgG1
. The IgG1 step had minimal impact on allergic response or long-term memory.
#Immunology
#Allergy
#Therapeutics
#Anaphylaxis
š Full article:
doi.org/10.1111/all....
about 1 year ago
0
2
0
reposted by
Type 2 Immunity & Allergy Lab
Vienna Airway Lab
about 1 year ago
Using a food allergy model in mice incapable of class switch recombination to IgG1, the Jordana-Waserman Lab showed that sequential class switching is redundant for the production of anaphylactic IgE and allergic recall responses.
onlinelibrary.wiley.com/doi/10.1111/...
#immunology
#Immunosky
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Allergic Reactivity and Memory Occur Independently of Sequential Switching Through IgG1
Sequential switching through IgG1 is not required to produce IgE with sufficient allergen-binding affinity to cause anaphylaxis against food allergens. Sequential switching through IgG1 does not conf....
https://onlinelibrary.wiley.com/doi/10.1111/all.16460
0
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1
The role of
#inflammation
has been underlined as central in several atopic
#diseases
, but, surprisingly, not in
#anaphylaxis
.
doi.org/10.1111/cea....
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Anaphylaxis: Spotlight on Inflammation
Click on the article title to read more.
https://doi.org/10.1111/cea.14610
about 1 year ago
0
1
0
reposted by
Type 2 Immunity & Allergy Lab
David Sancho
about 1 year ago
What is the effect of increased bacterial dissemination in distant organs? Check our
www.biorxiv.org/content/10.1...
1 Gut barrier disruption induces trained immunity in bone marrow progenitors 2 Enterococcus faecalis translocates to the bone marrow inducing trained immunity
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Translocation of gut Enterococcus faecalis trains myeloid bone marrow progenitors via the C-type lectin receptor Mincle
Impairment of the intestinal barrier allows the systemic translocation of commensal bacteria, inducing a pro-inflammatory state in the host. To address potential mechanisms underlying this link, we ex...
https://www.biorxiv.org/content/10.1101/2024.11.07.622236v1
1
3
3
reposted by
Type 2 Immunity & Allergy Lab
Andrew S. MacDonald
about 1 year ago
Fascinating new paper about how commensal
#fungi
can promote
#type2
responses in mice, a process involving fungal induction of
#IL-33
š š§Ŗ
#ImmunoSky
www.nature.com/articles/s41...
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Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature
Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.
https://www.nature.com/articles/s41586-024-08213-2
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reposted by
Type 2 Immunity & Allergy Lab
Cecilia Berin
about 1 year ago
Happy to share our latest paper on T follicular helper cell profiles that distinguish milk allergy from eosinophilic esophagitis
1
8
2
Congratulations to Dr. Emilio NuƱez-Borque on delivering an invited talk at
#SEAIC2024
about
#extracellular
#vesicles
and
#microRNAs
in
#anaphylaxis
!
about 1 year ago
0
1
0
reposted by
Type 2 Immunity & Allergy Lab
Arthur Mortha
about 1 year ago
Very excited to share the most recent work from
#theonlylabever
out in
@jexpmed.bsky.social
We show that a gut protozoan commensal acts as a natural adjuvant for IgA against oral and bacterial antigens to strengthen homeostasis. Hope you will find this interesting:
doi.org/10.1084/jem....
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The protozoan commensal Tritrichomonas musculis is a natural adjuvant for mucosal IgA | Journal of Experimental Medicine | Rockefeller University Press
The gut commensal protist Tritrichomonas musculis (T.mu) boosts T cellādependent IgA. T.mu-driven IgA modifies the commensal bacterial microbiota and impro
https://doi.org/10.1084/jem.20221727
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