Microbes that chew allergens mitigate anaphylaxis Preview of work demonstrating that oral & small intestinal bacteria can modulate IgE-mediated anaphylaxis through metabolic degradation of immunodominant peanut allergens. www.cell.com/cell-host-mi...

Microbes impact peanut allergy Mouth & gut contain peanut-degrading bacteria(Rothia) that metabolize PN allergens. Mice colonized w/Rothia show decreased anaphylaxis & allergic patients w/better PN tolerance have higher abundance of these bacteria www.cell.com/cell-host-mi...

Our April issue is now live! On the cover: Peanut allergy & microbes Bacteria in the oral cavity & small intestine can degrade immunodominant peanut allergens, limiting anaphylaxis www.cell.com/cell-host-mi...

New online! Bacterial allies against food anaphylaxis

Un recuerdo hoy (y todos los días) para todas las mujeres investigadoras, en el #DiaInternacionalDeLaMujer #8M seguimos implicados todos/as para conseguir la tan deseada igualdad entre hombres y mujeres lo antes posible. Ya vamos tarde. 💜 @cnb-csic.bsky.social @sebbm.bsky.social @csic.es @uam.es

#Peanut-processing #microbes ward off dangerous #allergic #shock www.nature.com/articles/d41...

IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and inhibitory CD300 family members @cp-cellreports.bsky.social www.cell.com/cell-reports...

The microbes that live in our mouth and gut may influence whether an allergic reaction to peanuts is mild or life-threatening, and could be harnessed to ward off a severe attack

Microbiota impact peanut allergy Saliva & jejunum harbor peanut-degrading bacteria(Rothia) that metabolize immunodominant PN allergens. Mice colonized w/Rothia show ⬇️anaphylaxis & allergic patients w/better PN tolerance have ⬆️abundance of these bacteria www.cell.com/cell-host-mi...

Delighted to share our new #preprint on #mastcell desensitization on @biorxiv-immuno.bsky.social We show that #mastcell #desensitization involves #IgE internalization and induces distinct #immunoregulatory #transcriptional program linked to #immune regulation. www.biorxiv.org/content/10.6...

Mast cell desensitization induces a distinct IgE-dependent transcriptional program associated with immune regulation https://www.biorxiv.org/content/10.64898/2026.02.28.708745v1

Muy agradecidos a El Mundo por divulgar nuestro trabajo en @cp-cellhostmicrobe.bsky.social donde demostramos que #bacterias orales degradan #alérgenos alimentarios, modulando respuestas #IgE y #anafilaxia. www.elmundo.es/ciencia-y-sa...

La saliva, clave contra la alergia al cacahuete, según el hospital La Princesa y la Universidad de Canadá: okdiario.com/salud/saliva...

Human oral microbes degrade peanut allergens, thereby reducing IgE recognition, systemic availability, mast cell activation, and anaphylaxis @cp-cellhostmicrobe.bsky.social www.cell.com/cell-host-mi...

Las bacterias de la saliva pueden ayudar a reducir las reacciones alérgicas al cacahuete: www.agenciasinc.es/Noticias/Las...

The microbes that live in our mouth and gut may influence whether an allergic reaction to peanuts is mild or life-threatening, and could be harnessed to ward off a severe attack

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes @cp-immunity.bsky.social www.cell.com/immunity/ful... @rockefeller.edu

🧵 1/6 Vaccinating allergic patients carries risks: the patient’s IgE recognizes allergen extracts and can trigger severe adverse reactions. To address this, Dr. Roy Patterson (1970s) proposed an innovative approach: modifying the extracts by polymerizing them with glutaraldehyde.

Today at #PreprintHub2, Elisa Sánchez from Universidad Autónoma de Madrid will present the preprint by @alexaweingarden.bsky.social, “Gut microbial composition modulates food-specific CD4+ T cells in food allergy” from the Marc K. Jenkins lab 🥜🤒❌ www.biorxiv.org/content/10.1...

@biorxivpreprint.bsky.social A single-cell atlas of intestinal immune cells across the day-night cycle reveals dynamic populations www.biorxiv.org/content/10.6... @jkpfeiff.bsky.social @utswim.bsky.social @lhooperlab.bsky.social

Review @natrevimmunol.nature.com How crosstalk at the immune synapse shapes T cell and dendritic cell biologys www.nature.com/articles/s41...

New tech adventure: co-founded Newton Biotwins together with @mirobueno.bsky.social. We're building #DigitalTwins for the lab — starting with a flow cytometry twin. Turning #biology into an information science! newtonbiotwins.com/en/home_en/

Preprint out! By controlling growth, via RNAP, we control the entire cellular machinery, and tune the cellular context into distinct, stable states. See how NOT gates behave! Kudos to @angeles-hg.bsky.social and @mirobueno.bsky.social 🔗https://www.biorxiv.org/content/10.64898/2025.12.19.695408v1

Grateful for the invitation to present at the 3rd Research Day of the METRI²A Group at @idibaps.bsky.social. A pleasure to discuss how #microbial metabolism of allergens impacts #allergicinflammation and #anaphylaxis.

Researchers in #ScienceTranslationalMedicine find a distinct #Bcell and antibody profile in infants and mothers in an Older Order Mennonite farming community, associated with lower incidence of egg #allergy. https://scim.ag/48rPBGS

We enjoyed discussing in @allergy-eaaci.bsky.social the findings by Cembellin-Prieto et al. (@johnshopkinsmmi.bsky.social) published in @natimmunol.nature.com, who identified a regulatory #mechanism mediated by #Bcell-derived #acetylcholine during #influenza #infection. doi.org/10.1111/all....

“The bad review will come from your list of suggested reviewers”

Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells @sciimmunology.bsky.social www.science.org/doi/10.1126/...

Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research go.nature.com/4hriohE

We #run for #science & type 2 #immunity in #Madrid! #YoCorroPorLaCiencia @csic.es

Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

SMI Member Eduardo Villablanca and colleagues review B cells in inflammatory bowel disease at Immunology Letters: www.sciencedirect.com/science/arti... #SMIMemberPaper #MucosalImmunology #Immunology

I’m excited to share a perspective that an incredible group of experts in the B cell field worked on over the past 2 years. The thoughtful conversations resulted in what we hope will be a helpful framework moving forward. An open access link is available below: urldefense.com/v3/__https:/...

Celia & Elisa participated at #SICAM at isciiisalud.bsky.social. Contrats to Elisa for winning the Best Oral Talk Award (sponsored by Inmunotek) on #Microbial #metabolism of food #allergens drives #IgE-mediated #anaphylaxis. A collaboration with the Caminero Lab at @mcmasteruniversity.bsky.social

"The day the paper was published should have been a moment of pride. Instead, it felt like a quiet erasure." #ScienceWorkingLife https://scim.ag/4p3eH5g

With deep gratitude, we thank Dr. Marc Jenkins for his decades of leadership, mentorship, and dedication to the Center for Immunology. The foundation he built will guide and inspire us for years to come.

👏Congratulations to Prof. Klaus Rajewsky on receiving the first ever #EFIS Lifetime Achievement Award which recognizes not only his groundbreaking science but also his mentorship of countless young researchers worldwide. We honor his vision, brilliance + generosity.Thank you for inspiring us all.

In Seminars in #Immunology, we comment how #microbes may be central to the developmemt and progression of #food #allergy and #celiac disease, and their therapeutic implications. doi.org/10.1016/j.sm...

Cysteinyl leukotrienes are important drivers of the anaphylactic response to ingested food antigens @science.org Comment: www.science.org/doi/10.1126/... on @rmedzhitov.bsky.social @stephanieeisen.bsky.social www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

Thanks to P’ng Loke and Oyebola Oyesola for highlighting our recent article on immune-stromal interactions in @cp-trendsparasitol.bsky.social!! IFNg does it all!! www.cell.com/trends/paras...

Take a look at our feedback 👉👈 www.preprintclub.com/preprint-rev...

Predatory practices—journals, meetings etc—are spoiling the research landscape and erasing trust in science. But what can be done? Here Timmis et al inspect the phenomenon & propose a few measures to contain and even revert the damage enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...

Online now: Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract

Today #preprinthub2’s @alisaiakupova.bsky.social will lead a discussion of this #preprint 🥜🐭🦠

ICYMI by First release - now in print @science.org Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection. buff.ly/3DjNQ1e By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al

Our article "Allergic #inflammation triggers #dyslipidemia via IgG signalling" published in Allergy received the award for "Best Scientific Publication of Young Researchers 2024" at the Princess Hospital Excellent Awards". doi.org/10.1111/all....

In this @biorxivpreprint.bsky.social @biorxiv-immuno.bsky.social, we show that #oral #bacteria can break down #food #allergens, potentially affecting their systemic absorption, #IgE recognition, and allergic reactions—including #anaphylaxis. www.biorxiv.org/content/10.1...

Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis https://www.biorxiv.org/content/10.1101/2025.02.17.638013v1

Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis https://www.biorxiv.org/content/10.1101/2025.02.17.638013v1