Postdoctoral position in the team of Alessandro Barducci in the CBS, focusing on multiscale simulations of RNA-driven condensates, with applications in synthetic biology. More information : www.cbs.cnrs.fr/images/jobs/... The position is expected to start in early 2026, with some flexibility.

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...

Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control! shorturl.at/B5XYD

P-bodies , microRNAs and cell fate ! Not everything is transcription in cell fate decisions ;)

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

Which city is the best for Cytoskeleton research? Dresden? Barcelona? Cambridge ? Noooo ... you all know its Paris, right? 😎 Registering to the annual meeting on Friday 14th of November is now open: pcd2025.sciencesconf.org Keynote speeches by @carter-lab.bsky.social and Verena Ruprecht !

Big Thanks @lisaheinke.bsky.social and Nature Reviews Molecular Cell Biology @natrevmcb.nature.com for the opportunity for our students, Chems and Emma, to write a Tools of the Trade piece on our recently published ControLD technique.

Do you know what happens if you squeeze a #cell? If the #confinement is high, the nucleus (green) will be super tense & the compressed cells will react like this👇🏽changing their #cytoskeleton (magenta) Full: www.science.org/doi/10.1126/... #scicomm #microscopy #sciencesky @focalplane.bsky.social 🧪🔬

The 2025 @cnrs.fr medal are out! Bronze medals for early career researchers: congrats to Aurélie Tchoghandjian at our institute @inp-marseille.bsky.social, and to @alexandra-colin.bsky.social who was nominated by the Cell biology section 🎉

A condensate-based approach reversibly sequesters lipid droplets (LDs) in cells, temporarily halting their functions and enabling detailed study of LD biology and the interactions of LDs with other cellular structures www.nature.com/articles/s41...

What if we could trap Lipid Droplets and control their dynamics in cells? Our latest work does just that, using Engineered Condensates to manipulate LD behavior. Exciting results by Chems Amari and the team! Great collab with ‪@abdourachidthiam.bsky.social‬ #Organelles #Condensates rdcu.be/emYpU

Hiro's paper is out! @hiro-cg5445.bsky.social Collaboration and Tour de Force with Richard Wheeler @zephyris-science.bsky.social and many other coauthors. Big congratulations and thank you to anyone involved! www.nature.com/articles/s41...

Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...

Oligo-LiveFISH enables high-res, live imaging of non-repetitive DNA loci in 3D across cell types, overcoming past limitations in dynamic genome studies. PMID:40239646, Cell 2025, @Cell https://www.cell.com/cell/fulltext/S0092-8674(25)00350-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. www.cell.com/cell/fulltex....

How can a cell control the size of its organelles? Excited to share a mechanism to control droplet size we recently found. a 🧵 www.nature.com/articles/s41...

We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology. www.nature.com/articles/s41...

Which synapses get stronger when we form a memory? We developed a technique to tag recently potentiated synapses in live mice. Pulse-chase labeling with membrane-impermeable HaloLigand dyes distinguishes fresh AMPA receptors from old ones. www.nature.com/articles/s41...

Very happy to share the recent paper of Lina El Hajji in Arnaud Gautier's team on the development of a tunable chemogenetic near-infrared fluorescent reporter for imaging proteins in live cells and organisms www.nature.com/articles/s41...

Excited to share our first story on nuclear paraspeckles! Led by @sneadlab.bsky.social, this is the culmination of a ~4 year effort in collab. with @shrinivaslab.bsky.social. Can’t wait to see more paraspeckle stories from the future Snead Lab at Northwestern 🫧 www.biorxiv.org/content/10.1...

Axonal RNA localization is essential for long-term memory www.nature.com/articles/s41...

New paper out! Why do condensates prefer some surfaces and not others? Check it out here: doi.org/10.1063/5.02...

@science.org Cryo-EM reveals mechanisms of natural RNA multivalency | Science www.science.org/doi/10.1126/... #RNAsky #RNAbiology #Cryo-EM

A small but special moment: My illustration is on the cover of the March issue of Nature Methods! A huge hug to @anwaiarchit.bsky.social and @cppape.bsky.social — it was a pleasure to work alongside you on this! www.nature.com/nmeth/volume...

The SCF-ChemBio Thesis Award has been granted to Lina El Hajji (@linaelhajji.bsky.social) for her outstanding doctoral work under the supervision of Arnaud Gautier in the Laboratoire des Biomolécules (now Chimie Physique et Chimie du Vivant), Paris ! Congratulations! 👏 #ChemBio

Do not miss the exceptional #ChemBio lineup of PSL Chemical Biology Symposium 2025 in Paris, @institutcurie.bsky.social - February 27-28 - Last 2 days to register!!! #ChemBioLovers

#Cellpose 3 paper now out. Not all images are perfect. Restore your images with Cellpose3 to get better segmentations, w/ @marius10p.bsky.social www.nature.com/articles/s41...

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/... Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social

Immagine you could image two cellular structures in the same fluorescent channel and still reliably get them separated afterwards… What would you do with this? Now… what would you do if that also worked with 4 structures at once? 👇 #MicroSplit #preview🧵

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin? By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient! #chromatin #3Dgenome #generegulation www.science.org/doi/10.1126/... 👇

#OPENACCESS: Separation of sticker-spacer energetics governs the coalescence of metastable condensates. Aniruddha Chattaraj and Eugene I. Shakhnovich.

Our first paper on BlueSky!! Remarkable work published in @currentbiology.bsky.social from Jing Xie, Javad Najafi and others, on how cell shape affects mitotic spindle positioning forces in embryos, by impacting cytoplasm flows. @ijmonod.bsky.social www.sciencedirect.com/science/arti...

We’re reopening applications! A 5-year position as Data Steward/Research Engineer for the chemistry departments of @psl-univ.bsky.social is available. 💼 New deadline: February 7th. 📄 More info & application details below. 🔁 Reposts appreciated! 🙌

1/ 🚨We’re thrilled to share our latest study: "Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟 www.biorxiv.org/content/10.1... How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️

Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development. Details below 👇👇 Please Repost !!! @ijmonod.bsky.social @cnrs.bsky.social

Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology @ramlabuw.bsky.social www.science.org/doi/10.1126/...

Dear #LipidDroplet friends, we just launched the website for the next #EMBOLipidDroplets Workshop in September 2025, again at beautiful Costa Brava. Check out the amazing lineup of speakers. Abstract submission deadline is 10 June 2025. Hope to see many of you there! #organelles #LipidMetabolism

Do you want to work at the interface of molecular simulations, structural biology experiments and #AI? Come to Paris for a PhD at @pasteur.fr 1 PhD position is available in our lab funded by ERC_Research. Please repost!! #compchem #compbio Info 👇 research.pasteur.fr/b/15Hr

🫧🔍Key breakthrough in #autism: pivotal role of #CPEB4 condensates revealed. 💊The study opens new avenues for the development of targeted treatments for autism. 📰 Nature @natureportfolio.bsky.social ✍️ Carla Garcia-Cabau, Anna Bartomeu et al. ➡️ bit.ly/3BfEGlR 📌 DOI: 10.1038/s41586-024-08289-w

Cool new work from Jenn Prescher and coworkers @ucirvine.bsky.social, “RNA lantern” technology for bioluminescence imaging of RNA transcripts www.nature.com/articles/s41...

Online @cellpress.bsky.social, we reveal a protein shell that helps diatoms fix 20% of global #CO2 🧪🌊🌾🧶🧬🌍 Shimakawa et al: www.cell.com/cell/fulltex... Nam et al: www.cell.com/cell/fulltex... @biozentrum.bsky.social press release: www.biozentrum.unibas.ch/news/detail/... Read on for more... 1/🧵

📰Mechano-dependent sorbitol accumulation supports biomolecular condensate 📌Extracellular matrix stiffness links mechanical cues with the control of glucose metabolism to sorbitol & biomolecular condensates in a breast cancer cell model. www.cell.com/cell/abstrac...

Delighted to share our new paper, exciting collaboration with Racki, Park and Grotjahn Labs @scripps.edu. Reentrant DNA shells tune polyphosphate condensate size. Congrats Jenna and Ravi, Tumara, all other authors! @natureportfolio.bsky.social #Condensates #Biophysics #SoftMatterPhysics

Messages loud & clear: Chris & Alex designed destabilized MS2 and PP7 coat proteins, which are degraded in cells except when bound to their cognate RNA hairpins. We used these probes to image distinct single mRNAs simultaneously in live cells, 'background-free.' AddGene soon! tinyurl.com/27p7hyt9

Meet the CALVADOS RNA model Ikki Yasuda, Sören von Bülow & Giulio Tesei have parameterized a simple model for disordered RNA. Despite it's simplicity (no sequence, no base pairing) we find that it captures several phenomena that depend on the charge, stickiness and polymer properties of RNA 🧬🧶🧪

Mix two motors of opposite polarity with microtubules and they will partition space ! Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns. #morphogenesis doi.org/10.1073/pnas... (1/n)

www.cell.com/current-biol... Sex differences in RNA biology. #RNASky

Great article in Le Monde (in French) about @manuelthery.bsky.social recent results on microtubule/motors patterned self-organization www.lemonde.fr/sciences/art...