Horrific story of a young woman dying of cancer complications after refusing cancer care under the guidance of her influencer mother who charges £70/y for an annual membership to her site & £195 for a consultation & personalised 12-week programme. Thanks to @profstevegriffin.bsky.social for sharing

it's the 10 year anniversary of a very important study

Vibe coding www.wired.com/story/vibe-c... #coding #programming #vibecoding

There is a false dichotomy drawn between "the ivory tower" and "the real world," and I'm here to report that in a post-industrial society, your real-world economy absolutely hinges on the university. University towns are factory towns. Universities drive economic activity, not the other way around.

A lipid nanoparticle–delivered base-editing therapy was custom designed for an infant with a ureacycle disorder. The affected infant was treated at approximately 7 and 8 months of age. Read the Brief Report: nej.md/42XF03F #ASGCT2025 #MedSky @asgct.bsky.social

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

A depressing article about drug pricing for cancer patients, specifically for multiple myeloma. The good news in this case is that generic competition should be coming next year. The bad news is there will be another case jaut like this. www.propublica.org/article/revl...

1/ A long standing paradox in my mind (from always seeing immune "strength" or reactivity drawn as a spectrum from immunodeficiency to autoimmunity) was resolved this year at #AAI #Immunology2025. WHY do SO many people have both simultaneously? Each infection brings risk of developing autoimmunity!!

“The visa fees are so exceedingly high that it makes coming here very difficult for some people. We are fishing for the best scientists in the world. They want to come and work here because we are such an effective country at science, but if we have these high costs, they can and will go elsewhere.”

Great collection from one of the best paper hounds out there!

Now this is the future La Guin and Wells imagined

This is a breakthrough in multi-modal single-cell technology

*pronouncing leo XIV like arXIV*

Wow, just implemented the new Cellpose-SAM from @computingnature.bsky.social in NimbusImage and it's *awesome*! Give it a try! nimbusimage.com

NEW Preprint Watch from Annette Wu & @wenjiang-nano.bsky.social @preprintclub.bsky.social reporting on @biorxiv-immuno.bsky.social preprint by @colinraposo.bsky.social et al. showing that checkpoint blockade drives expansion of exhausted T cell clones that develop functional memory rdcu.be/ek1kY

With NIH director Jayanta Bhattacharya dismissing my reporting as "false" and "spreading rumors" hours before releasing a policy that confirmed said "rumors," I feel compelled to respond. Here's an inside look into how this story was reported. It was a weird one. 🧵 www.nature.com/articles/d41...

British scientists are “over the moon” to be back in the EU’s Horizon funding programme after a 3-year Brexit lockout. New data reveals they have been awarded about £500m in grants since re-entry. International isolationism never works well. 🧪🔬⚛️🔭 www.theguardian.com/science/2025...

Really happy to share this amazing story from my talented colleague Felipe Galvez-Cancino and many others. Really interesting work about the nature of anti-tumour immunity in the brain and how it can be modulated, in mice and humans! www.sciencedirect.com/science/arti...

Nasty work. www.vanityfair.com/news/story/m...

You call it an ifelse statement, I call it a lightweight, agentic decision module operating within a deterministic inference framework

'What’s the problem? Well, pretty much everything. These aren’t species returned from extinction.' @oxfordgeography.bsky.social's Dr Richard Grenyer argues that extinction is, for the time being, a symptom of our global economic system ⬇️

"...remember: your work is an act of resistance. Every experiment, every line of code, every collaboration defies those who would silence science." Dear US researchers: break the outrage addiction. I survived the besieging of science. So can you www.nature.com/articles/d41...

Sobering analysis by @nature.com on the Trump administration's NIH cuts. ~ 800 research projects have been terminated with research on HIV/AIDS, health disparities, transgender health, vaccines and COVID-19 being hit hardest, with some labs forced to close entirely. www.nature.com/articles/d41...

Amazing 🚀 study w/ DNA seqFISH+, enabling mapping of 100,049 genomic loci, together with the nascent transcriptome for 17,856 genes, yielding unpredented insights into subnuclear structures in single cells www.nature.com/articles/s41...

George R. R. Martin on @biorxiv-evobio.bsky.social!

What if TCRs didn’t need to see peptides to bind MHC? A newly identified human TCR docks sideways onto HLA-DQ2.5—like an antibody. This could reshape how we think about antigen recognition 🧐🧐 @niclag.bsky.social @naturecomms.bsky.social

China is beating U.S. in biotech advances, report warns www.axios.com/2025/04/08/c...

Contrary to popular belief, what is important in science is as much its spirit as its product: it is as much the openmindedness, the primacy of criticism, the submission to the unforeseen, however upsetting, as the result, however new that may be. – Francois Jacob www.nature.com/articles/s41...

🔥New Night Science paper!! Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.

Detained in an ICE camp over a customs form technicality and facing deportation to Russia where she will be persecuted for vocal opposition to the invasion of Ukraine. She does bioinformatics

www.nature.com/articles/d41... So let me get this straight 1. Academics spend decades building the PDB openly 2. A company trains AlphaFold on it, releases limited code under pressure 3. Academics work hard to create fully open versions 4. Companies then use the open models to build closed products

Allotypic differences in peptides impact KIR recognition of HLA allowing NK cells to sense infection- or transformation-induced repertoire perturbations, particularly when intrinsic KIR/HLA interactions are of modest avidity @jimmunol.bsky.social doi.org/10.1093/jimm...

Exclusive: NIH officials have advised scientists to remove reference to mRNA vaccines from their grant applications, in expectation the Trump administration intends to abandon most research in the field. By @arthurallen202.bsky.social kffhealthnews.org/news/article...

Trying a slightly new model (for us at least) of #openscience. With @ronanchaligne.bsky.social and @karolisk.bsky.social, we pitted 10x Genomics Chromium GEM-X against Illumina PIPseq V head-to-head to understand these two platforms for single-cell genomics. Some thoughts off the bleeding edge: /1

Researchers from the Crick, @dkfz.bsky.social and the German Red Cross Blood Donation Centre have found beneficial genetic changes that arise in the blood stem cells of people who regularly donate blood cells. www.crick.ac.uk/news-and-fea...

Delighted to share a major update on our work investigating age-related deceleration in clonal haematopoiesis. Takehome: Widespread and substantial deceleration in fitness with age! Amazing effort by PhD student Hamish MacGregor 💪 www.biorxiv.org/content/10.1...

One of the most fascinating papers I’ve read in a while. Every unique aspect of biology has been allowed to evolve at the discretion of a single unifying (perhaps the only true) goal - combat infection

MacKenzie Scott has donated $19 billion. The impact? 'Transformational,' new study says - USA TODAY apple.news/A9xL6UoqkRSG...

Illumina will enter the Spatial-Omics market in 2026 with Connected Multiomics (ICM) open.substack.com/pub/albertvi...

To the tune 🎶 of Murder on the Dancefloor 🕺: Chaos in the Brickyard www.science.org/doi/10.1126/... - we're so busy making bricks, we forgot to assemble them into useful edifices, and now all the loose bricks are in the way!

My experience has been that while really trying to get to the bottom of a biological question, you end up with analysis you want to do but for which no method exists yet. And this is actually a perfect method to develop - no competition!

#BREAKING - 22 states sue to block Trump administration cuts to NIH research payments

Very exciting paper for bone marrow immunology fans that resolves some really fundamental Qs about myeloma immunology and has really exciting clinical implications

#ScienceSaturday 🧵 🧬 Personalized cancer vaccines (PCV) train the immune system to recognize mutations unique to a patient's tumor, helping the body mount a targeted immune response. ❓ Can this approach help prevent renal cell carcinoma (RCC) from returning after surgery?

This will kill science in the US. This is how China wins. Why is this not on the news? Why are people not more upset about this? grants.nih.gov/grants/guide...

A personalized cancer vaccine to prevent the return of high-risk kidney cancer @nature.com @braunmdphd.bsky.social @drchoueiri.bsky.social www.nature.com/articles/d41... www.nature.com/articles/s41...

For my own ongoing education and my improved mentoring of students during paper writing - can someone please tell me what use this sort of figure is? I would love a description of how you use it to understand immunology better: www.nature.com/articles/s41...