Such a beautiful example of monogenic IEIs uncovering incredible immunological processes. A subset of NLRP3 variants reported in CAPS cohorts weaken CRY binding and are associated with altered time-of-day patterns of inflammasome activation and MCC950 responsiveness!!

While it suggests ways to treat autoimmune diseases, this mechanism may be relevant to the autoinflammatory end of the spectrum—and the immunological continuum in between. Think: diseases where ongoing durable cytokine signaling lowers “flare” thresholds across pathways. 1/2

Timing of Glucocorticoid Treatment Dictates Glucocorticoid Receptor Actions Modulating the NLRP3‐Inflammasome Activation in Macrophages pmc.ncbi.nlm.nih.gov/articles/PMC...

Expanding the scope of human immunology in the JHI. In this Editorial, @petterbrodin.bsky.social, @macattacklab.bsky.social, @casanovalab.bsky.social, alongside JHI's Associate, Consulting, as well as Society Editors, outline a broader scope for the journal. rupress.org/jhi/article/...

A fascinating report, unifying MIS-C and MIS-A: Shared TCR Vβ21.3+ T cell immunological signature between MIS-A and MIS-C url: rupress.org/jhi/article/...

T follicular helper cells adopt alter egos and localize to diverse niches - what gene expression programs distinguish Tfh in the germinal center? After dissociating tissue samples into single-cell suspension, can we infer which Tfh were positioned in GCs? Check out our new preprint! bit.ly/3XVsrCI

—Long-Term Outcomes of COVID-19 Multisystem Inflammatory Syndrome in Children (MIS-C): A 4.5-Year Observational Study — MIS-C survivors face markedly elevated long-term multisystem risks, challenging the notion of full recovery #LongCovidKids

Avian coronavirus IBV-induced activation of the NLRP3–Caspase-1–IL-1β axis in renal collecting ducts contributes to nephropathogenesis journals.asm.org/doi/10.1128/...

A patient with recessive TBK1 deficiency and lethal viral disease: Recurrent severe viral infection in a child with inherited complete TBK1 deficiency url: rupress.org/jhi/article/...

#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇

Human genetic errors of immunity illuminate an adaptive arsenal model of rapid defenses www.cell.com/trends/immun...

Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Nirmatrelvir/ritonavir use reduces risk for long COVID in patients with immunodeficiency url: rupress.org/jhi/article/...

This paper strongly echoes the framework I have been developing and publicly advocating for over the last five years. #MISC #KD #LongCovidKids

Multisystem inflammatory syndrome in children is a SARS-CoV-2 triggered Kawasaki disease www.nature.com/articles/s41...

Gut microbiota alterations are linked to COVID-19 severity in North African and European populations www.nature.com/articles/s41...

NLRP3 as a protein thermosensor !

Common mechanisms across MIS-C, KD & IBD → the gut as a central driver Great perspective from @sanchoshimizu.bsky.social — Unravelling γδ T-cell dysregulation in the gut and its implications for immune-mediated diseases journals.biologists.com/dmm/article/...

Notably, WTA is not a PAMP. Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there? @jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social

An RGD motif on SARS-CoV-2 Spike induces TGF-β signaling and downregulates interferon | Journal of Virology From spike to suppression: the RGD motif fuels TGF-β and disables antiviral immunity #PASC #LONGCOVID journals.asm.org/doi/10.1128/...

How interactions between oxidized DNA and the NLRP3 inflammasome fuel inflammatory disease | Review www.sciencedirect.com/science/arti...

Auto-inflammation isn’t confined to rare syndromes. It can also be innate immune hypersensitivity / dysfunction expressed across a spectrum — from monogenic diseases like CAPS, through post-infectious syndromes like MIS-C and KD, to chronic conditions like ME/CFS and Long Covid.

www.publichealth.columbia.edu/news/overact... www.nature.com/articles/s44...

Very exciting to see a new NLRP3 inhibitor enter the clinic! Great work from BioAge Labs www.globenewswire.com/news-release...

Latest by us! An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | Science Translational Medicine www.science.org/doi/10.1126/...

Adding to the conversation—in the same spirit, I think this recent paper is important: 🔗 www.sciencedirect.com/science/arti...

#GlycoPower! @vijayrathinam.bsky.social @raflynn5.bsky.social @vinnieviruses.bsky.social &co show @nature.com that N-glycosylation of host small-RNAs present at cell surface prevents immune recognition by TLR3 and TLR7 upon apoptotic cells uptake avoiding autoinflammation!

Ethical and equitable considerations when establishing a diagnosis of an inborn error of immunity url: rupress.org/jhi/article/...

Longitudinal Analysis of Somatic Mosaicism and Clonal Hematopoiesis in Cryopyrin-Associated Periodic Syndrome acrjournals.onlinelibrary.wiley.com/doi/epdf/10....

Our MISC clinical trial results, just published! “Clinical Trial Finds Safe, Effective Treatment for Children with Severe Post-COVID Syndrome” massgeneralbrigham.org/en/about/newsr…#COVIDID @ScienceTM @biotium.bsky.social

Tobin and @macattacklab.bsky.social review #InbornErrorsOfImmunity that can present with rheumatologic and #autoimmune complications and the role of genetic testing for establishing a molecular diagnosis & devising personalized treatment plans to improve patient outcomes. rupress.org/jhi/article/...

Now online! Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment

pDCs drive immunopathology by sensing oxidized mitochondrial DNA and NLRP3 inflammasome activation Preview @natimmunol.nature.com www.nature.com/articles/s41... www.nature.com/articles/s41...

Science backs up the use of wastewater monitoring as a harbinger of disease. Hopefully, will lead to renewed investment in wastewater monitoring

Genome-wide association study of myocarditis and pericarditis following COVID-19 vaccination www.nature.com/articles/s41...

We love to know how our favorite immune pathway gets activated; here we simply ask how does it get inactivated - and if so is Casp1 regulating its own deactivation? Curious to see the answer; check out our preprint of a multidisciplinary and collaborative approach to untackle Casp1 activity in vivo!

Great work by the @inflammasomelab.bsky.social @s-burgener.bsky.social and colleagues showing in vivo the importance of caspase-1 inactivation in controlling inflammation! Impressive amount of work behind it, glad to see this out! www.biorxiv.org/content/10.1...

Advancing multidisciplinary management of pediatric hyperinflammatory disorders www.frontiersin.org/journals/ped...

Open access, peer reviewed, and co-owned, @jhumimmunity.org from @rupress.org represents a new business model in scientific publishing. Rockefeller's Jean-Laurent Casanova is the founding editor-in-chief.

Our new collection on Genes and Immunity highlights recent advances in the field of human inborn errors of immunity, incl. immune dysregulations w/ genetic bases leading to #autoimmunity, #inflammation, and increased susceptibility to infections 👉 rupress.org/jem/collecti... #HKS2025

The possibility exists that prolonged TLR hyporesponsiveness is one of the mechanisms driving long COVID, highlighting the need to monitor long-term consequences of MIS-C. #MISC #LongCOVID #Pediatrics

Multisystem Inflammatory Syndrome in Children—Emerging Insights From Large Datasets Invited Commentary jamanetwork.com/journals/jam...

Phenotypic Classification of Multisystem Inflammatory Syndrome in Children Using Latent Class Analysis Cases reported to the CDC— clustered into 3 groups w distinct symptoms and severity, highlighting the importance of recognizing the varied presentation of MIS-C jamanetwork.com/journals/jam...

stay tuned for this piece soon out on ERJ on very imp topic, hoping to wake up politics & funding agencies about the urgent need of facilitating pedi #longcovid trials w @putrinolab.bsky.social @binitakane.bsky.social @sammiemc.bsky.social @laelyonker.bsky.social @resiapretorius.bsky.social

I’m excited to be invited to attend and participate in CARRA’s Annual Scientific Meeting to share my family’s journey and discuss the challenges of understanding young developing immune systems and immune dysregulation. #CARRA2025 #parentadvocate #caregiver #researcher

Thank you for the spotlight. 🙏🏼Monoallelic expression in human immune cells: linking genotype to phenotype: Trends in Immunology www.cell.com/trends/immun...