#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

Now that I am no longer dealing with an infant with an infection (non-staphylococcal), time for a proper 🧵! If you’re interested in some combination of Staphylococcus aureus, innate immune sensing of bacteria, inflammasomes, and cell wall modifications, read on…

Notably, WTA is not a PAMP. Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there? @jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social

Thrilled to share my work from the @jkagan1.bsky.social lab! TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection! www.biorxiv.org/content/10.1... #microsky #immunosky

SAVE THE DATE ‼️ 📆 📢 BBM 2025 will be held on June 9-10th at the Harvard Science Center feat. the one and only Dr. Petra Levin as keynote! We can't wait to see you there. Registration and scholarship applications open next week.

So excited to have our new paper out now! Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. t.co/XgU6jt15aF 1/3 #innate_immunity #immunoSky #celldeath #ExtracellularVesicles @uconnresearch.bsky.social

I just made a first release of TNA - new tool to compare 2 bacterial genomes. Is shamelessly inspired by ACT, but should be simpler to use. Drag-n-drop two genomes: it runs BLAST for you and then you can visualize. For Mac, Windows 11, Linux tna.readthedocs.io

Wow—one of the most impressive bench-to-bedside stories you’re ever going to see out today @Nature Spatial proteomics of potentially fatal toxic epidermal necrolysis/Stevens-Johnson Syndrome drug reactions identifies JAK/STAT pathway inhibition as effective therapy! www.nature.com/articles/s41...

Publication Alert! Happy to share our new work published in CellReports of a collaboration with the Zychlinsky Lab (Max Planck Institute for Infection Biology). "Histone H1 kills MRSA". cell.com/cell-reports.... Enjoy!

Excited to share our review in @cellchembiol.bsky.social on inflammasome responses to bacteria! @jkagannotonbluesky and I discuss the mechanisms by which immune receptors and guard proteins trigger inflammasomes in response to bacteria - and bacterial strategies to evade these immune responses!