'Electron microscopy and electrical conduction analyses reveal that cancer cells degrade the nerve fibre myelin sheets. The injured neurons respond by autonomously initiating IL-6- and type I interferon-mediated inflammation to promote nerve healing and regeneration' www.nature.com/articles/s41...

We are so proud of Bella for all she accomplished this summer! Her curiosity, hard work, and enthusiasm made a real impact. A huge thank you to Nikhita for her thoughtful and dedicated mentorship- she created a positive and supportive learning experience.

Machine Learning of Serum Cytokine and Chemokine Profiles Can Classify Inflammatory Bowel Disease Beyond Clinical Diagnosis from SMI member Tadakazu Hisamatsu. www.sciencedirect.com/science/arti... #SMIMemberPaper

Review @cellcellpress.bsky.social @danielboehmer.bsky.social @lozanzi.bsky.social Interferons in health and disease www.cell.com/cell/fulltex...

I am beyond excited and incredibly proud to share that our work is now out in @nature.com This discovery was made possible thanks to the first author Kostas kelepouras, my fantastic lab , and the unique research environment here in Cologne in collaboration with the Hospital bambino Gesu in Rome.

Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators. @cp-immunity.bsky.social @kavithascranton.bsky.social @hotchkissbrain.bsky.social @ucalgary.bsky.social @ucalgarymed.bsky.social @libininstitute.bsky.social www.cell.com/immunity/abs...

70+ years of iron infusions—safe enough for pregnant women—and we still don’t fully know how they work. What goes into making a safe, effective formula? As always: macrophages are key! I got to be a small part of this fascinating story—link below: link.springer.com/article/10.1...

New perspectives on our work in CAR-T outcomes for ALL! Is it the fire (inflammation) or the forest (bone marrow health) that shapes patient responses? Read the commentary in Transplantation and Cellular Therapy:https://www.astctjournal.org/article/S2666-6367%2825%2901304-1/fulltext

It’s Fri-yay! A great day for science. So lucky to get to work with an amazing team!

1/ 🚨 Hot off the press in Nature Immunology: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. Hepatitis B virus (HBV) infection is just the proving ground—this is a paradigm shift in tissue immunity. www.nature.com/articles/s41... 🧵(1/11)

TRIF-mediated HIF-1α regulation exacerbates inflammasome activation under hypoxia in response to periodontitis-related bacterial infections, contributing to the progression of autoimmune diseases www.nature.com/articles/s41...

Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...

I am so excited to share this paper! We often focus on the cancer itself, but what about the immune system—especially during immunotherapy? We asked: can the state of the immune system explain who gets toxicity and who fails CD19 CAR T therapy in ALL? 📄 doi.org/10.1016/j.jt... 🧵

"Modeling the #HLH immune synapse uncovers critical roles for IS termination, cytokine intensity, and target cell death" We're pretty excited about this one. doi.org/10.1182/bloo...

⁦‪#InterferonPower! Hongbo Chi‬⁩ &co @stjude.bsky.social @stjuderesearch.bsky.social show ⁦‪@nature.com‬⁩ that VDAC2 deficiency facilitates tumor destruction by T cell-driven IFNgamma by causing mitochondrial (mt) damage & mtDNA sensing by cGAS–STING, which drives type I IFNs & tumor death!

Reading to kids about science today! Science matters. In the words of Ada Twist: “I’m a scientist and scientists never give up!”

🎓 The 10th Immunoschool course starts TWO WEEKS TODAY!!! 🎓 To hear the history of cytokine blockers, CAR-T cells and checkpoint inhibitors from the immunologists that developed them, including Marc Feldmann, Michael Sadelain, Rafi Ahmed, Miriam Merad & more, register for FREE here: immunoschool.org

Inhibition of NLRP1 Inflammasome Activation by Tyrosine Kinase Inhibitors Restores Erythropoiesis in Diamond-Blackfan Anemia Syndrome https://www.biorxiv.org/content/10.1101/2025.02.20.639294v1

Better sleep quality could reduce inflammation and improve health outcomes in obesity doi.org/10.1093/jimm... @jimmunol.bsky.social

Today, send a note to your NIH program officers to thank them for the amazing work they have done to support your research. They have been critical in making this country a leader in life sciences. Do it now.

A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis. rdcu.be/d9iRG

Exploring NLRP3-related phenotypic fingerprints in human macrophages using Cell Painting assay www.cell.com/iscience/ful...

Instead of refreshing eRA commons to see if I got a grant, I can refresh eRA commons to see if grants still exist

New: Lee et al. @harvardmed.bsky.social provide a compendium of early transcriptional responses to major inflammatory #cytokines across all major immunocyte lineages of the mouse, highlighting unappreciated relationships btwn these cytokines and with other cytokine families https://buff.ly/4gn71Fg

🧬New research published today in Cell shows how children’s immune systems react to different kinds of cancer depending on their age. This work has the potential to lead to new tailored treatments. @petterbrodin.bsky.social @imperialmed.bsky.social

Viewing windows at work are awesome! We get to see weekend dad media changes! #scienceparents

More nice research from Annie Curtis’ lab on the circadian rhythm and the #immunometabolism of macrophages. #immunosky #mitochondria #inflammasome Time‐of‐day control of mitochondria regulates NLRP3 inflammasome activation in macrophages faseb.onlinelibrary.wiley.com/doi/10.1096/...

Microglial NLRP3-gasdermin D activation impairs blood-brain barrier integrity through IL-1β-independent neutrophil chemotaxis upon peripheral inflammation in mice www.nature.com/articles/s41...

I had the privilege of participating in this program, and it was an amazing experience! There's just one week left to apply for the @immunologyaai.bsky.social Public Policy Fellows Program. Reach out if you want more information or need help with recommendations: www.aai.org/Public-Affai...

SCORPIO, a machine learning system using routine blood tests, successfully predicts cancer patients' responses to immunotherapy. by Yoo SK, Fitzgerald CW (...) Chowell D et 34 al. in Nat Med #MedSky 📖 read the article:

Congratulations @nickvitanza.bsky.social and team! This is incredible.

Happy New Year! Excited about our new study on a timed epigenetic switch controlling T cell and ILC lineage decisions in the thymus! In a nutshell: timing is everything. The study was led by the fantastic @nickpease.bsky.social. A thread: (1/n) doi.org/10.1242/dev....

In two replicate trials, depemokimab, an ultra-long-acting anti–interleukin-5 biologic therapy, reduced exacerbations in patients who had severe asthma with an eosinophilic phenotype @NEJM www.nejm.org/doi/full/10....

I’m excited to be a co-organizer this year for the SITC Winter School, where we focus on the core principles of #TumorImmunology & #CancerImmunotherapy. We’ll also be discussing advancements in drug development, biomarkers, & clinical trials. More info here: go.sitcancer.org/3XOCoBh Please join us!

Fascinating to see mutations in type I IFN receptor can differentially affect the activity of IFNa and IFNb. The susceptibility of this genotype to viral infections displays the relative importance of these type I IFN cytokines to host defence. V cool #immunosky #IDSky @jexpmed.bsky.social

"CBC indices in healthy adults fluctuate narrowly around setpoints, and ... setpoints are stable for decades and vary significantly among healthy adults....and they provide patient-specific context that may enhance accurate interpretation ...of ...tests" www.nature.com/articles/s41...

I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪

Interested in discovering novel therapeutics that benefit children? Seattle Children's, UW, Fred Hutch, and Benaroya Research Institute offer postdocs starting at $80K. Please spread the word! #academicsky #blacksky

Happy to share our latest preprint from 1st author & PhD student @vvazquez.bsky.social examining how GM-CSF potentiates cytokine responses in human monocytes during bacterial infection! Congrats to Victor, his undergrad mentees Allyson Lu & Madison Dresler, & postdoc @mikelhaggadone.bsky.social! 🧪

If you cant be at ASH to see Seattle Children’s and Children’s Oncology Group own Rachel Rau it’s worth checking out the paper! Out today in the NEJM. Blina for the win! www.nejm.org/doi/full/10....

If you are at @ash-hematology.bsky.social today at 2pm drop by to see the amazing results from Seattle Children’s and Children’s Oncology Group own rockstar Rachel Rau. Blina for the win! ash.confex.com/ash/2024/web...

Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9

Are you an early-career scientist looking to make a difference in science policy? 🔬 The AAI Public Policy Fellows Program is your opportunity to learn, network, and advocate. Apply now and join the movement: ow.ly/3rXg50UlbWx.

Critical role for HIF2α in driving the transition from stem-like to pathogenic Th2 cells in airway inflammation www.cell.com/immunity/ful...

Atlas of the plasma proteome in health and disease in 53,026 adults www.cell.com/cell/fulltex...

REVIEW: Cytosolic delivery of innate immune agonists www.cell.com/trends/immun...