Excited to share our new review in Molecular Cell on replicative single-stranded DNA gaps and their role in genome instability and cancer therapy. #DNARepair #ReplicationStress #GenomeStability #CancerResearch #MolecularBiology #PARPinhibitors​​​​​​​​​​​​​​​​ www.cell.com/molecular-ce...

Our lab is hiring! Please come join our lab in the department of @UCLRespiratory in @uclmedsci.bsky.social We have another fully funded postdoctoral position available, focusing on delineating the earliest stages of lung cancer development 🧪! Please apply using the link below: lnkd.in/gN4UK785

We just published a short conceptual review together with @angela-taddei.bsky.social on the spatial controls of homology search in both bacteria and eukaryotes. We discuss an emerging framework for homology search in cells with two main phases. Check it out: authors.elsevier.com/c/1mjyh,LqAZ...

Glad to have contributed to this study from @thomasmartinez.bsky.social’s lab identifying a new microprotein, NISM, implicated in nucleolar integrity! 🎉 Check out the link below: 🔗 www.biorxiv.org/content/10.6...

🥳 🎉 New preprint from the lab is out! It's time to officially introduce the world to the Nucleolar Integrity and Stress Microprotein (NISM)! Check out the preprint in the link below

🧵 Thread: What happens when transcription isn’t properly shut off during mitosis? Our new preprint explores just that 👇 www.biorxiv.org/content/10.6...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

Happy to share the results from my PhD thesis, in which we uncovered a function for FANCD2 on maintaining fork stability upon re-replication, now out in Nat. Commun! 📖 Read the full story here:  www.nature.com/articles/s41... Thanks to everyone who supported me along the way!

Excited to share our new Nature study! 🧬 We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability. Full paper: www.nature.com/articles/s41...

Thrilled to share our latest work - now available in full in Nature Communications - led in my lab by @vcherdy.bsky.social, with key collaborative contributions from @nitikataneja.bsky.social . rdcu.be/eVrxX

🚨 Exciting news! Our latest study is out in Nature Communications! We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair. 🔗 rdcu.be/eT1R9 #CancerResearch #BRCA2 #Genomics

Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n www.science.org/doi/10.1126/...

Finally published! Our work on how the #CircadianClock controls DNA repair. This has direct implications for cancer treatment: #Chronotherapy. @CABIMER @UniSevilla rdcu.be/eSwxl

New manuscript from the lab on @cddpress " H263A and SCAN1/H493R mutant TDP1 block TOP1-induced Double-Strand Break Repair during gene transcription in quiescent cells and promote cell death". rdcu.be/eSxtG @ibis-investigacion.bsky.social @unisevilla.bsky.social

💫NEW: Saur, Lesage et al. report that RNA:DNA hybrids arise at double-strand breaks in transcribed genes, independently of de novo recruitment of RNA polymerase II/III, as a result of DSB-induced transcriptional repression. @lablegube.bsky.social @cbitoulouse.bsky.social bit.ly/4kFWGr1

Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

New work from the lab! 🔬 We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n www.biorxiv.org/content/10.1...

Happy to share new work from my lab by co-authors Peng and Lee-when BRCA1 is absent, RAD51 is busy authors.elsevier.com/sd/article/S...

Thrilled to share our latest work, just published in @nature.com ⬇ www.nature.com/articles/s41... We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors. 🧵 (1/8)

New from us in @natrevmcb.nature.com -- @szmyd-radoslaw.bsky.social & @radoncdocgee.bsky.social explore how DNA repair actively shapes cancer cell fate following DNA damage, reframing repair as both a protective process & a driver of treatment response and cell death. www.nature.com/articles/s41...

Excited to share my first PhD paper published in @narjournal.bsky.social! This project was led by amazing supervisor Belén Gómez González in @aguilerloop.bsky.social lab. Thanks to all colaborators of Blanco and Diffley teams. I hope you like it! Now online here 👇🏼 academic.oup.com/nar/article/...

🚨Our new study out today in Nature Communications. Bats can asymptomatically host multiple viruses while remaining apparently healthy. Here we identify how interferon-mediated responses protect bats and identify molecular adaptations in GBP1. #LZCI Link: www.nature.com/articles/s41...

"In a competitive academic world, building bridges instead of walls may be our most powerful tool to accelerate discovery and rebuild public trust in science." I'm very happy with this article piece! 🥳 www.the-scientist.com/science-thri...

These tiny proteins are super cool! 😊 www.science.org/doi/10.1126/... www.nytimes.com/2025/06/12/s...

Join us NEXT WEEK for the #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," featuring a workshop lead by Drs. Laurie Sanders and Tobias Dansen, a keynote talk by Dr. Karlene Cimprich, and more! Register Today: emgs-us.org/event/OxiDNA...

Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...

Sharing our latest work tracking DNA damage inheritance by Live+QIBC www.nature.com/articles/s41.... Huge congrats to @apanagopoulos.bsky.social, M. Stout and all co-authors for this tour de force! Beautifully summarized by @s-j-aitken.bsky.social & E. Reilly www.nature.com/articles/d41...

Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...

Happy to share yet another story back from my days as a postdoc 👇 we uncovered how the J2 antibody specifically recognizes #dsRNA. J2 is a quintessential tool used to discover #RNA, QC #RNA therapeutics and much more

We describe how to perform Oligo-seq, a new method to map DNA motifs targeted by base editors. Validated with APOBEC3A and APOBEC3B, but adaptable to AID, CRISPR-Cas9, and more. 🧬 Full protocol 👉 www.sciencedirect.com/science/arti... Thanks to @buissonlab.bsky.social at @ucirvine.bsky.social!

Our latest study from my postdoctoral work has just been published in Science Advances! Grateful to my mentor and collaborators who made it possible! @buissonlab.bsky.social @ucirvine.bsky.social 🔗 www.science.org/doi/10.1126/...

I am excited to announce that my laboratory @ucl.ac.uk is now open! We are hiring so please contact us if you are interested. www.caswelllaboratory.com

Glad to see our PACT preprint published in @naturecomms.bsky.social! "Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA" Another step forward in understanding innate immunity. @buissonlab.bsky.social 🔗 www.nature.com/articles/s41...

Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. Congrats to María José and coauthors HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...

Really excited to share my co-first author paper with @cejkalab.bsky.social looking at how/which nucleases are involved in resecting ssDNA gaps generated by PARPi! Can’t wait to talk about our work at the DNA Replication Gaps, Cancer and Disease meeting in South Korea next month!

1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social www.science.org/doi/10.1126/...

Excited to share @joelrc.bsky.social 's new paper examining the factors underlying cell-to-cell heterogeneity in interferon induction during flu infection: www.biorxiv.org/content/10.1...

Pleased to launch the Palancade lab Bluesky account with our new paper 📝, now out at @naturecomms.bsky.social (1/8)

Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...

We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. ⬇️ www.cell.com/cell-reports...

Online Now: Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors Online now:

Join us on Tuesday, February 4th from 5-6 PM Rome Time for a lively discussion on genome integrity maintenance with great speakers Lumír Krejčí and Giulia Bastianello. Link: uniroma1.zoom.us/j/95149984403

Landing on Bluesky by sharing the latest preprint from the lab: nucleoplasmic Lamin A/C modulates RECQ1-mediated fork restart upon mild genotoxic stress, by regulating heterochromatin marks and ADP-ribosylation levels at replication factories www.biorxiv.org/content/10.1...

1/Delighted to announce the newest paper from our lab, “Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage”, is out today in @naturecellbiology.bsky.social, www.nature.com/articles/s41....

Check out our new pre-print! 🦠🧬🦠🧬🦠 We used a FACS-based CRISPR-Cas9 screening method that exploits translation levels as a readout and identified PACT as a key inhibitor (not an activator!) of PKR during RNA viral infections. @buissonlab.bsky.social www.biorxiv.org/content/10.1...

We’ve been using phase lock tubes to streamline phenol-chloroform extractions. Unfortunately they’ve been discontinued everywhere we’ve looked. We recently tried Molykote (vacuum grease with intermediate density compared to aqueous and organic phases) with great results. Also much cheaper.

New Lab Preprint! We show that ATR inhibition results in hyperactivation of PARP1 at replication forks, driven by APOBEC3B, UNG2, and APE1 reaction cascade targeting unprotected single-stranded DNA at the forks. www.biorxiv.org/content/10.1...

🧬 I'm happy to announce that our latest study, "ATR safeguards replication forks against APOBEC3B-induced toxic PARP1 trapping," is now available on bioRxiv! 🧬 Check it out here: biorxiv.org/content/10.1... @buissonlab.bsky.social