Yaiza and Lucia from our lab present their data on "POLL-driven 5hmdU misincorporation in FA cells" at the 2nd SECRIS symposium for early Career investigators. Congratulations!

We are celebrating our research institute @cabimer.bsky.social 20th anniversary!! Superb list of speakers!! And attendees!!

www.nature.com/articles/s42... Congrats @jourdainlab.bsky.social & team!!

#ÚLTIMAHORA | Muere a los 91 años la etóloga británica Jane Goodall

Our new study supports that aging begins in the early stages of embryo development, and not only in adulthood @canalugr canal.ugr.es/noticia/a-ne...

congratulations to our DB colleague Maria Jasin, recognized by the Greengard Prize! when she started her lab @mskcancercenter.bsky.social, she was the first to insert DNA into a defined location of a mammalian genome! her work underlies today's CRISPR-mediated HDR. here in convo with Rick Lifton.🧬

Si quieres hacer una tesis doctoral en tumorogenesis asociada a la inestabilidad genética, contáctanos!! Please RT!!

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...

Excited to share my first PhD paper published in @narjournal.bsky.social! This project was led by amazing supervisor Belén Gómez González in @aguilerloop.bsky.social lab. Thanks to all colaborators of Blanco and Diffley teams. I hope you like it! Now online here 👇🏼 academic.oup.com/nar/article/...

Happy to see this out, great work from Niels, combining kinetic analysis, cryoEM and an unexpected gain-of-function mutant, nice work from master students Jan and Nina, from Kaustav and from Alex for the kinetics ‪@oncodeinstitute.bsky.social‬, ‪@nkinl.bsky.social‬

A study in Nature shows that respiratory viruses trigger metastatic breast cancer cells to proliferate in lungs in mouse models of breast cancer. These findings are supported by human observational data. go.nature.com/4l7NZ8l #medsky 🧪

One often hears that DNA is the blueprint of life. Today, I read a really nice paper that begins with "proteins are the cornerstone of life". By that logic, I might start referring to RNA as the scaffold, and chromatin as the framework that shapes it all. Regardless, the paper is a must-read:

My grant application to follow up my research line has preliminary been accepted. Thanks to those involved in peer reviewing and to @CienciaGob for this great news! Let's keep science moving!!!

🧪To the science feed you go... if you like #neutrophil #metabolism #metastasis #UPP1 #Uracil #fibronectin, then you are in for a treat 👇

Now peer reviewed and in its final form @natcomms.nature.com www.nature.com/articles/s41...

New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage. doi.org/10.1101/2025...

🔴La convocatoria “Consolidación Investigadora” de este año vuelve a sufrir un recorte 📉Es un 50% menos que 2024, que a su vez ya fue recortada otro 50% respecto a 2023 👉¿Consecuencia? Aún más problemas para la estabilización @cienciagob.bsky.social @ageinves.bsky.social @dianamorantr.bsky.social 🧵

Really cool new cryoEM structure of RAD51 caught in the act of recombination initiation at a D-loop. elifesciences.org/reviewed-pre...

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

This is the reason why voting for right-hand parties must never be a choice! You 'll never know what they are capable of...

What is the E3 ligase/Deubiquinating enzyme for your protein?😁👇 UbiBrowser 2.0: a proteome-wide known & predicted E3/DUB-substrate interactions (~4k/1k & 1900k/300k) database in 39 eukaryotic species ubibrowser.bio-it.cn/ubibrowser_v... #NucAcisRes 2022 academic.oup.com/nar/article/...

What a great day to be at @childrensphila.bsky.social and @pennmedicine.bsky.social Published today: www.nejm.org/doi/full/10....

Investigadores sevillanos descubren un mecanismo que causa fragilidad cromosómica en la anemia de Fanconi www.diariodesevilla.es/sevilla/inve...

I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. www.australiancellcycle.org

Massively parallel jumping assay (MPJA) enables to test the jumping potential of thousands of transposons. Analysis of >160,000 Alu haplotypes identified transposition-asssociated domains. Amazing work by Navneet Matharu, Jingjing Zhao, Martin Kircher and many others. www.nature.com/articles/s41...

¿Quieres investigar sobre el desarrollo tumoral causado por las proteinas que se pegan en el ADN y provocan inestabilidad genética? Entonces solicita #JAEIntro JAEINT25_EX_0519!!

Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!

Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. Congrats to María José and coauthors HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...

Great Viva dissertation and defense by María José Peña-Gomez. Thanks to Juan Méndez, Paula Río, Rafael Ariza, Sonia Jimeno and Gonzalo Millán for being excellent examiners! Congratulations Mari!!

Nature research paper: Gene-modified pig-to-human liver xenotransplantation https://go.nature.com/421xqmT

Check out our new paper led by @seppai99.bsky.social from the Vindigni Lab in collaboration with @cejkalab.bsky.social delving into the role of nucleases resecting ssDNA gaps generated by PARPi. You can read more here: genesdev.cshlp.org/content/earl...

🧪 Join us in our Research Nodes #seminar this week, by Dr. Rafael Fernández-Leiro, from @cniostopcancer.bsky.social#seminar Register here ➡️ https://shorturl.at/c3pVU

Cardiorespiratory fitness is an indicator of future cardiac, metabolic, and health events and is a strong predictor of all-cause mortality. Brazile et al. review the basics of the cardiorespiratory response to exercise. Full article in NEJM Evidence: eviden.cc/3Pe9Ay8  #MedSky #CardioSky #PulmSky

Still time to apply to Keystone Conference on ssGapd in cancer and disease, organized by leading experts in the field!! Dont miss it out!! www.keystonesymposia.org/conferences/...

a great conference, and a tribute to a great scientist and man 👇

Would totally consider it if it didn't almost fully overlap with the #Candida meeting in Berlin. 😢

Long time not posting about #redoxepigenetics - today the focus is on HMCES a protein that binds to abasic DNA sites caused for instance by guanine oxidation and removed by BER - by protecing those sites HMCES prevents irreparable DNA damage www.cell.com/cell-reports...

Happy to share our study by Francien Talens and many colleagues on RAD51 foci formation as a functional marker for PARPi sensitivity in ovarian cancer PDX models. academic.oup.com/narcancer/ar...

Today I'm reading www.biorxiv.org/content/10.1...

My first post on BlueSky. Our latest review delves into the critical roles of ubiquitin E3 ligases in safeguarding genome integrity and their implications in human diseases. @drjhujh.bsky.social @profstewartlab.bsky.social portlandpress.com/biochemj/art...

Check out our latest paper on the role of SART1 as a modulator of PARP1 function. Samuele Lodovichi led this study at @accidentalgenet.bsky.social lab. www.cell.com/iscience/ful...

Happy to announce that the latest UniProt NAR paper is now out. Find out what we've been up to here academic.oup.com/nar/advance-...