CATH turns 30 years old this year! We are organising a 1-day symposium on September 16th at UCL, highlighting recent AI-based developments to enhance protein family classifications, annotations and analyses. www.eventbrite.co.uk/e/protein-an...

www.nature.com/articles/s41... From remote matches to @rfamdb.bsky.social models to the discovery of novel *vertebrate* riboswitches!

Beyond homology: This mind blowing work demonstrates the power of genomics driven analogy for discovery in the era of structure predictions. The diversity of defense systems emerged thx to "guilt by association approaches". New analogies to uncover molecular novelties 👇. 👏 Nitzan, Rotem & al.

New impact case study outlines the impressive economic & scientific value of UniProt - the world-leading open data resource for protein sequence & functional information. Users save up to 219 hours per year, equivalent to net benefits of up to €5,475 per user. www.ebi.ac.uk/about/news/a...

🚀 HUGE NEWS: Pfam 37.4 is LIVE! 318 brand-new protein families + 4 new clans! 🧬 Total collection now: 24,736 entries! 📈 Get exploring via InterPro website, API & Pfam FTP! 💻🧪

🔎 Isopeptor is available as a #Python-based tool that can be accessed via the command line, a Python API, or Google Colaboratory. Use it for automated isopeptide bond detection & validation in protein structures! Google Colab: https://t.ly/D4Lny GitHub:

"Isopeptor" introduces a #machinelearning-based approach to systematically identify isopeptide bonds in protein models. By integrating structure-guided template matching with a logistic regression classifier, Isopeptor enhances structural annotation and model accuracy.

🧩A new article in Bioinformatics Advances: "Isopeptor: A tool for detecting intramolecular isopeptide bonds in protein structures" Read more here: https://doi.org/10.1093/bioadv/vbaf049

📢 We’re looking for a new Team Leader! @enasequence.bsky.social is recruiting a Team Leader to shape the strategy and direction for the ENA and Biosamples open data resources. Interested?👇

Well this new paper is a real pleasure! Not every Masters student gets to publish their work, so special congratulations to Olivia Pratt. www.csbj.org/article/S200... She shows that AlphaFold 2, but not other tools, has a real blind spot with perfect sequence repeats. (1/n)

🚨🌱 Interested in making scientific computing greener? Here is a chance to do just that in Cambridge: 2 open research roles to work with me and the Green Algorithms project. More details about the roles below👇 and at www.lannelongue-group.org/join/ ⏳ Closing: Feb 4 for one, Feb 17 for the other

Amazing - the day Steve Jobs and Tim Berners Lee ‘met’. open.substack.com/pub/stephenf...

🧬 "CCfrag: Scanning folding potential of coiled-coil fragments with AlphaFold" introduces a fragment-based approach to improve protein structure prediction by leveraging overlapping sequence windows for better modeling of coiled-coils. Read more: doi.org/10.1093/bioa... #ProteinFolding #AlphaFold

🔬 How does #AlphaFold2 perform with minimal sequence input? "Dissecting AlphaFold2’s capabilities with limited sequence information" reveals insights into its ability to predict #ProteinStructures using structural templates without deep MSAs. Read more: doi.org/10.1093/bioa...

🧬 What's new in Pfam? Beta propellers uncovered through smart deduplication, fresh perspectives on haloarchaeal proteins, and more! Dive into our latest blog: xfam.wordpress.com/2024/12/09/p...

📝 Just published: Our latest blog walks you through InterPro's major updates - from redesigned protein views to improved data exploration. Read more: proteinswebteam.github.io/interpro-blo...

ICYMI, August 2024: "Current and future directions in network biology" shares insights into advancing cellular function and disease research through #MachineLearning, multimodal data integration, and personalized medicine. Read it here: doi.org/10.1093/bioa... #NetworkBiology #SystemsBiology

I will start my Bluesky life by sharing an opportunity for those who are interested in researching fungi and how they adapt to their environment. Awards of up to £3 million available, more details at the link below or in our webinar on 27th November. wellcome.org/grant-fundin...

Our friends at EMBL Australia have called for expressions of interest for the position of Scientific Head. It's a fantastic opportunity for senior scientists based in Aus to bring a vision, stakeholders, and resources to a network that has produced such vibrant scientists and discoveries. 🧪

🔔The ISCB November 2024 Newsletter is available! In this edition, we share new ISCB partnerships, reminders of upcoming deadlines, and information about sustainable computing in the ISCB Green Pages! 🔗 Read the newsletter here: t.ly/t8AXG

I woke up in the night hearing a large rumble. Was it an earthquake? Nope, but I was surprised at how often we get little quakes in the UK! Thanks @britgeosurvey.bsky.social.

Well this is interesting. Claude 3.5 Sonnet seems to have started to recognise the limits of its own understanding. This is much more useful than the usual confident sounding hallucinations we've got used to from LLMs.

Happy to announce that the latest UniProt NAR paper is now out. Find out what we've been up to here academic.oup.com/nar/advance-...

302 new entries in #PDBrelease (http:/PDBe.org/latest)! Here is the structure of thioredoxin glutathione reductase from 𝑆. 𝑚𝑎𝑛𝑠𝑜𝑛𝑖, solved using X-ray crystallography (pdbe.org/8pdd). This protein acts an important target for designing new anti-schistosomal drugs.