Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study! www.nature.com/articles/s41...

Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...

I was a ‘go, go, go’ academic. A fellowship abroad transformed my approach | Science | AAAS www.science.org/content/arti...

Our @costerlab.bsky.social review is out! It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course! www.sciencedirect.com/science/arti... @adityasethi.bsky.social @billiedelpino.bsky.social

🚨 Exciting news! Our latest study is out in Nature Communications! We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair. 🔗 rdcu.be/eT1R9 #CancerResearch #BRCA2 #Genomics

New York millionaires: threatening to flee the city since 2009

Joe Rogan spent a whole podcast episode spouting climate misinformation. @dananuccitelli.bsky.social broke down the tactics Rogan and other climate deniers use so you can call them out when you hear them.

Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science! www.science.org/doi/10.1126/...

See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina! www.nature.com/articles/s41...

Spotify is running ICE ads. I went to cancel on mobile and saw that this isn’t allowed on mobile. They make you cancel on desktop. You think that’s gonna stop me, Spotify? I will erase you and forget you ever existed. THOU SHALT CANCEL SPOTIFY!!!

What if the DNA methylation enzyme DNMT1 isn’t just about DNA? Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking. A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...

🧬 Preprint alert! "Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity." Read the manuscript here 👉 www.biorxiv.org/content/10.1...

@ewanbirney.bsky.social on the new version of Alphafold at the @emblebi.bsky.social www.ebi.ac.uk/about/news/t... AlphaFold has been a transformation not just in structural biology but also - due to its ability to be applied to all proteins - to molecular biology as a whole.

REVIEW: Modeling and targeting general and chromosome-specific aneuploidy in cancer. By Aleah Goldberg, Maria Trifas and Teresa Davoli Learn more here: ➡️ https://genesdev.cshlp.org/content/39/19-20/1132.abstract

RNF114 and RNF166 exemplify a new E3 ligases family that recognizes #MARUbylation –hybrid ADP-ribose/ubiquitin modifications– and extends them with K11-linked polyubiquitin @jnpruneda.bsky.social @michaelnadbio.bsky.social and colleagues www.embopress.org/doi/full/10....

Histone acetylation - not always about transcriptional activation: H4K16ac safeguards the genome replication program by repressing premature replication of heterochromatin. Well done Marta Milan! tinyurl.com/yuy9m8t3

New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com

This MRC course (and the references therein) is a great place to start. But it is a very broad topic - if you are looking to target e.g. membrane proteins, enzymes, RNA binding proteins you might get more specific sets of recommendations. youtube.com/playlist?lis...

This preprint title for the win! "The First of Us: Ophiocordyceps use a novel scramblase-binding peptide to manipulate zombie ants" doi.org/10.1101/2025... Science is cool too! Authors use #celegans to identify the targets... #cilia and scramblases

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up! www.biorxiv.org/content/10.1... A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

I'm more worried about the impact on my farmer neighbors but science is also affected by Trump's tariff insane policies

Online Now: Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication Online now:

Is there anyone here at one of the universities in Wellington, NZ, who would want to host me to give a talk around November 10th?

🚀 New preprint alert! We uncover SLFN11 as a molecular gatekeeper that restricts alternative lengthening of telomeres (ALT) by sensing telomere-associated replication stress and triggering apoptosis. 📄 Read the manuscript here: www.biorxiv.org/content/10.1...

#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer. doi.org/10.1038/s415...

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social www.cell.com/cell/fulltex...

Of course I signed this! Please join us.

I am so disturbed by this image of ICE agents at Stanford hospital. They do not belong here--actually, they don't belong anywhere.

A new paper reports direct ubiquitination of a small molecule BRD1732 in cells. BR31732 ubiquitination is E3 ligase-dependent and leads to inhibition of proteasomal degradation. www.nature.com/articles/s41...

Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ... In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️

new out in Nature www.nature.com/articles/s41...

Excited to see this work published online at @cp-cell.bsky.social today! www.cell.com/cell/fulltex...

Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability | Important finding by Kim, Tian, Ratcliffe and Keeley @ox.ac.uk @ispt-proteinterm.bsky.social #N-degron www.pnas.org/doi/10.1073/...

Aspiring PhD students, this is your chance to join us at the NKI to work on genomic instability and telomeres!: www.werkenbijavl.nl/vacatures/ph...

Thrilled to share our latest work, just published in @nature.com ⬇ www.nature.com/articles/s41... We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors. 🧵 (1/8)

WORK! I currently have 5 (!) open positions for postdocs/PhD students in our CDlab for projects: - Nanopore protein sequencing - Archaeal CDV cell division - Microfluidics for synthetic cells - Nuclear Pore Complex - Origami mimics of peroxisomes Please apply! ceesdekkerlab.nl/come-join-us/ RT=👍

I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌 www.cell.com/molecular-ce...

Apply now for the prestigious and independent #BiozentrumPhDFellowships. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until October 12, 2025. bit.ly/4caiqqX @biozentrum.unibas.ch @unibas.ch #fellowship #PhD#Switzerland

To have this paper appear the same day that RFK Jr is canceling all mRNA vaccine funding is further indication that irony is not dead, even though we might all be soon.

We have an open position for a PhD student to join our team. If you have an interest in cancer biology, genome maintenance, or both, please apply! Details can be found in the link below. With @marcelvanvugt.bsky.social. werkenbijumcg.nl/-/vacatures/...

Snails with human-like eyes?! Published in @natcomms.nature.com, the @planaria1.bsky.social & @accorsi-alice.bsky.social Labs have established apple snails as a novel model for studying vision restoration. They have complex camera-type eyes & the ability to regrow them in 28 days: bit.ly/4mvaxkq

🍂The 2025 Fall Session of GIIN webinars is here! Join us on the 1st Tuesday of each month at 5 PM CET (Rome) / 11 AM DET (NYC). No pre-registration needed, just click to join via Zoom: uniroma1.zoom.us/j/95149984403 Subscribe here for webinar reminders: docs.google.com/forms/d/e/1F...

Meet the 2025 ASCB Award Winners—trailblazing scientists honored for research, mentoring, education, and innovation. Celebrate excellence across all career stages in cell biology. Read more: www.ascb.org/society-news...

Dive into the step-by-step choreography of transcription-coupled DNA repair. In our new review published in Nature Cell Biology, we explore what we know and what’s next in this exciting field of research! www.nature.com/articles/s41...

New from us in @natrevmcb.nature.com -- @szmyd-radoslaw.bsky.social & @radoncdocgee.bsky.social explore how DNA repair actively shapes cancer cell fate following DNA damage, reframing repair as both a protective process & a driver of treatment response and cell death. www.nature.com/articles/s41...

Beautiful new story from Neil Johnson's lab, hard work driven by Wang, many collaborators incl' Jean Yves Masson, and small contribution from us. Super happy to see this in press! PALB2 and 53BP1 govern post-resection homologous recombination DNA repair: Molecular Cell www.cell.com/molecular-ce...

Starting up OnlyLabs, where people can pay to watch researchers who used to have federal funding do Hot Uncensored Cutting Edge science experiments.

The application deadline has been extended for a postdoc position in our lab until August 22. Please enquire/apply if you are interested in ADP-ribosylation, ubiquitination, genome stability or immunity. my.corehr.com/pls/uoxrecru...