Iván Núñez Martín
@ivannm97.bsky.social
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PhD student at @AguileraLab, @CABIMER. Interested in DNA replication and genome instability
reposted by
Iván Núñez Martín
CSIC
4 months ago
🔬Revelan factores potencialmente claves en la resistencia al daño de las células cancerosas 👩🔬Un equipo del
@cbm-csic-uam.bsky.social
ha identificado factores que amenazan la supervivencia celular cuando falla la vigilancia, como ocurre en los tumores ➡️
http://tiny.cc/tves001
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Excited to share my first PhD paper published in
@narjournal.bsky.social
! This project was led by amazing supervisor Belén Gómez González in
@aguilerloop.bsky.social
lab. Thanks to all colaborators of Blanco and Diffley teams. I hope you like it! Now online here 👇🏼
academic.oup.com/nar/article/...
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S-phase checkpoint protects from aberrant replication fork processing and degradation
Abstract. Replication stress, a hallmark of cancer cells, is detected by checkpoint mechanisms that trigger a range of cellular responses. Among these, the
https://academic.oup.com/nar/article/53/14/gkaf707/8219223?searchresult=1
5 months ago
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reposted by
Iván Núñez Martín
Pedro Ortega
9 months ago
Our latest study from my postdoctoral work has just been published in Science Advances! Grateful to my mentor and collaborators who made it possible!
@buissonlab.bsky.social
@ucirvine.bsky.social
🔗
www.science.org/doi/10.1126/...
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Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe
Upon ATR inhibition, APOBEC3B targets unprotected single-stranded DNA at replication forks, leading to fork breakage.
https://www.science.org/doi/10.1126/sciadv.adu0437
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reposted by
Iván Núñez Martín
Pedro Ortega
9 months ago
Glad to see our PACT preprint published in
@naturecomms.bsky.social
! "Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA" Another step forward in understanding innate immunity.
@buissonlab.bsky.social
🔗
www.nature.com/articles/s41...
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