Very excited to share our new Molecular Cell paper on missense mutations in Polycomb genes and how they can disrupt chromatin regulation to drive neurodevelopmental disorders. A huge thank you to everyone involved, and to our amazing collaborators! www.cell.com/molecular-ce...

Very excited to share our new Molecular Cell paper on missense mutations in Polycomb genes and how they can disrupt chromatin regulation to drive neurodevelopmental disorders. A huge thank you to everyone involved, and to our amazing collaborators! www.cell.com/molecular-ce...

@lluismorey.bsky.social we are looking forward to your presentation at our #FusionEpigenetics meeting in Portugal this October! Please share this with your followers to let them know you will speaking, and to register & submit today to join us 🔗 bit.ly/4rC6B45

Exciting news! The lab is moving to Colorado at @cuanschutz.bsky.social 🎉 We’ll be recruiting at all levels—stay tuned!

H3K79me2/3 is sufficient to antagonise PRC1 www.nature.com/articles/s41...

Come join us for a great week of science in Dublin this summer! @brianstrahl.bsky.social @vanrechemlab.bsky.social @bonalditiziana.bsky.social @garcialabms.bsky.social @metorrespadilla.bsky.social

Our #FusionEpigenetics speaker line-up is 🔥 Join us in Portugal in October 2026 to hear directly from the scientists shaping the field. See who’s speaking and save your spot here! ➡️ bit.ly/4sq1khf

Our recent paper with @batllelab.bsky.social is now available in Cancer Discovery formatted PDF here aacrjournals.org/cancerdiscov... Enjoy Xmas reading 😅🎄🍾

This story is absolutely wild. Did you know that avocados change sex over the course of a day? And that it's controlled by a single ancient balanced polymorphism? This is flat our crazy

Excited to share new manuscript on histone acylations, exploring how H4K16 acylations regulate inter and intranucleosomal interactions and how they confer resilience to metabolic challenges in vivo. Thanks to all authors +1 author @sandrani.bsky.social Enjoy 👇👇 www.sciencedirect.com/science/arti...

It was a pleasure to write this News & Views article for the 4D Nucleome flagship article: www.nature.com/articles/d41... With great editorial support from @hollyasmith.bsky.social! Read the 4D Nucleome paper here: www.nature.com/articles/s41...

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...

A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.

Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila | PNAS www.pnas.org/doi/10.1073/...

@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...

Excited to see the latest from the Klose lab out this morning! Our brilliant PhD student Alan, now Dr Au, has dissected how SET1/MLL complexes shape H3K4me3 and shows they regulate transcription independently of their cat activity. He teamed up with Aleks to explore how. A few surprises!

Can't believe it's that time of year - registration already open for next year's Transcription & Chromatin meeting. Almost half the talks are selected from the abstracts, so register soon before it fills up. This is a very lively meeting, with plenty of time to discuss over dinner & at the bar

Yesterday’s lab lunch felt really special. We took a moment to celebrate new papers, promotions, fresh faces in the lab—and, most of all, friendship. Grateful for this team. We’re stronger than ever.

We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas. www.biorxiv.org/content/10.1...

Bernie Sanders' office has put out a report this morning on Trump's NIH cuts: "Trump officials effectively cut $2.7 billion in [NIH] funding in the first three months of 2025 – including a 31 percent cut to cancer research through March, compared to the same timeframe last year."

Northwestern just announced that the university will meet the funding needs of any research that is being impacted by stop orders. LET'S GOOOOOOOOOOOOO! #edusky #academicsky wgntv.com/evanston/nor...

Seven New Cancer Grand Challenges Announced www.cancergrandchallenges.org/new-challenges With awards of up to £20m ($25m). Expressions of Interest are now open. @cancergrand.bsky.social #CancerGrandChallenges

Thank you to all the people who helped with making this work possible, inc. MSKCC Center for Epigenetic Research PJ Hamatd & Richard Koche @lluismorey.bsky.social . You all put a piece in this puzzle. Thank you to our editor &reviewers for being scientific allies,making our work better 🙏🏻

I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵 www.cell.com/cell/fulltex...

@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...

New paper from our lab is out! We investigated the function of the NuRD subunit CHD3 in cranial neural crest specification. CHD3 variants are the cause of Snijder-Block-Campeau Syndrome, which manifests with craniofacial anomalies and intellectual disability 1/n

Killing cancer research, Trump and Musk are killing cancer research

Today, along with 2,000 other NIH employees, I had to clear out my office 😭 It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.

Are you a postdoc or PhD student interested in Histone and DNA modifications? Join us for the GRS on Histone and DNA Modifications! 🗓 When: July 19-20, 2025 📍 Where: Lucca, Italy A great opportunity to present your work, engage in discussions, and network with peers. 🔗 Register now! Register here

You can read the letter for yourself 👉

Dear meeting organizers: Picking the same senior PIs to keynote/give talks at meetings, who's talks I've seen a dozen times already, is not a great use of everyone's time. Nor does it highlight all of the rich talent in your field from more junior folks and peeps not at "elite" institutions.

Very interesting paper by Philipp Voigt about nucleosomal asymmetry at bivalent domains. "Bivalency recruits H3K27me3 but not H3K4me3 readers, promoting a poised state" www.cell.com/molecular-ce...

The world's richest man managed to take $190 million away from a *child cancer research center* with his posts yesterday. Funding now stripped in the new bill.

We often speak about chromatin as being accessible or inaccessible, but what does it mean? We wrote a short review on this, 🔬 focused: sciencedirect.com/science/arti... A big thank you to Tom Fillot for his efforts on this and to @hansen_lab @marcelonollmann for their help as editors.

We have two fully funded #Postdoctoral positions: -One dark genome explorer to lead a curiosity-driven project on #lncRNA in #cancer #therapyresistance -One experienced researcher interested in working on #drugdevelopment in collaboration with industrial partners The links to apply below:

Has anyone had success modeling histone peptides (with PTMs) or nuclesomes (with histone tail PTMs) with chromatin reader proteins using Alphafold or Chai1? If so, any tips? Most iterations I try have the histone tail flopping off to the side #Chromatin #Alphafold #Epigenetics

Despite the intense research, very few mutations are specific of metastatic cells. However, mew research @cellpress.bsky.social shows that most of us carry a variant in PCSK9 that promotes metastasis www.cell.com/cell/abstrac...

I'm quite concerned that AI will now summarise a paper or make a podcast out of it so students don't have to actually read it. That means no looking at the data, no evaluating what was really done and how, no deciding what was really proven. That's the opposite of what research is about.

Hello to my small Bsky community. We have postdoc positions open to study epigenetic mechanisms contributing to resistance to chemo+immuno in TNBC, and projects related to epigenetic determinants of neurodevelopmental disorders. Feel free to reach out to me here/via email. Please like and repost!

I am recruiting a postdoc with experience in Protein Biochemistry, Structural Biology & Chromatin Biology. If you are passionate about the complex world of chromatin modifications, please contact me for more details 🙏. Location: SAiGENCI, Adelaide, Australia 🦘🍷🏄🏖️🇦🇺

Read the Letter From Nobel Laureates Urging That Mr. Kennedy Not be Confirmed www.nytimes.com/interactive/...

@robklose.bsky.social is on a roll! Another beautiful and insightful paper from Klose's lab. This time about the role of PNUTS in transcription pause release. www.cell.com/molecular-ce...

Very interesting paper from @mitchguttman.bsky.social previously in @biorxivpreprint.bsky.social out in Nature Genetics. "ChIP-DIP generates context-specific protein localization maps at consortium scale" www.nature.com/articles/s41...

Read our recent publication in the Journal of Proteome Research on an approach to improve the quantification of histone ubiquitination. pubs.acs.org/doi/10.1021/...

How does PRC1 counteract transcription? See this preview from @adrianbracken.bsky.social and I on an exciting new study from @robklose.bsky.social lab where they show ncPRC1 blocks the early stages of transcription. www.sciencedirect.com/science/arti... @conwayer1.bsky.social for title inspo!

new out in Nature www.nature.com/articles/s41...

Spinning Surfer Rosa after a long time, what a great album!

Beautiful and fundamental paper about Polycomb-mediated gene repression by @kjarmache.bsky.social Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1 www.nature.com/articles/s41...

Newest picture of the lab! We are seeking for postdocs to work on many cool projects in development and cancer!