Join us on Wednesday next week for two exciting talks on transcription regulation from @kasitc.bsky.social and @davidsuter.bsky.social! You can register at: us06web.zoom.us/webinar/regi...

Choose Science. Choose Europe. A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open. With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond. Apply by 10 September → europa.eu/!fBTMgF

Been a great couple of days of fantastic talks at @embl.org in Heidelberg! Presented a poster, and have thoroughly enjoyed learning about all the great epigenetics research going on and making lots of new friends!! #EMBLChromatin

🚨New paper🚨Our new study with the lab of Phil Cole uncovers how SIRT6 dynamically adapts structurally and enzymatically to target diverse histone acylations (e.g., H3K27ac) within nucleosomes. @jonmarkert.bsky.social doi.org/10.1016/j.jb... #Chromatin #SIRT6 #CryoEM

Come by my colleague!! Assistant professor position in molecular neurobiology at @mcgill.ca and the Lady Davis Institute! mcgill.wd3.myworkdayjobs.com/McGill_Caree... Montreal is an amazing city and the Lady Davis is a great institute to work at!

Enjoyed writing this review on classic & emerging techniques being used to elucidate neuroepigenetic mechanisms using biochemistry, chemical and molecular biology in both in vitro/vivo models, with a focus on how these can drive therapeutic strategies in the near future. www.cell.com/iscience/ful...

Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer. www.science.org/doi/10.1126/...

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

Spectacular news this morning for CRISPR gene editing to treat genetic disease from Beam Therapeutics. This method was developed by David Liu's lab at the Broad. = "academic" science produces innovations that enables the biotech sector to build medicines investors.beamtx.com/news-release...

🥁We are just 3 days away from our next #FragileNucleosome seminar! We are delighted to host, 2 amazing ECR researchers @rachelhoffman.bsky.social & @jonmarkert.bsky.social this Wed! PS1: Don't forget that US has switched to PDT PS2: The recurring registration link: us06web.zoom.us/webinar/regi...

I was that woman! I have frequently told the story of how Jeremy responded after my second NIH rejection. He said, “Whatever you do, don’t stop spending. If you run out of startup, we’ll find more money for you.” I didn’t need it in the end, but knowing he had my back was huge. Thank you!

At the #StandUpforScience protest in NYC—several hundred people turned out to Washington Square Park today to protest Trump’s cuts to public research

Maze lab at #standupforscience NYC! cut gels not funding!! 🧬

SO MANY STAND UP FOR SCIENCE EVENTS TO CHOOSE FROM—153 and COUNTING! To get more information on our local events and to register your own, head to www.standupforscience2025.org/local-event-information/ ☀️⬇️🌎

Yall better be both sharing the Stand up for Science posts /and/ figuring out how to get your butt to one of them! @standupforscience.bsky.social

I will be at the Stand Up for Science NYC event on Friday! Calling all NYC and New York area based scientists to join!!

Mechanism for local attenuation of DNA replication at double-strand breaks @nature.com www.nature.com/articles/s41...

Excited to share my main postdoctoral work and our new insights into epigenome inheritance! Huge thanks to an amazing team—especially Alva Biran (@biranalva.bsky.social) & Anja Groth (@groth-anja.bsky.social). 🧵👇

New research in Science represents a notable step forward in designing enzymes from scratch. With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins. scim.ag/41kZBOI

@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...

#Oncohistone #H3 #Histone #Chromatin #Cancer #BuddingYeast academic.oup.com/nar/article/...

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1...

Want to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at @embl.org We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇 embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

www.newsobserver.com/news/politic... Good to see local papers picking up this massive disruption to work going on in our state

Shout out to all the postdocs submitting K99/R00 grants this week. You and your fellow trainees are the future of science and we are rooting for you! 🧪 👩‍🔬 🍀

Very interesting epigenome editing work on the effect of K4me3 on both gene expression and recombination in plants! Well done @c-jake-harris.bsky.social & co!

This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...

Breaking news: 22 states are suing to block NIH’s cutting of indirect costs. See our updated story on the Friday night news and its aftermath. scim.ag/4hTJQ6v

On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...

Nuclear actin structure regulates chromatin accessibility www.nature.com/articles/s41...

Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏 www.nature.com/articles/s41...

Incredibly cool paper linking Acetyl-CoA synthesis and HATs in T cells, with differing mechanisms in 'exhausted' T-cells! Another publication showing the link between metabolism and chromatin modifications driving cellular phenotypes www.science.org/doi/10.1126/...

CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays https://www.biorxiv.org/content/10.1101/2025.02.03.636299v1

Hi! I’m well overdo for a 🦋 intro so here we go: I’m Ashley, a 5th-year PhD student @MountSinai in the Maze & Nestler labs & a DSPAN fellow ✨ Studying epigenetics in stress & mood disorders from two directions: 1️⃣ Transgenerational stress in dads 2️⃣ ELS effects on serotonin & histone serotonylation 🐭🧬

#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates. We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇 www.nature.com/articles/s41... (1/8) #ChemBio #ChemSky

The Internet Archive has to date downloaded 500 terabytes of US government websites, which it crawls at the end of every presidential term. The whole archive is fully searchable. This effort's housed by a donation-funded nonprofit, not a branch of the US government. blog.archive.org/2024/05/08/e...

Here is a growing list of conferences and schools in gene regulation for 2025 generegulation.org/conferences-.... You can order/filter this list by the date, deadline, location. Please reply here to suggest new events* *should be specific to gene regulation

We are ready to help pave a path for lower medication and healthcare costs for taxpayers journals.lww.com/fpmrs/fullte...

Scientists engaged in work to make research fields more inclusive face canceled contracts and expired grants. scim.ag/42xT1W4

How it feels to be working on a grant application right now.

2025 Fragile Nucleosome talks kick off this Wednesday with two great speakers! We'll hear about everything from tardigrades and cryo-EM of nucleosome bound factors to SWI/SNF, LTRs, and ovarian tumors. You won't want to miss this one, register here! us06web.zoom.us/webinar/regi...

In case you missed them, a number of our @fnucleosome.bsky.social talks from 2024 are now up on our youtube channel! Check out the recently uploaded seminars below: Julia Rogers: Notch induces transcription by stimulating release of paused RNA Pol II www.youtube.com/watch?v=GME2...

This week is an opportunity to explain things about how NIH works to your friends, family, etc that aren’t in the biz. This is the last available data from NIH, Fiscal Year 2023. The percentile rank is the relative merit score voted by various study section. Lower is better in the NIH parlance.

🧪🧬 Perfect example of how CUT&RUN can be used to profile transcription factors from a small number of cells isolated from tissues! Here, Lorzadeh et al. CUT&RUN Kit was used to profile CDX2, CTCF, and HNF4 from small numbers of mouse intestinal epithelial cells. www.nature.com/articles/s41...