PtdIns(3,5)P2 Is an Endogenous Ligand of STING in Innate Immune Signaling https://www.biorxiv.org/content/10.64898/2025.12.29.696917v1

Antibody-lectin chimeras for glyco-immune checkpoint blockade - @jcstark.bsky.social @carolynbertozzi.bskyverified.social go.nature.com/4aRDpk8

presented without comment

Five years of COVID taught us one thing: immunology didn’t fail, our public discourse did. My new Substack cuts through the noise with evidence, not ideology. If you want facts over fear, and science over spin, join here: marcveldhoen.substac... 1/2

What controls expansion & contraction of DNA repeats (e.g. Huntington's)? We were thrilled to collaborate w/ the lab of Marta Olejniczak to find out. Check out the cool screen from @sebasiegner.bsky.social and @matthiasmuhar.bsky.social that reads out repeat sequence. www.biorxiv.org/content/10.1...

#NoTimeToDie! Welcome mitoxyperiosis! ⁦‪Kanneganti, Wang‬⁩ &co show ⁦‪@cp-cell.bsky.social that energy starvation via carbon deprivation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria-driven plasma membrane oxidative damage!

My trainees are sick of me saying that we have the second worst health care system ever created. (The first being USA pre-Obamacare.) Here is a stellar summary of our many problems, where indeed money has become the mission.

"Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity" spkl.io/63326Ad0f6 Ya-Chieh Hsu & colleagues @cp-cell.bsky.social

‘Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice’ www.science.org/doi/10.1126/...

Annndddd it’s out! Here’s what came out of combining my virology background with the @brozlab.bsky.social’s cell death focus : a novel role for the cell death protein ninj1 during hsv1 infection. In brief, Ninj1 on mouse macrophages results in lower infection rates and higher cytokine secretion.

November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online. www.embopress.org/doi/full/10....

Dengue Virus NS1 Binds Ephrin B1 to Trigger Endothelial Dysfunction https://www.biorxiv.org/content/10.1101/2025.11.19.689067v1

@biorxivpreprint.bsky.social Regulation of lipid metabolism is a primordial function of STING @igmm-montpel.bsky.social www.biorxiv.org/content/10.1... @nadinelaguette.bsky.social

“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”

NEW: Jenna Norton, an NIH employee who is openly critical of Trump & RFK Jr, has been put on "non-disciplinary" administrative leave. She says the administration is trying to "scare and silence me." An HHS official, asked to comment, called her a radical leftist. www.nytimes.com/2025/11/13/u...

Termination of the integrated stress response | Science www.science.org/doi/10.1126/...

What is the most profitable industry in the world, this side of the law? Not oil, not IT, not pharma. It's *scientific publishing*. We call this the Drain of Scientific Publishing. Paper: arxiv.org/abs/2511.04820 Background: doi.org/10.1162/qss_... Thread @markhanson.fediscience.org.ap.brid.gy 👇

Interleukin-1β (IL-1β) is secreted primarily by dying monocytes rather than by live bystander monocytes, challenging established models. #cryopyrin #pyrin #immunology #science buff.ly/2cBb3sk

Early registration deadline for midwconfimmunol.org @midwinter-immun.bsky.social is this Friday!

Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-kB https://www.biorxiv.org/content/10.1101/2025.11.09.687461v1

Can we improve peer review? We think we can! Check out an experiment I helped with as part of @solvingforsci.bsky.social 's mission to make science better. And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings: solvingfor.org/news-posts-d...

Very cool work from my former mentor elucidating differential control of HIV by IFN alpha subtypes 🦠🧫🧬

Sphingolipid sensor degrades cGAMP to suppress antiviral host defense- #virus #lipids #hostdefense #innateImmunity www.cell.com/immunity/ful...

#Cytokines2025 will kick off with two special symposia! Check in early, get your badges, to attend these sessions.

Sad day for the folks who staked their reputations on lab leak conspiracy theories. www.telegraph.co.uk/global-healt...

Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here: www.biorxiv.org/content/10.1...

When 2 life science discoveries converge: solving a ~3 decade mystery of extraordinary longevity and healthspan + an essential cell danger sensor And related ongoing clinical trials! erictopol.substack.com/p/a-long-awa...

Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here: www.biorxiv.org/content/10.1...

@biorxivpreprint.bsky.social Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells @marionpepper.bsky.social www.biorxiv.org/content/10.1...

How does a “universal” transcription factor evolve to do species-specific jobs? Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes. Read it here 👉 www.biorxiv.org/content/10.1... #MolecularEvolution #Transcription

Impaired IFNγ responsiveness of lung monocyte-derived cells limits immunity to Mycobacterium tuberculosis https://www.biorxiv.org/content/10.1101/2025.10.06.680719v1

Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells https://www.biorxiv.org/content/10.1101/2025.10.03.680350v1

Timely piece on the importance and safety of “gain-of-function” research, from my brilliant PhD advisor Sarah Stanley www.statnews.com/2025/10/06/g...

“The job of teaching is not just to provide something worth noticing, but to protect students from everything that isn’t.” Interesting article by @carlhendrick.substack.com substack.com/@carlhendric...

I'm thrilled to announce I'll be joining the Department of Molecular Genetics & Microbiology at the University of Florida in January 2026! My lab will study RNA virus-host interactions with a particular focus on the spatial regulation of viral replication and innate immune activation. genoyerlab.com

So exhausting..

This is the official communication from the FDA to physicians on acetaminophen use in pregnancy. - They acknowledge the lack of a causal link with autism - Essentially tell physicians to keep doing what we've been doing anyway It's very different from the press conference. Pass it on.

@biorxivpreprint.bsky.social Endogenous retroelements promote tolerance to dietary antigens @belkaidlab.bsky.social www.biorxiv.org/content/10.1...

#Tuberculosis severity varies widely between people; why is this? This study uses the #CollaborativeCross mouse panel to identify the protease #cathepsin Z (CTSZ) as a conserved regulator of #TB outcomes via its influence on CXCL1 in mice & in humans @plosbiology.org 🧪 plos.io/4phwRA8

Join us at the amazing Midwinter Conference of Immunologists in January 2025 in beautiful Asilomar! 🚨There is a travel grant for underrepresented trainees, apply now! www.cvent.com/c/abstracts/... #blackinImmuno #BlackinMicro #Sacnas

A choanoflagellate cGLR-STING pathway reveals evolutionary links between bacterial and animal immunity https://www.biorxiv.org/content/10.1101/2025.09.04.674280v1

SMURF2 inhibits autophagic control of Mycobacterium tuberculosis in macrophages https://www.biorxiv.org/content/10.1101/2025.09.02.673599v1

Yes, it was carefully hidden in the New England Journal of Medicine. Pfizer/BioNTech vaccine (www.nejm.org/doi/pdf/10.1... ) 1/2

9 CDC Directors going back to 1977 speak out. What RFK Jr has done to our nation’s public health system "should alarm every American." It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...

E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription @natimmunol.nature.com www.nature.com/articles/s41...

Gianna Hammer & @brodskyigorlab.bsky.social are co-organizing the 64th annual Midwinter Conference of Immunologists Jan 24-27, 2026. It's a wonderful meeting with broad topics, incredible speakers, fantastic location & lots of awards for trainees. Can't wait to see you there! www.midwconfimmunol.org

Review @cellcellpress.bsky.social @danielboehmer.bsky.social @lozanzi.bsky.social Interferons in health and disease www.cell.com/cell/fulltex...

We're Hiring! Assistant Professor of Immunology and Molecular Medicine in MCB. Learn more and apply online: aprecruit.berkeley.edu/JPF05096

Interaction between breast milk antibodies and gut microbes shape immune responses during weaning @science.org www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...