A non biologic PCSK9 inhibitor could be a game changer! www.nytimes.com/2025/11/08/h...

Sphingolipid sensor degrades cGAMP to suppress antiviral host defense- #virus #lipids #hostdefense #innateImmunity www.cell.com/immunity/ful...

New England #foliage #sunsets #TalcottNotch #CT

What does the naked mole rat’s extreme healthspan have to do with ongoing clinical trials? open.substack.com/pub/erictopo...

Male mice that exercise can pass their newly gained fitness on to male offspring. If the same holds true in humans, researchers say, fathers could help improve the health of any future children by staying in shape themselves. https://scim.ag/47igpZm

Endothelial gateways for brain lipid uptake and metabolism: www.jci.org/articles/vie... A. Dushani Ranasinghe & Timothy Hla  Comment on Wenxin Song et al: www.jci.org/articles/vie...

Researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases go.nature.com/4fYoEwG

Duh!!

Another piece of the #glycoRNA puzzle revealed by @raflynn5.bsky.social and @vijayrathinam.bsky.social!! RNAs with modified base acp3U activate TLR3/7, but not when acp3U is N-glycosylated. This is how cell surface/secreted glycoRNAs avoid stimulating autoimmunity. www.nature.com/articles/s41...

Very good news and we should all continue to ask our colleagues to come here to Bluesky.

China’s Biotech Is Cheaper and Faster www.nytimes.com/2025/08/17/o...

Excellent review on lipids and CNS neurodegenerative diseases. A neglected area...Lipid and Lipoprotein Metabolism in Microglia: Alzheimer’s Disease Mechanisms and Interventions - Journal of Lipid Research www.jlr.org/article/S002...

#GlycoPower! @vijayrathinam.bsky.social @raflynn5.bsky.social @vinnieviruses.bsky.social &co show @nature.com that N-glycosylation of host small-RNAs present at cell surface prevents immune recognition by TLR3 and TLR7 upon apoptotic cells uptake avoiding autoinflammation!

Senators from both parties endorsed a $400 million increase to the budget of NIH. The Appropriations Committee vote represents a clear opposition of presidential plan to dramatically reduce the support for NIH. www.statnews.com/2025/07/31/n...

Future of NIH in the hands of five senators. Write to them if you are in PA -McCormick WV - Moore Capito ME - Collins AL - Britt LA - Cassidy

Latest paper from the lab - CD69 in endothelial cells..Inflamed endothelial cells express S1PR1 inhibitor CD69 to induce vascular leak - Journal of Biological Chemistry www.jbc.org/article/S002...

HDL bound S1P in adult neurogenesis and Alzheimer’s disease! www.nature.com/articles/s41...

• Happy to announce that our paper in @nature.com is finally out! Thanks to the perseverance of @taijamakinenlab.bsky.social and our many collaborators we finally pulled it off! A small 🧵 www.nature.com/articles/s41... Laymen video: www.nature.com/articles/d41...

Will senators save the NIH? prospect.org/politics/202...

Seems ApoM Rx may be beneficial for dry AMD in mice - excellent paper by #Javaheri and #Apte groups @WashU www.nature.com/articles/s41...

Great study from Srinivasan lab - #S1P #Lymphatics rupress.org/jem/article/...

happening today! www.lipidmaps.org/resources/ed...

Here Is All the Science at Risk in Trump’s Clash With Harvard www.nytimes.com/interactive/...

People With Severe Diabetes Are Cured in Small Trial of New Drug www.nytimes.com/2025/06/20/h... #DougMelton #Harvard

Given the sea change in science funding, policy and public disinterest - the center of gravity in biomedical science will likely shift in the coming years ! Hopefully freedom of expression and reporting of truth will not change... #VERITAS www.nature.com/articles/d41...

The US research ecosystem, the crown jewel of the world, is systematically getting destroyed. Will the public stand idly by? www.usatoday.com/story/news/p...

Less than a week to go… if you haven't registered for this month's #webinar, titled: ‘Biology and therapeutic approaches of sphingolipid chaperones and receptors’ with Timothy Hla (@hlatim.bsky.social), you can register here: bit.ly/3FeiBpT

June 12th is Loving Day, a holiday that commemorates the Loving v. Virginia case, which allowed interracial marriage in all parts of the U.S. NPR readers share how the case changed their lives.

#VitaminE_FriendOrFoe?! Garcia-Bermudez &co show @nature.com that tumors uptake lipoproteins enriched in Vitamin E protecting cancer cells from ferroptosis! Identification of sulfated glycans as port of entry of lipoproteins can be used therapeutically to force tumor ferroptotic cell death!

What Happens if ‘Harvard Is Not Harvard’? www.nytimes.com/2025/06/11/u...

Can the U.S. Be a Great Power Without Harvard? - Foreign Policy

Absolutely this 👇

“You can get a other job, but you cannot get another soul”.

Important study which shows HDL delivery of cholesterol to steroidogenic and bile producing tissues requires S1PR signaling - synaptotagmin is a key mediator rdcu.be/eosqR @natcellbio.nature.com

Time for blumens! La primavera …

supported 407,782 jobs and $94.58 billion in new economic activity nationwide, the largest figure in the history of the report. That translates to a return on investment of $2.56 for every $1 in awards.

Another serious contender for this year's bad idea olympics: www.nih.gov/news-events/.... Animal models provide the ground truth for any high-tech approach for studying disease and for most of translational medicine. Without animals, we'll quickly lose contact with reality.

At least 2,500 applications for research funding have been denied so far this year, more than double the previous two years https://go.nature.com/4dynTcw

We need a new model for funding -create a miniNIH funded by stakeholders- see #7 by Marks! www.nytimes.com/2025/05/19/o...

How Type 2 diabetes leads to blood vessel dysfunction and sequelae related to this adverse effect @jclinical-invest.bsky.social jci.org/articles/vie...

Want to live a longer and better life? Give creative people resources to make your life better. Harvard.edu

The 80-year recipe stoking America’s Prosperity: 1) Free-market capital investments in brilliant ideas… 2) enabled by Engineering Innovations… 3) based on Science Research in Universities… 4) funded by Grants from the US Government. It’s time more people understood this.

Urgent call for action to patient advocacy groups, Massachusetts pharma/biotech/VC leadership and the public concerned about biomedical research advances!

Existential crisis for HMS, FAS and HSPH faculty, students and staff due to US Government funding cuts - if the pharmaceutical, biotech and VC communities value the contributions of the Harvard Biomedical ecosystem, the time is now to PITCH IN and SUPPORT research www.thecrimson.com/article/2025...

Must read for everyone concerned with the health, prosperity, and global leadership of America

The Trump administration this week eliminated funding for Harvard research projects across a host of areas, from the origins of breast cancer and the impact of nutrition on fertility to antibiotic resistance.