Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...

Excited to share the first pre-print from our lab!! Check it out here! www.biorxiv.org/content/10.6... We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.

Our story about the poising and connectivity of human developmental enhancers is out! www.cell.com/cell-reports...

📢I'm setting up a new team at the @humantechnopole in Milan. We have several openings in AI applied to nationwide health data, biobank-scale -omics. Milan is a beautiful city and at @humantechnopole is top notch. You can find post-doc positions here: careers.humantechnopole.it/job/Postdoc/...

A MRC funded project called the Lung Immune Challenge study at Addenbrooke`s Hospital. Is currently recruiting volunteers with asthma. For more information about study please lungchallenge.org.uk or contact us on [email protected]

Who would have guessed

It’s Pride 🏳️‍🌈 Spare one repost for a small creator? 🥺 My science and sci fi pins raise money for homeless LGBTQ+ people. Just sent another £800 to @aktcharity.bsky.social bringing total to £47,521 New for Pride 2026: 🌈Scientist🌈 🏳️‍🌈🐥🦜🦅🏳️‍🌈 🌈pronouns🌈 www.jamiebgall.co.uk/shop

Happening today – don't miss out! Join here: www.varianteffect.org/seminar-seri... at ⏰ 9.00 (Pacific) ⏰ 12.00 (Eastern) ⏰ 17.00 (BST) ⏰ 18.00 (CEST)

Always check the raw data

⏰ Please note that due to unforeseen circumstance the Club Shop and Reception at SJP will be closed today. We apologise for any inconvenience. You can still shop online at: shop.exetercityfc.com #ECFC #SemperFidelis

I mean, if there were people that are paid to check these things... oh wait....

You can now find the Day 2 presentations from the MSS 2026 over on our YouTube channel. ⏯️ bit.ly/4tzo9hQ The final day's talks will be live soon, so watch this space! #VariantEffect26 #Genomics #DeepMutationalScanning #FunctionalGenomics #AtlasOfVariantEffects

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...

Download our updated database of postdoc fellowships from different foundations and agencies. We identified 275 fellowships. For each entry, we provide description of the fellowship, focus, amount, deadline, eligibility, etc. Download this database here: research.jhu.edu/rdt/funding-...

GWAS meta-analysed summary statistics for 72 long-term conditions from the GEMINI collaborative updated to v1.1 🌟 The input GWAS are the same but we have fixed several minor issues since the original release v1.0 See our GitHub for links (incl. to Zenodo) github.com/GEMINI-multi...

🧬 There's still time to submit your application to join the Variant Effect Seminar Series (VESS) Organizing Committee - but not much. Applications close tomorrow - April 30! ℹ️ Learn more and apply👇 forms.gle/vdLh3mu9Fuid... #VESS #VariantEffects #Seminar #Genomics #EarlyCareer

It is, today, the 55th anniversary of that gift to satire James Arkell, whose solicitors wrote to Private Eye on this day in 1971, prompting everyone’s favourite reply. You may know the story, but I put it to you that you cannot hear it enough. We begin with that initial letter... 🧵

May's Variant Effect Seminar features Thea Klarsø Schulze of the MRC Laboratory of Molecular Biology, Cambridge, UK and Jerome Freudenberg from the Pimentel lab at UCLA, USA. Bookmark the event in your calendar: www.varianteffect.org/seminar-seri... #AtlasOfVariantEffects

You can watch all our Variant Effects Seminars on YouTube. Yuta Yamamoto (Ashely lab, Stanford University, USA) delivered April's second talk on decoding genetic variants associated with hypertrophic cardiomyopathy using scalable functional genomics. Catch up now: youtu.be/w9dfXdETqNs?...

I'm going to have to get my butt in gear if I want to get one last publication out before retirement (www.nature.com/articles/s41...) 🤪

🧵/ The NHS is about to undergo one of the most radical – and scandalous - changes in its history. From 1st April (the public are the fools in this), GPs will be contractually obliged to seek remote “advice & guidance” from hospital clinicians, making it even harder to see an NHS specialist.

Excited to announce the release of The Human Genotype-Phenotype Map! * We processed 16k complex traits & 2.7M QTLs * Turned 49.3M significant colocalizations into 97k distinct groups * Upload your own GWAS to compare against all data Website: gpmap.opengwas.io Preprint: tinyurl.com/3ktsr9hw

Registration for MSS26 in Melbourne will close next Monday - we still have a few tickets available, and an amazing line-up of speakers across all areas of variant effects work, so if you were on the fence, check out our program and then smash that "Register now" button! www.mss2026.org

Update on UK science funding shambles 🚨 Pressing letter from @chionwurah.bsky.social (Science, Innovation and Technology Committee Chair) asking for some answers about what the hell UKRI are doing: committees.parliament.uk/publications... Lets hope she and we finally get some satisfactory answers 🤞

⚡This Wednesday! 🥁We've got two exciting chromatin talks coming up from @almassalha.bsky.social and @carmeloferrai.bsky.social 🐣If you haven't registered for the series, please register and join us: us06web.zoom.us/webinar/regi...

Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample? Yes, one can. with CUT&ID ✂️🪪 Spearheaded — singlehandedly — by @annanordin.bsky.social No need of transgenesis, cloning and overexpression. Check it out, it's fast and its works.

Kids born the same year that the term “RNA-seq” was coined are heading to college this fall. We are all unspeakably ancient.

Join our seminar next Tuesday, for two insightful talks from Julianne Funk and Nisha D. Kamath with powerful illustrations of how systematic variant characterization is accelerating precision medicine and expanding our therapeutic toolkit. #Genomics #CRISPR #Seminar #AtlasOfVariantEffect

One month to go until we open the doors on #MSS26 and we can't wait to see you there! Check out the program and register at: www.mss2026.org #MSS26 #MAVE #Genomics #PrecisionMedicine #Symposium #AtlasOfVariantEffectsAlliance

Tread -1- EpiSci - I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below) "The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A. www.biorxiv.org/content/10.6...

1/3 New bioRxiv preprint from the lab: “Minute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...

We've got two exciting chromatin talks coming up on Wednesday next week: @epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social! register and join us: us06web.zoom.us/webinar/regi...

🧪 My lab has an opening for a postdoc position soon! Please share/get in touch!

🚨 Applications open! 🚨 Medical students: Apply for our 8-week Summer Scholarship in medical mycology. Gain lab experience, study design & data analysis skills, no prior expertise needed! 📍 Exeter or partner institutions 📅 Deadline: 28 Feb 2026 👉 buff.ly/PrpeVN4

🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026! 📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...

You wish to do a #Postdoc supported by a unique network? My Lab will host PULSE #Postdoc Applicants Program by the prestigious @scilifelab.se Check this out and get in touch with me if you are interested in top-notch #Genomics, #DevBio and #Cancer Biology 👇 www.scilifelab.se/research/pul...

🚨New paper out! In our @MolCellNews paper, we solve a piece of the puzzle of how our genome folds. We found the two specific molecular "brakes" in the CTCF protein that stop DNA loop extrusion. One of the final pieces of my PhD! tinyurl.com/29uuc5by

Our new study defines a distinct #neurogenetic condition arising from recurrent structural variants at 16p13.3 palindrome. Individuals show progressive ataxia, cognitive decline, and a characteristic MRI pattern with caudate & cerebellar atrophy. #Genomics #RareDisease 🧵1/3

In ~5 hours…

Our latest work dissecting the interplay of endothelial and immune cells in non-communicable diseases genetics. We explained 815 loci (29% to 40%) and revealed the complex relationship between cell types and diseases. www.biorxiv.org/content/10.1... @nicolesoranzo.bsky.social @npirastu.bsky.social

Congratulations to @sarahibex.bsky.social and Team at the University of Exeter Medical school (@hls.exeter.ac.uk) on the breakthrough study on #diabetes pathology www.science.org/doi/10.1126/...

Please repost - Multiple PhDs available www.findaphd.com/phds/project... www.findaphd.com/phds/project... www.findaphd.com/phds/project...

both are right: the best is marine microbiology

Reminder! Deadline to apply is midday today!

Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one? Check our latest preprint, led by @mmasoura.bsky.social, to find out! www.biorxiv.org/content/10.1...

What is a promoter? And how does it work? We very happy to share our latest work trying to understand enhancer-promoter compatibility. I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters www.biorxiv.org/content/10.1...

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...