Tread -1- EpiSci - I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below) "The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A. www.biorxiv.org/content/10.6...

1/3 New bioRxiv preprint from the lab: “Minute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...

We've got two exciting chromatin talks coming up on Wednesday next week: @epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social! register and join us: us06web.zoom.us/webinar/regi...

🧪 My lab has an opening for a postdoc position soon! Please share/get in touch!

🚨 Applications open! 🚨 Medical students: Apply for our 8-week Summer Scholarship in medical mycology. Gain lab experience, study design & data analysis skills, no prior expertise needed! 📍 Exeter or partner institutions 📅 Deadline: 28 Feb 2026 👉 buff.ly/PrpeVN4

🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026! 📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...

You wish to do a #Postdoc supported by a unique network? My Lab will host PULSE #Postdoc Applicants Program by the prestigious @scilifelab.se Check this out and get in touch with me if you are interested in top-notch #Genomics, #DevBio and #Cancer Biology 👇 www.scilifelab.se/research/pul...

🚨New paper out! In our @MolCellNews paper, we solve a piece of the puzzle of how our genome folds. We found the two specific molecular "brakes" in the CTCF protein that stop DNA loop extrusion. One of the final pieces of my PhD! tinyurl.com/29uuc5by

Our new study defines a distinct #neurogenetic condition arising from recurrent structural variants at 16p13.3 palindrome. Individuals show progressive ataxia, cognitive decline, and a characteristic MRI pattern with caudate & cerebellar atrophy. #Genomics #RareDisease 🧵1/3

In ~5 hours…

Our latest work dissecting the interplay of endothelial and immune cells in non-communicable diseases genetics. We explained 815 loci (29% to 40%) and revealed the complex relationship between cell types and diseases. www.biorxiv.org/content/10.1... @nicolesoranzo.bsky.social @npirastu.bsky.social

Congratulations to @sarahibex.bsky.social and Team at the University of Exeter Medical school (@hls.exeter.ac.uk) on the breakthrough study on #diabetes pathology www.science.org/doi/10.1126/...

Please repost - Multiple PhDs available www.findaphd.com/phds/project... www.findaphd.com/phds/project... www.findaphd.com/phds/project...

both are right: the best is marine microbiology

Reminder! Deadline to apply is midday today!

Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one? Check our latest preprint, led by @mmasoura.bsky.social, to find out! www.biorxiv.org/content/10.1...

What is a promoter? And how does it work? We very happy to share our latest work trying to understand enhancer-promoter compatibility. I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters www.biorxiv.org/content/10.1...

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

A quick heads-up that we will have two PhD positions available to start in October 2026. One as part of MRC LMS PhD programme, and one as a transdisciplinary studentship with @srinjan.bsky.social and Thomas Ouldridge at Imperial.

🗣️ "You can get test kits sent to you - it's discreet and quick and easy." Jack Fitzwater is supporting Royal Devon NHS's RAPID-IBD study 👊 FREE testing kits are available for EX postcode volunteers aged 16–49 ➡️ bit.ly/IBDKit #ECFC #SemperFidelis

Very much looking forward to @axelvisel.bsky.social's talk "From Nucleotide to Megabase Scale: Enhancer Function in Development and Disease" in our @enhancedgenomics.bsky.social seminar series "The 3D Regulatory Genome" 📅 02 October 2025 (today!) ⏰ 4 pm GMT Join: us02web.zoom.us/webinar/regi...

As we wait for the final version in the journal, I leave here the last version that we uploaded on bioarchive. I hope you like it! www.biorxiv.org/content/10.1...

Next up! Two applications of MAVE! 🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants. 🦠Antibiotic resistance: @kroman.bsky.social (‪@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.

Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...

Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change. Ie: it's not us (Samtools team)! Be warned

Are you interested in applying for a studentship with us? Come along to our first online Candidate Support Webinar for tips on preparing your application. Thursday 11th September at 4pm (UK time). Click here to register: events.teams.microsoft.com/event/83d5eb...

Interested in a PhD to study the genetic determinants of protein abundance using paired RNA-seq and proteomic data? Join us with a @gw4biomeddtp.bsky.social funded project available in my group together with Nick Bray (Cardiff) and Kate Burley (Bristol)

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social! register here for the entire series: us06web.zoom.us/webinar/regi...

New work from @beckof.bsky.social and our lab's collaboration, with @alengronne.bsky.social! Multifaceted influence of transcription on yeast chromosome folding... loop extrusion of course but also active promoters making loops, bypassing centromeres boundaries www.sciencedirect.com/science/arti...

A big blow to All of Science, not just Harvard, not just the Fly community, not just Genetics. All of Science. Turbocharge was just switched off. Flies gave us so many insights.

Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression www.biorxiv.org/content/10.1...

My team has updated our free database of POSTDOC fellowships. This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria. Download this updated and expanded database here: research.jhu.edu/rdt/funding-...

Per chi volesse, presenterò il mio libro a Palmi (RC) il prossimo 2 agosto.

The Perturbation Catalogue is here! A new platform unifying perturbation data from CRISPR screens, multiplexed variant effect assays and gene expression data in one place. The beta version is now live. Find out more and try the platform: www.ebi.ac.uk/about/news/u... 🧬🖥️

Interested in using functional data to understand clinical variants? Been hunting for a good review of the topic? We just wrote one! rdcu.be/exaEU

A 6-year long study from the Lab is finally out @genomeresearch.bsky.social Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social Why is our work Important? Discover it in the quick Bluetorial 👇 genome.cshlp.org/content/earl...

🚨Our user survey is closing on 24 July. Only a few days left to share your views. Please take 10 minutes to help us demonstrate the value of the data resources we manage with our collaborators. Complete survey 👇 www.surveymonkey.com/r/QGFMBH8?ch... 🖥️🧬 #FAIRdata

Tw-Eat Sweet Currently available FREE as an eBook - anyone can read it with the free Kindle App. www.amazon.co.uk/dp/B094J9ZS8X #cookbooks #CookSky #FoodSky #BookSky #KindleDeal #BookGiveaway #FreeBook #Kindle #eBook #Foodie #SimpleRecipes

Registration for Transcription and Chromatin UK is OPEN! Taking place from September 17 to 19, 2025, this conference will showcase cutting-edge research and is a ‘must-attend’ event for the UK transcription and chromatin community & both at home and abroad. Pl register ow.ly/7QQb50W9Alo & share

"People don't do actual training in how to do animal experiments and there's such a lot that you need to think about that you just wouldn't realise unless somebody tells you." Apply by 31st August. Find out more about our Mouse Models for Human Disease Workshop: www.har.mrc.ac.uk/training/cou...

Thanks for the reminder @janemunday.bsky.social. Every summer, I repost this article DROWNING DOES NOT LOOK LIKE DROWNING. To date, I know of FOUR kids who were saved after someone who'd clicked on the link learnt how to spot actual drowning. Take time to read and pass on. slate.com/technology/2...

Textbooks: “Enhancers are just a bunch of TFBSs” But how do they REALLY work? New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social A 🧵 (1/n) Free access link: rdcu.be/erD22

Starting in an hour!

If you are in London a week today and are free early evening, please come along to my talk at @royalsociety.org (free!). If you can’t make it, it will be live-streamed and subsequently available online…

Delighted that the 'flagship' manuscript on our @genesandhealth.bsky.social 44k exomes (British Pakistanis & Bangladeshis) is now preprinted. Great academic-industry collaboration. Lots of new associations (mostly additive, a few recessive) and new insights into homoz knockouts & drug discovery.

"We are speaking on behalf of hundreds of NIH staff who are standing up together to say: WE DISSENT. I am so scared about doing this but I am trying to be brave for my kids because it's only gonna get harder to speak up." Thank you to Dr. Jenna Norton and NIH scientists for your courage!

Can you give blood?

Carer's Awards, funded by the Genetics Society, are available to support 3 participants of the First UK Zebrafish Meeting with caring responsibilities. @gensocuk.bsky.social More info at exeter.ac.uk/ukzfmeeting

Looking for a thesis internship? Join the Soranzo Group at @humantechnopole.bsky.social ! 🔬 Dive into cutting-edge science, develop new skills, and be part of a dynamic team. Apply now ➡️ careers.humantechnopole.it/o/curricular... #internship #research #genomics #bioinformatics #thesisopportunity

Interested in training for the role of a scientific journal peer reviewer? Curious how you can fine-tune your manuscript to shine its brightest for reviewers?. Mark your #EHA2025 agenda - HemaSphere has you covered! 🎓Peer Review Workshop 📆Friday, June 13 ⏱️13:30 - 15:00 📍Milan MiCo, Room Ocean 2