Delighted & excited to share our latest preprint on non-canonical enhancers in human pluripotent stem cells, the result of a fantastic and fun collaboration with @guenesdoganlab.bsky.social‬: www.biorxiv.org/content/10.1... 🧵 below

My interview as part of @dev-journal.bsky.social Development's Pathway to Independence is live! I had a great time chatting to Saanjbati Adhikari - thank you. journals.biologists.com/dev/article/...

We wrote this introductory review on how concepts from dynamical systems can help us understand developmental biology, hope it’s useful to somebody! It was a lot of fun to put together, and great to collaborate with brilliant colleagues across theory and experiments

Our new preprint 🧬🔗 www.biorxiv.org/content/10.1... BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social

This Friday 27th June, we have another exciting set of talks at our monthly Cell and Developmental Biology Networking Event @imperiallifesci.bsky.social with Daniela Dietrich joining us from Bristol and our very own Annabelle Wurmser from my lab. Please do join us!

📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪

📢 Don’t miss the first Cancer Biology and Medicine talk of 2025 tomorrow! Cancer stem cells, evolution and heterogeneity Prof Brian Huntley @scicambridge.bsky.social Thurs 9 Jan, 9:30-10:30 TC lecture theatre, School of Clinical Medicine @cambridge-scm.bsky.social All welcome!

Happy holi, the festival of UMAPs

Wanna learn what we know about why we need to sleep? Here's a fun podcast I recorded for the excellent @npr.org "Seeking a scientist" show, conducted by Kate the Chemist. Enjoy! @imperiallifesci.bsky.social @imperialcollegeldn.bsky.social www.kcur.org/podcast/seek...

Don't forget to come to Prof Doryen Bubeck's inaugural lecture, "Big Questions, Tiny Machines"! Open to all!! 📅 Wed, 12 March 2025 Understanding how pathogen proteins interact with human defence systems means we can develop new ways to prevent disease. @doryenbubeck.bsky.social #OurImperial

We are looking to recruit a highly motivated postdoc with cell or molecular biology expertise. Excellent #epigenetics, #chromatin training & networking opportunities @qmulepigenetics.bsky.social DM me for inquiries pl apply/share tinyurl.com/m6jnksk5

New paper from our lab is out! We investigated the function of the NuRD subunit CHD3 in cranial neural crest specification. CHD3 variants are the cause of Snijder-Block-Campeau Syndrome, which manifests with craniofacial anomalies and intellectual disability 1/n

New #preprint from the Basu & Stewart labs! We discover a non-catalytic role for H3K4me3 methyltransferase MLL2 in modulating 3D chromatin organisation and mobility as pluripotent cells are primed for differentiation. www.biorxiv.org/content/10.1...

Next friday February 7th, we have another exciting set of talks at our monthly Cell and Developmental Biology Networking Event @imperiallifesci.bsky.social with Ben Steventon joining us from Cambridge @bensteventon.bsky.social and our very own Floriane Tissot from the Lo Celso lab.

Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters. www.nature.com/articles/s41...

Exciting stuff, congrats to all involved!

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below. Please spread the word.

Basu lab hosted their first department social today @imperiallifesci.bsky.social My lab put together this amazing cell of food alongside fun games like cell fate charades. So proud of our masters students who coordinated everything from start to finish!!

🚨Abstract deadline- 13th December! 🚨 Join us next March in Liverpool for our Spring Meeting, joined with the BSCB and part of the Biologists@100 @biologists.bsky.social 🎉 Not to be missed! We have annual meetings grants! Next deadline is the 10th of Jan. +Info here : bsdb.org/membership/#...