In our latest preprint on bioRxiv, we present the in situ structure of the human gap junction at 14 Å resolution using cryo-ET. The structure provides a blueprint for investigating how connexin regulation shapes intercellular communication in health and disease.

Our latest story describes the amazing evolutionary battle between malaria parasite and human. The parasite evolved RIFINs to bind inhibitory KIR receptors and suppress immune cell function while humans have activating KIR receptors to bind these RIFINs to kill parasites!

Thank you everyone who sponsored the @doryenbubeck.bsky.social Bubeck lab to run the CRUK Pretty Muddy Race for Life. The team raised over £1200! #OurImperial fundraise.cancerresearchuk.org/page/doryens...

Join us for our next #ConvergingOnCancer seminar where we'll explore these topics with: ➡️Prof @doryenbubeck.bsky.social‬ (@imperialsci.bsky.social‬) ➡️Dr @claudioalfieri.bsky.social‬ (@icr.ac.uk‬ ) 📅 Thursday 5th June, 3-4pm 🖱️ For more information and how to register: bit.ly/3Z80SqS

⏰ Deadline approaching for postdoc position in my lab, Dunn School, University of Oxford. We work on how the cell's antenna receives and transmits essential signals through motor protein driven transport. ❄️ Cryo-EM/ET, smTIRF, cell biology methods 🧪🔬 30/5/25 ➡️ tinyurl.com/KToropovaPDRA

Still time to sponsor @doryenbubeck.bsky.social who ran the Pretty Muddy Race for Life for Cancer Research UK this weekend! Congrats Doryen! fundraise.cancerresearchuk.org/page/doryens...

Exciting progress in drug discovery - a cross-disciplinary team including @doryenbubeck.bsky.social, Tate and Kawamura researchers have developed the first macrocyclic peptide inhibitors for CD59 — a tricky cell-surface receptor often hijacked by bacteria. www.imperial.ac.uk/news/263433/...

We are looking for a postdoctoral fellow to join us to explore telomerase regulation by histones. Please get in touch if this may interest you.

Great day collecting cryo SIM data @diamondlightsource.bsky.social

Honored to have been chosen for this year’s GlaxoSmithKline Award from @biochemsoc.bsky.social. A big thank you to lab members past and present @imperialsci.bsky.social and @erc.europa.eu @cruk-si.bsky.social @wellcometrust.bsky.social for supporting our work.

Did you miss the @doryenbubeck.bsky.social inaugural lecture last week or just fancy re-watching?! 😀 Join Doryen in the fascinating world of proteins, the "tiny machines" that drive cellular functions, using cryo electron microscopy. www.youtube.com/live/H14PeFt... #OurImperial

We're excited that Facilities Manager Sam Horrell has made it to the London Final of FameLab, a science outreach competition with 3 minutes to explain a scientific topic in an engaging way. The final is on 2 April and is free - please come & support Sam! www.eventbrite.co.uk/e/london-fam...

Sad news about Karen Davies' passing. Karen was an inspiration in bioenergetics and cryoET. Her pioneering postdoctoral work on ATP synthase and respiratory supercomplexes marked turning points in the field. I created Scholar profile to acknowledge her contribution scholar.google.com/citations?hl...

Great live demonstration of how election microscopy works, and the signal to noise challenge in atomic imaging, at @doryenbubeck.bsky.social's inaugural lecture #imperialinaugural

Amazing inaugural lecture tonight from @doryenbubeck.bsky.social Proteins scatter electrons, but the images are noisy...check out how an electron microscope works as showcased by our Head of Department @dandavis101.bsky.social 😄😃🔬

Thanks so much @doryenbubeck.bsky.social for an amazing inaugural lecture tonight, 'Big Questions, Tiny Machines' nothing short of inspiring for our packed audience! 👩‍🏫 #OurImperial Did you miss it?! No worries if so, as you can check out the recording below: www.youtube.com/live/H14PeFt...

A highlight of Professor @doryenbubeck.bsky.social‘s inaugural lecture tonight was @dandavis101.bsky.social being pounded with electrons…

🎉 And that’s a wrap! The Wellcome-MRC Cryo-EM in Structural Biology 2025 course in Leeds was a fantastic week of learning, hands-on training, and great discussions. Huge thanks to our amazing instructors, speakers & enthusiastic participants for making it such a success! #CryoEM

Don't forget to come to Prof Doryen Bubeck's inaugural lecture, "Big Questions, Tiny Machines"! Open to all!! 📅 Wed, 12 March 2025 Understanding how pathogen proteins interact with human defence systems means we can develop new ways to prevent disease. @doryenbubeck.bsky.social #OurImperial

Really looking forward to this. Come along if you can!

🔬 Join us for Prof Doryen Bubeck's inaugural lecture, "Big Questions, Tiny Machines" @doryenbubeck.bsky.social @imperiallifesci.bsky.social 📅 Wed, 12 March 2025 Discover how structural biology has changed the game when studying proteins & their role in immune responses 👉 bit.ly/4aHdABe

1) We have an exciting job opportunity in correlative bioimaging at B24 at @diamondlightsource.bsky.social applying cryo soft x-ray microscopy (cryoSXT) and super-resolution 3D structured illumination fluorescence Microscopy (CryoSIM)

Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT | Nature Communications https://www.nature.com/articles/s41467-025-55834-w

Reminder that @arianebriegel.bsky.social compiled a nice list of women in #cryoEM . I often get asked to recommend people and this is a great place to start 😀 briegel-lab.org/women-in-cry...

Many Congratulations to Dan for a well-deserved MBE!! @dandavis101.bsky.social Read his books if you haven’t already. My favourite is the Beautiful Cure.

Congratulations to Dr Richard Zhou! And thanks to his lovely examiners @doryenbubeck.bsky.social and Yvonne Jones for giving him a really engaging viva. Watch out for his nice paper, coming soon. A proud supervisor.

Christmas lunch 2024

Okay, now onto membrane damage and repair! Dylan Noone (@doryenbubeck.bsky.social lab) tells us more about how CD59 inhibits the MAC to limit membrane damage, and @patrycja-kozik.bsky.social tells us about a fascinating role for endosomal permeabilisation in cross presentation of antigens! #UKMT2024

🥔 A new £5.9M study including @imperiallifesci.bsky.social's @tolgaboz.bsky.social and @doryenbubeck.bsky.social aims to unlock the mysteries of potato blight! This could pave the way to protecting global food security against devastating crop diseases www.imperial.ac.uk/news/259273/...

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.

#50ScientistsThatInspire 🧪 Christopher Barnes, a structural biologist investigating viral-host interactions, discusses the importance of #mentors "There are two things that I believe have the most impact on an individual’s success in science: mentorship & perseverance" @cobarnes27.bsky.social 🧵

#Pathogens are a huge threat to our crops, causing devastating disease such as the #potato blight. In this new £5.91 million study, Life Sciences researchers Prof Doryen Bubeck & Dr Tolga Bozkurt will work with partners to overcome this challenge. 🥔🧑‍🌾🧺🌾 www.imperial.ac.uk/news/259273/...

Excited to announce the start of a new research direction in the lab using #cryoEM to tackle one of the biggest challenges in food production @tolgaboz.bsky.social @imperiallifesci.bsky.social @ukri.org www.imperial.ac.uk/news/259273/...

Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m

Cool biochem/cryoEM study

Latest paper from our lab out now! #TeamTomo #CryoET www.nature.com/articles/s41...

Hey Bluesky! For my first post thought I'd share this awesome movie made by Phopho Biomedical Animation for our recent paper on the folding of bacterial outer membrane proteins in Nature Comms: doi.org/10.1038/s414... #cryoEM #AstburyCentre

I am about to be recruiting two post-docs to work on cryoEM and cryoET of amyloid aggregates... Anyone interested please drop me a line while the wheels of our HR department turn.............

Published today Steve and Justin’s story that finally reveals the basis for transmission of uni directional ion flow into bi-directional rotation of the bacterial flagellum doi.org/10.1038/s415...

Come work with us! Only a few days remaining to apply for the #cryoET / #CLEM facility scientist position at the @icrlondon.bsky.social! #cryoEM jobs.icr.ac.uk/vacancies/96...

Looking forward to a new platform for science! Help me build my #cryoEM #STEM network after jumping ship.