Watching Messi, incredible! I cannot believe how fortunate I have been to get to watch sports in this era. All time greats across every major sport

Tillman!!!

Does every enhancer work with every promoter? With @jengreitz.bsky.social and Will Greenleaf, we revisit this long-debated question and resolve an outstanding contradiction in the field. A tour 🧵👇 www.biorxiv.org/content/10.6...

My first PhD paper is out in Nucleic Acids Research! We describe "Ab-trapping" - an antibody artifact that distorts assays relying on antibody diffusion (microscopy, CUT&Tag, CUT&RUN). The revisions made the story much stronger. Check it out! doi.org/10.1093/nar/...

Excited to see James' Genome-wide Absolute Quantification of Looping paper out in @natsmb.nature.com : www.nature.com/articles/s41... This has been in collaboration with @lucagiorgetti.bsky.social @leonidmirny.bsky.social @zechnerlab.bsky.social labs. Brief thread below on some key updates

Interested in a faculty career in biomedical engineering #BME? Apply for the Rising Stars in Engineering in Health workshop for postdocs and PhD students interested in engineering, medicine & health: be.engineering.upenn.edu/home/rising-... Applications are open until July 31, 2026. Please share!

What's with all the NBA trades this year centered around second round picks? Is there some big change to the salary cap coming?

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: The competition between splicing and 3′ processing shapes the human transcriptome By Soles et al. and Yongsheng Shi ➡️ https://ow.ly/bXG150ZachI UC Irvine UC Irvine School of Medicine #RNAprocessing #splicing #mRNA #transcription

bioRxiv alert! CoPhasing resolves haplotype-specific 3D chromatin structures from GAM data, revealing extensive structural heterogeneity between human homologous chromosomes and its interplay with histone modifications and gene expression! Thanks to all coauthors! www.biorxiv.org/content/10.6...

What if you could watch chromatin change in live neurons…..IN REAL TIME?Share if this is your dream! My lab is making biosensors to make chromatin visible as neurons wire into circuits & are hiring an Associate Scientist to build, not just execute. Apply: stjude.wd1.myworkdayjobs.com/stjude/job/M...

(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...

Icy mountains of PLUTO captured by NASA’s New Horizons probe after 9 years and a 3-billion-mile journey

Wow! 🤯👇👇👇👇

I know Calvin’s dad is already having a moment, but every terrible “outsource precious and fleeting moments with your children to tech so that you can spend more time on your work” pitch makes me think of that one strip I never really cared about as a kid, but care a lot about as an adult.

I'm so tired of verifying I'm human and doing 2 factor authentication for every basic task. At this rate, verify tech in 20 years will require a full physical exam, blood work, and a notary form every time I need to check my email

An immense big thanks goes to @matthiasakyel.bsky.social @yomna96.bsky.social @priyakmr.bsky.social @ana Miguel Fernandes you are absolutely great and you should know how proud I am. Below I post again the link of the publication. Enjoy the reading! advanced.onlinelibrary.wiley.com/doi/10.1002/...

1/🧵 Can transcription factor condensate formation be explained without phase separation? Our new preprint introduces SPARK, a simulation tool that reproduces condensate behavior (clustering, fusion, FRAP) from diffusion & binding kinetics alone. Movie: 60 sec FRAP sim www.biorxiv.org/content/10.6...

Thrilled to see nano-CUT&Tag applied in Drosophila for the first time in an exciting collaboration with the lab of Mattias Mannervik! Long story short: It works beautifully Huge kudos to the computational team for turning complex single-cell chromatin data into exciting developmental landscapes.

1/n What fraction of the human genome is essential for cells? Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads. @sudpinglay.bsky.social @jshendure.bsky.social www.biorxiv.org/content/10.6...

Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

The most satisfying thing about science is learning something by being wrong

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇

Misteli group doing cool things: journals.biologists.com/jcs/article/...

www.pnas.org/doi/10.1073/... Interesting, curious about the Nash Equilibrium modeling. Weird dynamics may happen as people figure out cost asymmetry. 95% fail rate at N/C/S submission but insanely high review cost (time to review 8 figure monster over 2 years). Review letters, submit monsters.

Someone in the news departments of @nature.com or @science.org needs to take a look at this--its a huge scandal from the scientific supplier that has become a monopoly

CPGE in Biophysical Journal: "One Chromatin, Many Structures: From Ensemble Contact Maps to Single-Cell 3D Organization" SR-EV clarifies the probabilistic nature of genome architecture and provides a reference framework for interpreting multimodal genomic/imaging data www.cell.com/biophysj/ful...

Today I realized that online dating in 2026 is likely two AI chatbots communicating through human intermediaries #AI

Lamina-associated domains are mostly repressive, yet some genes “escape” and get transcribed. We explored this tunneling-like mechanism using polymer physics: chromatin adsorption+peripheral compaction may largely exclude proteins interacting with active chromatin. www.biorxiv.org/content/10.6...

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

(3/n) We expanded our studies from 2 to 5 cell lines during revisions. Surprisingly, 2 distinct behaviors: U2OS, RPE cells show straight power law MSD with a~0.3 across all time scales. mESCs, RH30 cells do not show power law behavior at all, but steepen over time. Dynamics-->cell specific

Our linker histone H1 paper is featured on the cover of the April 10 issue of #ScienceAdvances. www.science.org/doi/10.1126/... A molecular dynamics simulation of nucleosomes and linker histone H1, with single-H1 trajectories (background). 🎉 Full cover caption: www.science.org/toc/sciadv/1...

Median survival went from 6 months to 13 months. It may not sound like much, but for metastatic pancreatic cancer, this is big, IMO. We finally have something solid to build on in this field.

My first, first author paper is now on #ScienceAdvances ! Linker histone H1 is a liquid-like "glue" condensing chromatin, which revises textbooks! 📖✨ science.org/doi/10.1126/sc… Huge thanks to @kazu-maeshima.bsky.social , for supervision. Amazing collab with @rcollepardo.bsky.social ’s group! 1/

📽️ G&D Tapes 📽️ G&D Author, Tuo Zhang, tells us about their new study showing how embryonic stem cells attain a diapause-like state, and can maintain their pluripotency and metabolic dormancy. Read more here: ➡️ https://genesdev.cshlp.org/content/40/5-6/319.full The Rockefeller University

⚡This Wednesday! 🥁We've got two exciting chromatin talks coming up from @almassalha.bsky.social and @carmeloferrai.bsky.social 🐣If you haven't registered for the series, please register and join us: us06web.zoom.us/webinar/regi...

When gene expression goes wrong, it can cause abnormal cellular growth, cancer, & more. HHMI Investigator Michelle Wang (Cornell University) & collaborators have discovered that nucleosomes—long thought to be obstacles to gene expression—actually help the process work more smoothly. bit.ly/4q9xA6e

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...

Damn this is cool: www.nature.com/articles/s41...

Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social

Pretty neat paper: www.biorxiv.org/content/10.1...

Friday, Nov. 21 @ 12pm CT, Wendy Bickmore, PhD presents the Monthly Seminar on Physical Genomics live on Zoom: "Chromatin Folding And Gene Activation: From The Nucleosome To Transcription Hubs" Registration is free. Join us! tinyurl.com/f9njvnyu #chromatin #genomics #northwestern #biology #dna

We wrote the Strain on scientific publishing to highlight the problems of time & trust. With a fantastic group of co-authors, we present The Drain of Scientific Publishing: a 🧵 1/n Drain: arxiv.org/abs/2511.04820 Strain: direct.mit.edu/qss/article/... Oligopoly: direct.mit.edu/qss/article/...

umm... was there an update to ChatGPT that turned it belligerent?

A reminder:

Still beta-testing the app that helps people plan science, make it super clear, design their todos, and write a first version of the paper. Feeling overwhelmed by the countless aspects of doing science? Try this (for free): planyourscience.com