Enrique Ortega-Forte
@eortegaforte.bsky.social
📤 146
📥 541
📝 13
Postdoc in chemical biology at the Technical University of Denmark
reposted by
Enrique Ortega-Forte
about 15 hours ago
Celebrating Gerty Cori on
#WorldDiabetesDay
. Cori, a biochemist, co-discovered the Cori cycle which unlocked how the body regulates glucose--foundational for diabetes treatments & insulin therapy. She was awarded the 1947 Nobel Prize in Physiology or Medicine for the discovery.
#WomenInSTEM
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Roux Lab, Geneva
1 day ago
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons!
@biology-unige.bsky.social
@sciencesunige.bsky.social
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Science Magazine
9 days ago
Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis. Learn more this week:
https://scim.ag/4nFEGO7
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James Olzmann
17 days ago
Excited to share our study out in
@natcellbio.nature.com
! Led by
@mikelangelipid.bsky.social
, we identify the first
#LipidDroplet
lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated
#ferroptosis
.
www.nature.com/articles/s41...
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FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
https://www.nature.com/articles/s41556-025-01790-y
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Joachim Goedhart
about 1 month ago
Periodic reminder that the fluorescent compound in mammalian cell culture media, such as DMEM, is riboflavin (not phenol red)
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Lucas Sullivan
about 1 month ago
Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC,
@asbmbjournals.bsky.social
! Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process. See here:
www.sciencedirect.com/science/arti...
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Anne Carpenter
about 1 month ago
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
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Max Fürst
about 1 month ago
Un-frigging-believable. I have waited for something like this for so long!
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Journal of Cell Science
about 1 month ago
Mario Ledesma-Terrón, Diego Pérez-Dones, David Míguez and colleagues
@cbm-csic-uam.bsky.social
@ifimacuam.bsky.social
present OSCAR, a framework to quantify 3D stacks with high cellular density.
journals.biologists.com/jcs/article-...
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André Nadler
about 1 month ago
Very exciting work. Shows how interfering with the levels of one lipid class leads to changes of other lipids that are not directly metabolically connected as the cell tries to maintain both lipid flux balance and biophysical membrane properties.
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Science Magazine
about 1 month ago
New
#ScienceTranslationalMedicine
research reveals that cholesterol can disrupt signaling of the fertility-preserving medication progestin in endometrial cancer, and shows that an approved statin can restore progestin sensitivity in mice and a small patient group.
https://scim.ag/3IFlwtq
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Cholesterol desensitizes the response of endometrial cancer to progestin by attenuating progestin signaling
Cholesterol attenuates progesterone signaling through competitive binding of progesterone receptors.
https://scim.ag/3IFlwtq
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C&EN (Chemical & Engineering News)
about 1 month ago
Primatologist Jane Goodall's recent passing left an incredible legacy that transformed our understanding of chimpanzee behavior and intelligence. New insights show that great apes use medicinal plants to treat wounds like humans.
cen.acs.org/pharmaceutic...
#chemsky
🧪
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Chimpanzees use the same plants we do to treat similar illnesses
A new review of recent studies shows the great apes rely on medicinal plants to heal infections, but the plants’ chemistry remains mostly a mystery
https://cen.acs.org/pharmaceuticals/drug-discovery/Chimpanzees-use-same-plants-treat-we-do-to-treat-similar-illnesses/103/web/2025/08?sc=251002_sc_eng_bs_cen
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De Camilli Lab
7 months ago
"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL
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The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage
Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...
https://rdcu.be/ehbaL
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De Camilli Lab
about 2 months ago
"Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C" out now in PLOS Biology
journals.plos.org/plosbiology/...
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Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C
VPS13A and VPS13C are bridge-like lipid transport proteins with distinct subcellular localization and function, and their absence is linked with chorea-acanthocytosis and Parkinson's disease, respecti...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003393
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Sarah Cohen
about 2 months ago
Wonderful to see our paper on the
#organelle
signatures of
#neurons
and
#astrocytes
out in final form - congratulations, Shannon Rhoads and team!🎉
t.co/BPxKlbU6Ou
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John Ngo
about 2 months ago
🚀 Our new paper is out
@natmethods.nature.com
! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗
www.nature.com/articles/s41...
🧬
www.addgene.org/John_Ngo/
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Itay Budin
2 months ago
Very excited to share new work out today in
@natchembio.nature.com
on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n)
www.nature.com/articles/s41...
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Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
https://www.nature.com/articles/s41589-025-02021-z
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Elnaz
3 months ago
Just out of the oven
onlinelibrary.wiley.com/doi/10.1111/...
I’m so excited! Stay tuned for more posts about it and give it a read when you can🥰
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Bryon Silva
3 months ago
This is awesome! Lipid probes for quantitative imaging of lipid transport. A real need in the lipid field!
@nadlerlab.bsky.social
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Quantitative imaging of lipid transport in mammalian cells - Nature
Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.
https://www.nature.com/articles/s41586-025-09432-x
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Enrique Ortega-Forte
André Nadler
3 months ago
Out today in
@nature.com
: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
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Luca Laraia
3 months ago
Fantastic work by
@nadlerlab.bsky.social
and colleagues. A must read for all those interested in lipids and imaging!
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Gasser Group
4 months ago
Congrats to
@kirillkuznetsov.bsky.social
for his article just accepted in
@chemicalscience.rsc.org
on the (photo-)toxicity of some photocages, which were found to be far from being inert carriers. Wonderful collaboration with
@arthurhwinter.bsky.social
@cariouk.bsky.social
doi.org/10.1039/D5SC...
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Enrique Ortega-Forte
Nature Structural & Molecular Biology
4 months ago
ICYMI: New online: A marker for sterol-dependent metastatic tropism
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A marker for sterol-dependent metastatic tropism
Nature Structural & Molecular Biology, Published online: 11 July 2025; doi:10.1038/s41594-025-01626-1How metabolic fitness in cancer clones is established and selected during dissemination and colonization remains enigmatic. A study in Nature now shows that disseminated pancreatic cancer cells bifurcate to seed the lung or liver on the basis of PCSK9 levels and the availability of microenvironmental cholesterol.
https://go.nature.com/4kza4fA
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Enrique Ortega-Forte
Anupam Patgiri
4 months ago
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox
www.science.org/doi/10.1126/...
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ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox
Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmito...
https://www.science.org/doi/10.1126/science.adn2804
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Albert Gandioso Ubieto
5 months ago
🚨 We are looking for highly motivated postdocs to apply for a MSCA in our group at Universitat de Barcelona!
@ub.edu
Join us to develop light-activated drugs for photodynamic therapy & bioimaging 🔬💡 👉 Apply before July 9th! 📧
[email protected]
|
[email protected]
🔗 More info below
#PostdocPosition
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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ
5 months ago
Wow: Plastic → Tylenol? 🧪♻️💊 A biocompatible Lossen rearrangement—a reaction never seen in nature—occurring INSIDE E. coli Bacteria engineered to convert PET plastic → Tylenol in <24h, with 92% yield + low emissions Stunning blend of chemistry and synthetic biology
www.nature.com/articles/s41...
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A biocompatible Lossen rearrangement in Escherichia coli - Nature Chemistry
Biocompatible chemistry merges chemo-catalytic reactions with cellular metabolism for sustainable small-molecule synthesis. Now a biocompatible Lossen rearrangement has been demonstrated to control ba...
https://www.nature.com/articles/s41557-025-01845-5
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Enrique Ortega-Forte
Helena Klara Jambor
5 months ago
I gave in! After students asking for it, I now made a simple figure design checklist. To help all scientists w/o graphic skills create clear, accessible, and truthful charts! -> Out in @nature Cell Biology:
rdcu.be/erwl4
#DataVisualization
#PhD
#SciComm
Thx for review
@bethcimini.bsky.social
+ 2
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A checklist for designing and improving the visualization of scientific data
Nature Cell Biology - Creating clear and engaging scientific figures is crucial to communicate complex data. In this Comment, I condense principles from design, visual perception and data...
https://rdcu.be/erwl4
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Philip Ball
6 months ago
It's an interesting phenomenon that some of the deepest questions about how life works have become what looks like impossibly obscure molecular biology stuck right at the back of Nature, which will never get covered by the science media. Like this. /1
www.nature.com/articles/s41...
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DNA-guided transcription factor interactions extend human gene regulatory code - Nature
A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...
https://www.nature.com/articles/s41586-025-08844-z
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Enrique Ortega-Forte
Rushika M. Perera
6 months ago
Online today in
@nature.com
- our latest study led by superstar postdoc Gilles Rademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer
nature.com/articles/s41...
full text available here 👉
rdcu.be/em0VG
and thread 👇
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Enrique Ortega-Forte
Erdinc Sezgin
6 months ago
New paper out! Would you like to fluorescently label the plasma membrane in live, fixed or permeabilized cells? I tested different lipid structures and labelling approaches to decide what makes a good membrane labelling probe for such imaging experiments!
www.biorxiv.org/content/10.1...
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Plasma membrane labelling efficiency, internalization and partitioning of functionalized fluorescent lipids as a function of lipid structure
Labeling the plasma membrane for advanced imaging remains a significant challenge. For time-lapse live cell imaging, probe internalization and photobleaching are major limitations affecting most membr...
https://www.biorxiv.org/content/10.1101/2025.05.07.652622v1
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André Nadler
6 months ago
Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear.
@pavelbarahtjan.bsky.social
addresses this question:
www.biorxiv.org/content/10.1...
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Inorganic Chemistry Frontiers
6 months ago
📢Issue 09 of Inorganic Chemistry Frontiers is online! 👇Check out the outside front cover and the research behind the cover art——Achieving red-light
#anticancer
#photodynamic
therapy under hypoxia using Ir(iii)–COUPY conjugates
@eortegaforte.bsky.social
doi.org/10.1039/D4QI...
#Chemsky
#ICF_cover
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Achieving red-light anticancer photodynamic therapy under hypoxia using Ir(III)–COUPY conjugates
Despite the potential of photodynamic therapy (PDT), this oxygen-dependent oncological treatment is greatly restricted in the clinic by the well-known hypoxic feature of solid tumors. Here we provide ...
https://doi.org/10.1039/D4QI03369H
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Mike Lange
6 months ago
Fantastic new study from Raphael Rodriguez' lab shows that induced proximity concepts can be used to induce Ferroptosis! Inducing proximity of lysosomal iron and lipids induces lipid peroxidation! What a cool concept! Have a look at our News/Views with
@olzmannlab.bsky.social
shorturl.at/cbc8D
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Lipid-degrading small molecule kills cancer cells by ferroptosis
A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.
https://shorturl.at/cbc8D
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Joachim Goedhart
9 months ago
I made a little browser extension for Firefox that simplifies the sharing of preprints from
@biorxivpreprint.bsky.social
and
@medrxivpreprint.bsky.social
on Bluesky:
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Looks amazing —congratulations on the stunning cover art!
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7 months ago
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Itay Budin
7 months ago
Out today, we report how small chemical modifications in the metabolism of ergosterol are needed for yeast membranes to phase seperate into ordered yet fluid domains
www.science.org/doi/10.1126/...
(1/n)
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Structural dissection of ergosterol metabolism reveals a pathway optimized for membrane phase separation
The metabolism of ergosterol shapes this lipid to allow the formation of fluid membrane domains in yeast cells.
https://www.science.org/doi/10.1126/sciadv.adu7190
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Derek Lowe
7 months ago
The vintage antibiotic streptomycin might be useful in treating metastatic cancer. A surprising result:
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Streptomycin For Metastatic Cancer
https://www.science.org/content/blog-post/streptomycin-metastatic-cancer
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Derek Lowe
7 months ago
So what else do the proton pump inhibitors like omeprazole do inside the body? Some solid answers:
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Proton Pump Inhibitors Do More Than You Think
https://www.science.org/content/blog-post/proton-pump-inhibitors-do-more-you-think
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C&EN (Chemical & Engineering News)
7 months ago
By trading the positions of a carbon and a nitrogen within the skeleton of the compound LSD, chemists have created a molecule that alleviates depression in mice but does not prompt the animals to behave as though they are experiencing hallucinations.
cen.acs.org/pharmaceutic...
🧪
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LSD atom swap tunes out hallucinations
Compound spurs neuron growth without causing hallucinations in mice
https://cen.acs.org/pharmaceuticals/drug-discovery/LSD-atom-swap-tunes-hallucinations/103/web/2025/04?sc=250416_sc_eng_blue_cen
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Brian English
8 months ago
Dr. Eric Schreiter demo at
@hhmijanelia.bsky.social
#bioluminescence
#luciferase
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Liron Bar-Peled
8 months ago
I’m excited to share the latest work from our lab, led by a group of three amazing scientists: Junbing Zhang, Yousuf Ali and Harrison Chong, who describe @nature the discovery of a ROS sensor, VPS35, which links cytosolic H2O2 levels to regulation of mitochondrial translation and
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Oxidation of retromer complex controls mitochondrial translation - Nature
Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive ox...
https://www.nature.com/articles/s41586-025-08756-y
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Albert Gandioso Ubieto
8 months ago
🧪📣❗
#PhDPosition
to develop light-activated drugs for cancer phototherapy. We are seeking candidates with a strong background in
#OrganicChemistry
#ChemBio
and
#MedChem
to apply for FI-STEP predoctoral fellowships
#PDT
#Metallodrugs
#ScienceJobs
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Enrique Ortega-Forte
Carolyn Bertozzi
8 months ago
Discovery of a cool new anti-fungal natural project with new
#lipidtime
mechanism!
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Enrique Ortega-Forte
8 months ago
Excited to be part of this multidisciplinary paper! Congrats to all co-authors!
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Happy to see our paper in print! We developed an iridium-coumarin platform that selectively induces oxidative cell death upon red light exposure, even in low-oxygen conditions! 🧪 Congrats to the team for the hard work!!
doi.org/10.1039/D4QI...
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Achieving red-light anticancer photodynamic therapy under hypoxia using Ir(III)–COUPY conjugates
Despite the potential of photodynamic therapy (PDT), this oxygen-dependent oncological treatment is greatly restricted in the clinic by the well-known hypoxic feature of solid tumors. Here we provide ...
https://doi.org/10.1039/D4QI03369H
8 months ago
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Enrique Ortega-Forte
Nature Portfolio
8 months ago
Aspirin may enhance the immune response against cancer metastasis in mice, according to research published in Nature. The authors suggest that the findings could aid the development of effective anti-metastatic immunotherapies.
https://go.nature.com/3F3GWOB
🧪
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Enrique Ortega-Forte
M. Concepción Gimeno
9 months ago
See our collaborative article on Multimodal antiproliferative effects of oleanolic acid mitocans: In vi...
www.sciencedirect.com/science/arti...
. Congrats to all involved.
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Multimodal antiproliferative effects of oleanolic acid mitocans: In vitro and in vivo studies
Mitochondria-targeting drugs (mitocans) based on organic cations are emerging as powerful and selective cancer therapeutics. In this study, we have ev…
https://www.sciencedirect.com/science/article/pii/S0006295225000693
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Luca Laraia
9 months ago
We look forward to welcoming you
@eortegaforte.bsky.social
in our group! Great job putting together the
#MSCA
application - a very well deserved award!
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Absolutely delighted to share that I have been awarded a
#MSCA
postdoctoral fellowship with
@lucalaraia.bsky.social
at the Technical University of Denmark. Looking forward to starting the project!🧪
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9 months ago
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Albert Gandioso Ubieto
9 months ago
Thrilled to share our
#JACS
paper! Our new Ru(II)-COUBPY photosensitizer (PI >30,000) for hypoxic tumor treatment using red light with in vivo validation!.
@gassergroup.bsky.social
pubs.acs.org/doi/10.1021/...
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Ruthenium(II) Polypyridyl Complexes Containing COUBPY Ligands as Potent Photosensitizers for the Efficient Phototherapy of Hypoxic Tumors
Hypoxia, a hallmark of many solid tumors, is linked to increased cancer aggressiveness, metastasis, and resistance to conventional therapies, leading to poor patient outcomes. This challenges the effi...
https://pubs.acs.org/doi/10.1021/jacs.4c15036
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