Celebrating Gerty Cori on #WorldDiabetesDay. Cori, a biochemist, co-discovered the Cori cycle which unlocked how the body regulates glucose--foundational for diabetes treatments & insulin therapy. She was awarded the 1947 Nobel Prize in Physiology or Medicine for the discovery. #WomenInSTEM

Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social

Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis. Learn more this week: https://scim.ag/4nFEGO7

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...

Periodic reminder that the fluorescent compound in mammalian cell culture media, such as DMEM, is riboflavin (not phenol red)

Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social! Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process. See here: www.sciencedirect.com/science/arti...

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

Un-frigging-believable. I have waited for something like this for so long!

Mario Ledesma-Terrón, Diego Pérez-Dones, David Míguez and colleagues @cbm-csic-uam.bsky.social @ifimacuam.bsky.social present OSCAR, a framework to quantify 3D stacks with high cellular density. journals.biologists.com/jcs/article-...

Very exciting work. Shows how interfering with the levels of one lipid class leads to changes of other lipids that are not directly metabolically connected as the cell tries to maintain both lipid flux balance and biophysical membrane properties.

New #ScienceTranslationalMedicine research reveals that cholesterol can disrupt signaling of the fertility-preserving medication progestin in endometrial cancer, and shows that an approved statin can restore progestin sensitivity in mice and a small patient group. https://scim.ag/3IFlwtq

Primatologist Jane Goodall's recent passing left an incredible legacy that transformed our understanding of chimpanzee behavior and intelligence. New insights show that great apes use medicinal plants to treat wounds like humans. cen.acs.org/pharmaceutic... #chemsky 🧪

"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology rdcu.be/ehbaL

"Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C" out now in PLOS Biology journals.plos.org/plosbiology/...

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Just out of the oven onlinelibrary.wiley.com/doi/10.1111/... I’m so excited! Stay tuned for more posts about it and give it a read when you can🥰

This is awesome! Lipid probes for quantitative imaging of lipid transport. A real need in the lipid field! @nadlerlab.bsky.social

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

Fantastic work by @nadlerlab.bsky.social and colleagues. A must read for all those interested in lipids and imaging!

Congrats to @kirillkuznetsov.bsky.social for his article just accepted in @chemicalscience.rsc.org on the (photo-)toxicity of some photocages, which were found to be far from being inert carriers. Wonderful collaboration with @arthurhwinter.bsky.social @cariouk.bsky.social doi.org/10.1039/D5SC...

ICYMI: New online: A marker for sterol-dependent metastatic tropism

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox www.science.org/doi/10.1126/...

🚨 We are looking for highly motivated postdocs to apply for a MSCA in our group at Universitat de Barcelona! @ub.edu Join us to develop light-activated drugs for photodynamic therapy & bioimaging 🔬💡 👉 Apply before July 9th! 📧 [email protected] | [email protected] 🔗 More info below #PostdocPosition

Wow: Plastic → Tylenol? 🧪♻️💊 A biocompatible Lossen rearrangement—a reaction never seen in nature—occurring INSIDE E. coli Bacteria engineered to convert PET plastic → Tylenol in <24h, with 92% yield + low emissions Stunning blend of chemistry and synthetic biology www.nature.com/articles/s41...

I gave in! After students asking for it, I now made a simple figure design checklist. To help all scientists w/o graphic skills create clear, accessible, and truthful charts! -> Out in @nature Cell Biology: rdcu.be/erwl4 #DataVisualization #PhD #SciComm Thx for review @bethcimini.bsky.social + 2

It's an interesting phenomenon that some of the deepest questions about how life works have become what looks like impossibly obscure molecular biology stuck right at the back of Nature, which will never get covered by the science media. Like this. /1 www.nature.com/articles/s41...

Online today in @nature.com - our latest study led by superstar postdoc Gilles Rademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s41... full text available here 👉 rdcu.be/em0VG and thread 👇

New paper out! Would you like to fluorescently label the plasma membrane in live, fixed or permeabilized cells? I tested different lipid structures and labelling approaches to decide what makes a good membrane labelling probe for such imaging experiments! www.biorxiv.org/content/10.1...

Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...

📢Issue 09 of Inorganic Chemistry Frontiers is online! 👇Check out the outside front cover and the research behind the cover art——Achieving red-light #anticancer #photodynamic therapy under hypoxia using Ir(iii)–COUPY conjugates @eortegaforte.bsky.social doi.org/10.1039/D4QI... #Chemsky #ICF_cover

Fantastic new study from Raphael Rodriguez' lab shows that induced proximity concepts can be used to induce Ferroptosis! Inducing proximity of lysosomal iron and lipids induces lipid peroxidation! What a cool concept! Have a look at our News/Views with @olzmannlab.bsky.social shorturl.at/cbc8D

I made a little browser extension for Firefox that simplifies the sharing of preprints from @biorxivpreprint.bsky.social and @medrxivpreprint.bsky.social on Bluesky:

Looks amazing —congratulations on the stunning cover art!

Out today, we report how small chemical modifications in the metabolism of ergosterol are needed for yeast membranes to phase seperate into ordered yet fluid domains www.science.org/doi/10.1126/... (1/n)

The vintage antibiotic streptomycin might be useful in treating metastatic cancer. A surprising result:

So what else do the proton pump inhibitors like omeprazole do inside the body? Some solid answers:

By trading the positions of a carbon and a nitrogen within the skeleton of the compound LSD, chemists have created a molecule that alleviates depression in mice but does not prompt the animals to behave as though they are experiencing hallucinations. cen.acs.org/pharmaceutic... 🧪

Dr. Eric Schreiter demo at @hhmijanelia.bsky.social #bioluminescence #luciferase

I’m excited to share the latest work from our lab, led by a group of three amazing scientists: Junbing Zhang, Yousuf Ali and Harrison Chong, who describe @nature the discovery of a ROS sensor, VPS35, which links cytosolic H2O2 levels to regulation of mitochondrial translation and

🧪📣❗ #PhDPosition to develop light-activated drugs for cancer phototherapy. We are seeking candidates with a strong background in #OrganicChemistry #ChemBio and #MedChem to apply for FI-STEP predoctoral fellowships #PDT #Metallodrugs #ScienceJobs

Discovery of a cool new anti-fungal natural project with new #lipidtime mechanism!

Excited to be part of this multidisciplinary paper! Congrats to all co-authors!

Happy to see our paper in print! We developed an iridium-coumarin platform that selectively induces oxidative cell death upon red light exposure, even in low-oxygen conditions! 🧪 Congrats to the team for the hard work!! doi.org/10.1039/D4QI...

Aspirin may enhance the immune response against cancer metastasis in mice, according to research published in Nature. The authors suggest that the findings could aid the development of effective anti-metastatic immunotherapies. https://go.nature.com/3F3GWOB 🧪

See our collaborative article on Multimodal antiproliferative effects of oleanolic acid mitocans: In vi... www.sciencedirect.com/science/arti.... Congrats to all involved.

We look forward to welcoming you @eortegaforte.bsky.social in our group! Great job putting together the #MSCA application - a very well deserved award!

Absolutely delighted to share that I have been awarded a #MSCA postdoctoral fellowship with @lucalaraia.bsky.social at the Technical University of Denmark. Looking forward to starting the project!🧪

Thrilled to share our #JACS paper! Our new Ru(II)-COUBPY photosensitizer (PI >30,000) for hypoxic tumor treatment using red light with in vivo validation!. @gassergroup.bsky.social pubs.acs.org/doi/10.1021/...