If you want to do a deep dive into the data – here’s a website where you can browse through all the images, look at every detail and jump right into mass spectrometric lipid flux data: www.lipidimaging.org

Fantastic work by @nadlerlab.bsky.social and colleagues. A must read for all those interested in lipids and imaging!

Wow Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions ki.se/en/about-ki/...

I am looking to hire a protein #biochemist, #biophysicist or structural biologist: efzu.fa.em2.oraclecloud.com/hcmUI/Candid... - 2-year position working on lipid transport proteins. - Experience in protein expression, purification and biochemical and biophysical assay development. Please share!

It was a pleasure to present at this fantastic conference! Thanks to @rscmedchem.rsc.org for this great opportunity and the award!

I will soon be posting a postdoc position in protein biochemistry/biophyics! Interested candidates are welcome to reach out at [email protected]. Experience in protein expression, purification, and assay development is a must. Structural biology would be great! Please RT :)

It’s an honor to receive the ACS Chem Biol Young Investigator Award! I’m most grateful for the contributions from all past & present lab members — it is an award for all of you as much as for me. (& also grateful to still be considered young 😅) axial.acs.org/chemical-bio... @acsbiol.bsky.social 1/2

Any1 is a phospholipid scramblase involved in #endosome biogenesis, say Jieqiong Gao, Christian Ungermann and colleagues (Osnabrück University): rupress.org/jcb/article/... #Membrane #lipid #Organelles #Biochemistry

Are lipids actively sorted during clathrin mediated endocytosis like proteins? @mathilda95.bsky.social addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow. www.biorxiv.org/content/10.1...

🚨New preprint: There's this overlooked phospholipid with 3 acyl tails called NAPE that is made during ischemia. We identified its interactome & found it regulates lactate flux, suggesting metabolic functions in response to hypoxia. Congrats to Dylan Chiu! doi.org/10.26434/che... #lipidtime #chembio

Join us in Copenhagenfor the European Symposium on organic chemistry this summer: www.esoc2025.com

And if folks think it’s a tough situation with antibacterials, wait until they see what it looks like with antifungals!

We look forward to welcoming you @eortegaforte.bsky.social in our group! Great job putting together the #MSCA application - a very well deserved award!

Do you want to present your research to a global audience? Then you should check out, #RSCPoster, which will happen on March 4th to 5th. Very excited to chair the #ChemBio part #RSCChemBio together with Lyn Jones and Ali Tavassoli. Click this link for all information: www.rsc.org/our-events/r...

Most genome editing work to date has been DNA based. A new paper out today assessed a single dose of epigenetic editing (thru PCSK9) for marked (~70%) and durable reduction of LDL cholesterol [in non-human primates] www.nature.com/articles/s41...

We are pleased to announce that this year, the International Chemical Biology Society (ICBS) conference in joint with the ECBS (European Chemical Biology Symposium), will be at the Sorbonne Université in Paris, Oct 6 - 9! Stay tuned at: www.chemical-biology.org #chemicalbiology #ICBS2025 #ECBS2025

Ready to take off as a synthetic chemist? Check out this tutorial review we wrote with Frank Glorius and Jasper Tyler!

A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it. www.science.org/content/blog...

Interested in natural product-inspired compounds? Check out our new perspective in @chemsci.bsky.social: pubs.rsc.org/en/content/a... Deciding which synthesis strategy to pursue can be daunting, particularly as new strategies keep emerging! 1/2

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that. www.biorxiv.org/content/10.1...

New reactive groups for covalent inhibitors are key to expanding target scope. Natural products give inspiration for privileged structures. In Chemical Science, the group of @tbpoulsen.bsky.social synthesized cyclohelminthol I–IV and characterized their reactivity. (1/8) pubs.rsc.org/en/cont...

This one is for the #lipidtime and #sterol enthusiasts: Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters, now published in the Journal of Lipid Research: sciencedirect.com/science/arti... 1/5

Linking up gut bacteria, human exposure to industrial pollution, a new class of natural products, and. . .major depressive disorder?

www.nature.com/articles/s41... This is 💥 💥💥💥💥

Overjoyed and honestly relieved to share a Chem Rev magnum opus from Brian Chen & Julia Li titled Synthetic Lipid Biology! In it, we organize efforts across numerous fields to create, manipulate, and analyze lipids and biomembranes. Check it out! doi.org/10.1021/acs.... #lipidtime #chemsky #chembio

🎉Looking for an exciting opportunity in proteomics and data science?🎉 Join DTU Bioengineering as a #Data #Science Specialist in #Proteomics! Based at our state-of-the-art DTU Proteomics Core. You'll also collaborate with me and the DTU Bioengineering Data Science Hub. lnkd.in/d2zHaMys

mRNA display continues to astound. Fantastic collaboration with Alex Buell, led by the peerless @rasmusnorrild.bsky.social. ~100,000 peptides and their propensity to join the phase separation of a model disordered protein. doi.org/10.1101/2024...

Made one of these for lipids, will update continuously. Please share and let me know who I've missed go.bsky.app/A27yZA6

Great start to 2025 for the lab, as our latest paper on sterol transport protein ligands was just published open access in ACS Central Science! 1/4 #chemsky pubs.acs.org/doi/10.1021/...

Very cool #lipidtime preprint from Taki Nishimura and colleagues: engineering of new lipid-binding probes from PH domains and nanobodies from a high-throughput assay where liposomes bind to cell surfaces displaying members of the protein probe library. www.biorxiv.org/content/10.1...

We are hiring! Apply to join our dynamic team as a #chemicalbiology postdoc or research scientist below. Chemical biology: jobrxiv.org/job/universi... Mass spectrometry: jobrxiv.org/job/universi...

Super excited to finally share PANCS-Binders: our group's decade-long quest to accelerate protein binder discovery. TLDR: PANCS-binders is fast (2 days), cheap (pennies), has extremely high fidelity (low false positive and negatives), and high-throughput. 1/n

Expert's Dilemma: the more specialized you become, the less open you are to creative solutions from other fields. But the more you explore other fields, the more you risk losing credibility in your home field. Interdisciplinary work is still not really embraced by academia.

Interesting @biorxivpreprint.bsky.social by the @megamatthewslab.bsky.social. An alkyne probe of hydralazine reveals cysteamine dioxygenase as target through modification of a histidine. Interesting implications for treating preeclampsia and glioblastoma. #chemsky #ChemBio doi.org/10.1101/2024...

Very interesting to see the 50 new drugs that made it to FDA approval in 2024 in one place. A lot of really exciting small molecule chemistry with interesting functional groups, deuterations and covalent warheads. #chemsky #chembio www.linkedin.com/posts/chrisd...

1/14 Our latest study just out on BioRxiv [https://www.biorxiv.org/content/10.1101/2024.12.19.629450] has unusual personal significance for me. It connects two apparently unrelated diseases – (pre)eclampsia and glioblastoma – that have both impacted my family.

Closing date for this PhD project coming up on Monday - integrated approach to investigating mitotic kinases

Hey #ChemSky! I teach a primary-literature-based #ChemicalBiology course, and I'd like suggestions for updating the readings. Target audience is 1st-year PhDs and senior undergrads on their way to PhD. Each week I'll add another unit to the thread for your suggestions. Thanks for your help!!

"Here, we show that this Ab appears to be unreliable due to providing false-positive signals at the expected molecular weight of Bax in immunoblotting experiments and likewise provides false-positive signals in immunofluorescence-based detection of Bax expression" www.nature.com/articles/s41...

In @science.org this week, the Baran and Renata groups team up to streamline access to complex piperidines using customized enzymes in tandem with electrocatalysis chemsky 🧪 www.science.org/doi/10.1126/...

(1/5) 🚨 New Research Alert! 🚨 Excited to share our latest work in @embojournal.bsky.social "Towards routine proteome profiling of FFPE tissue: insights from a 1,220-case pan-cancer study" ✨ doi.org/10.1038/s443... 📌 Key Highlights:

Mass spec continues its relentless world takeover:

ChemBio fans please repost the #ChemicalBiology Feed bsky.app/profile/thor... @carolynbertozzi.bsky.social @ritastrack.bsky.social @stephanhacker2.bsky.social @stuartcantrill.bsky.social @laurahowes.bsky.social @dirktrauner.bsky.social @chemjobber.bsky.social @dereklowe.bsky.social #chemsky

Since I’m still laid up sick at home, I’ll show you this little goofball molecule from the pharmacopeia: benzonatate. This drug, for cough, is orally administered with a rapid onset (15-20 min) and up to 8 hour duration of action. 1/

What a perfect flag

#PhDposition available in my group at the @mpici.bsky.social! Join us to develop new #carbohydratematerials #chemistryjobs #researchjobs #glycotime jobs.mpikg.mpg.de/jobposting/a...

The Pictet-Spengler ligation is a nice vignette of how *new chemistry* saved an ADC company — after all the crazy protein engineering, a stable ketone ligation was the bottleneck (see doi.org/10.1073/pnas... and doi.org/10.1021/bc40...). @carolynbertozzi.bsky.social @ellensletten.bsky.social 3/2

Really like this from the Rovis Lab in Angewandte (ACIE) making pyrrolidone derivs from simple starting materials - will come in handy for med chem. Aldehydes plus cyPr amino esters and light. Imine can be manipulated as well - good stuff here #ChemSky