Joe Rogers
@josephrogers.bsky.social
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Cyclic peptide finder, protein folder, drug discoverer. Associate Prof. at University of Copenhagen.
pinned post!
mRNA display continues to astound. Fantastic collaboration with Alex Buell, led by the peerless
@rasmusnorrild.bsky.social
. ~100,000 peptides and their propensity to join the phase separation of a model disordered protein.
doi.org/10.1101/2024...
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Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins
The formation of biomolecular condensates is involved in compartmentalisation, regulation, and signalling across most living organisms. Condensation can be driven by phase separation of proteins, and ...
https://doi.org/10.1101/2024.12.21.629870
about 1 year ago
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Could you be our new professor in protein design? Join the Novo Nordisk Foundation Center for Protein Design (
cpd.ku.dk
) in beautiful Copenhagen. Superb new facilities, smart students and great colleagues. Apply:
jobportal.ku.dk/videnskabeli...
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Center for Protein Design – University of Copenhagen
To accelerate protein design by developing a deeper understanding of sequence-to-structure/function relationships in proteins, and methods to programme these into functional designed proteins
https://cpd.ku.dk/
4 months ago
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reposted by
Joe Rogers
Kresten Lindorff-Larsen
9 months ago
New €94M research centre for protein design will open at the University of Copenhagen and be led by Dek Woolfson Funded by the Novo Nordisk Foundation, the centre will operate across the Departments of Biology and & Drug Design and Pharmacology
novonordiskfonden.dk/en/news/new-...
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New Danish research centre to make designed proteins with vast potential - Novo Nordisk Fonden
https://novonordiskfonden.dk/en/news/new-danish-research-centre-to-make-designed-proteins-with-vast-potential/
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reposted by
Joe Rogers
Kalli Kappel
10 months ago
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out!
rdcu.be/eq975
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Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq
Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...
https://rdcu.be/eq975
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reposted by
Joe Rogers
Gabriel Rocklin
about 1 year ago
Small proteins can be more complex than they look! We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments?
@ajrferrari.bsky.social
experimentally tested >5,000 domains to find out!
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Stellar line up for our protein design conference. Copenhagen, Sept 1-4, 2025. 10 days to abstract deadline. Get applying!
benzon-foundation.dk/benzon-sympo...
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Benzon Symposium no. 69 - Protein structure prediction and design in biology and pharmacology - Benzon Foundation
Radisson Collection Hotel, Copenhagen, September 1-4, 2025 Organizers: Kresten Lindorff-Larsen, Birthe B. Kragelund, Joseph M. Rogers, Amelie Stein,Anders Krogh, Wouter Boomsma and Hanne Mørck Nielsen...
https://benzon-foundation.dk/benzon-symposium-no-69-protein-structure-prediction-and-design-in-biology-and-pharmacology/
about 1 year ago
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reposted by
Joe Rogers
Science Magazine
about 1 year ago
A long-awaited nonopioid pain drug has won approval from the U.S. Food and Drug Administration (FDA) to treat moderate to severe short-term pain.
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Nonopioid drug for acute pain wins FDA approval
Ongoing trials will reveal whether suzetrigine is also effective against chronic pain
https://scim.ag/4jFWKqz
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reposted by
Joe Rogers
Kresten Lindorff-Larsen
about 1 year ago
The variability across the 20 conformations in a typical NMR ensemble in the PDB represents the uncertainty from the lack of experimental data and not the dynamics of the protein in solution Thanks for coming to my TED talk
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reposted by
Joe Rogers
Itai Yanai
about 1 year ago
How to make a presentation? Don't save the best for last! Right from the start, describe your main question and a summary of your big idea. Everyone is listening at those first few minutes but they'll only continue to listen if you grab their attention.
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reposted by
Joe Rogers
Christian A. Olsen
about 1 year ago
We have an exciting PhD position available. In collaboration with researchers
@scripps.edu
, we will investigate bacterial communication within the gut microbiome for potential health benefits, using chemical tools. Deadline 9 February, see 👇
candidate.hr-manager.net/ApplicationI...
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PhD fellowship in Chemical Microbiology at Department of Drug Design and Pharmacology
Faculty of Health and Medical Sciences, University of Copenhagen We are offering a three-year PhD fellowship in Chemical Microbiology commencing 1 May 2025
https://candidate.hr-manager.net/ApplicationInit.aspx/?cid=1307&departmentId=19218&ProjectId=163324&MediaId=5&SkipAdvertisement=false
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reposted by
Joe Rogers
Kresten Lindorff-Larsen
about 1 year ago
Come to Copenhagen
add a skeleton here at some point
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reposted by
Joe Rogers
Kresten Lindorff-Larsen
about 1 year ago
How do proteins mis-fold? Paper led by Jacob Aunstrup from Alex Büll’s lab with MD simulations by Abigail Barclay, and key contributions from several others. We combined measurements of Φ-values with MD simulations to study the transition state for amyloid fibril growth
doi.org/10.1038/s415...
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reposted by
Joe Rogers
Timothy P. Jenkins
about 1 year ago
🚨 Revolutionising Snakebite Treatments with AI-Designed Proteins 🐍 I'm proud to share our latest study published in hashtag#Nature, driven by Susana Vazquez Torres, and co-led by David Baker (Institute for Protein Design, University of Washington) and myself.
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reposted by
Joe Rogers
Magnus Kjærgaard
about 1 year ago
PhD opportunities (yes, plural!) We will launch a center of excellence “Plat-PATH” with
@bjornppedersen.bsky.social
this summer. We have an opening for some PhD students to work on plant hormone transporter mechanism. - Details and application link:
tinyurl.com/44hf9zkd
Please repost 💚
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Structural and biophysical analysis of plant hormone transmembrane transport
https://tinyurl.com/44hf9zkd
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mRNA display continues to astound. Fantastic collaboration with Alex Buell, led by the peerless
@rasmusnorrild.bsky.social
. ~100,000 peptides and their propensity to join the phase separation of a model disordered protein.
doi.org/10.1101/2024...
loading . . .
Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins
The formation of biomolecular condensates is involved in compartmentalisation, regulation, and signalling across most living organisms. Condensation can be driven by phase separation of proteins, and ...
https://doi.org/10.1101/2024.12.21.629870
about 1 year ago
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reposted by
Joe Rogers
Janet Kumita
about 1 year ago
‼️Deadline 16th January 2025‼️Applications are open for the 2025 Experience Postgrad Life Sciences programme. Paid 8-week summer internships aimed to enhance diversity among life scientists of the future!!
@cambridgebiosci.bsky.social
@corpuscambridge.bsky.social
www.exppg.lifesci.cam.ac.uk
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Experience Postgrad Life Sciences | Enhancing diversity among life scientists of the future
https://www.exppg.lifesci.cam.ac.uk
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reposted by
Joe Rogers
bioRxiv Biophysics
over 1 year ago
Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins
https://www.biorxiv.org/content/10.1101/2024.12.21.629870v1
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reposted by
Joe Rogers
Nina Hartrampf
over 1 year ago
Our Synthesis Tag (SynTag) for the synthesis of aggregating peptides and proteins is now published in JACS 🥳 Congratulations to first authors Héloïse & Elyse and everyone else involved ✨✨
pubs.acs.org/doi/10.1021/...
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A Versatile “Synthesis Tag” (SynTag) for the Chemical Synthesis of Aggregating Peptides and Proteins
Solid-phase peptide synthesis (SPPS) and native chemical ligation (NCL) are powerful methods for obtaining peptides and proteins that are otherwise inaccessible. Nonetheless, numerous sequences are di...
https://pubs.acs.org/doi/10.1021/jacs.4c14247#
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