Monitoring the complexity and dynamics of mitochondrial translation

Delayed protein translocation protects mitochondria against toxic CAT-tailed proteins

MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death

Mitochondrial diseases have seemed intractable, but last month the Food and Drug Administration OK’d the first treatment targeting a mitochondrial flaw. https://scim.ag/4q3Ymxz

Dynamic TOM–TIM23 supercomplex directs mitochondrial protein translocation and sorting.

Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation

Super-resolution microscopy of mitochondrial mRNAs

Mitochondrial origins of the pressure to sleep

Small molecule OPA1 inhibitors amplify cytochrome c release and reverse cancer cells resistance to Bcl-2 inhibitors

Interaction with AK2A links AIFM1 to cellular energy metabolism

ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism

🔥🔥 Structural mechanism of mitochondrial membrane remodelling by human OPA1

Excited to visit LMU!

Mechanistic insights into Bcs1-mediated mitochondrial membrane translocation of the folded Rieske protein

Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d

What complex are you if you have a very versatile company in close proximity? The MICOS Complex. We present the MINDNet: Proximity Proteomics revealing the nanodomain interactome in the mitochondrial inner membrane, done by the talented Yulia and team.

Molecular machineries shaping the mitochondrial inner membrane.

Fmp30 is a phosphatidylinositol hydrolase that regulates CoQ biosynthesis https://www.biorxiv.org/content/10.1101/2025.05.01.651778v1

Structures of human organellar SPFH protein complexes

Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier

Small molecules restore mutant mitochondrial DNA polymerase activity

Running a genetic stop sign accelerates oxygen metabolism and energy production in horses

Oxidation of retromer complex controls mitochondrial translation

A splendid molecular factory: De- and reconstruction of the mammalian respiratory chain

In situ architecture of the human prohibitin complex

In-cell architecture of the mitochondrial respiratory chain

🔥🔥 Structure of human PINK1 at a mitochondrial TOM-VDAC array

Heterooligomerization drives structural plasticity of eukaryotic peroxiredoxins

Engineering mtDNA deletions by reconstituting end joining in human mitochondria

Structure of mitochondrial pyruvate carrier and its inhibition mechanism

MARIGOLD and MitoCIAO, two searchable compendia to visualize and functionalize protein complexes during mitochondrial remodeling: Cell Metabolism www.cell.com/cell-metabol...

My study section meeting just got postponed, which means ~100 ESI MIRA applications won’t be reviewed in a timely manner… One of the many postponed meetings now, but it just breaks my heart and makes me feel super bad for all the junior faculty out there. What a shame.

In some positive news - truly honored to be named a 2025 ASBMB Fellow. Humbled to be a part of this amazing cohort of researchers. -ok

Some good news (and fresh science) to break things up! Our work identifying a subpopulation of compositionally unique mitochondria that localize to filopodia and promote cell migration is now @currentbiology.bsky.social! Led by fantastic @madeleinempavey.bsky.social! www.cell.com/current-biol...

Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1

HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity

🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint.bsky.social ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: www.biorxiv.org/content/10.1... #mitochondria #mtDNA

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

🧪Thrilled to share the latest research from the lab of my awesome @umasschan.bsky.social colleague Jessica Spinelli (who isn't on here yet) and collaborators: www.cell.com/cell/fulltex...

Serine phosphorylation facilitates protein degradation by the human mitochondrial ClpXP protease

An avoidance segment resolves a lethal nuclear–mitochondrial targeting conflict during ribosome assembly

Mitochondria-plasma membrane contact sites regulate the ER-mitochondria encounter

The mitochondrial DNAJC co-chaperone TCAIM reduces α-ketoglutarate dehydrogenase protein levels to regulate metabolism: Molecular Cell www.cell.com/molecular-ce...

🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...