Extremely excited & proud to share our new preprint - we provide for the first time a single cell map of the mouse brain across sex, the estrous cycle, and peripartum! Data are 🔥 👇 "Single-cell map of the female brain across reproductive transitions" www.biorxiv.org/content/10.6...

Happy to see this out, go check it 🤩 !!!Congrats to all 🎉

📣 We're hiring a postdoc to join our growing team @exeter.ac.uk! Love developmental neurobiology, RNA regulation & cortical circuits? This might be for you 🧑‍🔬 Apply here 👉 tinyurl.com/2d659uj7 Please share!

For the first time, researchers have restored some vision to people with a common eye disease by using a prosthetic retinal implant. The treatment could improve the lives of an estimated one million people in the U.S. who lose their vision to the condition if it's approved for broader use.

We have a fully funded PhD studentship exploring glial cell development with techniques ranging from molecular neuroscience to system biology. tinyurl.com/2jxezabw Come and join our interdisciplinary team with Ruth Williams and Beatriz Bano Otalaro #multiomics #singlecell #physiology

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh 🧵 www.sciencedirect.com/science/arti...

How do epigenetic modifications contribute to human #neocortex #development? Excited to see our work out in #Neuron. We applied Epi-CyTOF and identified a novel role for PRC2 in regulating #ECM. @crtd-tud.bsky.social @cp-neuron.bsky.social www.sciencedirect.com/science/arti... A thread below 👇

Excited to share our new preprint on #thalamus development! 🧠 We reveal how sensory and non-sensory circuits are specified in embryogenesis #mutiomics, #spatialtranscriptomics, #lineagetracing. @neuroalc.bsky.social @glb-lab.bsky.social @jplopez-atalaya.bsky.social www.biorxiv.org/content/10.1...

1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵 www.biorxiv.org/content/10.1...

1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social @wellcometrust.bsky.social

🚨 New Paper Alert! 🚨 I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner. Link below 👇 www.cell.com/cell/fulltex... @cellpress.bsky.social @marinlab.bsky.social

12th Dev Brains: @junyuecao.bsky.social @alainchedotal.bsky.social @cecilecharrier.bsky.social @trayon.bsky.social Isabel Espinosa-Medina Beatriz Rico Michael Ziller Dwight Bergles news.ki.se/calendar/dev... @hjerling-leffler.bsky.social @ulrikakmarklund.bsky.social @flallemend.bsky.social

ATLAS, a rationally designed transsynaptic tracer is out today! Plasmids will soon be available on @addgene.bsky.social addgene nature.com/articles/s41... Many thanks to first authors Jackie Rivera and Haoyang Huang, and to collaborators @blsabatini.bsky.social @beherring.bsky.social

@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...

New paper from Julie Jézéquel and the Rico lab on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

The beginning of a beautiful collaboration 🤩 curious about what the result will be !

Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...

🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including @clembrnrd.bsky.social and @marinlab.bsky.social. Read the paper at www.nature.com/articles/s41....

Job alert 🚨 We are hiring a research assistant! This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34. Please spread the word!

Many of us use 2p scopes to image 3D volumes of brain. But then we analyze the data plane by plane, resulting in duplicated neurons, missed neurons, and low s/n. Let's go 3D! Suite3D: Volumetric cell detection for two-photon microscopy by @haydari.bsky.social & team. www.biorxiv.org/content/10.1...

Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...

How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social

📣 Postdoc opportunity ! Our lab is hiring a funded postdoc to explore the development of fear circuits using slice electrophysiology. If you have expertise in this area and are interested about cutting-edge neuroscience, reach out ! 🤗 klinglerlab.org Please share with your network 🙏

Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro Apply by: February 16th!

Scenes from the incredible turnout today at Berkeley's @standupforscience.bsky.social rally. @tedmiguel.bsky.social, @jenniferdoudna.bsky.social, and dozens of researchers, elected officials, and citizens defended science and the jobs, health benefits, and progress it creates for all Americans.

Super proud of this massive work led by Mar Anibal from the lab. Early rescaling of barrel maps is possible and thanks to a transcriptional switch in thalamic neurons! Check it out! @neuroalc.bsky.social

Our little update on the latest knowledge on interneuron wiring! www.sciencedirect.com/science/arti...

NEW: updated long-run gap in voting between young men and women in Germany: Gender divide continues to widen, but contrary to what is often assumed, young men continue to vote roughly in line with the overall population, while young women have swung sharply left. www.ft.com/content/29fd...

✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do. www.biorxiv.org/content/10.1...

Excited to share the latest work from our lab where we examined the role of pyramidal cells in regulating microglia development! As per tradition here is a graphical summary of our paper in comic form. www.science.org/doi/10.1126/...

this is appalling

#Cellpose 3 paper now out. Not all images are perfect. Restore your images with Cellpose3 to get better segmentations, w/ @marius10p.bsky.social www.nature.com/articles/s41...

The @ibdm.bsky.social look for new team leaders! Apply by March 30th if you want to join us to study developmental biology as a PI! www.ibdm.univ-amu.fr/we-are-recru...

[email protected] and colleagues at KI and Karolinska University Hospital have determined how the immune system reacts to different kinds of #ChildhoodCancer. The study published in @cp-cell.bsky.social can lead to new tailored cancer treatments #PrecisionMedicine news.ki.se/new-study-pa...

Brain cancer leverages the same tools as the developing brain 🧠! In our new study from the Kriegstein and Li labs, published today in @nature.com, we mapped neocortical development to explore brain cancer and neuropsychiatric risks. #stemcells #brainresearch www.nature.com/articles/s41...