Scheiffele Lab
@scheiffelelab.bsky.social
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neuroscientist, autism and RNA researcher, mountain lover, super dad
reposted by
Scheiffele Lab
Zeynep Okur
5 months ago
@scheiffelelab.bsky.social
and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs:
www.sciencedirect.com/science/arti...
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Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation
Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…
https://www.sciencedirect.com/science/article/abs/pii/S0959438825000911
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Great Lab and a great project!
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Postdoc position: Synaptic specificity in cortical and thalamocortical circuits - VIB
Overview The VIB-KU Leuven Center for Brain & Disease Research is part of the VIB Life Sciences Institute and is embedded within the KU Leuven, which ranks among the world’s top 50 universities. At ou...
https://jobs.vib.be/j/107147/postdoc-position-synaptic-specificity-in-cortical-and-thalamocortical-circuits
8 months ago
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Same here -
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How Canadians Are Directing Their Ire at the U.S. Over Trump’s Tariffs
Canadians are shunning American products and abandoning trips to the United States to protest the economic punishment President Trump has threatened to impose with tariffs.
https://www.nytimes.com/2025/02/28/world/canada/canada-us-trump-tariffs-reactions.html?smid=nytcore-ios-share
8 months ago
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Interesting integration of transcriptomic and imaging data from zebrafish optic tectum cells!
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Transcriptomic neuron types vary topographically in function and morphology - Nature
Transcriptomic profiling of neurons from the zebrafish optic tectum identified more than 60 cell types; functional imaging revealed that response tuning, morphology and connectivity of specific cell t...
https://www.nature.com/articles/s41586-024-08518-2
8 months ago
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Important article on the urgent question how to upkeep key information platforms for science
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Science must step away from nationally managed infrastructure
Scientific data and independence are at risk. We need to work with community-driven services and university libraries to create new multi-country organizations that are resilient to political…
https://www.thetransmitter.org/policy/science-must-step-away-from-nationally-managed-infrastructure/
9 months ago
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Super-interesting new preprint from the Greenberg lab on a systematic analysis of plasticity-associated gene regulation!
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Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus
Curiosity-driven interactions with novel cues in our environment represent a common behavioral trait across the animal kingdom. Exposure to a novel environment (NE) reshapes the brain by promoting str...
https://www.biorxiv.org/content/10.1101/2024.10.31.621351v1
9 months ago
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Exciting job opportunity in Europe!
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Group Leader - Molecular Mechanisms of Environmental Adaptation
We are seeking to recruit a highly motivated scientist to establish and lead an independent research laboratory at the EMBL Epigenetics and Neurobiology Unit in Rome. EMBL provides a unique environmen...
https://embl.wd103.myworkdayjobs.com/en-US/EMBL/job/Group-Leader---Molecular-Mechanisms-of-Environmental-Adaptation_JR333
9 months ago
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reposted by
Scheiffele Lab
bioRxiv Cell Biology
10 months ago
Nuclear Speckle Dynamics are Controlled by Polyphosphate Inhibition of CLK Proteins
https://www.biorxiv.org/content/10.1101/2025.01.15.633116v1
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Beautiful example of spatial proteomic dissection of synapse diversity from De Wit Lab!
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Synaptic signatures and disease vulnerabilities of layer 5 pyramidal neurons - PubMed
Cortical layer 5 (L5) intratelencephalic (IT) and pyramidal tract (PT) neurons are embedded in distinct information processing pathways. Their morphology, connectivity, electrophysiological properties...
https://pubmed.ncbi.nlm.nih.gov/39747884/
9 months ago
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reposted by
Scheiffele Lab
Harmit Singh Malik
9 months ago
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me. Please amplify. If you are also able to host fly strains, add your name as well.
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A great read!
pubmed.ncbi.nlm.nih.gov/39121543/
9 months ago
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reposted by
Scheiffele Lab
Shari Wiseman
11 months ago
Nature Neuroscience is hiring a computational/systems/cognitive editor! Come join our team! Happy to answer any questions.
springernature.wd3.myworkdayjobs.com/SpringerNatu...
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Associate or Senior Editor, Nature Neuroscience
Job Title: Associate or Senior Editor, Nature Neuroscience Location: New York, Jersey City, Philadelphia, Washington D.C., Berlin or Shanghai Application Deadline: January 6, 2025 About Springer Natur...
https://springernature.wd3.myworkdayjobs.com/SpringerNatureCareers/job/New-York/Associate-or-Senior-Editor--Nature-Neuroscience_JR101206
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…and another cool approach to uncover RNA-RNA interactions !
www.cell.com/cell/fulltex...
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snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification
Transcriptome-wide mapping of snoRNA targets reveals mRNA-snoRNA-7SL RNA ternary interactions, which facilitate nascent protein translocation to the ER and subsequent secretion.
https://www.cell.com/cell/fulltext/S0092-8674(24)01269-8
12 months ago
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Cool method!
www.cell.com/neuron/fullt...
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Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes
Al-Azzam et al. reveal that SmD1, a member of the SMN complex, regulates CHMP7 translocation. Reduced SmD1 expression in sporadic ALS leads to CHMP7 nuclear translocation, while overexpression prevent...
https://www.cell.com/neuron/fulltext/S0896-6273(24)00728-1
12 months ago
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reposted by
Scheiffele Lab
The Elowitz Lab at Caltech
12 months ago
"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing.
www.nature.com/articles/s41...
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The lives of cells, recorded - Nature Reviews Genetics
Recent advances in genome engineering are enabling the recording of cellular histories into genomes, with single-cell and spatial omics technologies enabling their reconstruction into cellular lineage...
https://www.nature.com/articles/s41576-024-00788-w
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Want a job in an exciting, science-driven environment? Genome Biology Unit Group leader call at EMBL Heidelberg:
www.embl.org/jobs/positio...
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EMBL Jobs
We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.
https://www.embl.org/jobs/position/HD02741
12 months ago
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Looking forward to AXON2025 - mark your calendars
12 months ago
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Interesting read!
www.sciencedirect.com/science/arti...
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Nonsynaptic encoding of behavior by neuropeptides
A basic tenet of neuroscience is that animal behavior is generated by neural circuits that operate through synaptic transmission. On top of this synap…
https://www.sciencedirect.com/science/article/pii/S2352154624001074
12 months ago
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Gold nugget?
www.biorxiv.org/content/10.1...
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Quantitative Comparison of Monomeric StayGold Variants Using Protein Nanocages in Living Cells
To standardize comparison of fluorescent proteins and independently determine which monomeric StayGold variant is best for live microscopy, we analyzed fluorescent protein tagged I3-01 peptides that s...
https://www.biorxiv.org/content/10.1101/2024.09.16.613379v1
12 months ago
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Apply for our PhD program - great rotation system and great labs!
www.biozentrum.unibas.ch/phd/internat...
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Biozentrum PhD Fellowships Program
The Biozentrum encourages talented, ambitious and highly motivated young scientists from all over the world to apply for the prestigious and sought after fellowships offered by the Biozentrum Basel In...
https://www.biozentrum.unibas.ch/phd/international-phd-program/phd-fellowships
12 months ago
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onlinelibrary.wiley.com/doi/10.1111/...
12 months ago
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