A cellular midbrain mechanism for executing fast and reliable escape https://www.biorxiv.org/content/10.64898/2026.07.01.734238v1

Looking forward to #FENS2026 next week in Barcelona! I will present a poster on effects of locus coeruleus and arousal on astrocytes and neurons in hippocampus: PS06-09PM-201 PhD student Shinjini Ghosh will present a poster on a Theremin-based auditory virtual environment for mice: PS04-08PM-568

I am excited to announce the latest paper from our lab, published in Science ! In this study, we show that thalamocortical-like circuits in the zebrafish brain process sensory information hierarchically across topographically organized forebrain circuits.

Dual thalamic drive defines the intra-amygdala wiring complexity https://www.biorxiv.org/content/10.64898/2026.06.29.735253v1

What if part of Huntington's disease wasn't just damage, but a circuit stuck in the wrong pattern? Our new paper, out today in Nature, tests that idea.

Our joint study with Takaki Komiyama @takakikomiyama.bsky.social is out in @nature.com! We found cell type-specific changes in the cortical circuit of Huntington’s disease mice. Optogenetic stimulation of VIP interneurons rescued circuit dysfunction and improved motor behavior.

Latest from the lab: @paricio-montesinos.bsky.social & team identified a circuit mechanism for sensory thalamus plasticity. TRN inhibition reshapes auditory thalamus activity to align sensory responses with learned value and action, enabling adaptive behavior. www.biorxiv.org/content/10.6...

Very excited for our new paper, now out in @cellcellpress.bsky.social! /🧵 The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms are not clear /1 authors.elsevier.com/sd/article/S...

The Importance of Synchrony in the Neural Control of Movement https://www.biorxiv.org/content/10.64898/2026.06.26.734805v1

SWC & @gatsbyucl.bsky.social are looking to sponsor early career researchers in mechanistic theories of neural computation for external fellowships. Join a collaborative, world-class community at the interface of theory and experiment. Apply by 16 July www.sainsburywellcome.org/content/fell...

We are happy to announce the 3rd edition of the “Subcortical Sensory Circuits” Meeting on the 9-12 February 2027 at in Trieste, Italy! www.subcortical2027.com Registration will start in August, and we invite you to submit your abstract for a poster or short talk.

Excited to share our first red ACh sensor! 🔴 We developed GRAB_rACh1h, the first genetically encoded red fluorescent sensor for recording acetylcholine dynamics in vivo. (1/3)

Excited to move to the Department of Neuroscience at the University of Minnesota in the fall. We will continue our work on neuromodulators and behavior. Positions available in the lab. Please get in touch if interested, and share broadly! hr.myu.umn.edu/jobs/ext/374... hr.myu.umn.edu/jobs/ext/374...

1/11 Excited to share my postdoc work from @schierlab.bsky.social and Rainer Friedrich! 🐟👃 How does the brain decide whether an odor is good or bad? In larval zebrafish, we find that odor preference is reflected in spatially cohesive neuronal domains of the olfactory bulb. 🧵

Check out our new paper, led brilliantly by Dr. Megan Brickner, in early view form at @natcomms.nature.com. We characterize BLA dopamine signaling in emotional learning - lots of insights into broad dopamine heterogeneity beyond classic value learning signals! www.nature.com/articles/s41...

New paper from the lab, led by Sangyoon Ko (and a long-term collaboration with John Vincent at CAMH). The study revisits a basic question in modeling PTCHD1-associated autism: which exon should be targeted to best capture the human disorder? 🧵 can01.safelinks.protection.outlook.com?url=https%3A...

Why does dopamine ramp up during approach to predictable rewards? In this preprint with Luke Priestley, we explore the idea that dopamine ramps occur when reward predictions inferred using a world-model are used to train striatal cached values.

Mice produce interneurons in the septum as a response to aversive experiences and antidepressant treatment. www.science.org/doi/10.1126/...

What can a neuron compute https://www.biorxiv.org/content/10.64898/2026.06.08.730984v1

Two brain circuits. Same learning problem. Shared learning outcomes. Different dynamical implementations. Our work shows that learning is not a single canonical solution but can emerge through distinct population dynamics shaped by circuit architecture. Excited to share our latest preprint! 🧵1/12

Hippocampal CA2 modulates trace fear conditioning through circuit-specific control of CA1 https://www.biorxiv.org/content/10.64898/2026.06.05.730478v1

🚨📢 New paper from the lab: Age-dependent vulnerability to spatial memory interference in APP/PS1 mice (a preclinical model of Alzheimer's disease) 🧵1/6 www.frontiersin.org/journals/agi...

Spread the word: We’re hiring a Director of Operations to lead scientific support at the FMI. This senior role enables cutting-edge research by partnering with scientists, overseeing technology platforms, ensuring safety & compliance, and representing the FMI externally: www.fmi.ch/education-ca...

New preprint from the lab. @markgergues.bsky.social and crew show that the PVT gates ventral hippocampal salience coding, shifting output between threat- and reward-weighted representations during associative learning and anxiety-related behavior. www.biorxiv.org/content/10.6...

Excited to announce big steps for electrical imaging in the brain! In 4 preprints, we and collaborators present 2 new GFP-based voltage sensors: ASAP6c for high-throughput spike recordings, and ASAP7y for subthreshold 1P and 2P imaging bit.ly/4x3k3kX bit.ly/3RKZhq3 bit.ly/4o4fKl3 bit.ly/4uHXuk3 🧵

Come and start your group at @ki.se! ki.se/en/about-ki/...

Directional elements: the preprints are out! 1/n Congratulations to our amazing team: biorxiv.org/content/10.6... biorxiv.org/content/10.6... biorxiv.org/content/10.6... We screened for principles governing global brain dynamics by developing a set of new methods: 1) conformal immersion microscopy;

🔥 Our latest work is state of the art 3D pose estimation, with video analysis from a single camera! 🎥 Just train with 3D data, and then only 1 camera is needed! 🖤 Presented this week at #CVPR2026 by lead author Ti Wang! Please repost🩵🙏🏼 xiu-cs.github.io/FMPose3D/ arxiv.org/abs/2602.05755

Still a week or so to apply for our course in Berlin this September, it's starting to fill up so don't linger... #Biophysics #SingleMolecule #SingleChannels

Thalamic input drives co-timed excitation and inhibition to suppress cortical neuronal variability during movement initiation https://www.biorxiv.org/content/10.64898/2026.05.21.722630v1

🚨🧠 Our paper is out! We introduce a simple computational model that generates macroscopic, long-timescale dynamics as seen in large-scale neural recordings. #neuroscience #dynamics @marius10p.bsky.social @zhong-lin.bsky.social @hhmijanelia.bsky.social Link: go.nature.com/4tRNjIu

Amazing research. A fundamental aspect of survival is detecting specific threats and determining the correct actions to take. New insights here:

CRISPR/Cas9-based knockout screening revealed GSK3β as a key regulator for structural plasticity of axon initial segment https://www.biorxiv.org/content/10.64898/2026.05.21.726787v1

Excited for the launch of our new Neuronal Networks Program at @dzne.science 🧠 🔬 Learn more about our activities here www.dzne.de/neuronal-networks and here:

In this new blog post, I review some several recent studies on dendritic voltage and calcium imaging in hippocampus: gcamp6f.com/2026/05/19/d... Great work by @bhlee1117.bsky.social, Xiang Wu, @adamezracohen.bsky.social, Attila Losonczy, Balazs Rosza, Kevin Gonzalez, and others!

Optogenetic cochlear stimulation evokes midbrain activity with near-physiological temporal fidelity https://www.biorxiv.org/content/10.64898/2026.05.16.724905v1

Presynaptic temporal dynamics flexibly set input weights in the mouse escape circuit https://www.biorxiv.org/content/10.64898/2026.05.18.724906v1

We are hiring a postdoc! We study neural activity and movement using holographic optogenetics, imaging, and recordings in awake mice. My first postdoc, Masashi, is starting his own lab, so now we have an opening. Seeking candidates excited about circuits, optics, coding, or ephys. oldenburglab.com

New method for identifying the fine transcriptomic types of thousands of neurons recorded in vivo!

New preprint with @lingqiz.bsky.social: Neurodata Without Boredom: Benchmarking Agentic AI for Data Reuse arxiv.org/abs/2605.12808 1/10

Excitatory synapses onto axonic spines jump-start action potentials and route information flow www.nature.com/articles/s41...

Upholding #AcademicFreedom is essential to ensure #Europe 's competitiveness and democratic resilience. Joint Statement of the G6 network of #research organisations ➡️ www.helmholtz.de/assets/g6/Do... #demogracy w/th @helmholtz.de @leibniz-gemeinschaft.de @maxplanck.de @cnrs.fr @csic.es

🧠We offer 1-2 Postdoc positions in Circuit Neuroscience!🧠 Join us at @dandrite.bsky.social to study thalamic circuits for visual processing, funded by an ERC starting grant and the Lundbeck foundation. Deadline: 14. Juni 2026 Apply here: international.au.dk/about/profil...

Rethinking hierarchy: the auditory system as an integrated cortical–subcortical network — a Review by Michael Lohse, Ben D. B. Willmore & Andrew J. King #neuroscience #neuroskyence www.nature.com/articles/s41...

NE release is very dynamic, tied to changes in behavioral state, and multimodal, with transient peaks of NE release. High-density electrophysiology paired with dual color imaging revealed that population activity and the firing of individual cortical neurons are strongly modulated around NE peaks.

Neurodata Without Boredom: Benchmarking Agentic AI for Data Reuse arxiv.org/abs/2605.12808

New paper from the lab. Using longitudinal ca imaging, activity-dependent tagging and optogenetics, we show that newly allocated fear engram neurons in amygdala undergo a brief period of coordinated “offline reverberation” immediately after learning. www.pnas.org/doi/10.1073/...

Shared early impairments of medial entorhinal cortex function across distinct Alzheimer's disease etiologies https://www.biorxiv.org/content/10.64898/2026.05.09.723018v1

happy to share our new protocol paper on wildDISCO for whole-body immunolabeling, tissue clearing & 3D imaging of intact mice at cellular resolution using standard IgG antibodies, for mapping of neuronal, vascular, lymphatic and immune systems across the entire body. www.nature.com/articles/s41...