Jan Gründemann
@jangrundemann.bsky.social
📤 579
📥 909
📝 26
Neuroscience.
pinned post!
New study on axon initial segment plasticity by Chloé Benoit and Dan Ganea. Using a deep brain imaging approach, we find that AIS length changes dynamically during associative learning. Thank you to the wonderful team and collaborators who made this work possible.
www.nature.com/articles/s41...
loading . . .
Axon initial segment dynamics during associative fear learning - Nature Neuroscience
Benoit, Ganea et al. show that changes in axon initial segment (AIS) length in the prefrontal cortex of mice accompany fear learning and extinction, revealing AIS plasticity as a key feature of neuron...
https://www.nature.com/articles/s41593-025-02152-5
5 months ago
1
54
9
reposted by
Jan Gründemann
Kristin Branson
about 11 hours ago
New preprint with
@lingqiz.bsky.social
: Neurodata Without Boredom: Benchmarking Agentic AI for Data Reuse
arxiv.org/abs/2605.12808
1/10
2
24
11
reposted by
Jan Gründemann
Ana Dorrego Rivas
about 13 hours ago
Excitatory synapses onto axonic spines jump-start action potentials and route information flow
www.nature.com/articles/s41...
loading . . .
Excitatory synapses onto axonic spines jump-start action potentials and route information flow - Nature Neuroscience
The axon initial segment was known to receive GABAergic synaptic inputs. Yang et al. show that it can be excited directly via specialized ‘axonic spines’. These spines thus boost neuronal firing and a...
https://www.nature.com/articles/s41593-026-02282-4
0
14
8
reposted by
Jan Gründemann
Max-Planck-Gesellschaft
about 21 hours ago
Upholding
#AcademicFreedom
is essential to ensure
#Europe
's competitiveness and democratic resilience. Joint Statement of the G6 network of
#research
organisations ➡️
www.helmholtz.de/assets/g6/Do...
#demogracy
w/th
@helmholtz.de
@leibniz-gemeinschaft.de
@maxplanck.de
@cnrs.fr
@csic.es
0
14
4
reposted by
Jan Gründemann
Fiona Müllner
3 days ago
🧠We offer 1-2 Postdoc positions in Circuit Neuroscience!🧠 Join us at
@dandrite.bsky.social
to study thalamic circuits for visual processing, funded by an ERC starting grant and the Lundbeck foundation. Deadline: 14. Juni 2026 Apply here:
international.au.dk/about/profil...
0
15
19
reposted by
Jan Gründemann
Nature Reviews Neuroscience
6 days ago
Rethinking hierarchy: the auditory system as an integrated cortical–subcortical network — a Review by Michael Lohse, Ben D. B. Willmore & Andrew J. King
#neuroscience
#neuroskyence
www.nature.com/articles/s41...
loading . . .
Rethinking hierarchy: the auditory system as an integrated cortical–subcortical network - Nature Reviews Neuroscience
The auditory system differs from other senses in the complexity of its subcortical pathways. King and colleagues examine how subcortical structures transform sound representations and integrate sensor...
https://www.nature.com/articles/s41583-026-01045-1?utm_source=bluesky&utm_medium=social&utm_campaign=nrn
0
5
1
reposted by
Jan Gründemann
Jess Cardin
5 days ago
NE release is very dynamic, tied to changes in behavioral state, and multimodal, with transient peaks of NE release. High-density electrophysiology paired with dual color imaging revealed that population activity and the firing of individual cortical neurons are strongly modulated around NE peaks.
1
16
4
Neurodata Without Boredom: Benchmarking Agentic AI for Data Reuse
arxiv.org/abs/2605.12808
loading . . .
Neurodata Without Boredom: Benchmarking Agentic AI for Data Reuse
Neuroscience data are highly fragmented across labs, formats, and experimental paradigms, and reuse often requires substantial manual effort. A persistent roadblock to data reuse and integration is th...
https://arxiv.org/abs/2605.12808
5 days ago
1
2
0
reposted by
Jan Gründemann
SJo
5 days ago
New paper from the lab. Using longitudinal ca imaging, activity-dependent tagging and optogenetics, we show that newly allocated fear engram neurons in amygdala undergo a brief period of coordinated “offline reverberation” immediately after learning.
www.pnas.org/doi/10.1073/...
loading . . .
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/10.1073/pnas.2602678123
2
56
20
reposted by
Jan Gründemann
bioRxiv Neuroscience
7 days ago
Shared early impairments of medial entorhinal cortex function across distinct Alzheimer's disease etiologies
https://www.biorxiv.org/content/10.64898/2026.05.09.723018v1
0
2
2
reposted by
Jan Gründemann
Ali Maximilian Erturk
6 days ago
happy to share our new protocol paper on wildDISCO for whole-body immunolabeling, tissue clearing & 3D imaging of intact mice at cellular resolution using standard IgG antibodies, for mapping of neuronal, vascular, lymphatic and immune systems across the entire body.
www.nature.com/articles/s41...
0
36
13
reposted by
Jan Gründemann
Mike Higley
6 days ago
You know GABA as an inhibitor, but that’s not all! We found that tonic GABAergic signaling, mediated by SST-interneurons and alpha5-type receptors, paradoxically facilitates dendritic calcium signals!
www.sciencedirect.com/science/arti...
loading . . .
SST interneurons facilitate dendritic calcium signaling via tonic activation of α5-GABA receptors
Brain activity is highly regulated by GABAergic activity, which can suppress neuronal excitability and synaptic integration. Tonic GABAergic conductan…
https://www.sciencedirect.com/science/article/pii/S0896627326002862
9
42
19
reposted by
Jan Gründemann
Talia Lerner
7 days ago
🚨Exiting new preprint from Lerner Lab postdoc AJ Miller-Hansen examining the thalamus as a physiological driver of local, acetylcholine-dependent dopamine release! 🚨 DA-ACh interactions have been 🔥but what’s really going on in vivo? We think we have some answers.
#neuroskyence🧪
add a skeleton here at some point
4
56
26
reposted by
Jan Gründemann
bioRxiv Neuroscience
9 days ago
Coordinated Representational Drift Across the Mouse Cortex
https://www.biorxiv.org/content/10.64898/2026.05.05.723038v1
0
10
7
reposted by
Jan Gründemann
Eduardo Maristany de las Casas
11 days ago
1/10 When the going gets tough, the dendrites get going. Here is a summary on our new paper just published in
@science.org
on flexible learning in frontal motor cortex. With
@mattlark.bsky.social
🔬.
#neuroskyence
#neuroscience
🔗
doi.org/10.1126/scie...
loading . . .
Tuft dendrites in frontal motor cortex enable flexible learning
Flexible learning relies on integrating sensory and contextual information to adjust behavioral output in different environments. The anterolateral motor cortex (ALM) is a frontal area critical for ac...
https://doi.org/10.1126/science.adx4358
4
68
26
Thalamus orchestrates local acetylcholine-dependent dopamine release in the learning striatum
add a skeleton here at some point
10 days ago
0
11
1
reposted by
Jan Gründemann
European Research Council (ERC)
10 days ago
What happens when science is free to ask any question? It leads to discoveries we didn’t plan for – but now depend on. This
#EuropeDay
, we support
#ProtectWhatMatters
, celebrating the freedom that makes frontier research possible. Read the stories 👉
buff.ly/SRCDWoW
and have a happy Europe Day! 🇪🇺
0
37
13
reposted by
Jan Gründemann
Laura Grima
10 days ago
Really pleased that this work with
@dudman.bsky.social
is now out in Neuron: A global dopaminergic learning rate enables adaptive foraging across many options
add a skeleton here at some point
12
124
42
reposted by
Jan Gründemann
Auditory-Visual Speech Association (AVISA)
12 days ago
Plasticity and language in the anaesthetized human hippocampus
www.nature.com/articles/s41...
Demonstrates the persistence of oddball discrimination, semantic processing & online prediction in individuals under general-anaesthesia-induced loss of consciousness ->complex processing when unconscious
loading . . .
Plasticity and language in the anaesthetized human hippocampus - Nature
In the hippocampus, complex processing of sensory stimuli occurs even in the unconscious state.
https://www.nature.com/articles/s41586-026-10448-0
0
8
4
reposted by
Jan Gründemann
Arkarup Banerjee
12 days ago
How did singing mouse evolve its song? Two research manuscripts published today shed light on peripheral and central circuit modifications underlying this novel vocal capacity.
3
44
25
reposted by
Jan Gründemann
Talmo Pereira
13 days ago
We tracked mice in space! This video shows our estimate of their self-induced centripetal force during circling in 3D 👩🚀 Preprint thread below 👇
add a skeleton here at some point
3
74
36
reposted by
Jan Gründemann
bioRxiv Neuroscience
13 days ago
Automated behavioral segmentation and markerless pose tracking of mice during spaceflight
https://www.biorxiv.org/content/10.64898/2026.04.30.721950v1
0
8
6
reposted by
Jan Gründemann
bioRxiv Neuroscience
14 days ago
NPY+ Interneurons in Basolateral Amygdala are Activated by Aversive Stimuli
https://www.biorxiv.org/content/10.64898/2026.04.30.722047v1
0
3
2
reposted by
Jan Gründemann
Paul Frankland
15 days ago
Sharing the latest from the lab. Led by Yunlong Liu, this work explores how microglia and engram neurons interact during fear extinction in the hippocampus.
rdcu.be/fgNH7
loading . . .
Microglia-dependent regulation of fear memory extinction
Nature Neuroscience - Liu et al. show in mice that microglia are recruited to the soma and dendritic processes of fear engram neurons during extinction learning and that they weaken fear memories...
https://rdcu.be/fgNH7
2
71
21
reposted by
Jan Gründemann
bioRxiv Neuroscience
16 days ago
Aging Impairs Temporal Integration in Supragranular but Not Thalamorecipient Layers of Primary Auditory Cortex
https://www.biorxiv.org/content/10.64898/2026.04.30.722032v1
0
0
1
Multimodal alignments of in vivo imaging and spatial biology datasets at cellular resolution
www.biorxiv.org/content/10.6...
loading . . .
https://www.biorxiv.org/content/10.64898/2026.04.28.719500v1
16 days ago
0
9
2
reposted by
Jan Gründemann
Nature Methods
17 days ago
PinkyCaMP: a red genetically encoded calcium indicator with improved brightness and stability.
@massecklab.bsky.social
www.nature.com/articles/s41...
loading . . .
PinkyCaMP: an mScarlet-based calcium sensor with enhanced brightness, photostability and multiplexing capabilities - Nature Methods
PinkyCaMP is a red genetically encoded calcium indicator with improved brightness and photostability. Derived from mScarlet, it does not exhibit photoswitching upon blue light illumination and is ther...
https://www.nature.com/articles/s41592-026-03065-2
0
16
8
reposted by
Jan Gründemann
bioRxiv Neuroscience
17 days ago
A dataset of simultaneous two-photon calcium imaging and auditory discrimination behavior
https://www.biorxiv.org/content/10.64898/2026.04.28.721534v1
0
3
3
reposted by
Jan Gründemann
bioRxiv Neuroscience
17 days ago
Thalamic Nuclei Functional Controllability Explains Cognition Over and Above Grey and White Matter Structure
https://www.biorxiv.org/content/10.64898/2026.05.01.722231v1
0
2
2
reposted by
Jan Gründemann
Tommaso Patriarchi
22 days ago
Check out the birghtest star in the room: PinkyCaMP - the latest member to the red GECI family! Amazing work led by Olivia Masseck and a wonderful team! Proud to contribute
add a skeleton here at some point
0
22
6
reposted by
Jan Gründemann
Jonas Wietek
25 days ago
Finally online
@natmethods.nature.com
www.nature.com/articles/s41...
This was a fun collaboration with
@finkryan.bsky.social
@massecklab.bsky.social
@tpatriarchi.bsky.social
@martinfuhrmann.bsky.social
@campbell-lab.bsky.social
@jangrundemann.bsky.social
🧪🧠🔬🧬
add a skeleton here at some point
5
86
32
reposted by
Jan Gründemann
Melissa Cooper, PhD
26 days ago
Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!
loading . . .
Astrocytes connect specific brain regions through plastic networks - Nature
Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.
https://www.nature.com/articles/s41586-026-10426-6
9
161
81
reposted by
Jan Gründemann
Agnès Landemard
about 1 month ago
How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states! Out today in Nature:
rdcu.be/fdC2A
@uclbrainscience.bsky.social
4
145
69
reposted by
Jan Gründemann
Jeremiah Cohen
about 1 month ago
Delighted to share our discoveries about one of the brain's neurotransmitter systems:
www.biorxiv.org/content/10.6...
Together with colleagues at the
@alleninstitute.org
, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1
loading . . .
https://www.biorxiv.org/content/10.64898/2026.04.10.717727v1
6
244
130
reposted by
Jan Gründemann
Julie Fabre
about 1 month ago
How do the basal ganglia turn what you see into what you do? New preprint w/
@kenneth-harris.bsky.social
,
@flickerfusion.bsky.social
&
@carandinilab.net
: we recorded across striatum, GPe & SNr in a Go/NoGo task. Striatum encodes which stimulus, GPe & SNr encode action. 🧵
biorxiv.org/content/10.6...
loading . . .
1
63
26
reposted by
Jan Gründemann
Simon Wiegert
about 1 month ago
www.nature.com/articles/s41...
Two-author papers are always special. Using optogenetic stimulation of hippocampal synapses in awake mice and tracking them over approx. 2 weeks, we link synaptic strength, spine volume and their stability. It's confirmed: bigger spines are stronger and more stable 😅
loading . . .
Functional synaptic connectivity shapes spine stability in the hippocampus - Nature Communications
In this study, the authors find that synaptic strength predicts spine size and long-term stability via in vivo imaging together with optogenetic stimulation in awake mice. While individual synapses sh...
https://www.nature.com/articles/s41467-026-71332-z
0
34
9
reposted by
Jan Gründemann
bioRxiv Neuroscience
about 1 month ago
Cortical inhibitory potentiation reverses maladaptive amygdala plasticity after noise-induced hearing loss
https://www.biorxiv.org/content/10.64898/2026.04.02.716147v1
0
0
1
reposted by
Jan Gründemann
Constantinople lab
about 2 months ago
Excited to share our recent review, which highlights algorithmic and implementational degeneracy in studies of cognition:
www.sciencedirect.com/science/arti...
loading . . .
Addressing degeneracy in rodent studies of cognition
In order to relate neural dynamics to cognitive computations, it is critical to determine whether subjects are employing behavioral strategies that ac…
https://www.sciencedirect.com/science/article/pii/S0959438826000267
0
39
13
reposted by
Jan Gründemann
Ross Williamson
about 2 months ago
Excited to share a new paper from our lab, just in time for Easter, where we characterize how arousal modulates different excitatory cell-types in the auditory cortex!
www.science.org/doi/10.1126/...
loading . . .
Pupil-linked arousal heterogeneously modulates cell-type–specific sensory processing
Two-photon imaging and pupillometry reveal how arousal modulates excitatory neuron subtypes in auditory cortex.
https://www.science.org/doi/10.1126/sciadv.adz6495
2
34
10
reposted by
Jan Gründemann
Gabrielle Girardeau
about 2 months ago
Our paper is out today!!! (not an April fool's day joke) Congrats to authors
@azulsilva.bsky.social
,
@belalima-paiva.bsky.social
, Ele Pronier, and mostly to the amazing scientist and human being who led this project
@facuumm.bsky.social
#neuroskyence
#hippocampus
www.nature.com/articles/s41...
loading . . .
Dorsoventral hippocampus neural assemblies reactivate during sleep following an aversive experience - Nature Neuroscience
Synchronization of sharp-wave ripples across the dorsoventral hippocampus during sleep supports coordinated reactivation that represents negative experiences more faithfully than positive ones.
https://www.nature.com/articles/s41593-026-02252-w
11
76
31
reposted by
Jan Gründemann
Georg Keller
about 2 months ago
Very excited to share new work by Leonardo Lupori. In mice, a single dose of the antipsychotic clozapine results in changes to behavior and cortical activity patterns that remain detectable a week later.
www.biorxiv.org/content/10.6...
loading . . .
https://www.biorxiv.org/content/10.64898/2026.03.27.714783v1-0
1
19
8
reposted by
Jan Gründemann
Torsten Schwede
about 2 months ago
Open Research Europe is stepping into an exciting new chapter to become a truly collective European diamond open access platform: Backed by 16 national funders and research institutions and continued European Commission involvement, ORE will be hosted by CERN in Geneva.
home.cern/news/news/kn...
loading . . .
CERN to host flagship European open access publishing platform
Open Research Europe (ORE), a non-profit, open access scientific publishing platform, will be hosted at CERN as of autumn 2026. Initiated by the European Commission in 2021 and supported by a consorti...
https://home.cern/news/news/knowledge-sharing/cern-host-flagship-european-open-access-publishing-platform
0
2
3
reposted by
Jan Gründemann
Silvia Viana da Silva
about 2 months ago
Incredible conference👏🧠 thank you for everything.
add a skeleton here at some point
0
5
1
reposted by
Jan Gründemann
Adam Carter
about 2 months ago
Excited to share our new J Neurosci paper showing how subcortical inputs are routed through ventromedial (VM) thalamus to layer 1 interneurons in the medial PFC, all done by my graduate student Sanne Casello:
sannemcasello.bsky.social
www.jneurosci.org/content/earl...
0
28
11
reposted by
Jan Gründemann
Fabrizio Musacchio
about 2 months ago
A great start to
#BonnBrain26
🧠 today, highlighted by the excellent young investigator talks by
@martipof.bsky.social
,
@samueleckmann.bsky.social
, Nicole Hoffmann, Carlo Castoldi, Karen Yu Chen Cheng,
@seidlcarina.bsky.social
,
@j-b-eppler.bsky.social
and Julia Schnermann 💫💪
#DZNE
#BonnBrain
1
11
5
reposted by
Jan Gründemann
Nadine Gogolla
about 2 months ago
New preprint! Follow the thread to find out about the exciting work of an outstanding postdoc in my lab
@merylneuro.bsky.social
!!!
add a skeleton here at some point
1
30
8
reposted by
Jan Gründemann
Monika Scholz
about 2 months ago
We are at
#BonnBrain26
! Find us tomorrow at the poster session to chat about smelling delicious things and then eating them, and how what is delicious and what you eat may evolve!
#celegans
#worms
#pharynx
0
17
5
Don’t miss our lab’s posters at
@bonnbrainconf.bsky.social
, featuring exciting new work from Eva Sebastian,
@paricio-montesinos.bsky.social
& Ziyan Huang on large-scale neuronal activity in sensory thalamus function, decision-making, sleep & inhibitory regulation. 🧠🔬
@dzne.science
#BonnBrain26
about 2 months ago
0
11
4
reposted by
Jan Gründemann
Naturalistic Neuroscience
3 months ago
Registration and abstract submission for our symposium Naturalistic Neuroscience – from perception to action and back (University of Bonn 28-29 May 2026) is no open!
www.nn2026.uni-bonn.de/en/registrat...
#NN2026
@unibonn.bsky.social
#naturalisticneuroscience
#neuroscience
#symposium
#cfa
loading . . .
Registration
https://www.nn2026.uni-bonn.de/en/registration
0
21
13
reposted by
Jan Gründemann
bioRxiv Neuroscience
about 2 months ago
Cardiac signals shape insular cortex activity and emotion coding
https://www.biorxiv.org/content/10.64898/2026.03.18.712676v1
0
4
3
Load more
feeds!
log in