Mazen Kheirbek
@mazenkheirbek.bsky.social
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Neuroscientist at UCSF www.kheirbeklab.org
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Mazen Kheirbek
Martin Kampmann
9 days ago
Apply by Oct 15 - please spread the word!
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New paper from the lab, from Jeremy Biane and team, out today, characterizing the principles of stimulus feature coding in populations of ventral CA1 neurons.
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about 2 months ago
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Mazen Kheirbek
Vikaas Sohal
3 months ago
New work! Learning is assumed to involve synaptic plasticity, but which specific synapses change to enable higher order cognitive functions? We actually find that cognitive flexibility involves potentiation of long-range GABAergic synapses from prefrontal PV neurons:
www.biorxiv.org/content/10.1...
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Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility
While glutamatergic synaptic plasticity is believed to be a fundamental mechanism mediating learning, the behavioral significance of plasticity at cortical GABAergic synapses remains less well underst...
https://www.biorxiv.org/content/10.1101/2025.06.27.662040v1.article-metrics
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Mazen Kheirbek
Alexandra Klein
4 months ago
Come to our symposium tomorrow morning at
#NeuroFrance2025
if you want to hear about extero- and interoceptive impact on emotions!
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Mazen Kheirbek
Josh Johansen
4 months ago
Iโm excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional memories, using an internal model to infer emotional associations and memories via projections to the amygdala. a๐งต(1/8)
rdcu.be/el19t
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Prefrontal encoding of an internal model for emotional inference
Nature - Neurons in the rodent dorsomedial prefrontal cortex encode a flexible internal model of emotion by linking directly experienced and inferred associations with aversive experiences.
https://rdcu.be/el19t
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Mazen Kheirbek
Paul Frankland
4 months ago
Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.
rdcu.be/el18q
A short thread follows for those interested. 1/n
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Systems consolidation reorganizes hippocampal engram circuitry
Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...
https://rdcu.be/el18q
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Mazen Kheirbek
Alex Kwan
6 months ago
A much-needed joint effort from five labs to see which behavioral effects of psilocybin in mice are reliable, and which may be spurious ๐๐
@theborislab.bsky.social
@mazenkheirbek.bsky.social
@indigenerd.bsky.social
Vikaas Sohal and Stephan Lammel ๐
www.biorxiv.org/content/10.1...
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A multi-institutional investigation of psilocybin's effects on mouse behavior
Studies reporting novel therapeutic effects of psychedelic drugs are rapidly emerging. However, the reproducibility and reliability of these findings could remain uncertain for years. Here, we impleme...
https://www.biorxiv.org/content/10.1101/2025.04.08.647810v1
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Mazen Kheirbek
AntonioFR
6 months ago
Excited to share our latest story! We found disentangled memory representations in the hippocampus that generalized across time and environments, despite the seemingly random drift and remapping of single cells. This code enabled the transfer of prior knowledge to solve new tasks
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Kate Wassum
7 months ago
๐จ๐New Wassum Lab Paper๐๐จ Out today,
@jackiegio.bsky.social
discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits ๐งต๐
www.nature.com/articles/s41...
Free full text:
rdcu.be/eaxEv
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A dual-pathway architecture for stress to disrupt agency and promote habit - Nature
Adaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain path...
https://www.nature.com/articles/s41586-024-08580-w
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Saul Kato
8 months ago
For our inaugural post on bsky, we're happy to share our preprint on tardigrades as a new model organism for neuroscience. Exciting times for these little critters!
www.focolab.org/post/our-pre...
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Our preprint "The tardigrade as an emerging model organism for systems neuroscience" is up.
We have been making the case for some time that tardigrades, aka water bears, would be an amazing new model organism for certain big systems neuroscience questions. We put this into a detailed paper o...
https://www.focolab.org/post/our-preprint-the-tardigrade-as-an-emerging-model-organism-for-systems-neuroscience-is-up
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Mazen Kheirbek
Paul Frankland
9 months ago
Scientist position at The Hospital for Sick Children in Toronto. We are looking for neuroscientists with interests in the molecular and cellular bases of cognition. The position is open-rank, and the successful candidate will also be appointed at U Toronto. Deadline is Feb 15th. Come join us!
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https://career.sickkids.ca:8001/psc/CRPRD/CAREER/HRMS/c/HRS_HRAM_FL.HRS_CG_SEARCH_FL.GBL?Page=HRS_APP_JBPST_FL&Action=U&FOCUS=Applicant&SiteId=1&JobOpeningId=21813&PostingSeq=1&
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Mazen Kheirbek
Josh Johansen
10 months ago
Check out our pre-print from Xiaowei Gu! It shows how the medial prefrontal cortex encodes an internal model of emotional associations which can be used for inference
biorxiv.org/content/10.1...
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https://biorxiv.org/content/10.1101/2024.04.22.590529v1
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Mazen Kheirbek
PessoaBrain
10 months ago
๐จ๐ป๐ฑ๐ฒ๐ฟ๐๐๐ฎ๐ป๐ฑ๐ถ๐ป๐ด ๐๐ต๐ฒ ๐ป๐ฒ๐๐ฟ๐ฎ๐น ๐ฐ๐ผ๐ฑ๐ฒ ๐ผ๐ณ ๐๐๐ฟ๐ฒ๐๐ ๐๐ผ ๐ฐ๐ผ๐ป๐๐ฟ๐ผ๐น ๐ฎ๐ป๐ต๐ฒ๐ฑ๐ผ๐ป๐ถ๐ฎ Looks like a very cool paper.
#neuroscience
doi.org/10.1038/s415...
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Mazen Kheirbek
10 months ago
A beautiful work with a wonderful team! A lot of new ideas and a huge number of elegant experiments
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Mazen Kheirbek
Frances Xia
10 months ago
Excited to share our new paper out now
@natureportfolio.bsky.social
, where we identified neural signatures of stress susceptibility and resilience in the amygdala-ventral hippocampal network to enable control of anhedonia! <https://www.nature.com/articles/s41586-024-08241-y> Thread below:
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Valeria Fascianelli
10 months ago
What is the neural code and statistical structure of neural states characterizing stress? Our new work in Nature answers these questions and more. Thanks to my amazing co-first
@fxia.bsky.social
@stefanofusi.bsky.social
@mazenkheirbek.bsky.social
for precious guidance
www.nature.com/articles/s41...
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I am excited that my first Bluesky post is to share our new paper in
@natureportfolio.bsky.social
- "Understanding the neural code of stress to control anhedonia." With
@fxia.bsky.social
,
@valeriafascianelli.bsky.social
and
@stefanofusi.bsky.social
.
www.nature.com/articles/s41...
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Understanding the neural code of stress to control anhedonia - Nature
Examination of the neural activity in the basolateral amygdala and ventral CA1 of mice during tasks or rest following exposure to social stress reveals signatures of resilience and susceptibility to s...
https://www.nature.com/articles/s41586-024-08241-y
10 months ago
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