Fong Kuan Wong
@brainotopia.bsky.social
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Brain development enthusiast 🧠 @ University of Manchester fongkuanwonglab.com
pinned post!
Excited to share the latest work from our lab where we examined the role of pyramidal cells in regulating microglia development! As per tradition here is a graphical summary of our paper in comic form.
www.science.org/doi/10.1126/...
7 months ago
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It was a pleasure writing this Perspective of our work. If you are interested in learning more about activity-dependent regulation of cortical cell numbers, do have a read.
tinyurl.com/4ede4jyb
15 days ago
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Fong Kuan Wong
Society for Developmental Biology
about 1 month ago
✨ Are you a pre-tenure faculty or advanced postdoc with an academic offer in hand? 🎓 Two weeks left to apply for the SDB New Faculty Boot Camp! 🚀 Deadline: Aug 22, 2025 Apply here 👉
tinyurl.com/SDBFaculty
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Monika is such an amazing scientist. It has been such a privilege to see this story grow and develop during my time at
@marinlab.bsky.social
. I am so happy to see this finally out. Well done to all authors.
@martijnselten.bsky.social
@clembrnrd.bsky.social
add a skeleton here at some point
2 months ago
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Fong Kuan Wong
Grubb Lab
2 months ago
The paper is out in journal format at EJN! We thank the reviewers for their insightful comments, and how they shaped the final form of this story. Check it out here:
onlinelibrary.wiley.com/doi/10.1111/...
As usual, it's open access! We're getting the data ready for sharing very soon 👀🧠🧪
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Fong Kuan Wong
Christian Mayer
3 months ago
Now out in
@natneuro.nature.com
: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors
@annrosebright.bsky.social
, Yana Kotlyarenko,
@flo-neuhaus.bsky.social
, and thanks to all collaborators!
www.nature.com/articles/s41...
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Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience
Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...
https://www.nature.com/articles/s41593-025-01999-y
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Fong Kuan Wong
Centre for Developmental Neurobiology
3 months ago
Dr. Katie Long is leading vital research, funded by an MRF award, to learn how pregnant people feel about vaccines during pregnancy. We want your views! Take this short survey:
tinyurl.com/vaccines-in-...
For more information on vaccines in pregnancy visit
tommys.org/vaccinations-pregnancy
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Fong Kuan Wong
Nicholas Clifton
3 months ago
New paper in
@oxfordacademic.bsky.social
Schizophrenia Bulletin exploring the effects of Setd1a happloinsufficiency on DNA methylation in the frontal cortex. Strong effects on the regulation of ribosomal genes with implications for understanding the genetics of schizophrenia.
doi.org/10.1093/schb...
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Setd1a Loss-of-function Disrupts Epigenetic Regulation of Ribosomal Genes via Altered DNA Methylation
AbstractBackground and Hypothesis. SETD1A, a histone methyltransferase, is implicated in schizophrenia through rare loss-of-function mutations. While SETD1
https://doi.org/10.1093/schbul/sbaf091
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Fong Kuan Wong
Gord Fishell
4 months ago
Here is the collective effort of 12 labs, lead by my own at the Broad to target the range of cortical interneuron subtypes! These tools should be a game changer for all of you using NHP and other less genetically amenable species! Have at it!
urldefense.proofpoint.com/v2/url?u=htt...
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https://urldefense.proofpoint.com/v2/url?u=https-3A__kwnsfk27.r.eu-2Dwest-2D1.awstrack.me_L0_https-3A-252F-252Fauthors.elsevier.com-252Fa-252F1l7-25257EF3BtfHC-25257ERe_1_01020196f35d0b11-2D22d04620-2D52da-2D4c83-2Da02f-2Dec1d912a9aa9-2D000000_zDtuX03GGi-5F9TcLxZK-2DWhqCqQak-3D427&d=DwMFaQ&c=WO-RGvefibhHBZq3fL85hQ&r=3kG29FrezGlbqQxLydpnuQCdt7hkW_81u08Hi538v6o&m=oxqDOM6FhuvOeXtQaA_UPHxOyzwGRHuxbMK2g3JIg7_0icR9RNFkq6_abUCtG6Hq&s=ARXdksjQmIIiOaDsfneFMI8dC0PIi9BVoIyLyMc7BSY&e=
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Fong Kuan Wong
Stein Aerts
4 months ago
One thousand candidate enhancers tested in vivo in the mouse brain! A massive resource and oh so useful as validation set for genome-wide enhancer prediction methods. Super fun to be involved in one of the papers: ‘the prediction challenge paper’ by Nelson&Niklas et al
www.cell.com/cell-genomic...
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Fong Kuan Wong
Shane Herbert
5 months ago
My first post on Bluesky! Very excited to share our work just published in
@science.org
. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues!
www.science.org/doi/abs/10.1...
www.science.org/doi/abs/10.1...
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Interphase cell morphology defines the mode, symmetry, and outcome of mitosis
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
https://www.science.org/doi/abs/10.1126/science.adu9628
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Fong Kuan Wong
Martijn Selten
5 months ago
🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including
@clembrnrd.bsky.social
and
@marinlab.bsky.social
. Read the paper at
www.nature.com/articles/s41...
.
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Fong Kuan Wong
Doug Dyer
5 months ago
So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4.
www.biorxiv.org/content/10.1...
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Fong Kuan Wong
Clem Bernard
5 months ago
I will soon start recruiting for a Wellcome-funded postdoc position! I’ll be at the
#BNA2025
meeting next week. If you like cortical development, wiring, and post-transcriptional regulation, do get in touch and we can have a chat in Liverpool! 😀
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Fong Kuan Wong
Clem Bernard
5 months ago
Job alert 🚨 We are hiring a research assistant! This 7-year position available
@exeter.ac.uk
from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details
tinyurl.com/23nyds34
. Please spread the word!
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Fong Kuan Wong
6 months ago
⏳🧠 Developmental timing is key during neocortex development. Our new review with
@takashi-namba.bsky.social
lab discusses the role of epigenetic and metabolic regulation of developmental timing in neocortex evolution.
www.sciencedirect.com/science/arti...
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Epigenetic and metabolic regulation of developmental timing in neocortex evolution
The human brain is characterized by impressive cognitive abilities. The neocortex is the seat of higher cognition, and neocortex expansion is a hallma…
https://www.sciencedirect.com/science/article/pii/S0166223625000566
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Fong Kuan Wong
Allen Institute
6 months ago
Advances in neuroscience have yielded massive, rich datasets from various analysis techniques and modalities. 🧠📈 In a
@natureneuro.bsky.social
perspective, researchers underscore the importance of an integrative approach to render a more complete picture of the brain.
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Integrating multimodal data to understand cortical circuit architecture and function - Nature Neuroscience
This paper discusses how experimental and computational studies integrating multimodal data, such as RNA expression, connectivity and neural activity, are advancing our understanding of the architectu...
https://www.nature.com/articles/s41593-025-01904-7
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Fong Kuan Wong
Sally Lowell
6 months ago
I absolutely love this beginners guide to scientific conferences by
@jens-cells.bsky.social
. It's not only useful for beginners either- there is lots of great advice even for those of us who have been attending conferences since the last millenium.
thenode.biologists.com/the-beginner...
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the-beginners-guide-to-scientific-conferences
The Beginners Guide to Scientific Conferences
https://thenode.biologists.com/the-beginners-guide-to-scientific-conferences/resources/
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We are showcasing our love for developmental biology for British Science Week this year with the different model organisms that we use in our division. 🪰🐸🐟🐣🐭🧠🔬🧬🧫
7 months ago
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Fong Kuan Wong
Hilary Ashe
7 months ago
Fun paper celebrations across the developmental biology and
@mcf-uom.bsky.social
groupings this afternoon. Celebrating our latest paper and papers from the
@brainotopia.bsky.social
@lovegrovelab.bsky.social
, Herbert, Manning, Bennett and Papalopulu labs. Congrats to all!
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Fong Kuan Wong
MRC Laboratory of Molecular Biology
7 months ago
Are you an undergraduate student considering a career in academic research? Don’t miss the opportunity to gain hands-on experience at the LMB with our Student Placement Scheme – open now for applications! Apply by 30th March. More info:
www2.mrc-lmb.cam.ac.uk/students/stu...
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Fong Kuan Wong
Cahir O'Kane
7 months ago
Multiple group leader positions in developmental biology in
@ibdm.bsky.social
Marseille, at an institute that produces some great work.
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We Are Recruiting Group Leaders - IBDM | Institut de Biologie du Développement de Marseille
The Institut de Biologie du Développement de Marseille (IBDM) is inviting applications for group leader positions. We are seeking innovative researchers who aim to address fundamental questions in bio...
https://staging.ibdm.univ-amu.fr/we-are-recruiting-group-leaders/
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Fong Kuan Wong
JB Manent
7 months ago
New work from
@antoinedechevigny.bsky.social
and colleagues in the team! Fantastic resource for those interested in gene expression dynamics throughout cortical histogenesis and ligand-receptor interactions between cortical neurons.
#neuroscience
#neuroskyence
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Fong Kuan Wong
Clem Bernard
7 months ago
Our little update on the latest knowledge on interneuron wiring!
www.sciencedirect.com/science/arti...
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Dynamic regulation of cortical interneuron wiring
Inhibitory interneurons play crucial roles in modulating the circuits and activity patterns of the cerebral cortex. In particular, interneurons must a…
https://www.sciencedirect.com/science/article/pii/S095943882500011X
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Fong Kuan Wong
the Node
7 months ago
Would you like to speak at an upcoming Development presents… webinar? We're looking for self-nominations from postdocs – based outside of the US and Europe – looking to transition to an independent position within the next year or so.
#DevBio
#StemCell
#FuturePI
@dev-journal.bsky.social
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Development presents... call for self nominations - the Node
Launched in 2020, Development presents... is a monthly Zoom webinar series covering the fields of developmental biology, stem cells and regeneration. Each
https://thenode.biologists.com/development-presents-call-for-self-nominations/development-presents/
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Excited to share the latest work from our lab where we examined the role of pyramidal cells in regulating microglia development! As per tradition here is a graphical summary of our paper in comic form.
www.science.org/doi/10.1126/...
7 months ago
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reposted by
Fong Kuan Wong
Richard Behringer
8 months ago
Here is the 2025 embryo alphabet from alligator to zebrafish. Developmental biology is stunning & leads to important discoveries for human medicine.
@socdevbio.bsky.social
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Fong Kuan Wong
Society for Developmental Biology
8 months ago
We are extending the
#ChooseDevelopment
application deadline to Wednesday, February 5, 11:59 PM ET. Undergrads from underrepresented racial or ethnic groups, first-generation college students, veterans & students with a disability are eligible.
bit.ly/3FwHqYp
#devbio
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Fong Kuan Wong
Adrian Liston
8 months ago
"Becoming a
#Scientist
: The Graphic Novel" goes through the stories of my amazing lab members. Every one has a unique pathway, overcoming personal challenges. They are an inspirational
#team
!
www.thegreatbritishbookshop.co.uk/products/bec...
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Becoming a Scientist
"Science changes the world every day. Curing diseases, designing super-computers, building green technology, creating wearable nanotechnology... You may know what science can do, but what do you know ...
https://www.thegreatbritishbookshop.co.uk/products/becoming-a-scientist
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