Cancer Research and Therapy (@fighting-cancer.bsky.social)

Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients In brief, Vernieri et al. conducted a pilot, randomized phase 2 trial showing that cyclic FMD plus preoperative chemotherapy results in excellent pCR rates in stage I–III TNBC patients. In tumors achieving pCR, bulk and single-cell RNA-seq analysis revealed early downmodulation of glucose metabolism in TNBC cells and in glycolytic intratumor cells. https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00450-9