Chris Fell
@cfell.bsky.social
📤 70
📥 97
📝 16
Postdoc AbuGoot lab
pinned post!
So excited to share our new paper out today in
@nature.com
. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵
www.nature.com/articles/s41...
loading . . .
Reprogramming site-specific retrotransposon activity to new DNA sites - Nature
A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large pa...
https://www.nature.com/articles/s41586-025-08877-4
7 months ago
3
30
13
reposted by
Chris Fell
Max Wilkinson
5 months ago
If you like transposons... If you you love genome editing... Or if you just like random bird animations, we have the paper for you! We (
@kedmonds.bsky.social
et al) are happy to share our work turning a songbird retrotransposon into a genome editing tool. 🐣 (1/n)
loading . . .
4
45
18
reposted by
Chris Fell
Addgene
7 months ago
STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions. Plasmids here
www.addgene.org/browse/artic...
add a skeleton here at some point
0
10
3
So excited to share our new paper out today in
@nature.com
. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵
www.nature.com/articles/s41...
loading . . .
Reprogramming site-specific retrotransposon activity to new DNA sites - Nature
A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large pa...
https://www.nature.com/articles/s41586-025-08877-4
7 months ago
3
30
13
🚨 Interested in precise, multi-kilobase scale insertions into the genome? Check out our detailed protocol describing PASTE, out in Nature Protocols
@natureportfolio.bsky.social
⬇️
www.nature.com/articles/s41...
loading . . .
Precise kilobase-scale genomic insertions in mammalian cells using PASTE - Nature Protocols
Programmable addition via site-specific targeting elements (PASTE) combines the specificity, efficiency and cargo size benefits of site-specific integrases with the programmability of prime editing fo...
https://www.nature.com/articles/s41596-024-01090-z#data-availability
11 months ago
0
27
8
you reached the end!!
feeds!
log in
