I absolutely loved reading this one recently! The authors show how AMPK (which is traditionally viewed as an stress-activated kinase) is also developmentally regulated by circulating adenosine levels in Drosophila. www.nature.com/articles/s41...

Our latest preprint! Into morphogenesis, Yap, ECM, signaling, vertex models, feedbacks/robustness? There is something here for everyone. We discovered a positive feedback loop that extends inner ear canals, and a built-in mechanism that shuts it down when morphogenesis is done. tinyurl.com/464wsjhd

It's online! In this series of perspectives @dev-journal.bsky.social, yours truly talks about the exciting open questions and many things to do in the field of dev bio and neuroscience #DevBio🧪 #PIsOfTomorrow journals.biologists.com/dev/article/...

Latest from ours: www.cell.com/cell-reports... This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

🚨 New preprint! We profile the transcriptome of the C. elegans distal tip cell: a persistent leader cell that invades basement membrane to shape the gonad. Our dataset defines the molecular signature of invasive leader cells & uncovers new regulators of collective cell invasion.

Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids journals.biologists.com/dev/article/...

Jane Goodall, who revealed the intimate lives of chimpanzees and gave the modern world a language of hope, has died at the age of 91. “Every individual matters. Every individual has a role to play. Every individual makes a difference,” she told audiences. Those words remain her truest epitaph.

How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite www.cell.com/cell/abstrac...

Cool Postdoc opportunity alert! UNC SPIRE (Seeding Postdoctoral Innovators in Research & Education)-it provides scholars with both high quality research training & the opportunity to develop research based teaching skills that will inspire students across the sciences 1/n spire.unc.edu/program-info/

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

This is very exciting! A small clinical trial using gene therapy for Huntington's disease has been successful. microRNAs were used to edit the Huntington mRNA, stopping it making mutant protein that can damage neurons. Huge hopes now for treating such a devastating condition

1/12 A very special moment for me! 🎉 My first paper as corresponding author—a @jcb.org Perspective on how contact-based decision-making in collective cell migration can itself encode blueprints for complex patterns and shapes. rupress.org/jcb/article/... #cellbio #devbio #science 🧵for details

The 2025-2026 #aECM club schedule is now posted on our website, where you can also find the link to sign up for access. I’m looking forward to lots of great talks and discussions! sundaramlab.com/blog/aecm-cl...

1🧵 Excited to share my first PhD paper, published in @dev-journal.bsky.social What if fish gills —often overlook —hold secrets about development, patterning, and function? We uncovered how early patterning shapes adult gill architecture. journals.biologists.com/dev/article/... #DevBio #Zebrafish

A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis! Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)

#Drosophila community - look at this amazing lineup for #InDRC2025 Registration for #InDRC2025 is now open! Visit indrc2025.in to register and submit your abstract. #genetics #devbio @flybase.bsky.social

🚨 The International Developmental Mechanics Zoom Seminar Series is back on Sept 25! 🎤 We have an exciting line-up of speakers this fall. See the image below for details 🌐 Website: sites.google.com/view/devmech... 📝 Interested in presenting? Sign up here: tinyurl.com/2munv5bv

”Please inhibit responsibly: Natural and synthetic actin toxins as useful tools in cell biology” I had a lot of fun going down different actin inhibitor rabbit holes with @onishilab.bsky.social on this perspective! www.molbiolcell.org/doi/10.1091/... www.molbiolcell.org/cms/10.1091/...

Hydra body axis balance: a fight between two transcription factors This Research Highlight showcases the work from Jaroslav Ferenc, Marylène Bonvin, Panagiotis Papasaikas, Jacqueline Ferralli, Clara Nuninger and Charisios D. Tsiairis: journals.biologists.com/dev/article/...

📢📢Hiring 2 Research Assistants & 2 Postdocs at Emory University in Atlanta to study cytoskeletal biophysics/biochemistry. Please RT. RAs: great for recent bachelor's/master's in Physics/Bio/Chem/Biochem. Email CV and interests to [email protected]. More info: www.shekharlab.org

Out in @science.org! We found that the intestine doesn’t just push out cells when crowded. Instead, cells are in a mechanical tug-of-war, and weaker ones are extruded. A new view of how our gut keeps its balance and stays healthy. www.science.org/doi/10.1126/...

@lschermelleh.bsky.social, Heintzmann, & Leonhardt provided a guide to super-resolution fluorescence #microscopy, just as these ground-breaking techniques were emerging in 2010 rupress.org/jcb/article/... 📕 #Reproducibility and Best Practices in Cell Biology: rupress.org/jcb/collecti...

🤔 Can migrating cells 'remember' their past trajectories? In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question: Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history! www.nature.com/articles/s41...

How does the #cochlea achieve its spiral shape? @prakash-patterns.bsky.social @earlab.bsky.social &co show that the expression of adhesion & polarity proteins pattern the #OrganOfCorti and drive the compartment-specific organisation to achieve the cochlea spiral @plosbiology.org 🧪 plos.io/4nmD8IW

RIP David Baltimore. He is famous for breakthrough work that challenged dogma that information flows from DNA to RNA. In viruses, it is the opposite. This took virology in a new direction. This was NIH funded research. We stand on the shoulders of giants before us. 🧪 www.salk.edu/news-release...

New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵

I'm thrilled to share that I have been awarded an NIH/NEI K99 Pathway to Independence Award. I'm deeply grateful to everyone who has supported me along the way, especially my mentor Jessica Treisman for her invaluable mentorship.

How is this possible? This ant can lay eggs of two different species, birthed by the same mother

We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌 @IBECBarcelona www.biorxiv.org/content/10.1...

Are different cell types like oil and water? Over a century ago, researchers found that dissociated sponges and embryonic tissues can self-assemble into functional structures. Join me, @benswedlund.bsky.social to explore the differential adhesion hypothesis & its applications in tissue engineering!

About 100 years the Mangold-Spemann organizer was published and this has been one of the most fruitful and inspiring concepts in Developmental Biology. But how can organizers self-organize? In this review we summarize the knowledge how cnidarians do that: doi.org/10.1016/j.cd...

Our new paper, “Organization of the apical extracellular matrix during tubular organ formation”, has been published in @elife.bsky.social! elifesciences.org/reviewed-pre...

Several @genetics-gsa.bsky.social opportunities for early career scientists are open - DeLill Nasser award for professional development, Peer review training program and Early career leadership program are all amazing opportunities for scientific career development. #academia #earlycareer

Your DNA sequence reveals a rare mutation. Will you get the disease, i.e. penetrance? A new study using machine learning predicts this across 10 common diseases, 1,600 genomic variants New @science.org science.org/doi/10.1126/...

Trouble imaging actin in ExM? Meet HAK-Actin, a probe for U-ExM, cryo-ExM & iU-ExM. Enables post-expansion labeling for max signal. www.biorxiv.org/content/10.1... Soon at @spirochrome.com Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social

🚨pre-print alert🚨 Excited to share the latest work on how cell specific secretion of chitin controls the shape of the fly corneal lens, an #aECM structure.

Supracellular control and coordination of tissue morphogenesis, through supracellular actomyosin assemblies, that is what my lab @cellbiol-mrclmb.bsky.social @pdncambridge.bsky.social and I like to dig into at the moment! Fascinating and beautiful! journals.biologists.com/dev/article/...

Delighted to share our latest collaborative work with Santosh Chauhan's group at CCMB, Hyderabad, out now in @embojournal.org We use the Drosophila hematopoietic progenitors in this study to investigate pro-self-renewal mechanisms! Congrats to all the authors! www.embopress.org/doi/full/10....

Collective cell motion has many forms, but rotation is the coolest of them all. I'm @onenimesa.bsky.social , and in this short🧵, I'll highlight some instances of global tissue rotation like this one from @BauschLab

The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share

Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns? To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠 #preprint thread ⬇️1/8

🚨 Imagine a bacterium that refuses to follow the textbook: It grows as tangled filaments, divides unevenly, reshapes its own membranes… and even builds grappling hooks. Meet Litorilinea aerophila — and here’s why it blew our minds.

July in preprints, the CellBio edition, is out now on the preLights website. Thanks to Girish Kale, Matthew Davies, Barbora Knotkova and Sristilekha Nath for their contributions. Have a look: prelights.biologists.com/prelists/jul... #PrePrints #Publishing #Biology #Research #CellBio #PreLights

Regulated development of cannibalistic supergiant cells https://www.biorxiv.org/content/10.1101/2025.08.19.671124v1

Cells can form patterns within themselves just like embryos do. How? Connie Yan's new preprint shows how the anterior-posterior cytoskeleton pattern in Stentor is dictated by regionalized scaffolding proteins www.biorxiv.org/content/10.1...

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...! Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more! Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

Heffler and @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) and @hennelab.bsky.social (doi.org/10.1016/j.ce...) that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum. rupress.org/jcb/article/...

Please RP. We are thrilled to announce that our lab’s first preprint is out! ”Whole-genome single-cell multimodal history tracing to reveal cell identity transition” We report HisTrac-seq, a multiomic single-cell molecular recording platform. www.biorxiv.org/content/10.1...

Some behaviors are genetic, not learned, which means, theoretically, that they are transferable. That is exactly what this experiment demonstrated. Manipulation of one gene made one species of fruit fly gain the behavior of another. 🧪 Link: www.science.org/doi/10.1126/...