NAR Cancer presents a curated collection of 17 articles on how advances in understanding the DNA damage response are reshaping cancer therapy. Explore the collection and read the editorial from guest editors Li Lan and Elise Fouquerel. New targets and new tools. academic.oup.com/narcancer/pa...

Most genetic interaction studies measure gene relationships in one condition, but environment can reshape which genes depend on each other. Today in Molecular Cell, Luke Gilbert & team deliver the first systematic, multi-condition map of genetic rewiring in human cells.

Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14

🧵 Thread: What happens when transcription isn’t properly shut off during mitosis? Our new preprint explores just that 👇 www.biorxiv.org/content/10.6...

Happy to share our new pre-print on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1. Outstanding work of @angelotaglialatela.bsky.social in collaboration with the Min, Lazzerini Denchi and @cejkalab.bsky.social laboratories! www.biorxiv.org/content/10.6...

Pleased to share that our latest paper is out now in NAR. We demonstrate that Pol η binds to and is a substrate of NEDD8. @ncmoreno.bsky.social @txelah.bsky.social @barneslab.bsky.social @irinabezsonova.bsky.social academic.oup.com/nar/article/...

Excited to share our latest study in Nature Communications ✨ We map how cells clear DNA damage–stalled RNA polymerase II using a stepwise TFIIH → ubiquitin/VCP mechanism, keeping transcription and genome stability on track. Paper: www.nature.com/articles/s41... #Genomics #DNADamage #CellBiology

Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself. www.science.org/doi/10.1126/...

I am excited to share our review on the mechanistic basis and functional consequences of cell cycle-specific mRNA decay and translational control. Fun work with Cheese lab's (@iaincheeseman.bsky.social) grad students Katya Khalizeva and Yi Fei Tao! rnajournal.cshlp.org/content/earl...

Nice to see some yeast genetics in a Cell paper, where the authors test models based on single-molecule in vitro analysis. The combination of genetics and biochemistry often addresses questions most effectively. www.cell.com/cell/fulltex...

📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open) 🗓 May 30–31, 2026 ✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators. Please RT & share with your labs! 🔗 sites.google.com/view/kumc-mi...

Our Science paper is out! 😃 www.science.org/doi/10.1126/...

Mitosis has a timing system. If chromosomes attach properly, cells divide on schedule and keep proliferating. If attachment is slow or incomplete, the delay is recorded — and daughter cells stop dividing. We explore this link in our new preprint. 🔗 www.biorxiv.org/content/10.6...

Congratulations on the beautiful story! What an amazing start to your lab! 😀

new PARP paper from our neigbhors in the Arnoult lab at CU Boulder: indicates that PARP inhibitors alone are not good enough; we need combo therapy by adding inhibitors of MMEJ. academic.oup.com/nar/article/....

We are seeking a motivated postdoctoral fellow to investigate mechanisms of DNA damage response, APOBEC-mediated mutagenesis, innate immunity, and double-stranded RNA sensing. Located in Southern California, UCI offers an outstanding scientific environment and exceptional quality of life.

New online: Transcription stress causes an inflammatory response via release of IL-1α

Online Now: IFI16 senses and protects stalled replication forks Online now:

The Expanding Roles of Homologous Recombination Proteins in Genome Stability @labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion link.springer.com/article/10.1...

We are excited to share that our latest work from the lab aimed at understanding how the tRNA nuclease SLFN11 is activated in response to DNA damage and replication stress has just been published in @natcellbio.nature.com! Open access link: www.nature.com/articles/s41... (1/9)

🐭 In vivo veritas 🐭 Now out in Nature Genetics: @josjonkers.bsky.social and I describe currently available mouse models of BRCA1/2 and their roles in understanding BRCA1/2 biology, particularly in normal development, tumor suppression and therapy response. www.nature.com/articles/s41...

Excited to announce a new review article that Andreas Villunger @villungerlab.bsky.social, Dario Rizzotto (not on bsky) and I wrote. In this article, we discuss mitosis as a central cell cycle stage for integrating DNA damage, cell death and inflammatory responses. www.nature.com/articles/s41...

🔬🧬@science.org #Chromosome shattering in #cancer | Science www.science.org/doi/10.1126/...

This was another fun collaboration with @professorantony.bsky.social and big thanks to lead authors (Poonam Roshan, Ayush Mistry and Vikas Kaushi) and to all the co-authors. www.nature.com/articles/s41...

🚨 Exciting news! Our latest study is out in Nature Communications! We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair. 🔗 rdcu.be/eT1R9 #CancerResearch #BRCA2 #Genomics

Our @costerlab.bsky.social review is out! It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course! www.sciencedirect.com/science/arti... @adityasethi.bsky.social @billiedelpino.bsky.social

A key step towards human genome synthesis. With thanks to @wellcometrust.bsky.social @mrclmb.bsky.social #SynHG doi.org/10.1126/scie...

Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n www.science.org/doi/10.1126/...

If you’re interested in aneuploidy, mark your calendar! The FASEB SRC on the Consequences of Aneuploidy will be held Sept 28 - Oct 1, 2026 in Melbourne, Florida. Many speaking slots are reserved for early-career researchers. Please help spread the word! events.faseb.org/event/Aneupl...

Good news- they are continuing to do administrative supplements but the specific dates for NIGMS are unclear!

Increasing TET expression and 5-hydroxymethylcytosine formation by a carbocyclic 5-aza-2'-deoxy-cytidine antimetabolite https://www.biorxiv.org/content/10.1101/2025.11.26.690736v1

A new #ScienceSignaling study sheds light on how a cell-cycle kinase inhibitor may be used most effectively to treat #OvarianCancer and hints that the protein p16 could be a useful marker for identifying those patients most likely to benefit. https://scim.ag/4ijSlte

Checkout the latest preprint from the lab - single-cell CIN signatures unlocked! Ongoing HRD improves PARPi sensitivity detection and ongoing NHEJ associates with subclonal diversification in TNBC

New study from the lab on genetic relationship between 53BP1-RIF1 and DNA-PKcs on DSB repair outcomes. Led by PhD student @kaelamakins.bsky.social www.nature.com/articles/s41...

Our protocol for imaging-based quantification of RNAPII clearance during transcription-coupled DNA repair is now online. 👇 Well done, Bram, Diana, and Paula! star-protocols.cell.com/protocols/45...

Check out this beautiful paper by @richardcsilva.bsky.social et al., out now in @natcomms.nature.com. Great new DSB sensors to track DNA break formation and repair in real-time www.nature.com/articles/s41...

Finally! We have a FANCM:RMI inhibitor that is cell active and specifically kills ALT+ cancer cells 🎯 @yuhenglau.bsky.social + my labs just published the first cell-active peptide inhibitors of this critical target in 10-15% of cancers. doi.org/10.1021/acs....

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

The magical LAB!!

What do the naked mole rat and bowhead whale (lives to ~200 years) have in common to explain their remarkable longevity? Enhanced DNA repair www.nature.com/articles/s41... erictopol.substack.com/p/a-long-awa...

What specific targets & roles are there for all distinct polyubiquitin chain types? Niels Mailand, Robert Shearer et al profile a panel of #ubiquitin replacement cell lines, implicating K29 chains in chromatin regulation via SUV39H1 destabilization www.embopress.org/doi/full/10....

H2B ubiquitination by RNF20/40 safeguards replication fork dynamics in human cells, by facilitating fork reversal and recruiting RNF169 that protects from excessive degradation of nascent DNA @penengolab.bsky.social and collaborators www.embopress.org/doi/full/10....

I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.

New publication!! 📑 Congrats to the Ulrich and @hopfnerlab.bsky.social labs on their latest work exploring how the INO80 chromatin remodeller facilitates DNA damage bypass via postreplicative gap repair. 🔎Read the paper here: www.embopress.org/doi/full/10.1038/s44318-025-00580-4

Congratulations to Forment, O’Connor and coworkers on an Editors' Choice study in NAR Cancer, unraveling the mechanism by which addition of PARP inhibitors to AR pathway inhibitor therapy improves prostate cancer survival, even in the absence of HRR defects. academic.oup.com/narcancer/ar...

🧬 Preprint alert! "Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity." Read the manuscript here 👉 www.biorxiv.org/content/10.1...

www.nature.com/articles/s41... saw @lablegube.bsky.social present this last week. Provides important clarity on RNA at chromosomal DSBs. Including rigorously debunking the nascent synthesis idea.

Histone acetylation - not always about transcriptional activation: H4K16ac safeguards the genome replication program by repressing premature replication of heterochromatin. Well done Marta Milan! tinyurl.com/yuy9m8t3

New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com