Our paper describing a toolbox of FRET biosensors for c-di-GMP measurements in the cell and its application to elucidate the interplay between c-di-GMP and bacterial motility just appeared: www.nature.com/articles/s41...

Added custom menus, including one to quickly add common monomers (detergents, buffers etc):

Rapid resistance evolution against phage cocktails #ISMEJournal by Baltus van der Steen, Matti Gralka, and @yuvalmulla.bsky.social academic.oup.com/ismej/advanc...

www.nature.com/articles/s41... Biological AI to interpret and generate DNA, RNA, proteins and cellular systems

What if plant immunity doesn’t stop bacteria from arriving - but from staying? Excited to share our new Dangl Lab paper (doi.org/10.1073/pnas.2535583123), asking a fundamental co-evolutionary question: which flagellar function is targeted by plant immunity? #Coevolution #Plant-Microbiome #PNAS 🧵1/8

Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications. Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101

How do you kill a MRSA superbug armed with 15 different anti-phage defense systems? You make a smarter phage. Check out our latest preprint on overcoming bacterial immunity using defense-guided engineering to build durable therapeutic phage cocktails! Led by Sarah Voss. doi.org/10.64898/202...

Check out the final version of this work, out today! @natcomms.nature.com www.nature.com/articles/s41...

Our lab is hiring! As our fierce technician is moving on to graduate school (GO ANNA!), we’re looking for a new tech to join our team studying bacteria-phage interactions. Ideal for recent grads interested in molecular biology and microbiology - please reach out with a CV to [email protected].

Happy to share the final version of my postdoc work on bacterial CBASS immunity with @aaronwhiteley.bsky.social published in @cp-cellhostmicrobe.bsky.social www.cell.com/cell-host-mi...

We’ve been sciencing! M abscessus makes a arabinanase toxin to chop up the cell wall of competitor mycobacteria! #glycotime 🦠 thanks to @wellcometrust.bsky.social for the funding that makes this collaborative work possible! Also Sam’s structures are 😍 and Jean-Lou did some lovely biochem

Excited to share our story published today @nature.com! 🔗 www.nature.com/articles/s41... Read about how we uncover the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! Have a quick read of some of the key events in the thread below🧵:

Only 9 days left to apply for this post doctoral position. Please share and forward to your colleagues.

Registration is open for the FASEB Virus Structure & Assembly meeting! Join us for exciting sessions on pandemic viruses, virus structure and replication, antiviral and bacteriophage therapies, and cutting-edge technologies. Short talks will be selected from submitted abstracts. #VirStrucSRC

Excited to share the first preprint from the lab! We show that ApeA defends against RNA phage infection by cleaving the phage genome: www.biorxiv.org/content/10.6...

ApeA cleaves genomic RNA to defend against RNA phage infection https://www.biorxiv.org/content/10.64898/2026.03.20.713152v1

I've written a review on what I think is an extremely exciting direction in cryo-EM: Cryo-EM of endogenous membrane proteins in their native lipid bilayer Open access in Quarterly Reviews of Biophysics: doi.org/10.1017/S003...

Gut phage Acrs Type II CRISPR-Cas systems dominate human gut w/diverse phage Acrs targeting these systems. Widespread family, GutAcraca, adopts similar structures to inhibit Cas9 & regulate its own expression, highlighting phage adaptation to gut ecology www.cell.com/cell-host-mi...

Had a bit of a break from the socials and forgot my Bluesky password, but really happy to belatedly share some great work from PhD student Jose Nakamoto on the diversity of toxin-antitoxin-chaperone systems www.sciencedirect.com/science/arti...

New preprint: Cyclic tri-adenylate signalling by a Panoptes anti-phage guard system with a CARF-TM effector. Great work led by Sabine Grüschow www.biorxiv.org/content/10.6...

Don't miss the opportunity to present your work in the 2026 Symposium on the Immune System of Bacteria - abstract submission deadline is today

Cyclic tri-adenylate signalling by a Panoptes anti-phage guard system with a CARF-TM effector https://www.biorxiv.org/content/10.64898/2026.03.13.711614v1

New paper 🔔 Collaboration @sullivan-lab.bsky.social Marissa Gittrich led the work Klebsiella phage biology has focused almost entirely on capsulated strains, but capsule loss is the #1 resistance mechanism under phage predation. We used a naturally acapsular host to reveal the receptor landscape

#NatMicroPicks Sending evolution into overdrive 🔧🦠 A Φ29‑based DNA replication system in E. coli enables stable and targeted hypermutation achieving evolution of enzyme activities within days #MicroSky www.nature.com/articles/s41...

Capturing dynamic phage–pathogen coevolution by clinical surveillance @nature.com @ucberkeleyofficial.bsky.social www.nature.com/articles/s41...

We’re happy to share our updated manuscript on Ninj1, incorporating measurements of membrane tension, cellular assays of ninj1 and ninj2 dimer stability and MD simulations of ninj1 oligmers opening and forming (see below!). @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Our work on bacterial Schlafens in phage defense is out today @natmicrobiol.nature.com! Check out the final version here: rdcu.be/e7Bmz We are looking for postdocs and students to expand our team! Official postings are coming soon. Please reach out if you're interested! #phage #phagesky #microsky

CBASS is a cyclic nucleotide-based antiviral system in bacteria that is related to cGAS-STING signaling in animals. One of the big questions is how CBASS is activated during phage infection? We made some progress on this during my final year in the Kranzusch lab. www.biorxiv.org/content/10.6...

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it. A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

🚨Preprint! Happy to share the research from my PhD “Genome delivery of a contractile tailed phage and its superinfection exclusion mechanism”. We use cryoEM to study the genome ejection of the phage T4, revealing how the tape measure protein regulates the process. www.biorxiv.org/content/10.6...

Out today: We discovered new viral proteins that target immune signaling molecules, solely based on their AlphaFold-predicted shapes www.science.org/doi/10.1126/... Congrats Nitzan Tal and coauthors! Thank you Kranzusch lab for the fun collaboration! Linking below previous thread on our findings

Cell death is a fundamental mechanism of antiviral immunity across diverse organisms, including bacteria. As my final PhD project with @jbdsf.bsky.social, I was curious whether cell death is required for successful immunity with the ancient cGAS pathway known as ‘CBASS.’ Spoiler – the answer is no!

Now online! The unique architecture of umbrella toxins permits a two-tiered molecular bet-hedging strategy for interbacterial antagonism

New post-doctoral research position in my phage-host interactions (Phi) laboratory in @otagomicroimmuno.bsky.social at @universityofotago.bsky.social New Zealand. The project is focused on defences against jumbo phages. Please share and if interested apply using the link in the comments.

Save the date for the next International Conference on Gram-Positive Bacteria which will take place between 29 June–2 July 2027. The organizers (@annadragos.bsky.social, @polonca32.bsky.social, and Ines Mandic-Mulec) look forward to welcoming you to Ljubljana, Slovenia

Out now! In collaboration with Leifu Chang, we uncover the molecular and structural underpinnings of CRISPR-Cas12f-like RNA-guided transcription systems! Links to the published articles: tinyurl.com/55kpavet tinyurl.com/sk6djwx3 Previous thread for the preprint: bsky.app/profile/did:...

Fantastic collaboration w/ @dbikard.bsky.social @audeber.bsky.social @rayanchikhi.bsky.social labs led by @jmouradesousa.bsky.social : We assessed the rates of variation of anti-phage systems in P4-like satellites and P2 helper phages. Quick conclusion: Huge variation! We focus on 4 key questions/5

In our latest work, we characterise the Tmn defence system. We reveal plasmolysis as a new way to block phage infection, dramatically reducing secondary infections.

Stunning new structural analysis and mechanism for Tmn anti-phage defense by @fnobrega.bsky.social www.biorxiv.org/content/10.6...

The new ChimeraX CubeNTube plugin allows erasing parts of maps using cube, cylinder, and custom shapes and has undo. Created by Tamino Cairoli. Available from ChimeraX menu Tools / More Tools....

Max Fels @mfels.bsky.social from our lab discovers giant DNA viruses that infect amoeba encode eIF4E and the entire suite of 4F complex proteins to control mRNA translation, including beautiful crystal structures of viral 4E bound to modified mRNA 5' caps: www.cell.com/cell/fulltex...

Congratulations to Sonomi Yamaguchi for her paper at @nature.com. Sonomi discovered Clover defense and explained how nucleotide signals control each step of viral sensing, immune regulation, and viral restriction – named for her beautiful "four-leaf" structures 🍀 www.nature.com/articles/s41...

If you are interested in investigating horizontal gene transfer by phages and virus-like particles using computational approaches, this postdoc position in the Callahan Lab could be for you jobs.ncsu.edu/postings/226...

Too much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @Yale www.nature.com/articles/s41...

The immune systems paradox Some widespread prokaryotic immune systems are absent in eukaryotes, whereas relatively rare ones became central to eukaryotic innate immunity @audeber.bsky.social & E. Koonin hypothesize the answer is #HGT shareable link: rdcu.be/e2EmD www.nature.com/articles/s41...

Amazing findings in geometry-based immune activation! Two bacterial defence systems detect phage-encoded ring oligomers, assemble high-order molecular complexes, and trigger abortive infection. www.nature.com/articles/s41... www.nature.com/articles/s41...

Join us at the 2026 GRC Microbial Stress Response to be held on July 19th-24th at Mount Holyoke College!! Here is the link for more information: www.grc.org/microbial-st...

🚨 Hiring Alert! 🚨My lab at Institut Pasteur is recruiting several Postdocs! We have exciting open projects in: 🦠 Synthetic Biology and🛡️ Bacterial Immunity. Come do great science with us in the middle of Paris! 🇫🇷🥐 research.pasteur.fr/en/job/postd...

Excited to share a new story that transformed how we think about membrane domains in the ER! rdcu.be/eR7Cn ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export Wondering what’s so new and exciting? Skytorial below! 1/9

“A student joining a lab is often presented with a hypothesis to work on and may see science as a hypothesis-testing endeavor. Many young postdocs have been told that as a PhD student their job was to answer questions—now they have to discover their own unknown unknowns.”