Uday Tak
@snowkaryote.bsky.social
📤 282
📥 559
📝 10
Bacteria and phage at UVA taklaboratory.org
reposted by
Uday Tak
Luuk Loeff
about 20 hours ago
Excited to see this online! The structure of the CAST type I holo-complex. Congrats to all involved! By the labs of
@martinjinek.bsky.social
&
@sternberglab.bsky.social
.
add a skeleton here at some point
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Uday Tak
cryoEM papers
about 21 hours ago
Structural basis of RNA-guided DNA integration by type I CRISPR-associated transposases
www.biorxiv.org/content/10.64898/2026.05.18.725949v1
#cryoem
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Uday Tak
Nela Nikolic
2 days ago
We are hiring! 🔬🧫 Join our lab at the Uni Southampton as a Research Technician working on bacteria-phage interactions to develop therapies for hard-to-treat infections. 2-year post Deadline: 27 May 2026 Position start date: 1 July 2026 or shortly after Apply:
jobs.soton.ac.uk/Vacancy.aspx...
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Dr Nela Nikolic receives Springboard funding to develop approaches to tackle bacterial infections
Dr Nela Nikolic receives Springboard funding to develop approaches to tackle bacterial infections
https://www.southampton.ac.uk/biosci/news/2026/04/dr-nela-nikolic-receives-springboard-funding-to-develop-approaches-to-tackle-bacterial-infections.page
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Uday Tak
Karolin Luger
1 day ago
Out today - structure of the human HIRA histone chaperone complex bound to nucleosomes. Ever wondered how nucleosomes are assembled in the wake of transcription? It takes a 'hulk of a protein complex'. Work by the amazing Wei Tian
weetian558.bsky.social
.
www.biorxiv.org/content/10.6...
🧵
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Uday Tak
RCSB Protein Data Bank
4 days ago
Try this new online training game from Leandro F. Estrozi designed for newcomers in structural biology, with a focus on cryo-EM and cryo-ET map interpretation:
rico.ibs.fr/helixplo...
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Uday Tak
Mary Weber (Weber lab)
4 days ago
We’re hiring in the Weber Lab at the University of Iowa! We study how intracellular pathogens (Chlamydia trachomatis and Orientia tsutsugamushi) manipulate host cells through secreted effector proteins. Two great opportunities for future scientists and research professionals.
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Uday Tak
Robert Jansen
about 1 month ago
Very excited to share our preprint on the discovery of the new metabolite GABA-trehalose and its biosynthetic enzyme in Mycobacterium tuberculosis. A thread.
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.04.15.718621v1
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Uday Tak
Franklin Nobrega
6 days ago
Very happy to share our Druantia III–Zorya II synergy story, now on bioRxiv:
www.biorxiv.org/cgi/content/short/2026.05.12.724681v1
It appears alongside several Druantia III papers from excellent colleagues, each telling a different part of the story. (links below)
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https://www.biorxiv.org/cgi/content/short/2026.05.12.724681v1
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Uday Tak
Luuk Loeff
6 days ago
Happy to share our latest pre-print on the Druantia defense system. We find that Type III Druantia uses a cooperative helicase-nuclease mechanism to sense and degrade replication-associated forked DNA structures.
www.biorxiv.org/content/10.6...
A🧵
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https://www.biorxiv.org/content/10.64898/2026.05.13.724313v1
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Uday Tak
Ahmad Jomaa
7 days ago
Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab
@simonemattei.bsky.social
@embl.org
www.nature.com/articles/s41...
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Uday Tak
Sorek Lab
27 days ago
We found that TIR domains in animal immune proteins, including the human TLR4, are enzymes that cleave NAD+ to produce the signaling molecule cADPR Read our new preprint by talented Bohdana Hurieva: “Conserved catalytic activity of immune TIR domains in animals”
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.04.20.719644v1
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Uday Tak
Sternberg Lab
8 days ago
1/9 New preprint from the Sternberg Lab in collaboration with the Nishimasu Lab! We uncover how the DRT3 antiphage immune system pairs two reverse transcriptases, one RNA-templated and one protein-templated, to build a double-stranded DNA effector.
doi.org/10.64898/202...
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Uday Tak
Mart Krupovic
9 days ago
With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the
#virosphere
. We describe all 10 viral realms and the logic behind them, and so much more. Check it out!
comptes-rendus.academie-sciences.fr/biologies/ar...
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Uday Tak
Mary Weber (Weber lab)
12 days ago
We’re hiring! Join the Weber Lab at the University of Iowa to study Chlamydia effector biology, centrosome regulation, vesicular trafficking, and innate immunity. Please share!
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reposted by
Uday Tak
Naama Aviram
12 days ago
That's a wrap on three days of incredible science at
#SISB2026
! Special thanks to
@rockefeller.edu
for hosting us on their beautiful campus, to our speakers and poster presenters, and most of all to this community that never fails to inspire. Can't wait for
#SISB2027
🫶
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reposted by
Uday Tak
bioRxiv Biochemistry
14 days ago
TIR-like NADases act in bacterial immunity and the RNA vault
https://www.biorxiv.org/content/10.64898/2026.05.01.722283v1
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Uday Tak
laurelrobbins.bsky.social
15 days ago
I’m thrilled to share an update to our work on bacterial NACHT domain containing proteins! In our last preprint, we reported that bNACHT11 is activated by multiple phage proteins. We’ve now expanded this work with structural insight and investigation of programmed cell death following activation.
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https://www.biorxiv.org/content/10.1101/2024.12.17.629029v2
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Uday Tak
Emmanuele Severi
22 days ago
#microsky
#phagesky
#phage
defence
academic.oup.com/nar/article/...
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The SAVED domain of the type III CRISPR protease CalpL is a ring nuclease
Abstract. Prokaryotic CRISPR-Cas immune systems detect and cleave foreign nucleic acids. In type III CRISPR-Cas systems, the Cas10 subunit of the activated
https://academic.oup.com/nar/article/52/17/10520/7737999?utm_source=researchgate.net
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Uday Tak
Ákos T Kovács
17 days ago
A Streamlined and High-Osmolarity Bacillus subtilis Cell-Free Platform for Rapid Characterization of Genetic Regulatory Elements
pubs.acs.org/doi/10.1021/...
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A Streamlined and High-Osmolarity Bacillus subtilis Cell-Free Platform for Rapid Characterization of Genetic Regulatory Elements
Lysate-based cell-free systems (CFS) mimic cellular functions in a controllable environment, making them versatile synthetic biology tools used from fundamental research to protein production and synt...
https://pubs.acs.org/doi/10.1021/acssynbio.6c00165
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Uday Tak
Dimitry Tegunov
17 days ago
We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by
@martenchaillet.bsky.social
. We think it's going to make your cryo-ET life a lot better. Preprint:
www.biorxiv.org/content/10.6...
Code:
github.com/warpem/miss-...
🧶 Thread:
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Uday Tak
Tera Levin
18 days ago
Bacterial immune proteins have repeatedly evolved to become parts of eukaryotic immunity. But how? Our new preprint uncovers a recent horizontal transfer event & shows how eukaryotes co-opted a toxic bacterial immune protein 🦠🧪🧵 1/
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Uday Tak
Waggoner Lab
19 days ago
Altering gene syntax, defined by the relative order and orientation of neighboring genes, changed DNA supercoiling and affected both the level and variability of gene expression
@science.org
www.science.org/doi/10.1126/...
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reposted by
Uday Tak
Cress Lab
20 days ago
Our lab is proud to present our latest work harnessing Bridge Recombinase for genome-scale editing in diverse bacteria, microbiome editing, and programmable horizontal gene transfer.
add a skeleton here at some point
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Uday Tak
ASM
21 days ago
ASM's Mechanism Discovery Unit, focused on advancing research into the basic principles of microbial life, has launched! The unit is led by Glen McGugan, Ph.D., & Alison Criss, Ph.D., & guided by a Scientific Advisory Council of 14 experts. Read more:
asm.org/press-releas...
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Uday Tak
Karolin Luger
21 days ago
New work from Sashi Weerawarana on how TFAM compacts mitochondrial DNA 🧬 TFAM oligomerizes on DNA to form compact, homogeneous higher-order complexes (see beautiful mass photometry data below), that still retain dynamic behavior. Congratulations Sashi and Wei.
www.biorxiv.org/content/10.6...
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Uday Tak
Alexandria Miller
22 days ago
www.linkedin.com/posts/alexan...
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We are excited to share the first structure of a potassium channel from fungi, TOK1 from Candida albicans, a major human fungal pathogen, and it's a weird one! The first four helices form a… | Al...
We are excited to share the first structure of a potassium channel from fungi, TOK1 from Candida albicans, a major human fungal pathogen, and it's a weird one! The first four helices form a tetraspan...
https://www.linkedin.com/posts/alexandria-miller-167ab43_we-are-excited-to-share-the-first-structure-activity-7454569673720848384-hlbK
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Uday Tak
Kenneth Loi
22 days ago
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.
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Uday Tak
Kranzusch Lab
22 days ago
Congratulations to
@aragucci.bsky.social
and
@sadieantine.bsky.social
for their nuclease-NTPase work now online in final form at
@natmicrobiol.nature.com
www.nature.com/articles/s41...
add a skeleton here at some point
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Uday Tak
Bohdana Hurieva🇺🇦
27 days ago
🎉Excited to share our new preprint! TIR domains from diverse animals, including human TLR4, are catalytically active and produce cyclic ADP-ribose (cADPR). This enzymatic activity is widespread in animals and conserved across the tree of life.
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.04.20.719644v1
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Uday Tak
Kranzusch Lab
29 days ago
Structures of the QatBC complex from Angela Gao and Doug Wassarman in our group reveal an evolutionary link between QatABCD and Type IV CBASS and a role for protein deazguanylation in diverse anti-phage defense systems
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
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Uday Tak
Addgene
30 days ago
Bacteriophages are in a constant arms race with bacteria 🦠 The Phage ORFeome pooled library from the Aaron Whiteley lab contains phage proteins that activate antiphage defense systems — a tool to dissect the mechanisms of bacterial immunity.
Aaron Whiteley
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Addgene: Phage ORFeome Library
Use the Phage ORFeome Library to uncover the triggers responsible for immune activation.
https://twp.ai/4hqB5Z
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Uday Tak
Rémi Fronzes
29 days ago
ComEC structure is out!! 😍 Congratulations to the authors! That’s not an easy one. We have been trying for years to get that structure… We failed and gave up.
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Structural basis for DNA processing and membrane translocation by ComEC in natural transformation
Natural transformation is one of the major pathways of horizontal gene transfer in bacteria, enabling the acquisition of extracellular DNA and its integration into the host genome. ComEC is a membrane...
https://www.science.org/doi/10.1126/science.aea3485
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Uday Tak
Laurence Ettwiller
about 1 month ago
Those amazing
#phages
🦠 figured out 5mC chemistry before we did: 📄 Out today in @MolecularCell we describe a 5mC-selective
#deaminase
family in environmental phage genomes with broad applications for
#5base
#sequencing
#epigenetics
#DNAmethylation
#genomics
#NGS
🧬🧪
www.cell.com/molecular-ce...
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Uday Tak
Kranzusch Lab
about 1 month ago
Congratulations to Karen Maxwell
@themaxwelllab.bsky.social
on the 2026 Peter Gilgan Canada Gairdner Momentum Award! An amazing selection and leader in the bacterial immunity field!
www.youtube.com/watch?v=u0pg...
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2026 Peter Gilgan Canada Gairdner Momentum Award, Karen Maxwell
YouTube video by CanadaGairdnerAwards
https://www.youtube.com/watch?v=u0pgCh3nNCU
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Uday Tak
Pujuan Poppy Deng
about 1 month ago
I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA.
www.science.org/doi/10.1126/...
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Uday Tak
Alex Gao
about 1 month ago
Excited to share our new findings in
@science.org
on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze!
www.science.org/doi/10.1126/...
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Science | AAAS
https://www.science.org/doi/10.1126/science.aed1656
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Uday Tak
Emma Banks
about 1 month ago
Delighted to share our latest work on gene transfer agents (GTAs). We found a lysis control hub which allows GTAs to escape their bacterial host cells and transfer DNA 🧬 between bacteria. Thanks to
@tunglejic.bsky.social
, all co-authors, and our amazing collaborators!
www.nature.com/articles/s41...
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A bacterial CARD–NLR-like immune system controls the release of gene transfer agents - Nature Microbiology
An immunity-like system functions as a lysis control hub to promote gene transfer agent particle release from host bacterial cells, suggesting that bacterial immune systems may be co-opted to promote ...
https://www.nature.com/articles/s41564-026-02316-4
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Uday Tak
Thomas P200 Burke
about 1 month ago
I'm happy to share a review that our lab put together on innate immune responses to Rickettsia. One interesting tidbit - different Rickettsia species have distinct interactions with xenophagy, where some species co-opt ubiquitylation, while others avoid it!
www.sciencedirect.com/science/arti...
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Innate immune responses to Rickettsia: emerging themes and contrasts between species
Over 10 species of Rickettsia cause serious human disease across the globe, including deadly spotted fever and typhus. These arthropod-borne microbes …
https://www.sciencedirect.com/science/article/pii/S1369527426000482
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Uday Tak
Raphael Laurenceau
about 1 month ago
🔈Paper out! We turned the most fascinating phage host-switch mechanism, diversity-generating retroelements, into a programmable mutagenesis tool, DGRec. You can perform targeted hypermutation of any 50-200bp sequence directly in vivo in E. coli
www.nature.com/articles/s41...
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Diversity-generating retroelements for programmable targeted hypermutagenesis - Nature Biotechnology
Diversity-generating retroelements are engineered for directed evolution in E.coli.
https://www.nature.com/articles/s41587-026-03078-4
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Uday Tak
Karolin Luger
about 1 month ago
Finally published at long last (at least in the pre-view version). Explore the wild and woolly world of archaeal histones! Interactive archaeal histone graph incluced
rdcu.be/fdFjv
. Congratulations to first author Shawn Laursen
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Uday Tak
Kranzusch Lab
about 1 month ago
Thank you to
@vcallier.bsky.social
and Quanta Magazine for highlighting our lab along with the incredible research from
@soreklab.bsky.social
@audeber.bsky.social
@aaronwhiteley.bsky.social
@benmorehouse.bsky.social
@teralevin.bsky.social
@algao.bsky.social
Eugene Koonin, L. Aravind and others!
add a skeleton here at some point
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Uday Tak
Molecular Microbiology
3 months ago
The next International Conference on Gram-Positive Bacteria will take place between 29 June – 2 July 2027 in Ljubljana, Slovenia.
#subtiwiki
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Uday Tak
Melanie Blokesch
about 1 month ago
Excited to share our new paper out today in
@science.org
🎉 We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩 Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/
#microsky
#phagesky
www.science.org/doi/10.1126/...
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https://www.science.org/doi/10.1126/science.aed0645
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Uday Tak
Chase Morgan
about 1 month ago
Excited to share the last installation of my PhD work. Worked with an all-star team on this one who really made this all come together beautifully.
@ranidreamer.bsky.social
@amardeeep.bsky.social
@benadler.bsky.social
and many others.
www.cell.com/cell-reports...
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The phage nucleus synergizes with an anti-defense protein to resist bacterial immunity
Morgan et al. show that a phage-encoded protein functions as an antitoxin to counter DarTG2-mediated phage defense. They further explore the interplay between this anti-defense protein, the phage nucleus replication compartment, which encloses chimallivirus genomes, and the DarTG2 phage defense system.
https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00297-4
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Uday Tak
Malcolm White
about 1 month ago
Postdoc position available in St Andrews for a structural biologist:
www.vacancies.st-andrews.ac.uk/Vacancies/W/...
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Research Fellow - AR3262
Research Fellow - AR3262, School of Biology Salary: Grade 6 / £38,784 pa Start date: 1 July 2026 Full time Fixed term: 36 months, <p><span>Applications are sought for a committed Post-doctoral Research Fellow to work with Dr Rafael Guimaraes da Silva conducting research for a Leverhulme Trust Research Grant funded project to dissect catalysis and allostery in a gut microbiome ATP phosphoribosyltransferase enzyme. The primary duties will be to uncover the catalytic and allosteric mechanisms via protein crystallography and enzymology.</span></p> <p><span>The successful applicant will have (or be near to completion of) a PhD in Biochemistry or Structural Biology with expertise in X-ray crystallography and enzymology. </span></p> <p><span>The post is available for 36 months starting 1<sup>st</sup> July 2026 or as soon as possible thereafter. </span></p> <p><span>Further information and informal enquiries may be directed to Dr Rafael Guimaraes da Silva at </span>
[email protected]
</p> <p> </p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><strong>Benefits:</strong></p> <ul style="margin-top: 0px; margin-bottom: 1rem; padding-left: 2rem;"> <li style="margin: 0cm 0cm 4pt; text-align: justify; line-height: normal;"><span style="line-height: normal;"> </span><span>Financial contribution to </span><a href="https://www.st-andrews.ac.uk/hr/payandpensions/removalandrelocationpolicy/" style="color: #565661; background-color: transparent;">relocation</a> <span>(subject to eligibility)</span></li> </ul> <ul style="margin-top: 0px; margin-bottom: 1rem; padding-left: 2rem;"> <li style="margin: 0cm 0cm 4pt; text-align: justify; line-height: normal;"><span style="line-height: normal;"> </span><span>Membership of the USS Pension Scheme with generous employer contributions of 14.5%</span></li> </ul> <ul style="margin-top: 0px; margin-bottom: 1rem; padding-left: 2rem;"> <li style="margin: 0cm 0cm 4pt; text-align: justify; line-height: normal;"><span style="line-height: normal;"> </span><span>A hybrid working environment, including partial homeworking where appropriate and a range of family friendly policies, supporting work-life balance</span></li> </ul> <ul style="margin-top: 0px; margin-bottom: 1rem; padding-left: 2rem;"> <li style="margin: 0cm 0cm 4pt; text-align: justify; line-height: normal;"><span style="line-height: normal;"> </span><span>Staff discount scheme for local and national goods and services</span></li> </ul> <ul style="margin-top: 0px; margin-bottom: 1rem; padding-left: 2rem;"> <li style="margin: 0cm 0cm 4pt; text-align: justify; line-height: normal;"><span style="line-height: normal;"> </span><span>Free staff parking, employee Carshare and Cycle to Work Schemes and subsidised local bus travel</span></li> </ul> <ul style="margin-top: 0px; margin-bottom: 1rem; padding-left: 2rem;"> <li style="margin: 0cm 0cm 4pt; text-align: justify; line-height: normal;"><span style="line-height: normal;"> </span><span>Subsidised sports membership, reduced tuition fees on degree programmes for staff, access to training and development opportunities including LinkedIn Learning, access to library facilities, salary sacrifice scheme</span></li> </ul> <ul style="margin-top: 0px; margin-bottom: 1rem; padding-left: 2rem;"> <li style="margin: 0cm 0cm 4pt; text-align: justify; line-height: normal;"><span style="line-height: normal;"> </span><span>34 Days Annual Leave plus 5 Public Holidays.</span></li> </ul> <p><span><br> </span></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><em>At St Andrews, equality, diversity, and inclusion are central to who we are and form a core pillar of our University Strategy. We are committed to creating a fair, inclusive and supportive workplace, reflected in our participation in national diversity charters and awards, including Athena Swan, Carer Positive and the Race Equality Charter. </em></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><em>We particularly welcome applications from people from Black, Asian, minority ethnic and minority religions backgrounds and from LGBTQ+ and disabled people. </em></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"> </p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><strong>Closing date: 17 April 2026</strong></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><strong>Interview date: 11 May 2026</strong></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><strong>Job Description: <a href="https://www.vacancies.st-andrews.ac.uk//ViewAttachment.aspx?enc=jmxpV+AcVus8i/wvT3FZXrrCOvCUGNWd9uca/tGZrAJOxn0uaIw998B27m1Z2faQPrIL0fNvKayeQQ9Vm6dRjh8e9IpvpaUCTN3uAzHFqby4lpmr7kDQu7hbKVYB1s1b" target="_blank" title="AR3262RS FPs.pdf">AR3262RS FPs.pdf</a><br> </strong></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><strong>Ref no: AR3262RS</strong></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;"><strong> </strong></p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;">School of Biology</p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;">Salary: Grade 6 / £38,784 pa</p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;">Start date: 1 July 2026</p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;">Full time</p> <p style="margin-top: 0px; margin-bottom: 1rem; text-align: justify;">Fixed term: 36 months</p>, Working Hours : Full Time School/Unit : School of Biology Job Family : Academic (Research) ,
https://www.vacancies.st-andrews.ac.uk/Vacancies/W/4533/0/466285/889/research-fellow-ar3262
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Uday Tak
Daan C. Swarts
about 1 month ago
PostDoc position available! (links in post below) Feel free to share!
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Uday Tak
George O'Toole (he/him/his)
about 2 months ago
Pls share: A postdoctoral researcher position is available in the Scharf lab in the Department of Biological Sciences at Virginia Tech to study motility and chemotaxis in the symbiotic soil bacterium Sinorhizobium meliloti.
jobs.apply.vt.edu/jobs/postdoc...
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Postdoctoral Associate - Blacksburg, Virginia, United States
Job Description A full-time postdoctoral researcher position is available in the Scharf lab in the Department of Biological Sciences at Virginia Tech to study motility and chemotaxis in the symbioti...
https://jobs.apply.vt.edu/jobs/postdoctoral-associate-blacksburg-virginia-united-states-c25ac13d-6020-4df8-9ed9-863f92387c10
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Uday Tak
Artem Nemudryi
about 1 month ago
‼️Please share‼️ Nemudryi lab is looking for postdocs to join our team and study: 🦠 Bacterial phage defense mechanisms 🧬 RNA repair & CRISPR-based RNA editing Excited about RNA, host-virus interactions & mechanistic biology? Let's talk! Apply:
explore.jobs.ufl.edu/en-us/job/53...
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University of Florida - Details - Postdoctoral Associate
https://explore.jobs.ufl.edu/en-us/job/539450/postdoctoral-associate
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Uday Tak
Daria Van Tyne
about 1 month ago
My lab at Pitt is looking for a Research Scientist to help us make phage therapy for patients with antibiotic-resistant infections. Please share and apply!
cfopitt.taleo.net/careersectio...
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Research Scientist
Click the link provided to see the complete job description.
https://cfopitt.taleo.net/careersection/pitt_temp_external/jobdetail.ftl?job=26001943&tz=GMT-04%3A00&tzname=America%2FNew_York
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