New antibiotics might still come from places you’d think were completely mined out. Which is good news:

This discovery has been a long and exhilarating journey! It started in 2019 and proceeded through many challenges and thrilling highs. A journey that has opened new perspectives that we long to explore !

Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences. Our @nature.com article demonstrates that these predictions miss thousands of protein sequences present in human tissues. www.nature.com/articles/s41... 1/

Case of the Month: A 43 year old woman underwent a hysterectomy for dysmenorrhea. Representative sections of a myometrial mass are shown here. What is your diagnosis? View the case: www.pathologyoutlines.com/caseofweek/c... #Pathology #PathologyOutlines #Diagnosis #PathSky

#IDBoardReview 25 M living with HIV (CD4: 20, VL 100k) with painful dysphagia, EGD w/ volcano ulcers. most likely Diagnosis? #medEd #idsky #idmeded

From earlier this week: What happens when GLP-1 weight-loss drugs are stopped and then restarted? Thomas H. Leung & team asked this question in mice — cycling treatment made the drugs less effective over time and increased fat gain compared with continuous treatment: doi.org/10.1172/jci....

New from the lab: ML classification of maternal inflammatory response from whole slide images: www.sciencedirect.com/science/arti... Performance is pretty good. Errors are borderline, and possibly reflect human interobserver variability.

As a general rule, subcut administration of tablets is not an effective treatment for anything. #PathSky

I assigned random gender/ethnicity labels to scientific abstracts from the literature and then asked Claude to do a thematic analysis. Claude identified a clinical versus computational split for female/male authors and a DEI focus for Black/URM authors. All in completely random data.

Is it low carb?

There are many widely available health & wellness apps that will remind you to periodically get up from your desk and walk around but I can personally recommend my own low-tech method which is to continuously drink ungodly amounts of tea.

Yesterday I went down a wormhole of bats giving birth... Bless their hearts.. upside, fighting gravity and sometimes those things are just hanging by an umbilical cord before they can get their footing.

There’s a LOT going on as researchers and public health experts race to respond to the Ebola Bundibugyo outbreak in DRC and Uganda before it grows bigger. Some really important questions still open, but also a few answers coming into view🧪 My overview in @science.org is here (and thread coming):

hey john. its your cousin marvin. marvin cage! you know that new sound youve been looking for? well listen to this *hangs up phone*

19 on my K99 resubmission! Massive thanks to my mentors and letter writers for all their support. Hard to tell if it will actually translate to funding in this climate, but I'll take the win regardless!

Seriously, huge thank you and sincere Vulcan salutes to all of these artists for all your work on 5 seasons of #LowerDecks. You did brilliant work, and I’m so grateful for this show. Thanks for this book, @megantrevino.bsky.social! Thanks for this show, @mikemcmahan.bsky.social! 🖖

Oh my god!! I'm in the credits!!! Right under @stupidartpunk.bsky.social

Image of the Week! Contributed by: Mahyar Khazaeli, M.D. Textbook topic: Skin nonmelanocytic tumor Diagnosis: PEComa of skin Textbook topic link: www.pathologyoutlines.com/topic/skintu... #Pathology #PathologyOutlines #PathSky

Nephrology Image Podocyte zebra bodies in LMX1B-associated nephropathy: a Fabry mimic doi.org/10.1016/j.kint.2025.09.029 #NephSky #MedSky #PathSky

I’m a President now. @acog.org @acogd2.bsky.social

Some people say we don’t build beautiful things anymore and, like, lol. Motherfuckers, we built this:

Case of the Month: A premenopausal woman with a 0.8 cm suspicious mass on breast imaging underwent breast core biopsy. What is your diagnosis? Follow the link in the comments for the case! #Pathology #PathologyOutlines #Diagnosis #PathSky

Thanks for sharing our work! Super excited to see this story out in @insight.jci.org

New solution: ask the guard how many of them always speak the truth.

Image of the Week! Contributed by: Eman Abdelzaher, M.D., Ph.D. Textbook topic: CNS & pituitary tumors Diagnosis: Desmoplastic infantile ganglioglioma / astrocytoma Textbook topic link: www.pathologyoutlines.com/topic/cnstum... #Pathology #PathologyOutlines #PathSky

Today’s poem is called ‘An Invention of Collective Nouns’.

Today’s poem is called ‘Word Crunching’.

Doing the periodic cleaning of used plasmid miniprep columns and realized in honor of Earth Day it may be worth reminding you molecular biologists: Plasmid miniprep columns can be cleaned and reused essentially indefinitely! Just add 1 M HCl, soak overnight and wash 3x w/ water. Save $ and plastic

Txp biopsy with rare probable cystine crystals in interstitial mononuclear cells in a patient with history of cystinosis. Rarely seen post-txp not clinically significant to my knowledge. #renalpath #pathsky #nephsky

One of many skin lesions removed. Standard level of Australian solar elastosis. Invasive nests, vague peripheral palisading. #PathSky

We've updated our preprint characterizing the spatiotemporal impact of cold ischemia in mouse kidney to better understand the molecular underpinnings of cold-storage injury in kidney transplants. Check it out: www.biorxiv.org/content/10.1... 🧵👇

It's not always just diabetic GS Case of diabetic GS with chronic TMA 2/2 tyrosine kinase inhibitor (TKI) 🔸Anti-VEGF effects 🔸Most within weeks to months after starting TKI 🔸TMA +/- PAS+ pseudothrombi pmc.ncbi.nlm.nih.gov/articles/PMC... pubmed.ncbi.nlm.nih.gov/19054798/ #renalpath #pathsky

not many people know this, but Barilla has a line of 3D printed pasta it sells mostly to the fine dining industry. I don't want the pasta. I want the pasta printer

Image of the Week! Contributed by: Aliya N. Husain, M.D. Textbook topic: Lung Diagnosis: Carcinosarcoma, lung Textbook topic link: www.pathologyoutlines.com/topic/lungtu... #Pathology #PathologyOutlines

Physicist has written a fascinating big beautiful paper.Let’s not be afraid to call it what it is - groundbreaking. arxiv.org/abs/2603.21852

A 64 y/o woman was admitted for acute kidney injury w/ nephrotic range proteinuria. Prior, she had 3 months of duskiness of distal fingertips w/ mottling. Renal biopsy showed glomerulonephritis w/ focal immune deposits that stained exclusively for C3 Clinical images in ACROR doi.org/10.1002/acr2...

Image Quiz! The tumor pictured is the most common salivary gland malignancy in the larynx. What is the diagnosis? A. Adenoid cystic carcinoma B. Epithelial myoepithelial carcinoma C. Pleomorphic adenoma D. Polymorphous adenocarcinoma Answer linked in the comments. #Pathology #PathologyOutlines

Congratulations to recent PMI graduate Morgan Jackson-Strong from the @gottschalklab.bsky.social on her new paper!

This Day in Labor History: April 14, 1975. The Bunker Hill Mining Company in Kellogg, Idaho announced a new policy in response to worries about female workers suffering reproductive problems due to lead exposure. They had to be sterilized to work!!!! Let's talk about this horrible policy!

#idboardreview 65 M s/p splenectomy 5yrs ago due to accident, from Connecticut admitted in July w/ 1wk of fevers, drenching sweats, fatigue, dark-colored urine, jaundice. Hb 8.5, plt 85k, Tbili 3.5, LDH 650, haptoflobin<10. Treatment? #idsky #idmeded #meded

Autopsy case with incidental ALECT2 amyloidosis with lung involvement. Essentially invisible by light microscopy. Wonder how often this is overlooked. 94% of cases had alveolar involvement in this study (PMID: 26912093). #pathksy #renalpath

This is either the biggest dork shit ever or beautiful or both. Amazing: the viral pacers bickering couple were actually yakking about uh the Ben Sasse podcast and hashing out ways to rejigger liberal arts education www.si.com/nba/pacers/v...

Artemis II Recovery Preparations www.flickr.com/photos/nasah... #Artemis 🧪🔭

old computing ads are amazing

How it started, how it's going Left: Lunar Orbiter I, 1966 Right: Artemis II, 2026 flic.kr/p/8Grtp2 flic.kr/p/2s68RXM #Artemis 🧪🔭

you guys have a gander at these cool blue mushrooms i saw 😊 werewere-kōkako (entoloma hochstetteri)

Metastasis in motion. Tumour tracking towards the already pretty chockers lymph node.

Shortlist of actors for TNG