New research published in @natimmunol.nature.com by @poholeklab.bsky.social shows how the transcription factor BLIMP1 controls the identity of cells involved in allergic asthma in mice. Read more: www.immunology.pitt.edu/news/blimp1-...

Thanks for sharing our work! Super excited to see this story out in @insight.jci.org

Rachel A. Gottschalk @gottschalklab.bsky.social, Satarupa Ganguly @satarupa2025.bsky.social & team show lung macrophages lacking GATA2 during inflammation promote metabolic dysfunction & profibrotic gene expression in mice: doi.org/10.1172/jci....

I’ve been warned that by engaging in politics, I might undermine myself as a scientist. Or worse, reduce the trust that people have in me or scientists as a whole. This latter point is the thesis of a recent article by Byron Hyde: link.springer.com/article/10.1... I disagree for multiple reasons.

People who use ChatGPT to write will never experience the pure joy of taking the rest of the day off after writing three very good paragraphs* *whether these still read like good paragraphs the next day is not guaranteed **given rate of editing, my June R01 proposal will be ready by August

In Pittsburgh, it’s parking chair season. Disrespect the Steel City code and you might get a “jagoff” note on the windshield. 🔗 on.wsj.com/4tiQyti

In a study following 23 million people age 18-59 (pretty young) for 4 years…despite the fact that the ones who got the COVID vaccine were overall older and sicker at baseline, they not only had 74% lower risk of dying from COVID than the unvaccinated but 25% lower risk of dying from any other cause!

Political leaders at FDA continue to overstate the risks of COVID vaccines while underrating their benefits. Read the whole story here. insidemedicine.substack.com/p/scoop-fda-...

New York Times article on science funding with some depressing but familiar curves with interactive graphics. www.nytimes.com/interactive/...

Yay! @mcfreeid.bsky.social Congrats!

🌏 Despite substantial progress, asthma still poses a serious health burden globally. A Lancet—@lancetrespirmed.bsky.social Series provides new insights into the genetics, prevention, & risk factors of the disease: spkl.io/63322Abjbm

Some of my newest work - amidst everything going on, we're still trying to deliver excellent care to really sick children. But the system is under a lot of strain:

This paper does a great job with a "It's a Wonderful Life" scenario about NIH, supposing the consequences of the bottom 40% of the funding NIH grants never existed. www.science.org/doi/10.1126/... tl:dr The world would lose a lot, but directly and indirectly

Today’s ACIP meeting promoted false claims and misguided information about vaccines. AAP will continue stepping up and working with our local, state and federal partners to make sure every child in every community continues to have access to immunizations. bit.ly/4puP4uf

3 former Surgeon Generals issue a warning: "The CDC is more than just an agency. It is the cornerstone of public health... The recent turbulence at the CDC threatens to undermine this legacy, and we feel this is not just a bureaucratic or political issue. It’s truly a matter of life and death."

Acetaminophen/Tylenol use during pregnancy was not associated with children’s risk of autism, ADHD, or intellectual disability in sibling control analysis. This suggests associations observed in other, less rigorous analyses may have been attributable to familial confounding (aka erroneous finding):

As national medical, scientific, public health and patient organizations, we call for the resignation of HHS Secretary Robert F. Kennedy Jr. to ensure the health of the American people. Read our statement: asm.org/press-releas...

New York Times story with profiles of researchers whose grants were terminated. [Gift Link] www.nytimes.com/2025/08/24/o...

In child development, timing matters when it comes to immunization. Just like kids have developmental stages, their immune systems have stages, too, and vaccines work best when their bodies are ready to respond. Learn more. www.healthychildren.org/English/safe...

Over the next 25 years, if proposed cuts in NIH funding are made real, “In a population of more than 340 million, this reflects **82 million** fewer years of life.” In the US alone. jamanetwork.com/journals/jam...

I think this really says it all: www.science.org/content/arti...

For decades, Sec. Kennedy has spread lies about vaccines. Now, his misinformation will lead to preventable illness & death. Firing independent experts is a dangerous move that makes it harder for Americans to access vaccines that are safe, effective & essential to saving lives.

I worry that not enough of a big deal is being made about how long-term the devastation of these budget cuts to our scientific and health agencies will be, beyond the absolute ruin they will cause in the acute period.

There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd. It's not just budgets but research, institutions, expertise, and training the next generation.

Here's the NIH's proposed budget - from $48 billion to $27 billion. NIAID, current ~$7 billion cut to ~$4.2 billion. The proposed 15% cap on indirect costs remains. Again, these budgets are passed, and our leadership in science, technology, and innovation is gone. www.hhs.gov/sites/defaul...

25 years ago, I came to Stanford on a J1 visa and worked so hard to be worthy of that privilege. Today, I lead Immunology at Mount Sinai and I am the one who feel privileged when brilliant international trainees chose to join us.

Excited to share the first official paper from the Eddens lab published in @jimmunol.bsky.social. How an infant responds to a respiratory virus is very different than adults... and tightly regulated. academic.oup.com/jimmunol/adv...

People who design & study vaccines are wondering why the #NIH is sinking half a billion dollars into trying to develop a platform for universal flu & covid vaccines using a decades-old production approach. “There is incredible work going on. This is not it." www.statnews.com/2025/05/03/n...

RFK Jr. ordered the NIH’s Integrated Research Facility in Frederick to stop all research on serious infectious diseases yesterday at 5:00 PM. They study pathogens like Ebola there. You may be familiar with it from The Hot Zone. www.wired.com/story/hhs-ni...

Deaths from heart disease down 75%, that’s NIH. Deaths from stroke down 75%, that’s NIH. HIV/AIDS no longer a death sentence, that’s NIH. 99% of FDA approved drugs in the last decade, that’s NIH. Please show this video to anyone who doesn’t understand why the NIH is so important.

The TV show "The Pitt" has been praised for its accurate depiction of life in the ER. Dr. Sylvia Owusu-Ansah of @pittpediatrics.bsky.social, who served as a medical consultant on the show, joins us to discuss how it captures real emergency room experiences.

The plan for NIH is in, source with full 64 page proposal for all of HHS is linked. Reported in WaPo. This is catastrophic. Reduction to 8 centers. 40% cut in budget. 15% IDC cap. This will decimate science across America open.substack.com/pub/insideme...

“It’s amazing that others in this room underwrote electing a man who, in the last week, single-handedly destroyed all of American science. It’s amazing how much good science you can destroy with $320 million and RFK Jr, very fast.” — Seth Rogen’s censored remarks presenting the Breakthrough Prize

More from Peter Marks on RFK Jr and the FDA This extends beyond anti-vax to unproven use of stem cells Gift link www.wsj.com/health/healt...

The myth that the childhood vaccine against measles, mumps, and rubella (MMR) causes autism is based on a discredited study falsely linking the vaccine to autism. Find out more: ow.ly/EqeC50VlKva. #ImmunologyExplained #Measles #MedSky #MMR

Some 1,900 leading researchers accused the Trump administration in an open letter on Monday of conducting a “wholesale assault on U.S. science” that could set back research by decades and that threatens the health and safety of Americans.

Trump has cut the NIH budget by more than half in defiance of Congressionally mandated appropriations for the agency. No comparison historically, not even the Great Recession. This is clearly not legal and Congress needs to address it.

NEW: The move — along with the CDC’s explanation — is a sign that the nation’s top public health agency may be falling in line under HHS Secretary Robert F. Kennedy Jr., a longtime critic of vaccines. By @sheinvestigates.bsky.social

The NIH grant that has supported 38 years of training the best pediatrician-scientists in the country (I’m a proud former recipient) was cancelled. It was just approved for a 5 year renewal. The PSDP has supported the careers of many NIH-funded pediatrician-scientists and thought leaders

From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA

Elon Musk says that no one has died because he slashed humanitarian aid. I went to South Sudan to check if that's true. It's not. Meet Peter, Achol and Evan, ages 10, 8 and 5. The reckless actions of the world's richest men are killing the world's poorest kids www.nytimes.com/interactive/...

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...

Let the brain drain commence! www.univ-amu.fr/en/public/ac...

RFK Jr. is poised to begin a catastrophic brain drain at NIH www.rollingstone.com/politics/pol...

RFKJr is trying to undermine trust in vaccines. His spreading of disinformation will lead to more deaths. Especially deaths of the most vulnerable among us. Please make sure you are up to date on vaccines. apnews.com/article/meas... www.cdc.gov/measles/data... www.chop.edu/vaccine-educ...

Science in the 'Burgh I am planning to be there and looking forward to seeing you there too (if you are local and available)

Studies show that funding from the National Institutes of Health (NIH) contributed to 354 of 356 drugs (99.4%) approved by the FDA from 2010 to 2019. Recklessly slashing NIH funding will mean that patients will be waiting much longer for life-saving treatments.

Everyone who ever got funding through NIAID should be aware of this bill and start sending messages to their US legislators. The bill intends to dissolve NIAID. This is Project 2025 www.congress.gov/bill/119th-c...