Kidney Tertiary #LymphoidTissues and Poor #Immunosuppressive Response in #IgANephropathy #IgAN #VisualAbstract by Elba Medina https://www.kireports.org/article/S2468-0249(25)00677-1/fulltext

One of the more subtle cases of amyloidosis I have seen. Few spicules on silver stain. Minimal congo red positivity. Despite early amyloid deposition, pt had nephrotic syndrome. Likely AL type (pt has LPL); MS pending. #renalpath #pathsky #nephsky

🚨 New paper alert in @asnpublications.bsky.social ⬇️ 🔑 Preimplantation Histopathologic Assessment of Deceased Donor Kidneys. Recommendations from the Banff Time-Zero Biopsy Working Group ‼️ Potential/Pitfalls/Future Research 🔗 journals.lww.com/jasn/abstrac...

RPS and Banff Activity/Chronicity Working Group WITH REGISTRATION LINK us02web.zoom.us/webinar/regi... #renalpath #pathsky #nephsky #nephrology

So many eosinophils in this case of tubulointerstitial nephritis secondary to recent antibiotic administration. Few tiny granulomas as well. Eos seen in EM as well. #renalpath #pathsky #nephsky

Reduce variability and inconsistency in your approach to #amyloidosis diagnosis and laboratory workup! New #CAPguideline: brnw.ch/21wXMU6 #pathsky #pathology #CAPGuidelines

Another interesting @kidneyint.bsky.social cohort study www.kidney-international.org/article/S008... Infection risk in kidney disease - lupus > ANCA, perhaps as ANCA is one and done (usually) whereas #lupus is never done? Lupus > other primary and ADPKD is not surprising #NephSky

#UrinarySediment from a pt with #AKI #RPGN due to suspected MPO-AAV-GN inspected with Sternheimer stain: WBC cast (bright field), broad RBC cast (bright), waxy cast (bright), and granular cast w/Ca Oxalate monohydrate crystals (oblique). #OchsnerNephrology #UrineMicroscopy

#RenalPath AJKD Atlas of Renal Pathology: Lysozyme-Associated Nephropathy bit.ly/3Jq0ijC (FREE)

Review by Anthony Bleyer et al: Autosomal Dominant Tubulointerstitial Kidney Disease: A Review bit.ly/3VgPMNS (FREE)

Hilar variant of focal segmental glomerulosclerosis, with segmental sclerosis at the vascular pole with hyalinosis and adhesion (Jones silver stain) bit.ly/49P5wQP (FREE) #FSGS #renalpath

#Quiz from October 2025: A 16-year-old male patient presented to an ED with a 3-week history of progressive headaches, nausea, vomiting, and bilateral blurry vision. Over the past 3 days, he developed chest pain and shortness of breath. bit.ly/47iQnEo

#RenalPath: C1q nephropathy w. segmental sclerosis w. increased mesangial matrix, obliteration of capillary lumens, adhesion to Bowman capsule (right half of tuft) Open left portion of glomerulus shows mild to moderate increase in mesangial cellularity bit.ly/3XadOLx

Diagnosis unmasked. Young F with 2g proteinuria, weak +dsDNA. Membranous pattern, IF with C3 dominant staining. Pronase IF --> IgG-k. Membranous-like glomerulopathy with masked monotypic IgG-k deposits. Considered to be autoimmune; not MGRS. #renalpath #pathsky #nephsky.

Unfortunate but not rare IgAN presentation. Pt in their 30's, no PMHx, presented with HTN emergency, CKD, hematuria, proteinuria. Advanced IgAN with severe IFTA, focal active crescents (M1 E1 S1 T2 C1). Wish we could catch these cases earlier. #renalpath #pathsky #nephsky

Unusual granular casts with annular appearance. Light chain, hemoglobin, myoglobin, chromogranin casts excluded. Patient on IV vancomycin. Suspicious for vancomycin cast nephropathy. pubmed.ncbi.nlm.nih.gov/31871855/ #renalpath #pathsky #nephsky

BK nephropathy Clues: - Heavy but focal tubulointerstitial inflammation - Increased plasma cells - Viral cytopathic change - Features of CNI toxicity ->over immunosuppression (isometric vacuolization shown here) -SV40 IHC confirmatory #renalpath #pathsky #nephsky

Urine crystals in a patient with Crohn’s Answer: www.kidney-international.org/article/S008... in @kidneyint.bsky.social #NephSky

Join RPS-GlomCon Renal Pathology Webinar Series Update on CKDu/CINAC Speaker: Cynthia Nast, MD Date: November 30, 2025 Webinar info: renalpathsoc.org/event-6113942 #renalpath #PathTwitter @glomcon.org

Arteriole with features of a old recanalized thombus in a transplant kidney biopsy. Multiple slit like vascular spaces within the fibrotic lumen. Not a lesion I see often. Pt had clinically diagnosed TMA a few months prior. #renalpath #pathsky #nephsky

NELL-1 IHC can also be tricky to interpret as there is significant podocyte cytoplasmic staining in the negative control. Must show granular capillary wall deposits which match deposits by IF and EM. #renalpath #pathsky #nephsky

Illustrative example of a segmental membranous nephropathy pattern (segmental granular IgG staining) which is often seen with NELL-1+ (IHC) MN as in this case. Deposits present in only some loops by EM. #renalpath #pathsky #nephsky

Interpreting Metabolomics and Proteomics in Kidney Disease: A Practical Guide by Insa M. Schmidt and Eugene P. Rhee bit.ly/4ooxkQ6

AJKD Atlas of Renal Pathology: Crystalglobulin-Induced Nephropathy bit.ly/41jvO7T (FREE) #RenalPath Image: Large bright eosinophilic crystals within glomerular capillaries (arrow, Jones silver stain)

RPS International Renal Pathology Conference abstract deadline extended to November 15th All information for registration is available at the RPS-Website: renalpathsoc.org/6thIRPC Chair 6th IRPC Carmen Avila-Casado MD, PhD #renalpath #nephsky #pathsky #nephrology

Thanks @amyaimei.bsky.social for giving an excuse to share some #UrinarySediment pics. See below for context 👇🏼

Great start of ‚Hot topics in lupus nephritis’ session chaired by @saynanorouzi.bsky.social and Juan M. Mejia-Vilet, with an excellent lecture of @kronbichlerlab.bsky.social on 25’ treatment targets #KidneyWk @asnkidney.bsky.social

Cellular variant of focal segmental glomerulosclerosis, with endocapillary hypercellularity with foam cells and mononuclear cells (top; Jones silver stain)" bit.ly/4nNJdy2 (FREE) #renalpath #FSGS

Clinicopathological spectrum and treatment outcomes of cryofibrinogen-associated nephropathies #nephsky #nephrology www.kireports.org/article/S246...

Single-cell spatial transcriptomics reveal intraglomerular cell activation and ligand-receptor relationships in chronic, active antibody mediated rejection #nephsky

Renal tubular epithelial cell cast (Sternheimer-Malbin stain) under 1000x bright field. Pt with nephrotic range proteinuria, suspected GN. Note small lipid droplets on most inferior cell in the cast.

Intimate contact between endothelial cell and mesangial cell cytoplasm. A reminder that no GBM separates the blood space from the mesangium. I wonder what secrets they are sharing. #renalpath #pathsky #nephsky

Severe vascular rejection hiding in the IF tissue. Fibrinoid necrosis really pops on the H&E and further confirmed by fibrinogen IF. #renalpath #pathsky #nephsky

Energy requirements of renal proximal tubular cells depend on mitochondrial fatty acid β-oxidation. Read these Clinical Insights on long-standing low-molecular-weight proteinuria: A proximal tubular mitochondrial enzyme impairment & EHHADH mutation. link.springer.com/article/10.1...

The deadline to submit an abstract for the 6th IRPC is October 25, 2025 (tomorrow) For more info & to submit your abstract, please visit: renalpathsoc.org/6thIRPC On behalf of the 6thIRPC Organizing Committee Dr. Carmen Avila-Casado Dr. Vicente Sanchez-Polo #renalpath #pathsky #nephsky #nephrology

Genetic screens of imaging-derived kidney volumes identify genes linked to kidney function doi.org/10.1016/j.kint.2025.08.0 #OpenAccess #MedSky #NephSky #kidneydisease #GWAS @uniklinik-fr.bsky.social @columbiakidney.bsky.social @columbiauniversity.bsky.social @kirylukk.bsky.social

#Quiz from October 2025: A 16-year-old male patient presented to an ED with a 3-week history of progressive headaches, nausea, vomiting, and bilateral blurry vision. Over the past 3 days, he developed chest pain and shortness of breath. bit.ly/47iQnEo

#RenalPath: The collapsing pattern in collapsing glomerulopathy is evident here, with accentuation of each lobule due to the collapse of the tuft. There is also overlying glomerular visceral epithelial cell hyperplasia with protein droplets. bit.ly/2LapiYx (Free)

Submit abstract for 6th International Renal Pathology Conference - Feb 11– 14, 2026 @ Antigua, Guatemala Deadline: Oct 25, 2025 For more info, visit: 👉 renalpathsoc.org/6thIRPC On behalf of 6th IRPC Committee: Carmen Avila-Casado & Vicente Sanchez-Polo #renalpath #SLANH #pathsky #nephsky #nephrology

📣 Only 1 week left until the deadline! It’s time to finalize your abstract submission! ➡️ lite.spr.ly/6002MMQu

Cynthia Nast, an #ASNCJASN Top Reviewer of 2025 shares that peer review "benefits the reviewer by fostering a broad understanding of the literature and staying abreast of new information the reviewer’s area of expertise." Thank you, Cynthia! @lm-if-em.bsky.social

Actionable genes in CKD ca. 2024 from @kdigo.org #RKDSummit #Nephpearls #NephSky 👉 kdigo.org/guidelines/c...

Treatment targets 🎯 in IgA Nephropathy #IgAN and the positioning of drugs ca. 2025 from @kdigo.org #Nephpearls #RKDSummit #NephSky 📌 Proteinuria >/= 0.5 g/day (or equivalent) ~ at risk of progressive loss of kidney function 👉🏼 kdigo.org/guidelines/i...

Do you sign out surgical pathology aortic specimens? Make sure you’re familiar with the normal regional variability to avoid overcalling degenerative features! Learn more at: www.sciencedirect.com/science/arti... #pathsky #medsky #cardiosky

Teenager with nephrotic syndrome. Biopsy revealed unusual case of membranous nephropathy in a peds patient. PLA2R positive (IHC). PLA2R most common antigen in peds MN. EXT1/2 also common, SEMA3B less common. (pubmed.ncbi.nlm.nih.gov/38025223/) #renalpath #pathsky #nephsky

📣 Only two weeks left to submit your WCN’26 abstract! Don’t miss the chance to: 🌍 gain recognition at the 2026 global kidney care event 🏆 win one of 3 prestigious awards 📰 get your work published in KIReports® congress supplement Submit by October 22➡️http://lite.spr.ly/6...

Core Curriculum by Kristen Tillquist et al. The Nephrologist’s Perspective in Evaluation and Management of Localized Renal Masses bit.ly/4o6z0NG #OpenAccess

Renal hypodysplasia (RHD) is a common & severe form of congenital anomalies of the kidney and urinary tract, often leading to CKD in children. Read this Original Article on characteristics of RHD in children: insights from a 10-yr single-center cohort. link.springer.com/article/10.1...

A startling biopsy. Severe acute TMA in a pt with suspected scleroderma renal crisis. Massive vascular thrombosis, mucoid intimal edema, and early onion skin change associated with severe cortical necrosis. #renalpath #nephsky #pathsky

Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis. doi.org/10.1016/j.kint.2025.07.037 #OpenAccess #NephSky #MedSky #CKD #FSGS #chronickidneydisease @parcc-inserm.bsky.social @rwth.bsky.social