CUBN-AMN pathway loss in chronic benign proteinuria - Kidney International www.kidney-international.org/article/S008...

Interesting finding of large multi-nucleated endothelial cells in a txp biopsy with chronic active AMR. IHC stain is ERG (endothelial cell marker). Probably just a manifestation of chronic endothelial cell injury in this setting #renalpath #pathsky #nephsky

Unmasking The Great Masquerader with Mass Spectrometry - Kidney International www.kidney-international.org/article/S008...

Disappearance of the Defining Organized Ultrastructural Lesion in CLL-Associated Monoclonal Immunotactoid Glomerulopathy After Ibrutinib Therapy - Kidney International Reports www.kireports.org/article/S246...

Association of FHR5 with disease severity in ANCA-associated vasculitis - Kidney International Reports www.kireports.org/article/S246...

Renal Pathology Society's Case in Focus Middle-aged male with HTN & CKD presented with nephrotic range proteinuria Rita Santarsiere & Nicolas Kozakowski English: renalpathsoc.org/page-1075904 Links to translations (Spanish, Portuguese, French, Chinese) in post below #renalpath #pathsky #nephsky

IAP Satellite sessions on renal pathology is available by the international experts in Sydney on May 27, and Brisbane on May 28. Free sponsored events. Click on link for more info: renalpathsoc.org/event-6697565 Dr. Seethalakshmi Viswanathan University of Sydney #renalpath #pathsky #nephsky

Beyond biological risk: socioeconomic vulnerability and adverse pediatric kidney transplant outcomes

Case Record of the Massachusetts General Hospital: A 50-Year-Old Woman with Vaginal Bleeding and Anemia https://nej.md/4uLoU8o #Hematology

Case of HTRA1 Membranous Nephropathy With Polytypic IgG Concurrent With New Plasma Cell Dyscrasia. Coincidence or related? www.sciencedirect.com/science/arti... #renalpath #pathsky #nephsky

Exuberant capillary wall spicules in this case of amyloidosis, AHL type. Amyloid spike by EM ('Bart Simpson sign'). #renalpath #pathsky #nephsky

Case report: X-Linked immune dysregulation, polyendocrinopathy, and enteropathy (IPEX) syndrome with concurrent membranous and IgA nephropathy: a case report #nephsky

Image Quiz! Which of the following immunostains is shown in the image below and would be positive in the foam cells that characterize crystal storing histiocytosis? A. CD1a B. CD68 C. CD138 D. S100 Answer linked in the comments. #Pathology #PathologyOutlines #Diagnosis #PathSky

One of my favorite incidental EM findings. Crystalline proto-renin granules in JGA cells. #renalpath #nephsky #pathsky

It's not always diabetic nephropathy. Pt with DN, HTN, and nephrotic range proteinuria. Elevated K/L ratio. Bx with Light and Heavy Chain deposition disease mimicking nodular diabetic glomerulopathy. #renalpath #pathsky #nephsky

Nephrology Image Podocyte zebra bodies in LMX1B-associated nephropathy: a Fabry mimic doi.org/10.1016/j.kint.2025.09.029 #NephSky #MedSky #PathSky

Immunofluorescence Patterns in IgA Nephropathy are Associated with Active, Necrotizing Lesions - Kidney International Reports www.kireports.org/article/S246...

The Cornell Travel Grant With generous support from @lynncornell.bsky.social, RPS is pleased to offer 2 travel grants for the 2026 Banff Conference. Applicants should be RPS members; non-members may apply for membership when submitting: renalpathsoc.org/Join-RPS #renalpath #pathsky #nephsky

Striking viral inclusion in this case of polyomavirus nephropathy. SV40 stain is confirmatory. #renalpath #pathsky #nephsky

A 60-year-old woman with follicular lymphoma was evaluated for swelling and proteinuria that had persisted for 2 weeks. The patient’s plasma was clear at 37°C but turbid at 4°C. A kidney biopsy was performed. Read the full case details: https://nej.md/4tDDm2e #Hematology #Nephrology

Clinical and Histologic Predictors of Non-Diabetic Kidney Disease in Patients with Diabetes Mellitus doi.org/10.1016/j.kint.2026.03.015 #NephSky #MedSky #OpenAccess #diabeticnephropathy @arkanalabs.bsky.social @stanforddeptmed.bsky.social @jhu.edu

#Metabolic Dysfunction-Associated Steatotic #LiverDisease and #KidneyTransplant Outcomes #VisualAbstract by morgan-mccord.bsky.social https://www.kireports.org/article/S2468-0249(26)02709-9/fulltext

A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease doi.org/10.1016/j.kint.2026.03.020 #MedSky #NephSky @ashkarlab.bsky.social @kpmproject.bsky.social @umich.edu @clevelandclinic.bsky.social @uwmedicine.bsky.social

Finding the etiology of membranoproliferative glomerulonephritis doi.org/10.1016/j.kint.2026.02.030 #NephSky #MedSky @mayoclinicpath.bsky.social

Serine protease HTRA1 is a common autoantigen in membranous nephropathy in patients of 80 years and older doi.org/10.1016/j.kint.2026.02.036 #MedSky #NephSky #kidneybiopsy #pathsky #renalpath #kidneypath @uofuhealth.bsky.social @arkanalabs.bsky.social @meharrymed.bsky.social

Nodular diabetic GS can have double contours..But not this much This case has superimposed chronic TMA related to VEGF inhibitor 🔸Some can have PAS-positive pseudothrombi (also described with TKI inhibitors) pubmed.ncbi.nlm.nih.gov/30014486/ pmc.ncbi.nlm.nih.gov/articles/PMC... #renalpath #pathsky

It's not always just diabetic GS Case of diabetic GS with chronic TMA 2/2 tyrosine kinase inhibitor (TKI) 🔸Anti-VEGF effects 🔸Most within weeks to months after starting TKI 🔸TMA +/- PAS+ pseudothrombi pmc.ncbi.nlm.nih.gov/articles/PMC... pubmed.ncbi.nlm.nih.gov/19054798/ #renalpath #pathsky

MPO+ANCA GN with concurrent low grade membranous nephropathy. MPO positivity in the MN deposits helps support a unifying etiology is such cases. pubmed.ncbi.nlm.nih.gov/40485711/ #renalpath #nephsky #pathsky

A 64 y/o woman was admitted for acute kidney injury w/ nephrotic range proteinuria. Prior, she had 3 months of duskiness of distal fingertips w/ mottling. Renal biopsy showed glomerulonephritis w/ focal immune deposits that stained exclusively for C3 Clinical images in ACROR doi.org/10.1002/acr2...

Autopsy case with incidental ALECT2 amyloidosis with lung involvement. Essentially invisible by light microscopy. Wonder how often this is overlooked. 94% of cases had alveolar involvement in this study (PMID: 26912093). #pathksy #renalpath

Thrombotic Microangiopathy During Pregnancy: Role of Soluble Fms-like Tyrosine Kinase-1–Placental Growth Factor Ratios bit.ly/3KMpv8m (OPEN ACCESS)

🔓 Open Access "The Banff 2024 Kidney Meeting Report: Rejection as a spectrum of phenotypes and focus on differential diagnostic reasoning," Naesens et al. www.amjtransplant.org/article/S160... #Transplantation #KidneyTransplant #Banff #TransplantPathology #DifferentialDiagnosis #OpenAccess

Finding the etiology of MPGN (EDITORIAL: SPECIAL REPORT )

Transplant bx for renal dysfunction in a patient with shortness of breath. Granulomatous tubulointerstitial nephritis. AFB stain +. Sputum + for TB. Good sample key for making the diagnosis. 2 rounds of AFB stain to find the organism. #renalpath #pathksy #nephsky

Bx for AKI in a pt on checkpoint inhibitor: neutrophil rich tubulointerstitial nephritis. We would usually think pyelonephritis, high risk neutrophil rich variants of CKI inhibitor AIN have been characterized. pubmed.ncbi.nlm.nih.gov/41727781/ #renalpath #pathsky #nephsky

A pediatric case of C3 glomerulonephritis initially misclassified as IgA nephropathy with a favorable response to C3-targeted therapy #nephsky

Approach to immune checkpoint inhibitor (ICI) nephrotoxicity and rechallenge #ISNWCN 🇯🇵 #WCN26 🇯🇵 #WCN2026 🇯🇵 #Onconephrology 🦀 #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/32775813/

🤔 What makes IgA pathogenic in IgAN❓ 👉🏻 A subgroup of GdIgA1with strong affinity for the glomerulus 🫘 💡 IgA type anti-MEsangial Cell Antibodies (Ig-MESCA) are GdIgA1-Ab. 🎯 Mesangial cells 🧫 Molecular mimicry with oral bacteria #ISNWCN @theisn.org

Amazing! Paola Romagnani #ISGD #ISNWCN with “Podocytopathies: Knowns and Unknowns” 👉🏻Podocyte loss and regeneration 👀Autoimmune, genetic, adaptive, infectious, toxic, monoclonal 🎯Anti-slit autoantibodies-> ⬇️ prognosis #GlomerularDisease #Yokohama 🌸

Bx for pt with AKI and nephrotic range proteinuria. Hx of IV drug abuse (with skin popping), and chronic staph infections. AA amyloidosis was the unsurprising finding. #renalpath #pathsky #nephsky

Anti-PLA2R1 IgG-mediated podocyte PLA2R1 cleavage drives glomerular subepithelial immune complex deposition in membranous nephropathy doi.org/10.1016/j.kint.2026.02.021 #NephSky #MedSky #OpenAccess #membranousnephropathy

Review: Adenine phosphoribosyltransferase deficiency and 2,8-dihydroxyadeninuria #openaccess #nephsky buff.ly/ifexeeG

A KDIGO commentary on B Cell and Complement guided therapy in IgAN www.kidney-international.org/article/S008... in Kidney Int Perfectly timed for #NephMadness (and this will be the champion)

Clinical feature analysis of pediatric Castleman disease with renal involvement #nephsky

Severe renovascular hypertension in an infant with a SMAD3 gene variant #nephsky #hypertension @ped-neph.bsky.social #pedsky link.springer.com/article/10.1...

Classic powdery electron dense deposits along GBMs, TBMS, and in vascular walls by EM in this case of light chain deposition disease. #renalpath #pathsky #nephsky

Don't confuse these for crystals. Limiting membrane of peroxisomes in proximal tubules. Normal tubular structure. Mimic of light chain proximal tubulopathy. #renalpath #pathsky #nephsky

Renal hemosiderosis in paroxysmal nocturnal hemoglobinuria - Kidney International www.kidney-international.org/article/S008...

Empagliflozin-associated Armanni-Ebstein lesions in IgA nephropathy - Kidney International www.kidney-international.org/article/S008...