Grace Choung, MD 박영이
@gracechoung.bsky.social
📤 154
📥 186
📝 81
Renal pathologist @CedarsSinai
#renalpath
#kidneydisease
opinions are my own
CUBN-AMN pathway loss in chronic benign proteinuria - Kidney International
www.kidney-international.org/article/S008...
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CUBN-AMN pathway loss in chronic benign proteinuria
This case demonstrates that persistent isolated proteinuria, maintained for over a decade with entirely normal serum albumin and kidney function, can be the hallmark of a renal-limited cubilin-amnionl...
https://www.kidney-international.org/article/S0085-2538%2826%2900314-5/fulltext
3 days ago
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Grace Choung, MD 박영이
Jonathan Zuckerman MD PhD
4 days ago
Interesting finding of large multi-nucleated endothelial cells in a txp biopsy with chronic active AMR. IHC stain is ERG (endothelial cell marker). Probably just a manifestation of chronic endothelial cell injury in this setting
#renalpath
#pathsky
#nephsky
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Unmasking The Great Masquerader with Mass Spectrometry - Kidney International
www.kidney-international.org/article/S008...
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Unmasking The Great Masquerader with Mass Spectrometry
A 23-year-old man presented with edema, nephrotic range proteinuria (12 g/24 hours), serum albumin 2.2 g/dL and creatinine 1.3 mg/dL. Testing for Hepatitis B, C, HIV, dsDNA, C3, C4 was unrevealing (Su...
https://www.kidney-international.org/article/S0085-2538%2826%2900425-4/fulltext
4 days ago
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Disappearance of the Defining Organized Ultrastructural Lesion in CLL-Associated Monoclonal Immunotactoid Glomerulopathy After Ibrutinib Therapy - Kidney International Reports
www.kireports.org/article/S246...
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Disappearance of the Defining Organized Ultrastructural Lesion in CLL-Associated Monoclonal Immunotactoid Glomerulopathy After Ibrutinib Therapy
A 61-year-old man was referred for nephrotic syndrome with a urine protein-to-creatinine ratio of 5.97 g/gCr, serum albumin of 2.6 g/dL, and serum creatinine of 0.71 mg/dL (Figure 1A, Supplementary Ta...
https://www.kireports.org/article/S2468-0249%2826%2902875-5/fulltext
4 days ago
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Association of FHR5 with disease severity in ANCA-associated vasculitis - Kidney International Reports
www.kireports.org/article/S246...
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Association of FHR5 with disease severity in ANCA-associated vasculitis
Alternative complement activation is pivotal in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) pathogenesis. Growing evidence highlights an important role of complement factor ...
https://www.kireports.org/article/S2468-0249%2826%2902855-X/fulltext
4 days ago
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Grace Choung, MD 박영이
Renal Pathology Society (RPS)
10 days ago
Renal Pathology Society's Case in Focus Middle-aged male with HTN & CKD presented with nephrotic range proteinuria Rita Santarsiere & Nicolas Kozakowski English:
renalpathsoc.org/page-1075904
Links to translations (Spanish, Portuguese, French, Chinese) in post below
#renalpath
#pathsky
#nephsky
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Grace Choung, MD 박영이
Renal Pathology Society (RPS)
16 days ago
IAP Satellite sessions on renal pathology is available by the international experts in Sydney on May 27, and Brisbane on May 28. Free sponsored events. Click on link for more info:
renalpathsoc.org/event-6697565
Dr. Seethalakshmi Viswanathan University of Sydney
#renalpath
#pathsky
#nephsky
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Renal Pathology Society - IAP Satellite Events @ 2026 IAP Meeting
https://renalpathsoc.org/event-6697565
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Grace Choung, MD 박영이
14 days ago
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Dual pathogenic variants in ADAMTS13 and CFHR1/CFHR3 deletion: divergent thrombotic microangiopathy phenotypes in siblings - Pediatric Nephrology
Two male siblings, aged 15 and 13 years, born to consanguineous parents, presented with hereditary anemia and thrombocytopenia associated with unexplained hepatosplenomegaly. Both were initially…
https://buff.ly/J53kGkZ
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reposted by
Grace Choung, MD 박영이
14 days ago
Beyond biological risk: socioeconomic vulnerability and adverse pediatric kidney transplant outcomes
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Beyond biological risk: socioeconomic vulnerability and adverse pediatric kidney transplant outcomes - Pediatric Nephrology
Background Adverse social determinants are known contributors to poorer long-term allograft outcomes. Yet optimal measures of social determinants are lacking. We sought to evaluate the association…
https://buff.ly/ss8CKSa
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Grace Choung, MD 박영이
NEJM.org
14 days ago
Case Record of the Massachusetts General Hospital: A 50-Year-Old Woman with Vaginal Bleeding and Anemia https://nej.md/4uLoU8o
#Hematology
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Grace Choung, MD 박영이
Jonathan Zuckerman MD PhD
21 days ago
Case of HTRA1 Membranous Nephropathy With Polytypic IgG Concurrent With New Plasma Cell Dyscrasia. Coincidence or related?
www.sciencedirect.com/science/arti...
#renalpath
#pathsky
#nephsky
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reposted by
Grace Choung, MD 박영이
Jonathan Zuckerman MD PhD
20 days ago
Exuberant capillary wall spicules in this case of amyloidosis, AHL type. Amyloid spike by EM ('Bart Simpson sign').
#renalpath
#pathsky
#nephsky
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Grace Choung, MD 박영이
22 days ago
Case report: X-Linked immune dysregulation, polyendocrinopathy, and enteropathy (IPEX) syndrome with concurrent membranous and IgA nephropathy: a case report
#nephsky
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X-Linked immune dysregulation, polyendocrinopathy, and enteropathy (IPEX) syndrome with concurrent membranous and IgA nephropathy: a case report - BMC Nephrology
Background X-linked immune dysregulation, polyendocrinopathy, and enteropathy (IPEX) syndrome is a rare X-linked disorder caused by mutations in the forkhead box P3 (FOXP3) gene. It typically…
https://buff.ly/3Ykl61S
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Grace Choung, MD 박영이
PathologyOutlines.com
25 days ago
Image Quiz! Which of the following immunostains is shown in the image below and would be positive in the foam cells that characterize crystal storing histiocytosis? A. CD1a B. CD68 C. CD138 D. S100 Answer linked in the comments.
#Pathology
#PathologyOutlines
#Diagnosis
#PathSky
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Grace Choung, MD 박영이
Jonathan Zuckerman MD PhD
about 1 month ago
One of my favorite incidental EM findings. Crystalline proto-renin granules in JGA cells.
#renalpath
#nephsky
#pathsky
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Grace Choung, MD 박영이
Jonathan Zuckerman MD PhD
about 1 month ago
It's not always diabetic nephropathy. Pt with DN, HTN, and nephrotic range proteinuria. Elevated K/L ratio. Bx with Light and Heavy Chain deposition disease mimicking nodular diabetic glomerulopathy.
#renalpath
#pathsky
#nephsky
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reposted by
Grace Choung, MD 박영이
Kidney International
about 1 month ago
Nephrology Image Podocyte zebra bodies in LMX1B-associated nephropathy: a Fabry mimic
doi.org/10.1016/j.kint.2025.09.029
#NephSky
#MedSky
#PathSky
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Immunofluorescence Patterns in IgA Nephropathy are Associated with Active, Necrotizing Lesions - Kidney International Reports
www.kireports.org/article/S246...
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Immunofluorescence Patterns in IgA Nephropathy are Associated with Active, Necrotizing Lesions
IgA nephropathy (IgAN) is characterized by profound heterogeneity, yet therapeutic decisions often rely on a
https://www.kireports.org/article/S2468-0249%2826%2902800-7/fulltext
about 1 month ago
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Grace Choung, MD 박영이
Renal Pathology Society (RPS)
about 1 month ago
The Cornell Travel Grant With generous support from
@lynncornell.bsky.social
, RPS is pleased to offer 2 travel grants for the 2026 Banff Conference. Applicants should be RPS members; non-members may apply for membership when submitting:
renalpathsoc.org/Join-RPS
#renalpath
#pathsky
#nephsky
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Grace Choung, MD 박영이
Jonathan Zuckerman MD PhD
about 1 month ago
Striking viral inclusion in this case of polyomavirus nephropathy. SV40 stain is confirmatory.
#renalpath
#pathsky
#nephsky
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reposted by
Grace Choung, MD 박영이
NEJM.org
about 1 month ago
A 60-year-old woman with follicular lymphoma was evaluated for swelling and proteinuria that had persisted for 2 weeks. The patient’s plasma was clear at 37°C but turbid at 4°C. A kidney biopsy was performed. Read the full case details: https://nej.md/4tDDm2e
#Hematology
#Nephrology
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Grace Choung, MD 박영이
Kidney International
about 1 month ago
Clinical and Histologic Predictors of Non-Diabetic Kidney Disease in Patients with Diabetes Mellitus
doi.org/10.1016/j.kint.2026.03.015
#NephSky
#MedSky
#OpenAccess
#diabeticnephropathy
@arkanalabs.bsky.social
@stanforddeptmed.bsky.social
@jhu.edu
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Grace Choung, MD 박영이
about 1 month ago
#Metabolic Dysfunction-Associated Steatotic #LiverDisease and #KidneyTransplant Outcomes #VisualAbstract by
morgan-mccord.bsky.social
https://www.kireports.org/article/S2468-0249(26)02709-9/fulltext
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Grace Choung, MD 박영이
Kidney International
about 1 month ago
A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease
doi.org/10.1016/j.kint.2026.03.020
#MedSky
#NephSky
@ashkarlab.bsky.social
@kpmproject.bsky.social
@umich.edu
@clevelandclinic.bsky.social
@uwmedicine.bsky.social
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Grace Choung, MD 박영이
Kidney International
about 2 months ago
Finding the etiology of membranoproliferative glomerulonephritis
doi.org/10.1016/j.kint.2026.02.030
#NephSky
#MedSky
@mayoclinicpath.bsky.social
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Grace Choung, MD 박영이
Kidney International
about 1 month ago
Serine protease HTRA1 is a common autoantigen in membranous nephropathy in patients of 80 years and older
doi.org/10.1016/j.kint.2026.02.036
#MedSky
#NephSky
#kidneybiopsy
#pathsky
#renalpath
#kidneypath
@uofuhealth.bsky.social
@arkanalabs.bsky.social
@meharrymed.bsky.social
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Nodular diabetic GS can have double contours..But not this much This case has superimposed chronic TMA related to VEGF inhibitor 🔸Some can have PAS-positive pseudothrombi (also described with TKI inhibitors)
pubmed.ncbi.nlm.nih.gov/30014486/
pmc.ncbi.nlm.nih.gov/articles/PMC...
#renalpath
#pathsky
about 2 months ago
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It's not always just diabetic GS Case of diabetic GS with chronic TMA 2/2 tyrosine kinase inhibitor (TKI) 🔸Anti-VEGF effects 🔸Most within weeks to months after starting TKI 🔸TMA +/- PAS+ pseudothrombi
pmc.ncbi.nlm.nih.gov/articles/PMC...
pubmed.ncbi.nlm.nih.gov/19054798/
#renalpath
#pathsky
about 2 months ago
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Grace Choung, MD 박영이
Jonathan Zuckerman MD PhD
about 2 months ago
MPO+ANCA GN with concurrent low grade membranous nephropathy. MPO positivity in the MN deposits helps support a unifying etiology is such cases.
pubmed.ncbi.nlm.nih.gov/40485711/
#renalpath
#nephsky
#pathsky
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Grace Choung, MD 박영이
ACR Journals
about 2 months ago
A 64 y/o woman was admitted for acute kidney injury w/ nephrotic range proteinuria. Prior, she had 3 months of duskiness of distal fingertips w/ mottling. Renal biopsy showed glomerulonephritis w/ focal immune deposits that stained exclusively for C3 Clinical images in ACROR
doi.org/10.1002/acr2...
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Grace Choung, MD 박영이
Jonathan Zuckerman MD PhD
about 2 months ago
Autopsy case with incidental ALECT2 amyloidosis with lung involvement. Essentially invisible by light microscopy. Wonder how often this is overlooked. 94% of cases had alveolar involvement in this study (PMID: 26912093).
#pathksy
#renalpath
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Grace Choung, MD 박영이
American Journal of Kidney Diseases
about 2 months ago
Thrombotic Microangiopathy During Pregnancy: Role of Soluble Fms-like Tyrosine Kinase-1–Placental Growth Factor Ratios
bit.ly/3KMpv8m
(OPEN ACCESS)
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Grace Choung, MD 박영이
American Journal of Transplantation
about 2 months ago
🔓 Open Access "The Banff 2024 Kidney Meeting Report: Rejection as a spectrum of phenotypes and focus on differential diagnostic reasoning," Naesens et al.
www.amjtransplant.org/article/S160...
#Transplantation
#KidneyTransplant
#Banff
#TransplantPathology
#DifferentialDiagnosis
#OpenAccess
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Grace Choung, MD 박영이
about 2 months ago
Finding the etiology of MPGN (EDITORIAL: SPECIAL REPORT )
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Finding the etiology of MPGN
Membranoproliferative glomerulonephritis (MPGN) has undergone a change in classification that is focused on the etiology of MPGN. Thus, MPGN is classified into immune-complex (IC)-mediated MPGN and…
https://buff.ly/hhmwY7C
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Grace Choung, MD 박영이
Jonathan Zuckerman MD PhD
2 months ago
Transplant bx for renal dysfunction in a patient with shortness of breath. Granulomatous tubulointerstitial nephritis. AFB stain +. Sputum + for TB. Good sample key for making the diagnosis. 2 rounds of AFB stain to find the organism.
#renalpath
#pathksy
#nephsky
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Grace Choung, MD 박영이
Jonathan Zuckerman MD PhD
2 months ago
Bx for AKI in a pt on checkpoint inhibitor: neutrophil rich tubulointerstitial nephritis. We would usually think pyelonephritis, high risk neutrophil rich variants of CKI inhibitor AIN have been characterized.
pubmed.ncbi.nlm.nih.gov/41727781/
#renalpath
#pathsky
#nephsky
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Grace Choung, MD 박영이
2 months ago
A pediatric case of C3 glomerulonephritis initially misclassified as IgA nephropathy with a favorable response to C3-targeted therapy
#nephsky
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A pediatric case of C3 glomerulonephritis initially misclassified as IgA nephropathy with a favorable response to C3-targeted therapy - Pediatric Nephrology
C3 glomerulopathy is an ultra-rare kidney disease driven by dysregulation of the alternative complement pathway fluid phase C3 convertase. We report the case of a previously healthy 13-year-old girl…
https://buff.ly/3HeKxQq
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Grace Choung, MD 박영이
Edgar V. Lerma 🇵🇭
2 months ago
Approach to immune checkpoint inhibitor (ICI) nephrotoxicity and rechallenge
#ISNWCN
🇯🇵
#WCN26
🇯🇵
#WCN2026
🇯🇵
#Onconephrology
🦀
#Nephpearls
#NephSky
👉
pubmed.ncbi.nlm.nih.gov/32775813/
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Grace Choung, MD 박영이
International Society of Glomerular Disease
2 months ago
🤔 What makes IgA pathogenic in IgAN❓ 👉🏻 A subgroup of GdIgA1with strong affinity for the glomerulus 🫘 💡 IgA type anti-MEsangial Cell Antibodies (Ig-MESCA) are GdIgA1-Ab. 🎯 Mesangial cells 🧫 Molecular mimicry with oral bacteria
#ISNWCN
@theisn.org
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Grace Choung, MD 박영이
International Society of Glomerular Disease
2 months ago
Amazing! Paola Romagnani
#ISGD
#ISNWCN
with “Podocytopathies: Knowns and Unknowns” 👉🏻Podocyte loss and regeneration 👀Autoimmune, genetic, adaptive, infectious, toxic, monoclonal 🎯Anti-slit autoantibodies-> ⬇️ prognosis
#GlomerularDisease
#Yokohama
🌸
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Grace Choung, MD 박영이
Jonathan Zuckerman MD PhD
2 months ago
Bx for pt with AKI and nephrotic range proteinuria. Hx of IV drug abuse (with skin popping), and chronic staph infections. AA amyloidosis was the unsurprising finding.
#renalpath
#pathsky
#nephsky
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Grace Choung, MD 박영이
Kidney International
2 months ago
Anti-PLA2R1 IgG-mediated podocyte PLA2R1 cleavage drives glomerular subepithelial immune complex deposition in membranous nephropathy
doi.org/10.1016/j.kint.2026.02.021
#NephSky
#MedSky
#OpenAccess
#membranousnephropathy
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Grace Choung, MD 박영이
2 months ago
Review: Adenine phosphoribosyltransferase deficiency and 2,8-dihydroxyadeninuria
#openaccess
#nephsky
buff.ly/ifexeeG
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Adenine phosphoribosyltransferase deficiency and 2,8-dihydroxyadeninuria - Pediatric Nephrology
Adenine phosphoribosyltransferase (APRT) deficiency is a rare autosomal recessive disorder of purine metabolism causing 2,8-dihydroxyadenine urinary tract stones and crystal nephropathy. Disease…
https://link.springer.com/article/10.1007/s00467-026-07187-9
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Grace Choung, MD 박영이
Swapnil Hiremath 🍁🇨🇦
2 months ago
A KDIGO commentary on B Cell and Complement guided therapy in IgAN
www.kidney-international.org/article/S008...
in Kidney Int Perfectly timed for
#NephMadness
(and this will be the champion)
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reposted by
Grace Choung, MD 박영이
2 months ago
Clinical feature analysis of pediatric Castleman disease with renal involvement
#nephsky
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Clinical feature analysis of pediatric Castleman disease with renal involvement - Pediatric Nephrology
Background Pediatric Castleman disease (CD) is a rare lymph node disorder, and renal involvement is uncommon in pediatric CD. This study aimed to investigate the clinical features of pediatric CD…
https://buff.ly/ZulkKJe
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Grace Choung, MD 박영이
Joseph Flynn, MD
2 months ago
Severe renovascular hypertension in an infant with a SMAD3 gene variant
#nephsky
#hypertension
@ped-neph.bsky.social
#pedsky
link.springer.com/article/10.1...
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Severe renovascular hypertension in an infant with a SMAD3 gene variant - Pediatric Nephrology
Introduction Renal artery stenosis is one of the severe secondary hypertension (HTN) causes in children and may lead to hypertension-mediated organ damage (HMOD), including left ventricle hypertrophy ...
https://link.springer.com/article/10.1007/s00467-026-07221-w
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Grace Choung, MD 박영이
Jonathan Zuckerman MD PhD
2 months ago
Classic powdery electron dense deposits along GBMs, TBMS, and in vascular walls by EM in this case of light chain deposition disease.
#renalpath
#pathsky
#nephsky
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reposted by
Grace Choung, MD 박영이
Jonathan Zuckerman MD PhD
3 months ago
Don't confuse these for crystals. Limiting membrane of peroxisomes in proximal tubules. Normal tubular structure. Mimic of light chain proximal tubulopathy.
#renalpath
#pathsky
#nephsky
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Renal hemosiderosis in paroxysmal nocturnal hemoglobinuria - Kidney International
www.kidney-international.org/article/S008...
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Renal hemosiderosis in paroxysmal nocturnal hemoglobinuria
A middle-aged man presented with >10 years of intermittent dark-colored urine. Laboratory tests showed hemoglobin, 112 g/l; serum creatinine, 75.7 μmol/l; and elevated lactate dehydrogenase, 26.88 μka...
https://www.kidney-international.org/article/S0085-2538%2826%2900059-1/fulltext
3 months ago
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Empagliflozin-associated Armanni-Ebstein lesions in IgA nephropathy - Kidney International
www.kidney-international.org/article/S008...
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Empagliflozin-associated Armanni-Ebstein lesions in IgA nephropathy
A 26-year-old woman with 3-year Nutcracker phenomenon initially had intermittent mild proteinuria (urine protein-to-creatinine ratio <0.2 g/g) and microscopic hematuria, untreated as asymptomatic. Eig...
https://www.kidney-international.org/article/S0085-2538%2826%2900058-X/fulltext
3 months ago
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