Bx for progressive CKD in a pt with CML, in remission. Limited biopsy with prominent debris filled proximal tubule lysosomes + for lysozyme (no evidence for light chain restriction (F/P) or chromogranin). Suspicious for lysozyme nephropathy. #renalpath #pathksy #nephsky

#UrinarySediment from a pt with #AKI #RPGN due to suspected MPO-AAV-GN inspected with Sternheimer-Malbin stain: RBC cast (bright field), WBC cast (oblique illumination), fibrinous cast (dark field), and renal tub epi cell cast (oblique). #OchsnerNephrology

IgG3κ Monoclonal Membranous Nephropathy Associated With Acquired Lecithin Cholesterol Acyltransferase Deficiency bit.ly/3Le1OFK

Another interesting @kidneyint.bsky.social cohort study www.kidney-international.org/article/S008... Infection risk in kidney disease - lupus > ANCA, perhaps as ANCA is one and done (usually) whereas #lupus is never done? Lupus > other primary and ADPKD is not surprising #NephSky

Reduce variability and inconsistency in your approach to #amyloidosis diagnosis and laboratory workup! New #CAPguideline: brnw.ch/21wXMU6 #pathsky #pathology #CAPGuidelines

One of the more subtle cases of amyloidosis I have seen. Few spicules on silver stain. Minimal congo red positivity. Despite early amyloid deposition, pt had nephrotic syndrome. Likely AL type (pt has LPL); MS pending. #renalpath #pathsky #nephsky

Kidney Tertiary #LymphoidTissues and Poor #Immunosuppressive Response in #IgANephropathy #IgAN #VisualAbstract by Elba Medina https://www.kireports.org/article/S2468-0249(25)00677-1/fulltext

RPS and Banff Activity/Chronicity Working Group WITH REGISTRATION LINK us02web.zoom.us/webinar/regi... #renalpath #pathsky #nephsky #nephrology

🚨 New paper alert in @asnpublications.bsky.social ⬇️ 🔑 Preimplantation Histopathologic Assessment of Deceased Donor Kidneys. Recommendations from the Banff Time-Zero Biopsy Working Group ‼️ Potential/Pitfalls/Future Research 🔗 journals.lww.com/jasn/abstrac...

Excited to join hands with @hswapnil.medsky.social & @theisn.org in this new venture, Kidney International Case Reports. KICR seeks submissions from authors worldwide - Publication fees will be waived for all authors between Dec 1, 2025, and Dec 31, 2026. www.sciencedirect.com/journal/kidn...

RPS and Banff Activity/Chronicity Working Group WITH REGISTRATION LINK us02web.zoom.us/webinar/regi... #renalpath #pathsky #nephsky #nephrology

So many eosinophils in this case of tubulointerstitial nephritis secondary to recent antibiotic administration. Few tiny granulomas as well. Eos seen in EM as well. #renalpath #pathsky #nephsky

The RPS is inviting you to a webinar Spectrum of Transplant Rejection: Towards the Implementation of Activity and Chronicity Indices Tuesday, December 2, 2025 8:00 AM PST / 11:00 AM EST / 5:00 PM CET For more info & to register: renalpathsoc.org/event-6445938 #renalpath #PathTwitter #nephrology

Join RPS-GlomCon Renal Pathology Webinar Series Update on CKDu/CINAC Speaker: Cynthia Nast, MD Date: November 30, 2025 Webinar info: renalpathsoc.org/event-6113942 #renalpath #PathTwitter @glomcon.org

Unusual granular casts with annular appearance. Light chain, hemoglobin, myoglobin, chromogranin casts excluded. Patient on IV vancomycin. Suspicious for vancomycin cast nephropathy. pubmed.ncbi.nlm.nih.gov/31871855/ #renalpath #pathsky #nephsky

Unfortunate but not rare IgAN presentation. Pt in their 30's, no PMHx, presented with HTN emergency, CKD, hematuria, proteinuria. Advanced IgAN with severe IFTA, focal active crescents (M1 E1 S1 T2 C1). Wish we could catch these cases earlier. #renalpath #pathsky #nephsky

Diagnosis unmasked. Young F with 2g proteinuria, weak +dsDNA. Membranous pattern, IF with C3 dominant staining. Pronase IF --> IgG-k. Membranous-like glomerulopathy with masked monotypic IgG-k deposits. Considered to be autoimmune; not MGRS. #renalpath #pathsky #nephsky.

#RenalPath: C1q nephropathy w. segmental sclerosis w. increased mesangial matrix, obliteration of capillary lumens, adhesion to Bowman capsule (right half of tuft) Open left portion of glomerulus shows mild to moderate increase in mesangial cellularity bit.ly/3XadOLx

#Quiz from October 2025: A 16-year-old male patient presented to an ED with a 3-week history of progressive headaches, nausea, vomiting, and bilateral blurry vision. Over the past 3 days, he developed chest pain and shortness of breath. bit.ly/47iQnEo

Hilar variant of focal segmental glomerulosclerosis, with segmental sclerosis at the vascular pole with hyalinosis and adhesion (Jones silver stain) bit.ly/49P5wQP (FREE) #FSGS #renalpath

#UrinarySediment from a pt with #AKI #RPGN due to suspected MPO-AAV-GN inspected with Sternheimer stain: WBC cast (bright field), broad RBC cast (bright), waxy cast (bright), and granular cast w/Ca Oxalate monohydrate crystals (oblique). #OchsnerNephrology #UrineMicroscopy

The RPS is inviting you to a webinar Spectrum of Transplant Rejection: Towards the Implementation of Activity and Chronicity Indices Tuesday, December 2, 2025 8:00 AM PST / 11:00 AM EST / 5:00 PM CET For more info & to register: renalpathsoc.org/event-6445938 #renalpath #PathTwitter #nephrology

BK nephropathy Clues: - Heavy but focal tubulointerstitial inflammation - Increased plasma cells - Viral cytopathic change - Features of CNI toxicity ->over immunosuppression (isometric vacuolization shown here) -SV40 IHC confirmatory #renalpath #pathsky #nephsky

Urine crystals in a patient with Crohn’s Answer: www.kidney-international.org/article/S008... in @kidneyint.bsky.social #NephSky

Arteriole with features of a old recanalized thombus in a transplant kidney biopsy. Multiple slit like vascular spaces within the fibrotic lumen. Not a lesion I see often. Pt had clinically diagnosed TMA a few months prior. #renalpath #pathsky #nephsky

Join RPS-GlomCon Renal Pathology Webinar Series Update on CKDu/CINAC Speaker: Cynthia Nast, MD Date: November 30, 2025 Webinar info: renalpathsoc.org/event-6113942 #renalpath #PathTwitter @glomcon.org

IgA Vasculitis A kidney biopsy is mandatory in patients with persistent proteinuria ≥0.5 g/day for more than 4 weeks, impaired kidney function, or suspicion of rapidly progressive glomerulonephritis (RPGN). #NephJC

Rituximab in pediatric refractory nephrotic syndrome: a systematic review and meta-analysis evaluating therapeutic efficacy and adverse event profiles #nephrology #nephsky link.springer.com/article/10.1...

AJKD Atlas of Renal Pathology: Crystalglobulin-Induced Nephropathy bit.ly/41jvO7T (FREE) #RenalPath Image: Large bright eosinophilic crystals within glomerular capillaries (arrow, Jones silver stain)

Novel Treatment Paradigms: #Complement #Inhibition in Antineutrophil Cytoplasmic Autoantibody Vasculitis https://doi.org/10.1016/j.ekir.2025.07.015 #KIRReview #ANCA

Should nephrologists further implement genetic testing in patients with CKD? In this #ASNJASN study of adult CKD management, genetic testing showed diagnostic and clinical utility in the year following the reporting of test results. Read more: kidney.pub/JASN0913#ASNJASN

#RenalPath AJKD Atlas of Renal Pathology: Lysozyme-Associated Nephropathy bit.ly/3Jq0ijC (FREE)

Review by Anthony Bleyer et al: Autosomal Dominant Tubulointerstitial Kidney Disease: A Review bit.ly/3VgPMNS (FREE)

Illustrative example of a segmental membranous nephropathy pattern (segmental granular IgG staining) which is often seen with NELL-1+ (IHC) MN as in this case. Deposits present in only some loops by EM. #renalpath #pathsky #nephsky

NELL-1 IHC can also be tricky to interpret as there is significant podocyte cytoplasmic staining in the negative control. Must show granular capillary wall deposits which match deposits by IF and EM. #renalpath #pathsky #nephsky

Chronic active ABMR in patient with worsening proteinuria, renal function, positive DSA *Glomerulitis (shown in image) *Transplant glomerulopathy (shown in image) *Peritubular capillaritis *Diffuse C4d+ in PTCs on IF #renalpath #transplant #pathsky #nephsky #medsky

#RenalPath: Antibody-mediated acute rejection with glomerulitis: increased intracapillary leukocytes (arrows) in glomerular tuft (Jones silver stain). bit.ly/2uShEyu (FREE)

Biopsy for nephrotic syndrome in an adult. Anyone want to venture a diagnosis? or any additional tests? #renalpath #nephrology #pathsky

Patient w AKI. Biopsy of mostly medulla shows what appears at first to be pyelonephritis. Lots of neutrophils in medulla and no crescents. IF: negative. BUT...there are areas of interstitial hemorrhage🤔 ANCA came back positive!😮 -->Medullary angiitis in ANCA vasculitis #renalpath #pathsky #nephsky

#RenalPath: Bile nephrosis with intratubular casts that are dark green by Hall stain. bit.ly/2l29w80 (FREE)

Classic example of collapsing glomerulopathy injury pattern. Hypertrophied epithelial cells with prominent cytoplasmic protein reabsorption droplets overlying compressed capillary loops. #renalpath #pathology #nephrology

Pt with CMML & subnephrotic proteinuria & renal dysfunction Extramedullary hematopoiesis •Hematopoietic tissue outside BM •Due to hematologic malignancy/lack BM hematopoiesis (HP) •Histology: TIN + trilineage HP #renalpath #pathsky #nephsky #hemepath

FREE The tip lesion variant of focal segmental glomerulosclerosis (FSGS) is associated with nephrotic syndrome and usually responds to steroid therapy. This #FSGS variant has the lowest risk for progression to kidney failure. bit.ly/47tgF8l #RenalPath

RPS International Renal Pathology Conference abstract deadline extended to November 15th All information for registration is available at the RPS-Website: renalpathsoc.org/6thIRPC Chair 6th IRPC Carmen Avila-Casado MD, PhD #renalpath #nephsky #pathsky #nephrology

Cure IgAN through bone marrow transplant or reprogramming the B-cells 😳 #KidneyWk

Interpreting Metabolomics and Proteomics in Kidney Disease: A Practical Guide by Insa M. Schmidt and Eugene P. Rhee bit.ly/4ooxkQ6

Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself) Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵

Flashback #FluorescenceFriday to some of the first light-sheet imaging we were doing. Video shows the collecting duct system of the developing kidney labeled with a pan-cytokeratin antibody. Courtesy of former talented technician Deanna Hardesty.

Clinicopathological spectrum and treatment outcomes of cryofibrinogen-associated nephropathies #nephsky #nephrology www.kireports.org/article/S246...

Cellular variant of focal segmental glomerulosclerosis, with endocapillary hypercellularity with foam cells and mononuclear cells (top; Jones silver stain)" bit.ly/4nNJdy2 (FREE) #renalpath #FSGS