@aspneph.bsky.social
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Using a multi-institutional pediatric learning health system to characterize induction therapy for incident lupus nephritis in children
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Using a multi-institutional pediatric learning health system to characterize induction therapy for incident lupus nephritis in children - Pediatric Nephrology
Background Childhood-onset systemic lupus erythematosus (SLE) poses unique challenges compared to adult-onset SLE, with higher rates of kidney involvement, tissue damage, and mortality. Despite this,…
https://buff.ly/NdzmdYu
about 2 hours ago
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Suppressor of cytokine signaling 2 is associated with growth impairment in pediatric chronic kidney disease.
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about 5 hours ago
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A novel clinical score to predict breakthrough urinary tract infection in children with VUR: meta-analytic derivation and real-world validation
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A novel clinical score to predict breakthrough urinary tract infection in children with VUR: meta-analytic derivation and real-world validation - Pediatric Nephrology
Background Breakthrough urinary tract infection (BT-UTI) among children with vesicoureteral reflux (VUR) receiving continuous antibiotic prophylaxis (CAP) remains a clinical challenge with…
https://buff.ly/22n9MoM
about 10 hours ago
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Ultrasound cardiac output monitoring compared to the renal angina index for early prediction of pediatric acute kidney injury
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Ultrasound cardiac output monitoring compared to the renal angina index for early prediction of pediatric acute kidney injury - Pediatric Nephrology
Background Acute kidney injury (AKI) is a significant concern within pediatric intensive care units (PICUs), leading to increased morbidity, longer hospitalization, and increased healthcare costs.…
https://buff.ly/GyZFgoO
about 10 hours ago
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Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN
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Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN | NEJM
C3 glomerulopathy and primary immune-complex membranoproliferative glomerulonephritis (MPGN) generally result in glomerular C3 deposition and irreversible kidney damage. The efficacy and safety of ...
https://buff.ly/GwhgaR9
about 12 hours ago
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Kidney transplantation in mitochondrial diseases: a systematic review
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Kidney transplantation in mitochondrial diseases: a systematic review - Pediatric Nephrology
Background Primary mitochondrial diseases are a group of rare, heterogeneous, multisystem disorders. While renal involvement is increasingly recognised, especially in paediatric patients, data on…
https://buff.ly/MAB48JT
about 14 hours ago
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Accuracy of validated blood pressure measuring devices for out-of-office measurement in children and adolescents: a systematic review and meta-analysis
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Accuracy of validated blood pressure measuring devices for out-of-office measurement in children and adolescents: a systematic review and meta-analysis - Pediatric Nephrology
Background Blood pressure (BP) measuring devices must demonstrate clinical accuracy proven by proper validation testing in the intended population, following recommendations published by scientific…
https://link.springer.com/article/10.1007/s00467-025-06974-0
about 23 hours ago
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Join us this
#GivingTuesday
! Your donation to the ASPN Foundation fuels research, education, and advocacy for children with kidney disease. Every gift makes a difference. Donate now:
buff.ly/T1wH6Iq
#ASPNFoundation
#GivingTuesday
3 days ago
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This Thanksgiving, we’re extra thankful for pediatric nephrologists - the only people who can make kidneys sound fascinating before the pumpkin pie hits. Thank you for all you do for kids and families!
8 days ago
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Lung ultrasonography for assessment of fluid overload in children with acute kidney injury undergoing hemodialysis: a prospective pilot study
#nephsky
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Lung ultrasonography for assessment of fluid overload in children with acute kidney injury undergoing hemodialysis: a prospective pilot study - Pediatric Nephrology
Background B-line quantification by lung ultrasonography (LUS) is a non-invasive method to assess pulmonary edema and fluid overload. This study evaluated the change in the number of B-lines on LUS…
https://buff.ly/Y8N4pB5
8 days ago
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Review: Current status and future directions for the use of artificial intelligence in pediatric critical care nephrology
#AI
#nephsky
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Current status and future directions for the use of artificial intelligence in pediatric critical care nephrology - Pediatric Nephrology
Artificial intelligence (AI) has the potential to significantly improve the practice of medicine. However, its application in pediatric critical care nephrology remains underdeveloped. This scoping…
https://buff.ly/7JJ03Ci
8 days ago
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Case report: Belimumab combined with mycophenolate mofetil in a child with frequently relapsing, steroid-dependent nephrotic syndrome
#nephsky
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Belimumab combined with mycophenolate mofetil in a child with frequently relapsing, steroid-dependent nephrotic syndrome - Pediatric Nephrology
Frequently relapsing, steroid-dependent nephrotic syndrome (FRNS/SDNS) remains a therapeutic challenge. Rituximab, a B-cell-depleting agent, is effective and widely used for FRNS/SDNS, but its use…
https://buff.ly/pNIna7Y
9 days ago
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Review: Viral tubulointerstitial nephritis in children: A narrative review with a focus on adenovirus
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Viral tubulointerstitial nephritis in children: A narrative review with a focus on adenovirus - Pediatric Nephrology
Viral infections are well-known causes of systemic illness in children, but their kidney involvement, particularly acute tubulointerstitial nephritis (TIN), remain underdiagnosed and clinically…
https://buff.ly/uXnLDqG
9 days ago
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All recordings are LIVE! The ASPN Pediatric Nephrology Board Review Course is now available on-demand. Your pace. Your schedule. Your board prep.
buff.ly/mcfs7PK
đź”—
#ASPN
#PediatricNephrology
#BoardPrep
9 days ago
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Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial
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Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial | NEJM
The cytokine A proliferation-inducing ligand (APRIL) is considered a key driver of the pathogenesis of IgA nephropathy. Sibeprenlimab, a humanized IgG2 monoclonal antibody, selectively binds to and...
https://buff.ly/NUdnOGT
10 days ago
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The Role of the Vascular Niche in Regulating Kidney Tubulo-Interstitial Fibrosis (review)
10 days ago
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One-year creatinine predicts long-term graft survival in pediatric kidney transplant recipients
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One-year creatinine predicts long-term graft survival in pediatric kidney transplant recipients - Pediatric Nephrology
Background In pediatric kidney transplant, recipients’ long-term graft survival remains variable necessitating methods to predict the timing of graft failure. Studies in adults have identified…
https://buff.ly/G9DLQ68
10 days ago
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High adherence to angiotensin-converting enzyme inhibitor in children and adolescents with Alport syndrome: objective verification using liquid chromatography-mass spectrometry
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High adherence to angiotensin-converting enzyme inhibitor in children and adolescents with Alport syndrome: objective verification using liquid chromatography-mass spectrometry - Pediatric Nephrology
Background Kidney failure (KF) in children and adolescents leads to reduced lifespan and compromised health. Alport syndrome (AS) is a leading hereditary cause of KF in children.…
https://buff.ly/h4PyESX
10 days ago
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Serum renin levels refine acute kidney injury prediction in critically ill children
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Serum renin levels refine acute kidney injury prediction in critically ill children - Pediatric Nephrology
Background Studies demonstrate that elevated renin is associated with adverse outcomes in critical illness. We aimed to evaluate whether serum renin enhances acute kidney injury (AKI) risk…
https://buff.ly/45HwArz
10 days ago
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Tiopronin safety in cystinuria: first real-world pharmacovigilance analysis using the FDA Adverse Event Reporting System (FAERS): an EAU YAU and Endourology sections review
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Tiopronin safety in cystinuria: first real-world pharmacovigilance analysis using the FDA Adverse Event Reporting System (FAERS): an EAU YAU and Endourology sections review - Pediatric Nephrology
Background Cystinuria is a rare genetic disorder that causes recurrent cystine stones and significant morbidity, particularly in children. Tiopronin, the main pharmacologic therapy when conservative…
https://buff.ly/tyluHj2
11 days ago
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High early fluid and sodium intake as risk factors for acute kidney injury in very-low-birthweight infants
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High early fluid and sodium intake as risk factors for acute kidney injury in very-low-birthweight infants - Pediatric Nephrology
Background Acute kidney injury (AKI) is common in very-low-birthweight (VLBW) infants. Both fluid overload and dehydration can lead to AKI. Our aim was to examine the associations between early fluid…
https://link.springer.com/article/10.1007/s00467-025-07049-w
11 days ago
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Immunogenicity of the 23-valent polysaccharide pneumococcal vaccine in children with steroid sensitive nephrotic syndrome
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Immunogenicity of the 23-valent polysaccharide pneumococcal vaccine in children with steroid sensitive nephrotic syndrome
Background Idiopathic nephrotic syndrome (INS) is the most common chronic kidney disease in childhood, with steroid sensitive nephrotic syndrome (SSNS) as the predominant form. Children with SSNS are...
https://buff.ly/d9MaX8b
13 days ago
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Heart-kidney transplants linked to better outcomes compared to heart-only transplants in children with non-dialysis-dependent advanced chronic kidney disease
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Heart-kidney transplants linked to better outcomes compared to heart-only transplants in children with non-dialysis-dependent advanced chronic kidney disease
Background Chronic kidney disease (CKD) causes significant morbidity and mortality among children with heart failure. Although the survival benefit of a simultaneous heart-kidney transplant has been demonstrated...
https://buff.ly/3MPgb9g
13 days ago
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Ultrasonography in pediatric urinary stone diagnosis: clinical utility and diagnostic limitations in light of CT findings
Background Ultrasonography (US) is the preferred first-line imaging modality for suspected urinary calculi in children because it is non-invasive and avoids radiation exposure. However, its diagnostic...
https://buff.ly/LzDrxiP
13 days ago
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Re-evaluating the MYH9 p.I1816V variant in a patient with atypical clinical presentation
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Re-evaluating the MYH9 p.I1816V variant in a patient with atypical clinical presentation
MYH9-related disease (MYH9-RD) is an autosomal dominant disorder typically characterized by macrothrombocytopenia, leukocyte inclusion bodies, and variable non-hematologic manifestations such as hearing...
https://buff.ly/H4UOrHE
14 days ago
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Correlation of serum beta-2 microglobulin with hemodialysis prescription and comorbid factors in children undergoing chronic hemodialysis
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Correlation of serum beta-2 microglobulin with hemodialysis prescription and comorbid factors in children undergoing chronic hemodialysis - Pediatric Nephrology
Background Hemodialysis (HD) is a method of kidney replacement therapy designed to remove uremic toxins from the body. Beta-2 microglobulin (beta-2 MG) is a middle molecule not yet effectively…
https://buff.ly/KTMlY9L
14 days ago
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Clinicopathological characteristics and cyclosporine-responsive proteinuria in nail-patella syndrome with a novel LMX1B mutation
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Clinicopathological characteristics and cyclosporine-responsive proteinuria in nail-patella syndrome with a novel LMX1B mutation
Background Nephropathy in nail-patella syndrome (NPS) has limited therapeutic options. Progressive nephrotic-range proteinuria often persists despite maximal renin–angiotensin–aldosterone system inhibitor...
https://buff.ly/jywLFVn
14 days ago
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The dietary management of sodium in children with kidney diseases—clinical practice recommendations from the Pediatric Renal Nutrition Taskforce
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The dietary management of sodium in children with kidney diseases—clinical practice recommendations from the Pediatric Renal Nutrition Taskforce
Sodium imbalance is a common concern in children with kidney diseases, presenting as either sodium excess or sodium deficit, each with significant clinical implications. Sodium excess contributes to fluid...
https://buff.ly/59a4qLm
15 days ago
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Relationships between galectin-3, sclerostin and arterial stiffness in children with renal scar
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Relationships between galectin-3, sclerostin and arterial stiffness in children with renal scar - Pediatric Nephrology
Background Renal scar can lead to hypertension and cardiovascular disease in children. Arterial stiffness is an important endpoint in the development of cardiovascular diseases and is a guide in the…
https://buff.ly/R8GYOWu
15 days ago
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Giving monocytes their due: How CD47–SIRP-α reframes allograft rejection
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Giving monocytes their due: How CD47–SIRP-α reframes allograft rejection
Despite decades of therapeutic innovation targeting adaptive immunity, such as the development of calcineurin inhibitors and B-cell–depleting agents like rituximab, long-term graft survival rates…
https://buff.ly/jkFNivd
15 days ago
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From RAAS blockade to regenerative medicine: evolving treatment strategies in Alport syndrome (review)
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From RAAS blockade to regenerative medicine: evolving treatment strategies in Alport syndrome
Alport syndrome (AS) is a hereditary glomerulopathy caused by mutations in the COL4A3, COL4A4, or COL4A5 genes, leading to progressive kidney decline and extrarenal manifestations. Advances in genetic...
https://buff.ly/TJ7Sz6z
15 days ago
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Which glomerular filtration rate estimation equations should be used in youth with type 1 diabetes?
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Which glomerular filtration rate estimation equations should be used in youth with type 1 diabetes?
Background Diabetic kidney disease (DKD) is the primary cause of kidney failure in type 1 diabetes (T1D). Early identification of subclinical DKD is based on albuminuria and glomerular filtration rate...
https://buff.ly/eaBPjIo
16 days ago
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Prolonged hypotension in children with bilateral kidney absence: a case series and pathophysiologic insights
#nephsky
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Prolonged hypotension in children with bilateral kidney absence: a case series and pathophysiologic insights - Pediatric Nephrology
Background The renin–angiotensin–aldosterone system is essential for blood pressure regulation, and its absence in children with bilateral kidney loss predisposes them to hypotension unresponsive to…
https://buff.ly/0sI6Lks
17 days ago
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The impact of urine pH on lithogenic risk profile in children with urolithiasis
#openaccess
#nephsky
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The impact of urine pH on lithogenic risk profile in children with urolithiasis - Pediatric Nephrology
Background Urinary pH is known to influence the solubility and excretion of lithogenic substances, yet its relationship with other metabolic parameters in pediatric stone formers remains…
https://buff.ly/5yOnnWi
17 days ago
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Review: Neonatal acute kidney injury: where are we now?
#nephsky
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Neonatal acute kidney injury: where are we now? - Pediatric Nephrology
Neonatal acute kidney injury (AKI) affects approximately one third of newborns admitted to neonatal intensive care units and is associated with increased morbidity and mortality. The etiology of…
https://buff.ly/LF2UFjP
18 days ago
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Biomarker kinetics reveal early underestimation of
#AKI
severity by pRIFLE: a simulation-based study
#nephsky
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Biomarker kinetics reveal early underestimation of AKI severity by pRIFLE: a simulation-based study - Pediatric Nephrology
Pediatric Nephrology -
https://buff.ly/WT3fErw
18 days ago
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Risk factors for loss of Varicella immunity after pediatric kidney transplantation
#openaccess
#nephsky
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Risk factors for loss of Varicella immunity after pediatric kidney transplantation - Pediatric Nephrology
Background Varicella zoster (VZV) vaccination pre-kidney transplant (Tx) can help prevent severe disseminated VZV in immunosuppressed recipients; however, studies have shown loss of humoral immunity…
https://buff.ly/9XC3m5K
18 days ago
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Hematuria as a diagnostic marker in pediatric
#nephrolithiasis
without acute obstruction or infection
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Hematuria as a diagnostic marker in pediatric nephrolithiasis without acute obstruction or infection - Pediatric Nephrology
Background The prevalence of pediatric nephrolithiasis has been rising globally, with hematuria being one of its most frequent diagnostic markers. However, the relationship between stone…
https://buff.ly/nmzgizJ
19 days ago
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Prognosis and predictive factors in pediatric IgA nephropathy
#openaccess
#nephsky
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Prognosis and predictive factors in pediatric IgA nephropathy - Pediatric Nephrology
Background IgA nephropathy (IgAN) is a common glomerular disease in children that may progress to chronic kidney disease (CKD) and kidney failure. Identifying reliable prognostic markers is important…
https://buff.ly/FbXXI2d
19 days ago
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Review: Early diagnosis and intervention in congenital lower urinary tract obstruction: time to revise our approach?
#LUTO
#openaccess
#nephsky
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Early diagnosis and intervention in congenital lower urinary tract obstruction: time to revise our approach? - Pediatric Nephrology
Abstract Congenital lower urinary tract obstruction (cLUTO) describes a heterogeneous spectrum of congenital lower urinary tract defects with variable postnatal outcomes, ranging from high morbidity…
https://buff.ly/UCzXVkr
20 days ago
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Changes in maintenance immunosuppression after pediatric kidney transplantation—a report from the Nordic pediatric kidney transplantation registry
#nephsky
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Changes in maintenance immunosuppression after pediatric kidney transplantation—a report from the Nordic pediatric kidney transplantation registry - Pediatric Nephrology
Background Few studies are available on changes in maintenance immunosuppression after pediatric kidney transplantation (KT). This is a retrospective registry analysis of the long-term medication…
https://buff.ly/HcNDwPs
20 days ago
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Neurodevelopmental outcomes in children with chronic kidney disease: a scoping review
#nephsky
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Neurodevelopmental outcomes in children with chronic kidney disease: a scoping review - Pediatric Nephrology
Background Chronic kidney disease (CKD) exhibits unique clinical characteristics in the pediatric population, including growth disturbances and alterations in neurocognitive development. Given the…
https://buff.ly/pTKZQZU
21 days ago
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Safety and utility of open kidney biopsy in children: a single-center retrospective study
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Safety and utility of open kidney biopsy in children: a single-center retrospective study - Pediatric Nephrology
Background Few reports have focused on the complications of pediatric kidney biopsy, and no comparative studies between open kidney biopsy (OB) and percutaneous needle kidney biopsy (NB) in pediatric…
https://buff.ly/1dgAQ6L
21 days ago
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Efficacy and safety of telitacicept in the treatment of pediatric IgA nephropathy: a retrospective study
#nephsky
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Efficacy and safety of telitacicept in the treatment of pediatric IgA nephropathy: a retrospective study - Pediatric Nephrology
Background Recent investigations have indicated that telitacicept significantly diminishes proteinuria levels in adult patients diagnosed with IgA nephropathy (IgAN). The therapy has been correlated…
https://buff.ly/AriYoB9
21 days ago
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A multi-center collaborative highlights the differences in
#nephrotoxic
medication exposure and associated
#AKI
in pediatric bone marrow transplant, oncology, and pulmonary service lines
#nephsky
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A multi-center collaborative highlights the differences in nephrotoxic medication exposure and associated AKI in pediatric bone marrow transplant, oncology, and pulmonary service lines - Pediatric Nephrology
Background Nephrotoxic medication (NTMx) exposure is a common cause of hospital-acquired acute kidney injury (AKI) in non-critically ill, hospitalized children. NINJA (Nephrotoxic Injury Negated by…
https://buff.ly/Jqu5ded
21 days ago
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Case report: An unusual presentation of UMOD-associated autosomal dominant tubulointerstitial kidney disease in a pediatric patient
#openaccess
#nephsky
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An unusual presentation of UMOD-associated autosomal dominant tubulointerstitial kidney disease in a pediatric patient - Pediatric Nephrology
Autosomal dominant tubulointerstitial kidney disease (ADTKD-UMOD) is a chronic and progressive kidney disease that typically presents with elevated serum creatinine and gout between the second and…
https://buff.ly/0sjXywh
22 days ago
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Case report: Long-term kidney function stabilization with fludrocortisone in autosomal recessive renal tubular dysgenesis: a case report @ped_neph
#openaccess
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Long-term kidney function stabilization with fludrocortisone in autosomal recessive renal tubular dysgenesis: a case report - Pediatric Nephrology
Renal tubular dysgenesis (RTD) is a rare disorder characterized by impaired development of the proximal tubules and kidney dysfunction due to decreased fetal renal plasma flow and renin-angiotensin…
https://buff.ly/5e1zHqH
22 days ago
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Rituximab in pediatric refractory nephrotic syndrome: a systematic review and meta-analysis evaluating therapeutic efficacy and adverse event profiles
#openaccess
#nephsky
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Rituximab in pediatric refractory nephrotic syndrome: a systematic review and meta-analysis evaluating therapeutic efficacy and adverse event profiles - Pediatric Nephrology
Background Rituximab is considered a therapeutic option in children with refractory nephrotic syndrome (RNS). However, the efficacy and safety of rituximab treatment remain unclear. Objective This…
https://buff.ly/iIi9vaI
22 days ago
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A Pooled Analysis of Sex Differences in Lupus Nephritis
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A Pooled Analysis of Sex Differences in Lupus Nephritis
Lupus nephritis (LN) has been reported to be more severe and have worse outcomes in males than females. In order to determine if sex differences exist in disease severity at diagnosis or relapse,…
https://buff.ly/CVArKFr
25 days ago
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Thirst, sodium, and the hospitalized child: rethinking hypernatremia (Editorial Commentary )
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Thirst, sodium, and the hospitalized child: rethinking hypernatremia - Pediatric Nephrology
Pediatric Nephrology -
https://buff.ly/k9zx33m
25 days ago
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