Corticosteroids are the cornerstone of therapy for steroid-sensitive nephrotic syndrome, yet the best dosing strategy remains uncertain. Read this Systematic Review /Meta-analysis of single-dose vs. multi-dose steroid therapy in pediatric NS. Open Access link.springer.com/article/10.1...

Hemoadsorption devices are a major advancement in extracorporeal organ support therapies. Read this Educational Review of technicalities, current evidence, & clinical indications of hemoadsorption in critically ill children. Free access this month. bit.ly/4b8ix74

AI is rapidly transforming many areas of medicine, & pediatric nephrology may be a field of particular relevance. Read this Review of AI in pediatric nephrology: current applications & emerging frameworks. Open Access link.springer.com/article/10.1...

Clinical significance of positive urine cultures in febrile infants w/negative dipsticks remains debated. Read this Original Article on urine cultures in low-risk febrile infants < 3 months old w/negative urine dipsticks. Open Access link.springer.com/article/10.1...

Anti-CD20 monoclonal antibodies (mAbs), which act as B-cell–depleting therapies, are important treatments for a range of pediatric kidney diseases. Read this Educ Review of infection prophylaxis following mAbs in childhood kidney diseases. Open Access link.springer.com/article/10.1...

Therapeutic complement inhibitors, which target complement pathway components, could revolutionize treatment for a broad range of kidney diseases. Read this Review of targeted treatments for glomerular diseases. Open Access link.springer.com/article/10.1...

Children w/chronic liver disease are at increased risk of AKI, which could be non-hepatorenal syndrome AKI (non-HRS-AKI) or hepatorenal syndrome AKI (HRS-AKI). Read this Review of terlipressin in pediatric HRS-AKI. Open Access link.springer.com/article/10.1...

Idiopathic nephrotic syndrome (NS) is the most common glomerular disease in children. Read this Systematic Review /Meta-analysis of steroid-induced adrenal insufficiency in children w/NS. Open Access link.springer.com/article/10.1...

Antenatal hydronephrosis (HN) is the most common congenital urinary tract abnormality, but mgmt is controversial. Read this Original Article on safely limiting antibiotic prophylaxis & invasive testing in asymptomatic children w/antenatally detected HN. link.springer.com/article/10.1...

Primary hyperoxaluria type 2 is a rare genetic disorder of oxalate due to a defect in the glyoxalate reductase/ hydroxypyruvate reductase enzyme. Read this Original Article on characteristics & outcomes in a pediatric population in Pakistan. link.springer.com/article/10.1...

Despite an increasing number of therapeutic options for pediatric patients w/steroid-resistant nephrotic syndrome (SRNS), treatment resistance & risk of progression to kidney failure are still high. Read this Review of outcomes & ongoing trials in SRNS. link.springer.com/article/10.1...

Magnetic resonance urography (MRU) examinations allow assessment of kidney functions through recently developed image post-processing techniques. Read this Original Article on prediction of split renal function & obstruction w/MRU. Open Access link.springer.com/article/10.1...

Hypercholesterolemia is considered a consequence of nephrotic syndrome secondary to hypoalbuminemia-induced hepatic overproduction of lipoproteins. Read this Research Letter on serum total cholesterol as an early indicator of proteinuria in children. link.springer.com/article/10.1...

Acute rheumatic fever (ARF) & acute poststreptococcal glomerulonephritis (APSGN) are serious non-suppurative complications of group A β-hemolytic streptococcal infections. Read this Systematic Review /Meta-analysis of coexistence of APSGN & ARF. Open Access link.springer.com/article/10.1...

Kidney scarring (KS) secondary to urinary tract infections is a common cause of secondary hypertension in children. Read this Original Article on the association between serum cystatin C levels & hypertension in children w/KS. link.springer.com/article/10.1...

The effect of continuous kidney replacement therapy w/regional citrate anticoagulation on bone mineral disease of AKI disease has not been well studied. Read this Original Article on prevalence of bone mineral disease in children w/AKI disease on CKRT. link.springer.com/article/10.1...

An underlying medical condition as a cause for elevated blood pressure is suspected when hypertension occurs in younger children or those w/markedly high readings. Read these Clinical Insights into polycythemia vera as a cause of systemic hypertension. link.springer.com/article/10.1...

The urinary calcium-to-citrate (Ca/Cit) ratio is an indicator of lithogenic risk in older children, but no reference data exist for infants & toddlers. Read this Original Article on Ca/Cit ratio & kidney stone risk in children under 2 years. Open Access link.springer.com/article/10.1...

A 2017 survey of neonatologist & pediatric nephrologist perceptions & practice showed that neonatal AKI was underappreciated. Read this Original Article on an updated survey: have perceptions & practices changed w/increased awareness of AKI? link.springer.com/article/10.1...

Children w/cancer have had many improvements in cure rates through advancements in surgery, chemotherapy & radiation therapy. Read this Educational Review of nephrotoxicity of immunotherapy & targeted therapies treating pediatric cancer. Free access this month. bit.ly/3ZJw8fx

AKI is common in critically ill children, frequently necessitating continuous kidney replacement therapy. Procalcitonin (PCT) is widely used as an infection biomarker. Read this Original Article on PCT kinetics in critically ill children. Open Access link.springer.com/article/10.1...

CKD is a common non-communicable disease in children, & kidney dysfunction is the leading metabolic risk factor for death. Significant inequities exist in access to care worldwide. Read this Review of global disparities in pediatric CKD. Open Access link.springer.com/article/10.1...

Recurrent focal segmental glomerulosclerosis (rFSGS) is a major cause of graft failure in pediatric patients. Read this Systematic Review/ Meta-analysis of low-density lipoprotein apheresis for rFSGS in pediatric kidney transplant recipients. Open Access link.springer.com/article/10.1...

AKI is a significant complication for preterm infants, impacting both short- & long-term outcomes. Read this Original Article on perinatal risk factors & 2-year neurodevelopmental outcome of early AKI in preterm & low birth weight infants. Open Access link.springer.com/article/10.1...

Around half of children w/steroid-sensitive nephrotic syndrome are eventually diagnosed w/frequently relapsing or steroid-dependent disease. Read this Original Article on how prednisone predicts course of childhood nephrotic syndrome. link.springer.com/article/10.1...

The selective cytopheretic device for pediatrics (SCD-PED) was granted a Humanitarian Device Exemption in 2024 by the US FDA. Read this Original Article on post-approval experience of the SCD-PED for AKI requiring kidney replacement therapy. Open Access link.springer.com/article/10.1...

Despite major advances in antiretroviral therapy, HIV infection remains a significant global public health challenge. Read this Systematic Review /Meta-analysis of prevalence of HIV-associated nephropathy in children. Open Access link.springer.com/article/10.1...

Although kidney transplantation (KT) improves kidney function, children w/CKD often show incomplete recovery of physical function. Read this Original Article on a telerehabilitation exercise program in pediatric patients after KT. Open Access link.springer.com/article/10.1...

Early & accurate detection of AKI in children is difficult because serum creatinine rises late & lacks sensitivity. Read this Systematic Review /Meta-analysis of diagnostic accuracy of serum cystatin C for pediatric AKI. link.springer.com/article/10.1...

Infection-related glomerulonephritis (IRGN) is the leading cause of acute glomerulonephritis in children worldwide, particularly in low- and middle-income countries. Read these AsPNA Clinical Practice Guidelines for the management of IRGN. link.springer.com/article/10.1...

Neonatal AKI is a frequent & severe complication in critically ill newborns. Read this Original Article on the efficacy of the STARZ stratification score in determining risk of AKI in critically ill neonates. link.springer.com/article/10.1...

Evidence regarding the risk of incident kidney failure based on developmental disabilities remains scarce. Read this Original Article on the association between intellectual disability & autism spectrum disorder w/kidney failure. Open Access link.springer.com/article/10.1...

Fluid overload in children on dialysis can lead to serious complications, i.e., left ventricular hypertrophy (LVH) & cardiac dysfunction. Read this Original Article on subclinical hypervolemia causing LVH in euvolemic children on dialysis. Open Access link.springer.com/article/10.1...

AKI increases morbidity & mortality risk, yet data about pediatric trauma are limited. Read this Original Article on incidence & outcomes of stage 3 AKI in the setting of pediatric trauma. link.springer.com/article/10.1...

In preterm neonates, the postnatal course of serum creatinine (sCr) is influenced by maternal sCr levels & physiological changes. Read this Original Article on early postnatal changes in sCr from birth to peak & subsequent decline in preterm neonates. link.springer.com/article/10.1...

Steroid-resistant nephrotic syndrome (SRNS) is a severe glomerular disorder frequently progressing to kidney failure, particularly in children. Read this Original Article on consanguinity-linked genetic variants in Algerian patients w/SRNS. link.springer.com/article/10.1...

Children w/cancer have had many improvements in cure rates through advancements in surgery, chemotherapy, & radiation therapy. Read this Educational Review of nephrotoxicity of immunotherapy & targeted therapies treating pediatric cancer. Free access this month. bit.ly/3ZJw8fx

Autosomal recessive polycystic kidney disease (ARPKD) is the prototype of the hepato-renal fibrocystic diseases, a subset of the broader ciliopathy disorders. Read this Educational Review of fibrocystin/polyductin: insights into ARPKD pathogenesis. Open Access link.springer.com/article/10.1...

Persistent hematuria has increasingly been interpreted as a therapeutic target & a causal driver of kidney injury. Read this Research Letter on microscopic hematuria as a marker of glomerular injury rather than a direct cause of kidney damage. link.springer.com/article/10.1...

AKI in children is a major cause of morbidity & mortality & is associated w/dehydration, sepsis, or nephrotoxic exposures. Read these Clinical Insights into T-cell lymphoblastic lymphoma presenting w/type B lactic acidosis & AKI in an adolescent. link.springer.com/article/10.1...

Children w/CKD are at risk of hypertension & increased arterial stiffness. Read this Original Article on BP & kidney function in development of arterial stiffening in children w/early CKD. A longitudinal study from the HOT-KID cohort. Open Access link.springer.com/article/10.1...

AKI is a frequent complication in critically ill neonates & is associated w/adverse outcomes. Read this Original Article comparing creatinine- & cystatin C–based definitions of AKI in neonates w/congenital diaphragmatic hernia. Open Access link.springer.com/article/10.1...

An outbreak of AKI among children in The Gambia caused 66 deaths among 82 cases, linked to medicines contaminated w/diethylene glycol (DEG) & ethylene glycol. Read this Original Article on phenotypes & severity stratification in pediatric DEG poisoning. link.springer.com/article/10.1...

Children & adolescents w/CKD often exhibit reduced physical fitness due to physical inactivity, fatigue, & muscle weakness. Read this Original Article on an m-Health-based exercise program among children & adolescents w/CKD. link.springer.com/article/10.1...

Steroid-resistant nephrotic syndrome (SRNS) constitutes the 2nd most common cause of CKD in children. Read this Original Article on identification of monogenic variants in SRNS & steroid-sensitive NS. link.springer.com/article/10.1...

For mycophenolic acid (MPA), therapeutic drug monitoring (TDM) is recommended due to its complex pharmacokinetics, & a non-invasive TDM approach using saliva is promising. Read this Original Article on plasma-saliva correlations for MPA in children w/NS. link.springer.com/article/10.1...

Pediatric hypertension is increasing in prevalence & is associated w/cardiovascular & kidney outcomes in adulthood. Read this Review of how environmental stressors drive pediatric hypertension risk. link.springer.com/article/10.1...

AKI is common in children treated w/extracorporeal membrane oxygenation (ECMO) & is associated w/increased morbidity & mortality. AKI may also increase risk of long-term CKD. Read this Original Article on kidney & BP sequelae after pediatric ECMO. link.springer.com/article/10.1...

Cyclosporine A is an effective steroid-sparing agent for steroid-dependent nephrotic syndrome, but long-term use can cause chronic kidney injury. Read this Original Article on how corticosteroids augment cyclosporine nephrotoxicity in pediatric NS. link.springer.com/article/10.1...

BK polyomavirus–associated nephropathy is a challenge in kidney transplant recipients, often leading to allograft dysfunction. Read these Clinical Insights into treatment of severe, refractory polyomavirus disease in a pediatric kidney recipient. link.springer.com/article/10.1...