Editorial in AC&R describes collaborative efforts of the Office of Autoimmune Disease Research, the Office of Data Science Strategy & National Library of Medicine to support development of Common Data Elements for autoimmune disease research https://doi.org/10.1002/acr.70026

Editorial on this study in A&R: "Jannat-Khan et al’s study results suggest that low-dose glucocorticoids (prednisone-equivalent dose of 6.6 mg/d [IQR: 3.3, 12.3]) are not associated with worse survival in RA patients with lung cancer treated with ICI" doi.org/10.1002/art.... #Medsky

DNA methylation analysis of patients with childhood-onset SLE identified distinct patterns associated with disease activity, molecular subgroups, and sex Arthritis & Rheumatology doi.org/10.1002/art....

In a cohort of youth with childhood-onset SLE, over one-quarter screened in moderate or higher range for depression or anxiety. A mental health care navigator model may help facilitate screening & psychosocial assessment for cSLE patients ACR Open Rheumatology doi.org/10.1002/acr2... #Medsky

Results of a case-control trial showed no association of prior COVID-19 vaccination within 30 days of idiopathic inflammatory myositis onset, suggesting no increased risk of developing IIM after COVID-19 vaccination Arthritis Care & Research doi.org/10.1002/acr.... #Medsky

The ACR Journals extend a special thank you to the peer reviewers whose invaluable time and efforts and dedication make our journals possible and further rheumatology science. Peer reviewers who reviewed in 2025: A&R: acr.tw/44O5AwI AC&R: acr.tw/4oPhHRh

We asked the editors-in-chief of the ACR journals what new and exciting research topics and trends they see emerging this year in rheumatology. 🧪 What research are you excited to see this year? https://youtu.be/hdfUmu9O5p8 #Medsky

Wishing all a happy, healthy new year!

Dec A&R In This Issue → • IL-1 blockade does not reduce MAS in Still disease • PD effects from phase 2 study of litifilimab in lupus • Abatacept ineffective for relapsing, nonsevere GPA • CV safety of NSAID vs colchicine when initiating gout ULT https://acr.tw/4jgQoy1

December A&R Clinical Connections • Peripheral Blood Gene Expression Profiling and Prognostic Significance for Course of SSc-ILD • Systemic Autoimmune Rheumatic Disease Risk: Association With Long-Term Exposure to Fine Particulate Matter https://acr.tw/3YhG6nL

Top 10 most-viewed articles published in ACR Open Rheumatology in 2025 1️⃣ Effect of Glucagon-Like Peptide 1 Receptor Agonists on Patients With Rheumatoid Arthritis https://doi.org/10.1002/acr2.70103 ➡️ PDF of the complete top 10 list: https://acr.tw/4j3zGlK

Top 10 most-viewed articles published in Arthritis Care & Research in 2025 1️⃣ 2024 ACR Guideline for the Screening, Treatment, and Management of Lupus Nephritis https://doi.org/10.1002/acr.25528 ➡️ PDF of the complete top 10 list: https://acr.tw/4iZL56b

Top 10 most-viewed articles in Arthritis & Rheumatology in 2025 1️⃣ ACR Guidance Statement for Diagnosis and Management of VEXAS Developed by the International VEXAS Working Group Expert Panel https://doi.org/10.1002/art.43287 ➡️ PDF of the complete top 10 list: https://acr.tw/4afR3xp

Swedish national registry data 2003-2022 showed rates of preeclampsia, preterm delivery, small for gestational age birth and Cesarean delivery have decreased among SLE pregnancies, particularly among nulliparous pregnancies Arthritis & Rheumatology doi.org/10.1002/art.... #Medsky #OBsky

In an SLE cohort (N=452), 36.2% reported urinary incontinence at least monthly. Higher disease activity was independently associated with 3-fold higher prevalence odds of urinary incontinence ACR Open Rheumatology doi.org/10.1002/acr2... #Medsky

✨ Top 10 most-viewed articles published in ACR Open Rheumatology in 2025 ✨ 2️⃣ Treatment With Avacopan in Patients With Respiratory Tract Manifestations of ANCA-Associated Vasculitis https://doi.org/10.1002/acr2.11795

✨ Top 10 most-viewed articles published in Arthritis Care & Research in 2025 ✨ 2️⃣ Effects of Pharmacologic and Nonpharmacologic Interventions for the Management of Sleep Problems in People With Fibromyalgia: Systematic Review and Network Meta-Analysis of RCTs https://doi.org/10.1002/acr.25505

✨ Top 10 most-viewed articles in Arthritis & Rheumatology in 2025 ✨ 2️⃣ Expert Perspective: How, When, and Why to Potentially Stop Antiresorptive Drugs in Osteoporosis https://doi.org/10.1002/art.43179

Patterns of physical activity may be associated with mortality risk in people with or at risk of knee OA. Analysis of Osteoarthritis Initiative data showed inactivity in the morning and evening was associated with increased mortality risk Arthritis Care & Research doi.org/10.1002/acr.... #Medsky

✨ Top 10 most-viewed articles published in ACR Open Rheumatology in 2025 ✨ 3️⃣ Safety of Avacopan for the Treatment of ANCA-Associated Vasculitis: Combined Data From Three Clinical Trials https://doi.org/10.1002/acr2.70001

✨ Top 10 most-viewed articles published in Arthritis Care & Research in 2025 ✨ 3️⃣ Global Trends in Risk Factors for Low Back Pain: An Analysis of the Global Burden of Disease Study Data From 1990 to 2021 https://doi.org/10.1002/acr.25520

✨ Top 10 most-viewed articles in Arthritis & Rheumatology in 2025 ✨ 3️⃣ Incidence of Major Adverse Cardiovascular Events in Patients With RA Treated With JAKi Compared With Biologic DMARDs: Data From an International Collaboration of Registries https://doi.org/10.1002/art.43188

This study developed an evidence-based approach using decision trees to identify and classify pediatric patients with syndrome of undifferentiated recurrent fevers (SURF) Arthritis & Rheumatology doi.org/10.1002/art.... #Medsky

✨ Top 10 most-viewed articles published in ACR Open Rheumatology in 2025 ✨ 4️⃣ Discontinuation of Oral Glucocorticoids and Achievement of Remission in Patients With EGPA Treated With Benralizumab or Mepolizumab https://doi.org/10.1002/acr2.70096

✨ Top 10 most-viewed articles published in Arthritis Care & Research in 2025 ✨ 4️⃣ ACR Guidance Statements for Addressing Mental Health Concerns in Youth With Pediatric Rheumatologic Diseases https://doi.org/10.1002/acr.25519

✨ Top 10 most-viewed articles published in Arthritis & Rheumatology in 2025 ✨ 4️⃣ Expert Perspective: Diagnosis and Treatment of Castleman Disease https://doi.org/10.1002/art.43269

Data on SLE patients in the Taiwan NHIR database showed higher-dose HCQ (≥400mg/d) was assoc with greater effectiveness & reduced risks of coronary artery disease & VTE. For patients younger than 45 years, there was no dose-related difference in HCQ retinopathy A&R https://doi.org/10.1002/art.70022

✨ Top 10 most-viewed articles published in ACR Open Rheumatology in 2025 ✨ 5️⃣ Associations Between Pre-Existing Autoimmunity and Chimeric Antigen Receptor T Cell Therapy Toxicity for Cancer Treatment https://doi.org/10.1002/acr2.70112

✨ Top 10 most-viewed articles published in Arthritis Care & Research in 2025 ✨ 5️⃣ Recommendations for the Use of DMARDs in Pregnancy and Reproductive Health for Patients With Rheumatic Disease: A Scoping Review https://doi.org/10.1002/acr.25558

✨ Top 10 most-viewed articles published in Arthritis & Rheumatology in 2025 ✨ 5️⃣ Long-Term Safety and Efficacy of Mepolizumab in Eosinophilic Granulomatosis With Polyangiitis https://doi.org/10.1002/art.43146

Post-hoc analysis of RITAZAREM trial (repeat-dose MTX for relapsing ANCA-assoc vasculitis; patients achieving remission by month 4 randomized to RTX or AZA maintenance) found varying risk factors for short-term relapse that differed by treatment phase A&R https://doi.org/10.1002/art.70025

✨ Top 10 most-viewed articles published in ACR Open Rheumatology in 2025 ✨ 6️⃣ How (Ultra)Rare Gene Variants Improve Our Understanding of More Common Autoimmune and Inflammatory Diseases (review) https://doi.org/10.1002/acr2.70003

✨ Top 10 most-viewed articles published in Arthritis Care & Research in 2025 ✨ 6️⃣ Pregnancy Outcomes of Targeted Synthetic DMARDs Among Patients With Autoimmune Diseases: A Scoping Review https://doi.org/10.1002/acr.25502

✨ Top 10 most-viewed articles published in Arthritis & Rheumatology in 2025 ✨ 6️⃣ Peripheral Biomarker Signatures in Rheumatoid Arthritis-Associated Interstitial Lung Disease https://doi.org/10.1002/art.43149

Analysis of systemic sclerosis plasma samples revealed positive feedback systems involving mitochondrial DNA, platelets, and NETs, which were associated with type I IFN signaling and may exacerbate inflammation in SSc A&R https://doi.org/10.1002/art.70027

✨ Top 10 most-viewed articles published in ACR Open Rheumatology in 2025 ✨ 7️⃣ Clinical Manifestations and Treatment in Patients With Relapsing Polychondritis: A Multicenter Observational Cohort Study https://doi.org/10.1002/acr2.70027

✨ Top 10 most-viewed articles published in Arthritis Care & Research in 2025 ✨ 7️⃣ Metabolic Consequences of Rheumatoid Arthritis (review) https://doi.org/10.1002/acr.25537

✨ Top 10 most-viewed articles published in Arthritis & Rheumatology in 2025 ✨ 7️⃣ Associations of Fire Smoke and Other Pollutants With Incident Rheumatoid Arthritis and Rheumatoid Arthritis-Associated Interstitial Lung Disease https://doi.org/10.1002/art.43113

Adoption of an EHR sidecar application to visualize key rheumatoid arthritis outcomes had no significant short-term effects on measures of patient decision-making, self-efficacy, medication beliefs, or adherence Arthritis Care & Research doi.org/10.1002/acr.... #Medsky

✨ Top 10 most-viewed articles published in ACR Open Rheumatology in 2025 ✨ 8️⃣ JAK Inhibitors for Treatment of SAPHO Syndrome: A Systematic Review of 72 Cases https://doi.org/10.1002/acr2.70101

✨ Top 10 most-viewed articles published in Arthritis Care & Research in 2025 ✨ 8️⃣ Sex-Related Differences in Efficacy and Safety Outcomes in Axial Spondyloarthritis Randomized Clinical Trials: A Systematic Literature Review and Meta-Analysis https://doi.org/10.1002/acr.25512

✨ Top 10 most-viewed articles published in Arthritis & Rheumatology in 2025 ✨ 8️⃣ Clinical Factors Associated With Pneumocystis Pneumonia Despite Its Primary Prophylaxis: When to Stop Prophylaxis? https://doi.org/10.1002/art.43167

Two-year post-intervention impacts of a 16-week remotely supervised exercise and weight loss intervention in older adults with rheumatoid arthritis ACR Open Rheumatology doi.org/10.1002/acr2... #Medsky

✨ Top 10 most-viewed articles published in ACR Open Rheumatology in 2025 ✨ 9️⃣ Comparative Efficacy of Immunosuppressive Therapies in the Treatment of Diffuse Cutaneous Systemic Sclerosis https://doi.org/10.1002/acr2.70004

✨ Top 10 most-viewed articles published in Arthritis Care & Research in 2025 ✨ 9️⃣ Two-Year Follow-Up of a Multidisciplinary Lifestyle Intervention for Rheumatoid Arthritis and Osteoarthritis https://doi.org/10.1002/acr.25553

✨ Top 10 most-viewed articles published in Arthritis & Rheumatology in 2025 ✨ 9️⃣ Efficacy and Safety of Dotinurad Versus Febuxostat for the Treatment of Gout: A Randomized, Multicenter, Double-Blind, Phase 3 Trial in China https://doi.org/10.1002/art.43261

Evaluating long-term outcomes of reduced intensity conditioning prior to autologous hematopoietic stem cell transplantation in patients with severe manifestations of systemic sclerosis showed it to be an effective and safe treatment option Arthritis & Rheumatology doi.org/10.1002/art.... #Medsky

✨ Counting down the top 10 most-viewed articles published in ACR Open Rheumatology in 2025 ✨ 🌟 At #10: Cerebrovascular Involvement in Systemic Sclerosis (review) https://doi.org/10.1002/acr2.70032

✨ Counting down the top 10 most-viewed articles published in Arthritis Care & Research in 2025 ✨ 🌟 At #10: Clinical Conditions Associated With a High Antinuclear Antibody Titer in Individuals Without Autoimmune Disease https://doi.org/10.1002/acr.25682

✨ Counting down the top 10 most-viewed articles published in Arthritis & Rheumatology in 2025 ✨ 🌟 At #10: A Phase 2 Trial of Hydroxychloroquine in Individuals at Risk for Rheumatoid Arthritis https://doi.org/10.1002/art.43366