Obs. study with development & validation cohorts found that a panel of peripheral biomarkers assoc. with idiopathic pulmonary fibrosis was similarly assoc. with prevalent & incident ILD among people with RA, supporting value for RA-ILD risk stratification A&R doi.org/10.1002/art.... #Medsky

Recommendations for cardiac screening in SSc often include use of EKGs. This study found similar prevalence of conduction and rhythm abnormalities between SSc and controls. More SSc patients had evidence of right atrial enlargement or underlying cardiomyopathy ACROR doi.org/10.1002/acr2... #Medsky

In a multi-national SLE cohort receiving usual care, 30% did not achieve either LLDAS or DORIS-remission targets over a median of 2.5 years. Flare occurrence and damage accrual were still substantial after reaching low disease activity or remission AC&R doi.org/10.1002/acr.... #Medsky

Analysis of IBD patients claims data from 2000 to 2022 showed a decreasing trend in prescription NSAID fills despite ongoing high rates of opioid prescription and a doubling of codes for musculoskeletal pain Arthritis Care & Research doi.org/10.1002/acr.... #Medsky

T cell phenotyping of patients with psoriasis at risk of psoriatic arthritis development revealed overlapping T cell endotypes among patient subgroups and highlights potential role for CD4+ TEM, Th17 and Tc17 cells in migrating to joints & entheses during transition A&R doi.org/10.1002/art....

A 29 y/o man was referred w/ 4-year history of persistent mandibular pain & swelling following a tooth extraction. Exam revealed swelling of the left lower jaw, acneiform eruptions on chest and back, bilateral shoulder pain, & sternoclavicular joint swelling. CT demonstrated new osteolytic lesions

New in ACR Open Rheumatology → Preop factors assoc. w/ falls following THA in older adults doi.org/10.1002/acr2... Review: Precision medicine approach in IgA vasculitis doi.org/10.1002/acr2... RTX/CYC combo therapy in pediatric patients with severe rheum manifestations doi.org/10.1002/acr2...

New papers in Arthritis Care & Research → Open-label phase 3 trial: baricitinib for refractory pediatric JIA uveitis doi.org/10.1002/acr.... Effect of orthoses in people w/ midfoot pain doi.org/10.1002/acr.... Care pathway vs usual care for people w/ rheumatoid arthritis doi.org/10.1002/acr....

New this week in Arthritis & Rheumatology → Variation in psoriatic arthritis care across US regions doi.org/10.1002/art.... Emulated target trial: cyclosporine, IFNα-2a, & adalimumab in adults with Behçet disease uveitis doi.org/10.1002/art.... ↓ continues #Medsky

What do rheumatologists & hematologists need to know about Castleman disease? In our NEWEST episode, we unpack diagnosis, treatment, & the evolving understanding of this complex condition LISTEN NOW🎙️→ acr.tw/48lersf

Single-center study of pediatric patients with severe manifestations of rheumatic disease found combination RTX/CYC therapy to be safe and effective and enabled reduced glucocorticoid exposure ACR Open Rheumatology doi.org/10.1002/acr2... #Medsky

Discussion on this study upcoming at #ACR25

Results of phase 2 SMILE RCT of hydroxychloroquine in patients at risk of SLE (incomplete lupus) showed that HCQ treatment did not affect progression to classification for SLE compared with placebo Arthritis & Rheumatology doi.org/10.1002/art.... K-M curves for time to progression to SLE #Medsky

Osteoarthritis mouse model study investigated role of ZBTB20 in regulating articular cartilage growth during postnatal development. ZBTB20 regulated genes for articular development and had a protective role in progression of age-related OA Arthritis & Rheumatology doi.org/10.1002/art....

Do care pathways using guideline-based best practices and team-based care improve rheumatoid arthritis outcomes? In an RA cohort, patients in the care pathway were more likely to achieve remission but had higher per member per month costs of care AC&R doi.org/10.1002/acr.... #Medsky

IL-23 receptor expression was found to be increased in podocytes from patients with lupus nephritis & from lupus-prone mice. IL-23 signaling disrupts the cytoskeleton in podocytes & increases their mobility, leading to glomerulonephritis development Arthritis & Rheumatology doi.org/10.1002/art....

Emulated target trial compared cyclosporine, IFNα-2a, & adalimumab in adults with Behçet disease uveitis. IFNα-2a was assoc. with reduced uveitis relapse compared with cyclosporine, while adalimumab showed stronger assoc. with reduced relapse than IFNα-2a A&R doi.org/10.1002/art.... #Medsky

New exploratory study of orthoses in people with midfoot pain showed over 12 weeks, pain and bone marrow lesion size were reduced more in the foot orthoses group compared to the control sham group Arthritis Care & Research doi.org/10.1002/acr.... #Medsky

Cross-sectional study of patients with psoriatic arthritis in the RISE registry 2020 to 2023 found PsA characteristics & care vary across US. Those in the South & Midwest were more often managed with higher dose prednisone & csDMARDs vs biologics or tsDMARDs A&R doi.org/10.1002/art.... #Medsky

Open-label trial of baricitinib for pediatric JIA uveitis refractory to MTX or bDMARDs showed the primary endpoint (% responders at week 24) was not met. Use of an adaptive design trial with comparator arm may be beneficial for future pediatric studies AC&R doi.org/10.1002/acr.... #Medsky #Pedsky

#ACR25 abstracts now online! 🎉 Browse over 3,100 abstracts representing the highest-impact research in the field of #rheumatology NOTE: Information that goes beyond that contained in the abstract is under media embargo until Oct. 25 at 10:00 AM CT. View 👀 → acr.tw/30RaIzl #Medsky

The multiorgan nature of IgA vasculitis & unpredictable disease course challenge timely diagnosis & approach to management Review in ACR Open Rheumatology highlights 3 areas in which precision medicine may have a role in advancing patient outcomes in IgA vasculitis doi.org/10.1002/acr2... #Medsky

Retrospective EHR study of adults ≥65 years who underwent THA between 2012 & 2022 showed 15.2% had at least one fall within 1 year post-THA. History of falls within 1 year pre-THA and depression were strongest risk factors associated with falls 1-year post-THA ACROR doi.org/10.1002/acr2... #Medsky

Case report discusses two patients with anti-RuvBL1/2 antibody–positive myositis: one patient with scleromyositis and cardiac involvement, and another with immune-mediated necrotizing myopathy, SSc, Sjögren disease, and ILD ACR Open Rheumatology doi.org/10.1002/acr2...

New in ACROR Elevated rates of severe maternal morbidity among veterans w/ SLE or RA doi.org/10.1002/acr2... Reported falls in a cohort of adults w/ SLE doi.org/10.1002/acr2... Patients w/ RA & BMI≥27 prescribed GLP-1RA show improved disease activity & CV risk factors doi.org/10.1002/acr2...

New in AC&R Post hoc analysis of COLCHICORT trial identifies factors predictive of acute CPP crystal arthritis resolution doi.org/10.1002/acr.... Race-specific vs race-neutral pulmonary function test reference equations lead to diff. in classifying lung disease severity doi.org/10.1002/acr....

New in A&R Role of oxidative stress in pathogenesis of atherothrombosis in SLE doi.org/10.1002/art.... Immunology Series: Cytokine pathways assoc. w/ extra-articular RA & common comorbidities doi.org/10.1002/art.... Editorial: Antibody sialylation in autoimmunity doi.org/10.1002/art.... #Medsky

Use of race-specific vs race-neutral pulmonary function test reference equations may lead to clinically significant differences in classification of restrictive lung disease severity among Black and White individuals with systemic sclerosis Arthritis Care & Research doi.org/10.1002/acr.... #Medsky

Retrospective review of patients with rheumatoid arthritis and BMI≥27 prescribed GLP-1RA (semaglutide or tirzepatide) showed improved disease activity & cardiovascular risk factors vs controls. Nearly one-third of GLP-1RA group discontinued during study period ACROR doi.org/10.1002/acr2... #Medsky

No passport needed for the next Global Journal Club webinar, Sept. 17, 7:00-8:00 PM ET. This interactive session will focus on 2 recently published articles in A&R & is free for all ACR/ARP members. Registration required. LEARN MORE → acr.tw/3R73yQR

Editorial in A&R on the below study: Differences in IgG Sialylation Distinguish Asymptomatic from Symptomatic Anti-Nuclear Antibody Positive Individuals More Than Just ANA: Antibody Sialylation May Tip the Balance in Autoimmunity doi.org/10.1002/art....

Cytokine networks play a central role in mediating rheumatoid arthritis pathogenesis. New installment in the A&R Immunology for the Rheumatologist series reviews cytokine pathways assoc. with RA articular disease & extends these insights to extra-articular RA & its common co-morbidities #Immunosky

Cross-sectional study investigated potential role of oxidative stress in pathogenesis of atherothrombosis in SLE. SLE patients showed increased leukocyte ROS production, particularly upregulation of NADPH oxidase activity in circulating neutrophils A&R doi.org/10.1002/art.... #Medsky

Post hoc analysis of the COLCHICORT trial (colchicine vs prednisone for acute CPP crystal arthritis) identified factors predictive of arthritis resolution. Prednisone appeared to perform better in achieving pain relief after 2 days of treatment AC&R doi.org/10.1002/acr.... #Medsky

In a cohort of adults with SLE, nearly one-third (30.7%) reported falling in the past year, and 19.2% reported falling twice or more. Taking ≥10 medications was associated with a substantially higher odds of reported falls ACR Open Rheumatology doi.org/10.1002/acr2... #Medsky

Analysis of VA admin data compared rates of severe maternal morbidity (SMM) among veterans with & without SLE or RA. Veterans with SLE may have elevated risk of SMM, and veterans with SLE and RA may have higher rates of pregnancy loss ACR Open Rheumatology doi.org/10.1002/acr2... #OBsky

Clinical images in A&R show progressive systemic calcification in a woman w/ 30-year history of SLE. In 2006, pelvic radiograph & CT revealed subcutaneous calcifications (A & B). By 2024, intrapelvic &subcutaneous calcifications had further progressed (E & F, arrows) doi.org/10.1002/art.... #Medsky

NEW EPISODE! Alain Sanchez-Rodriguez, MD, joins the podcast to discuss delays in #lupus diagnosis & care based on findings from the Lupus Midwest Network (LUMEN) 🎙️Listen → https://acr.tw/3UWKCXi #Medsky

New in Arthritis & Rheumatology Phase 2 trial: HCQ does not prevent RA in individuals with high anti-CCP levels doi.org/10.1002/art.... Spermidine reproduces anti-inflammatory effects of intermittent fasting in crystal-induced arthritis mouse model doi.org/10.1002/art.... ↓ #Medsky

New in Arthritis Care & Research Validity of the UCLA Scleroderma Clinical Trial Consortium GI Tract 2.0 PRO instrument in pediatric SSc populations doi.org/10.1002/acr.... Survey study on patient perceptions about hyperuricemia and urate-lowering therapy doi.org/10.1002/acr.... ↓ #Medsky

New in ACR Open Rheumatology Cerebrospinal fluid proteomic patterns in SLE doi.org/10.1002/acr2... Anti-IL-5/R monoclonal antibody for EGPA enables stopping GC while avoiding relapse doi.org/10.1002/acr2... Effect of ancestry on JIA category & disease state at presentation doi.org/10.1002/acr2...

Analyzing skin biopsies from patients w/ diffuse cutaneous SSc revealed baseline fibroblast immunophenotype, but not mod Rodnan skin score (mRSS), varied by disease duration. Skin fibroblast & immune profiles may have improved prognostic value over mRSS alone A&R doi.org/10.1002/art.... #Dermsky

In a multiancestral Canadian JIA cohort, differences in cJADAS10 scores at presentation were largely explained by JIA categories across ancestry groups, with differences between British & French ancestry among others, & minimal effects of geographic region ACROR doi.org/10.1002/acr2... #Medsky

Mouse model study found short-term intermittent fasting prevented crystal-induced inflammation & induced production of anti-inflammatory metabolites, such as ketone body BHB, corticosterone, & spermidine. Spermidine supplementation reproduced anti-inflammatory effects A&R doi.org/10.1002/art....

Survey study of people with history of ACL injury examined views on acceptable potential treatments to delay or prevent posttraumatic osteoarthritis Arthritis Care & Research doi.org/10.1002/acr.... #Medsky

Post hoc analysis of the phase 3 MANDARA study using more stringent definition of remission reinforced anti-IL-5/R monoclonal antibody therapies benralizumab and mepolizumab for EGPA can enable GC discontinuation while avoiding relapse ACR Open Rheumatology doi.org/10.1002/acr2... #Medsky

Using the UCLA Scleroderma Clinical Trial Consortium GI Tract 2.0 PRO instrument to characterize GI manifestations in juvenile-onset systemic sclerosis demonstrated acceptable face & content validity, reinforcing suitability in pediatric populations AC&R doi.org/10.1002/acr.... #Medsky

International survey study of people with asymptomatic hyperuricemia looked at perceptions about hyperuricemia and urate-lowering therapy. Hyperuricemia was not well understood, and most perceived minimal consequences of asymptomatic hyperuricemia AC&R doi.org/10.1002/acr.... #Medsky

Exploring cerebrospinal fluid proteomic patterns in patients with SLE identified 3 patient clusters with different disease phenotypes. Higher abundance of CNS-derived proteins in cerebrospinal fluid was linked with nephritis and neuronal damage ACR Open Rheumatology doi.org/10.1002/acr2... #Medsky

Phase 2 trial: Among individuals with anti-CCP antibody levels ≥2x upper limit of normal, 12 months of hydroxychloroquine treatment did not prevent the development of clinical rheumatoid arthritis at 36 months Arthritis & Rheumatology doi.org/10.1002/art.... #Medsky #Rheumsky