"The selfish ribosome" paper is now published in @plosbiology.org . Have a look! Many thanks to the editors and reviewers! doi.org/10.1371/jour...

Exciting to see this out in its final form! Wonderful work led by @probablycarmen.bsky.social. Want to know why protrusions are better at initiating immune signaling in #Tcells? Look no further. Link to Carmen’s 🧵 on the preprint bsky.app/profile/prob...

impressive!

Thinking about this more, the 2 and 3 year bans are real career killers… who’d hire a tenure track candidate, or an (associate) professor that has one of those hanging around their necks?

Phosphoregulated SMCR8-FIP200 interaction connects the ALS/FTD-linked C9orf72 complex to autophagy initiation and mitochondrial quality control https://www.biorxiv.org/content/10.64898/2026.04.16.718395v1

Drosophila models have been highly useful in dissecting the physiological roles of PINK1 and Parkin in #mitophagy Led by 3 talented PhD students, we wrote a review summarising recent exciting discoveries and discussed these in context of current in vitro studies portlandpress.com/biochemj/art...

1/13 🧵 ‼️Preprint alert. Are you interested in synthetic protein binders? Do you need to generate them? I present to you IARA: a fast, slim ML model that tells you which protein surfaces are good for binder design. www.biorxiv.org/content/10.6...

PhD students reflect on how their supervisors made a meaningful difference — from quiet acts of kindness to career-shaping guidance go.nature.com/422vHhs

We're gearing up to generate iPSCs stably expressing ASAPs, and are compiling a list of potential users who might want these to study cell fate pathways for neurons or cardiomyocytes, or to perform drug screening. If these would be useful to you, please message me in the chat

Out now in @science.org Pearling drives mitochondrial DNA nucleoid distribution | Science www.science.org/doi/10.1126/...

A high-affinity split-HaloTag for live-cell protein labeling. And much more. www.nature.com/articles/s41...

Take a look at our Research Highlight: Adriana Golding et al. www.nature.com/articles/s41... We highlight the work by Ghoochani et al., who generated an atlas of brain lysosomal proteins and identified SLC45A1-associated disease as a lysosomal disorder: www.cell.com/cell/fulltex...

Cells drastically downregulate mRNA translation to save energy during stress. A study by the Weis lab (IBC) shows that mRNAs transcribed after stress escape repression while pre-existing mRNA don’t, in a timing mechanism that is independent of mRNA sequence. More: biol.ethz.ch/en/news-and-...

Interesting study about the gender gap in publishing. Not sure if 7% longer review time for female scientists is really something, but I do know that indeed we must prove competence more than our male counterparts journals.plos.org/plosbiology/...

In a new #SciencePolicyForum, researchers discuss the risks of malicious “#AI swarms,” which enable a new class of large-scale, coordinated disinformation campaigns that pose significant risks to democracy. https://scim.ag/49FIhrM

FYI: New online! Whole-genome spatial transcriptomic imaging with RAEFISH

After a long review process, I'm excited that our paper is finally in print: www.cell.com/cell/fulltex... TL;DR: We use CRISPR screens in iPSC-derived neurons to find a new tau E3 ligase and a relationship between oxidative stress, the proteasome, and tau proteolytic fragments. More below 👇

Mitophagy is critical for cellular health & associated with multiple diseases. @baehreckelab.bsky.social &co show that the OMM protein Mtch regulates #mitophagy during #Drosophila intestinal development, by modulating the insertion of mitophagy receptor BNIP3 @plosbiology.org 🧪 plos.io/45uyBhg

A study published in Nature Communications reveals that exposure to certain food preservatives, including potassium sorbate and sodium nitrite, correlates with a higher risk of developing type 2 diabetes. 🧪

Emotional - Uri Manor @manorlaboratory.bsky.social was so wonderfully open & an inspiration to listen on #TheMicroscopists Uri talks about growing up with hearing loss & a winding path through baseball-music-restaurant work led him to physics & then biology - pls share Stream bit.ly/microscopist...

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

#spatialgeneexpression #RNAlocalizatiom #RNAsky www.nature.com/articles/s41...

A team involving @uclqsion.bsky.social scientists has, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s disease.

Spotiflow, our deep learning based spot detection method for microscopy, is now published in @natmethods.nature.com! Since the pre-print, we have added many features, notably native 3D detection! @maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social Paper: rdcu.be/epIB7 (1/N)

What is RNA velocity in situ? ChatGPT kept getting it wrong... So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0 #AcademicSky

Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...

#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added! #Mito #Mitochondriac go.bsky.app/J6Bu5fL

Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by Conor Loynd, Soumya Roy, and Sarah Canarelli! We introduce a new generation of BONCAT tools for the versatile characterization of newly synthesized proteins in pathogenic bacteria. rdcu.be/eI4M5

🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉 🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3

check out Nadja’s beautiful work on cytokinesis, many congratulations 👏👏

Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF

SEPTIN9 locally activates the RhoGEF ARHGEF18 to promote early stages of mitochondrial fission, say Rachel Shannon, William Trimble and colleagues @sickkidsto.bsky.social @utoronto.ca: rupress.org/jcb/article/... #Cytoskeleton #Biochemistry #Mitochondria #septins

Join us at the LS2 Annual Meeting 2026 in Zürich!

many congratulations for such beautiful work André and co👏👏

www.biorxiv.org/content/10.1... Excellent Jasper van den Ende in Esther's lab @esthernoltethoen.bsky.social. Using Marvin's @marvintanenbaum.bsky.social SUNtag system to monitor EV cargo access to cytoplasm allows real time quantification of the process. #EV #extracellular vesicles

🍹@mariamls.bsky.social et al. identify ER–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact sites dictates #ferroptosis sensitivity in #BreastCancer. @agostinislab.bsky.social bit.ly/4l93AUW

We demonstrated how to make and dissolve #RNA #condensates through strand displacement using synthetic genes - excited to see this new paper out in @narjournal.bsky.social Collab w/ the Andersen group @esandersen.bsky.social academic.oup.com/nar/article/...

Die Kürzungen sind ein absoluter Skandal, die Wissenschaft ist eine der grossen Stärken Berlins. Wir sidn eine der Besten Unis Deutschlands mit vergleichsweise wenig Mitteln, diese noch zu kürzen ist Wahnsinn. Wie sollen wir kompetitiv bleiben? Eine Abwärtsspirale droht.

Come all next week to the online seminar on "Imaging for Cell Biology" of the @dgz.bsky.social Tuesday June 24th at 12:00 on zoom, info see below.

Thank you @jcellsci.bsky.social, Sara Morais da Silva and Co for highlighting me as “cell scientists to watch”! It means a lot to me and I feel so honored as you guys are such a great community of amazing cell biologists! journals.biologists.com/jcs/article/...

Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell great work by Martin Picard www.scientificamerican.com/article/why-...

The 2025 version of Biomembrane Days is online for registration! Sign up now, it is going to be spectacular as always! Looking forward to an outstanding lineup of speakers both invited and selected. We look forward to having experts in the Cell Biology and Biophysics of membranes!

Join us in Engelberg for an exciting #EMBO workshop on #mitochondria in the nervous system #EMBOmitoNervousSys. Great speaker line up and opportunities for short talks from early career scientists! Submit your abstract until May 30st! meetings.embo.org/event/25-mit...

☕Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with #Alzheimers. Studies of endolysosomes and proteostasis suggest a role for lysosomal quality control in Alzheimer’s disease pathology. bit.ly/4lSORPV

Check out also our post to see how the @mrcharwell.bsky.social contributed to the work and what we think it will me for #preclinical in vivo studies and better #TranslationalResearch outcomes www.har.mrc.ac.uk/news/new-fra...

Happy #FluorescenceFriday! Here are some (sm)FISHy iNeurons imaged on a spinning disk🐠 magenta: mitochondria, cyan: GAPDH mRNA, yellow: Map2

Mark your calendar to learn about pleiotropic roles of #mitochondria in neurons and glia cells. Apply now for EMBO Workshop "Mitochondria in the Nervous System" in Engelberg, Switzerland, 28 September–2 October Deadline: 30 May meetings.embo.org/event/25-mit... #EMBOmitoNervousSys #EMBOevents 🧪

Are lipids actively sorted during clathrin mediated endocytosis like proteins? @mathilda95.bsky.social addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow. www.biorxiv.org/content/10.1...

thrilled to be part of the @hfspo.bsky.social community, a great honor! Check out my research proposal summary below👇 Thank you to all my mentors, past and especially present🙏

A preprint from the lab - a new method for light-induced RNA translation employing morpholino oligonucleotides- www.biorxiv.org/content/10.1...