#spatialgeneexpression #RNAlocalizatiom #RNAsky www.nature.com/articles/s41...

A team involving @uclqsion.bsky.social scientists has, for the first time, directly visualised and quantified the protein clusters believed to trigger Parkinson’s disease.

Spotiflow, our deep learning based spot detection method for microscopy, is now published in @natmethods.nature.com! Since the pre-print, we have added many features, notably native 3D detection! @maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social Paper: rdcu.be/epIB7 (1/N)

What is RNA velocity in situ? ChatGPT kept getting it wrong... So I made this video explaining how RNA velocity in situ infers gene expression dynamics by distinguishing nuclear vs. cytoplasmic expression in spatial transcriptomics data: youtu.be/z9Oxf1hvum0 #AcademicSky

Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...

#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added! #Mito #Mitochondriac go.bsky.app/J6Bu5fL

Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by Conor Loynd, Soumya Roy, and Sarah Canarelli! We introduce a new generation of BONCAT tools for the versatile characterization of newly synthesized proteins in pathogenic bacteria. rdcu.be/eI4M5

🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉 🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3

check out Nadja’s beautiful work on cytokinesis, many congratulations 👏👏

Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF

SEPTIN9 locally activates the RhoGEF ARHGEF18 to promote early stages of mitochondrial fission, say Rachel Shannon, William Trimble and colleagues @sickkidsto.bsky.social @utoronto.ca: rupress.org/jcb/article/... #Cytoskeleton #Biochemistry #Mitochondria #septins

Join us at the LS2 Annual Meeting 2026 in Zürich!

many congratulations for such beautiful work André and co👏👏

www.biorxiv.org/content/10.1... Excellent Jasper van den Ende in Esther's lab @esthernoltethoen.bsky.social. Using Marvin's @marvintanenbaum.bsky.social SUNtag system to monitor EV cargo access to cytoplasm allows real time quantification of the process. #EV #extracellular vesicles

🍹@mariamls.bsky.social et al. identify ER–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact sites dictates #ferroptosis sensitivity in #BreastCancer. @agostinislab.bsky.social bit.ly/4l93AUW

We demonstrated how to make and dissolve #RNA #condensates through strand displacement using synthetic genes - excited to see this new paper out in @narjournal.bsky.social Collab w/ the Andersen group @esandersen.bsky.social academic.oup.com/nar/article/...

Die Kürzungen sind ein absoluter Skandal, die Wissenschaft ist eine der grossen Stärken Berlins. Wir sidn eine der Besten Unis Deutschlands mit vergleichsweise wenig Mitteln, diese noch zu kürzen ist Wahnsinn. Wie sollen wir kompetitiv bleiben? Eine Abwärtsspirale droht.

Come all next week to the online seminar on "Imaging for Cell Biology" of the @dgz.bsky.social Tuesday June 24th at 12:00 on zoom, info see below.

Thank you @jcellsci.bsky.social, Sara Morais da Silva and Co for highlighting me as “cell scientists to watch”! It means a lot to me and I feel so honored as you guys are such a great community of amazing cell biologists! journals.biologists.com/jcs/article/...

Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell great work by Martin Picard www.scientificamerican.com/article/why-...

The 2025 version of Biomembrane Days is online for registration! Sign up now, it is going to be spectacular as always! Looking forward to an outstanding lineup of speakers both invited and selected. We look forward to having experts in the Cell Biology and Biophysics of membranes!

Join us in Engelberg for an exciting #EMBO workshop on #mitochondria in the nervous system #EMBOmitoNervousSys. Great speaker line up and opportunities for short talks from early career scientists! Submit your abstract until May 30st! meetings.embo.org/event/25-mit...

☕Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with #Alzheimers. Studies of endolysosomes and proteostasis suggest a role for lysosomal quality control in Alzheimer’s disease pathology. bit.ly/4lSORPV

Check out also our post to see how the @mrcharwell.bsky.social contributed to the work and what we think it will me for #preclinical in vivo studies and better #TranslationalResearch outcomes www.har.mrc.ac.uk/news/new-fra...

Happy #FluorescenceFriday! Here are some (sm)FISHy iNeurons imaged on a spinning disk🐠 magenta: mitochondria, cyan: GAPDH mRNA, yellow: Map2

Mark your calendar to learn about pleiotropic roles of #mitochondria in neurons and glia cells. Apply now for EMBO Workshop "Mitochondria in the Nervous System" in Engelberg, Switzerland, 28 September–2 October Deadline: 30 May meetings.embo.org/event/25-mit... #EMBOmitoNervousSys #EMBOevents 🧪

Are lipids actively sorted during clathrin mediated endocytosis like proteins? @mathilda95.bsky.social addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow. www.biorxiv.org/content/10.1...

thrilled to be part of the @hfspo.bsky.social community, a great honor! Check out my research proposal summary below👇 Thank you to all my mentors, past and especially present🙏

A preprint from the lab - a new method for light-induced RNA translation employing morpholino oligonucleotides- www.biorxiv.org/content/10.1...

With the huge challenges facing scientists, I call on peer reviewers to reflect on their role as gatekeepers to trainee career development and scientific progress. You can maintain high standards for rigor while being kind and not demanding an extra year of studies for every paper revision.

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that. www.biorxiv.org/content/10.1...

Thrilled to share our paper is out in @plosbiology.org! 🎉 We explore how satellite DNA organization is linked to transposon repression. A huge thanks to my amazing co-first author Ankita Chavan and all the collaborators who made this possible! 💕 jagannathanlab.com #Proteomics Check it out here 👇👇

What Would a Dream Research Institute Look Like? Key point: Small, focused teams (around 15 members) boost efficiency, foster better mentorship, and encourage collaboration. Keeping teams lean ensures senior researchers stay actively involved in science rather than being bogged down by admin work.

The single best career advice that I give PhDs is that there are multiple different pathways to success. It is the detours that make your insights unique. This is why @immunolcellbiol.bsky.social made #PathwaysToSuccess - get inspired from different journeys! onlinelibrary.wiley.com/page/journal...

Ilastik: a machine learning image analysis platform to interrogate stem cell fate decisions across multiple vertebrate species https://www.biorxiv.org/content/10.1101/2024.12.21.629913v1

Three must read papers for PhD students. #scisky #PhD #science #research #academicsky 1. The importance of stupidity in scientific research Open Access journals.biologists.com/jcs/article/...

Did you ever wonder how cytoplasmic properties influence mitotic spindle architecture? Come join us for an exciting seminar next Wednesday by @simonereber.bsky.social

Blog post on using AI in academia from @arjunraj.bsky.social and the great folks at Mid Career PI Slack! Finally, a How To guide for how to use AI effectively in academia. arjun-raj-lab.gitbook.io/arjun-rajs-t...

Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance www.cell.com/cell-metabol...

A PSA for PIs: If you have a light microscope, please have watch your lab watch these short practical videos on how to prevent damage to your objective lenses! Trust me on this one, they need it... #savetheobjectives youtube.com/playlist?lis...

How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...

Finally moved to #Bluesky and happy to share our recent work! We found that hexokinase 1 rapidly forms rings around #mitochondria during energy stress to regulate mitochondrial fission: www.cell.com/molecular-ce... For a quick summary of our findings, check out the comment section.

Just saw this and hopefully its the gamechanger for our system www.biorxiv.org/content/10.1...

Review team complete! @tatjanakleele.bsky.social and @julius-w.bsky.social now also in 🦋 definitely worth following!

PINK1 and BNIP3 mitophagy inducers have an antagonistic effect on Rbf1-induced apoptosis in Drosophila. https://www.biorxiv.org/content/10.1101/2023.12.10.568976v1

Just published: "Multiplexed expansion revealing for imaging multiprotein nanostructures in healthy and diseased brain", led by Jinyoung Kang and Margaret Schroeder! multiExR enables antibody staining of >20 proteins in a sample w/registration error down to 25 nm. www.nature.com/articles/s41...

great talk today here at @ethzurich.bsky.social by @biosim-lab.bsky.social about her work on alpha-synuclein aggregation modeling and cyclic peptide design for apoptosis inhibition. Always great to see fellow Romanian expats doing great science!

If you are interested in mitochondria, mitophagy and/or PD follow the mito911 Webinar series! Events calendar and registration at this link parkinsonsroadmap.org/events/