Human heart organoids reveal a regenerative strategy for mitochondrial disease https://www.biorxiv.org/content/10.64898/2025.12.18.695153v1

CISTR-ACT was the 1st lncRNA involved in inter-chromosomal contacts and in Mendelian disease (brachydactyly). We now revealed CISTR-ACT’s molecular mechanism: tinyurl.com/CISTR-ACT, @sickkidsto.bsky.social, @uoftpress.bsky.social, @natcomms.nature.com, @natureportfolio.nature.com

A systems genetics approach to uncover mitochondrial drivers of heart failure reveals mitochondria-nuclear cross talk in genetically diverse mouse strains https://www.biorxiv.org/content/10.64898/2025.12.12.693865v1

First day of the #Microbiome Symposium at #Georg-Speyer-Haus organized by LOEWE-FCI professor Canan Arkan was a great success. Thanks to all speakers & supporters (Cathrin Schleussner from Schleussner Stiftung and Martin Zörnig, Else-Kröner-Fresenius-Stiftung). Looking forward to the second day!

Now online! RNA innate immunity constitutes a barrier for interspecies chimerism

🍾🥂 @melanietichet.bsky.social of @loewe-fci.bsky.social is an awardee of the Metastasis Prize of the Beug Foundation 2️⃣0️⃣2️⃣5️⃣. We congratulate👏🏼 and look forward to the progress the research will bring to the treatment of metastatic melanoma in older patients➡️https://www.beugstiftung-metastase.de/tichet/

Happy to welcome Wael Mansour from MSNZ Hamburg / Universitätsklinikum Hamburg Eppendorf on November 25 2025; 1:30 p.m. "From mutation to medication: Personalizing prostate cancer treatment via targeting DNA repair pathways" Venue: Georg-Speyer-Haus, Lecture Hall Hosts: Anne Fassl & Henning Reis

Are you looking to establish yourself as a scientific group leader? BRIC is recruiting 1-2 junior group leaders to join our research centre in the heart of Copenhagen. See more at www.bric.ku.dk Please repost and get in touch if you are curious.

1 Milliarde Euro gehen der Allgemeinheit jedes Jahr durch Steueroasen verloren. Mit dem @zdfmagaz.in haben wir Gemeinden in Deutschland ausfindig gemacht, in denen Konzerne & Promis von einem extrem niedrigen Gewerbesteuerhebesatz profitieren. Klickt euch durch auf steueroasen.watch!

Regulated decay of microRNAs plays a critical role in controlling body size in mammals! Check out our new paper in @genesdev.bsky.social and see thread previously posted with our pre-print 👇 for more info. Congrats to Collette LaVigne, Jaeil Han, and all authors! genesdev.cshlp.org/cgi/content/...

🧬Science Minister Timon Gremmels today presents the 🆕funding notification to @loewe-fci.bsky.sociall, which will continue to receive state funding in 2026+2027 – a recognition of the outstanding achievements of the LOEWE Center!💪🏼🔬➡️ www.linkedin.com/posts/goethe...

Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

📢 Paper Alert: tinyurl.com/yzy2d864. We characterized tRNA-overlapping lncRNA loci = tROLs! tROL perturbations silence codon-biased genes in inter-chromosomal proximity. tROLs bridge the non-coding and coding genomes. @sickkidsto.bsky.social @uoftpress.bsky.social

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

A paper in Nature Communication reports on a new method to produce strong, biodegradable plastic from bamboo. The bioplastic resembles oil-based plastics in strength, shapeability, and thermal stability but can biodegrade in soil within 50 days. go.nature.com/4h1xv0X 🧪

The world has lost its most powerful advocate for nature and hope. Yet many remain who will continue her legacy and I know she will continue to inspire generations more.

Excited to share our first preprint! We developed an image-based pooled screen to uncover regulators of HP1 condensates and discovered a link with intronic RNA and RNA processing. 👏 Congrats to all authors, especially Matthew, Shaopu & Chris!

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

Only single cell sequencing of the all these post docs will reveal why

Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis. www.biorxiv.org/content/10.1...

Very excited to see the first Beisaw lab publication out in its final form 🥳🥳 rdcu.be/ei1I7 if you’re interested in zebrafish heart regeneration and how cardiomyocytes replace the fibrotic injured tissue (spoiler alert: macrophages play an important role), then read it here 👇

Sehr zu empfehlender Podcast; nicht nur weil ich mich selbst mit Genetik befasse. Wie wichtig ist doch die Grundlagenforschung …

It is always great to visit Lausanne and even better for such an interesting event. I am looking forward to some great discussions with PhD student generegulationworkshop.ch#home

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...

This is it. The act of science -like art- is not the output, it is the interaction and the process. What makes us the kind of scientists we are is how we approach the problem 🧪

Sky poetry

Join us in person or online for the 24th edition of the Gene Regulation Workshop at Uni Lausanne on Sept 1st, with an again fantastic group of speakers 🥳 Edouard Bertrand Antonio Giraldez Phillip Grote @phillipgrote.bsky.social Susan Mango Danny Nedialkova Lucia Strader @luciastrader.bsky.social‬

What makes the human brain distinctive? A new study published in @cp-cell.bsky.social identifies two genes linked to human brain features and provides a road map to discover many more. Learn more @ucdgenomecenter.bsky.social @ucdavismind.bsky.social www.ucdavis.edu/news/finding...

Publication rates before and after tenure: clear decline post-tenure in non-lab-based fields and sustained in lab-based fields. Super interesting. arxiv.org/pdf/2411.10575

A study in Nature reports on the development of a method to trace intercellular transfer of mitochondria and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabilities. go.nature.com/4l2J2yh #medsky 🧪

Are you interested in how cells talk to each other to promote regeneration in the heart? @bailinwu.bsky.social @florian-constanty.bsky.social and I are and we wrote a review about it ❤️🐟🐭 Check it out here 👇 www.sciencedirect.com/science/arti...

Now online! Rewriting regulatory DNA to dissect and reprogram gene expression

A trial in Nature Medicine shows that transition to a Western diet resulted in pro-inflammatory changes, whereas transition to an African heritage diet rich in fruits and vegetables, legumes and fermented products led to opposite effects. https://go.nature.com/4cC97AT #foodstudies 🧪

So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵 www.nature.com/articles/s41...

What role does our diet play in the development of colorectal cancer? The team behind a paper in Nature Communications shares how their work evolved from tracking changes in the gut microbiome to investigating how dietary changes can affect disease outcomes. 🧪

Blackrot.

Excited to share our lab’s first review, focusing on RNA localization! #RNA #RNAlocalization genomebiology.biomedcentral.com/articles/10....

Have a protein of unknown function? Try this www.tatta.bio/blog/gaia ! This is imo one of the best ai tools I have seen since alphafold alpha fold. I recommend you look at the paper too! #bioinformatics #biologicalDarkMatter #Gaia #tatta

Why do RBPs need multiple RNA-binding domains? We show transcriptome-wide that the endosomal mRNA transporter Rrm4 uses its three RRMs to differentiate functional binding sites from accessory ones. Great collaboration with @koenig-lab.bsky.social and Zarnack lab www.biorxiv.org/content/10.1...

🚨Registration is now open for the SFB 1531 | GfMVB International Meeting on Perspectives in Cardiovascular Biology in Frankfurt, April 2025! We are proud to welcome so many outstanding speakers - more info and registration at pcvb2025.de Join us and secure your spot!

The EU wasn’t formed to screw anyone. Quite the opposite. It was formed to maintain peace, to build respect among our nations, to create free and fair trade, and to strengthen our transatlantic friendship. As simple as that. 🇪🇺🇺🇸

Agree

A study in Nature Cancer provides genetic evidence that intrinsic developmental heterogeneity can prime individual, lifelong cancer susceptibility. https://go.nature.com/3PZla0G #Medsky 🧪

📢1/12 Happy to share our first bluetutorial & our latest preprint. In this work, we discovered RSRC2 as a novel RNA-binding protein (RBP) with a dual function in cell division whose activity can be (lnc)RNA-mediated. #lncRNA #RBP #Mitosis www.biorxiv.org/content/10.1...

Calling all cardiovascular scientists.... @WeinsteinConf is in Milwaukee May 14-16! Abstract submission now open. Registration portal is imminent! childrenswi.org/weinstein Are you a trainee and want to be considered for a platform talk - abstract due Feb 21!

Last week, Finland's Publication Forum announced that it is downgrading its classification of 271 journals to the lowest level, zero. This includes 187 MDPI and 82 Frontiers journals. Read more by @deevybee.bsky.social here: