Excited to share our first preprint! We developed an image-based pooled screen to uncover regulators of HP1 condensates and discovered a link with intronic RNA and RNA processing. 👏 Congrats to all authors, especially Matthew, Shaopu & Chris!

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

Only single cell sequencing of the all these post docs will reveal why

Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis. www.biorxiv.org/content/10.1...

Very excited to see the first Beisaw lab publication out in its final form 🥳🥳 rdcu.be/ei1I7 if you’re interested in zebrafish heart regeneration and how cardiomyocytes replace the fibrotic injured tissue (spoiler alert: macrophages play an important role), then read it here 👇

Sehr zu empfehlender Podcast; nicht nur weil ich mich selbst mit Genetik befasse. Wie wichtig ist doch die Grundlagenforschung …

It is always great to visit Lausanne and even better for such an interesting event. I am looking forward to some great discussions with PhD student generegulationworkshop.ch#home

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...

This is it. The act of science -like art- is not the output, it is the interaction and the process. What makes us the kind of scientists we are is how we approach the problem 🧪

Sky poetry

Join us in person or online for the 24th edition of the Gene Regulation Workshop at Uni Lausanne on Sept 1st, with an again fantastic group of speakers 🥳 Edouard Bertrand Antonio Giraldez Phillip Grote @phillipgrote.bsky.social Susan Mango Danny Nedialkova Lucia Strader @luciastrader.bsky.social‬

What makes the human brain distinctive? A new study published in @cp-cell.bsky.social identifies two genes linked to human brain features and provides a road map to discover many more. Learn more @ucdgenomecenter.bsky.social @ucdavismind.bsky.social www.ucdavis.edu/news/finding...

#RNA #RNASky

Publication rates before and after tenure: clear decline post-tenure in non-lab-based fields and sustained in lab-based fields. Super interesting. arxiv.org/pdf/2411.10575

A study in Nature reports on the development of a method to trace intercellular transfer of mitochondria and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabilities. go.nature.com/4l2J2yh #medsky 🧪

Are you interested in how cells talk to each other to promote regeneration in the heart? @bailinwu.bsky.social @florian-constanty.bsky.social and I are and we wrote a review about it ❤️🐟🐭 Check it out here 👇 www.sciencedirect.com/science/arti...

Now online! Rewriting regulatory DNA to dissect and reprogram gene expression

A trial in Nature Medicine shows that transition to a Western diet resulted in pro-inflammatory changes, whereas transition to an African heritage diet rich in fruits and vegetables, legumes and fermented products led to opposite effects. https://go.nature.com/4cC97AT #foodstudies 🧪

So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵 www.nature.com/articles/s41...

What role does our diet play in the development of colorectal cancer? The team behind a paper in Nature Communications shares how their work evolved from tracking changes in the gut microbiome to investigating how dietary changes can affect disease outcomes. 🧪

Blackrot.

Excited to share our lab’s first review, focusing on RNA localization! #RNA #RNAlocalization genomebiology.biomedcentral.com/articles/10....

Have a protein of unknown function? Try this www.tatta.bio/blog/gaia ! This is imo one of the best ai tools I have seen since alphafold alpha fold. I recommend you look at the paper too! #bioinformatics #biologicalDarkMatter #Gaia #tatta

Why do RBPs need multiple RNA-binding domains? We show transcriptome-wide that the endosomal mRNA transporter Rrm4 uses its three RRMs to differentiate functional binding sites from accessory ones. Great collaboration with @koenig-lab.bsky.social and Zarnack lab www.biorxiv.org/content/10.1...

🚨Registration is now open for the SFB 1531 | GfMVB International Meeting on Perspectives in Cardiovascular Biology in Frankfurt, April 2025! We are proud to welcome so many outstanding speakers - more info and registration at pcvb2025.de Join us and secure your spot!

The EU wasn’t formed to screw anyone. Quite the opposite. It was formed to maintain peace, to build respect among our nations, to create free and fair trade, and to strengthen our transatlantic friendship. As simple as that. 🇪🇺🇺🇸

Agree

A study in Nature Cancer provides genetic evidence that intrinsic developmental heterogeneity can prime individual, lifelong cancer susceptibility. https://go.nature.com/3PZla0G #Medsky 🧪

📢1/12 Happy to share our first bluetutorial & our latest preprint. In this work, we discovered RSRC2 as a novel RNA-binding protein (RBP) with a dual function in cell division whose activity can be (lnc)RNA-mediated. #lncRNA #RBP #Mitosis www.biorxiv.org/content/10.1...

Calling all cardiovascular scientists.... @WeinsteinConf is in Milwaukee May 14-16! Abstract submission now open. Registration portal is imminent! childrenswi.org/weinstein Are you a trainee and want to be considered for a platform talk - abstract due Feb 21!

Last week, Finland's Publication Forum announced that it is downgrading its classification of 271 journals to the lowest level, zero. This includes 187 MDPI and 82 Frontiers journals. Read more by @deevybee.bsky.social here:

Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy www.nature.com/articles/s41...

The perfect gift for a scientist is as many of these as possible, because you know they will disappear the moment you put them down and look away! #iykyk @addgene.bsky.social

Meine beiden Lieblingspodcasts in einer Folge (7h30m). Das erste Geschenk ....🎁 @lagedernation.org @christophamend.bsky.social @wegner.io www.zeit.de/politik/2024...

Very short notice: starts in 1h

We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer 🧬💊! Preprint led by Disha #chemsky 🧪 @uclchemistry.bsky.social @oxfordchemistry.bsky.social chemrxiv.org/engage/chemr...

I just had the joy of listening to an amazing talk by Colinda Scheele (scheelelab.sites.vib.be/en). Such important work involving great mouse models to study breast cancer initiation www.nature.com/articles/s41...

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

(please amplify) 4% of scientists face an important barrier to an the ENTIRE FIELD of single-cell genomics and here is why

@embl.org is searching for a "highly experienced, inspirational and dynamic leader" to serve as its new director general. Who do we wish to see at this position?

How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...

Extensive binding of uncharacterized human transcription factors to genomic dark matter www.biorxiv.org/content/10.1...

A language model-based deep learning approach for #RNA 3D structure prediction www.nature.com/articles/s41...

Interesting findings by the Zarnack and König labs: www.cell.com/molecular-ce... #RNAbiology

Our fantastic collaboration with the lab of Nils Blüthgen @molsysbio.bsky.social has been published: www.embopress.org/doi/full/10.... #RNASky #RNAbiology @mdc-berlin.bsky.social

Done go.bsky.app/TzBHeud

It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

Hi everyone! I'm once again looking for cool images/drawings to feature on the cover of CSH Protocols! If you have anything related to Drosophila & chromatin, or anything about Maize or Maize genetics, please let me know! I've already selected 2 covers from such open calls😊

👍🏻5. Rhein-Main #Cancer Retreat erfolgreich beendet: Die Organisatoren – LOEWE-Frankfurt Cancer Institute @loewe-fci.bsky.social, Deutsches Konsortium für Translationale #Krebsforschung DKTK + Mildred-Scheel-Nachwuchszentrum MSNZ – blicken positiv ins nächste Jahr! #LOEWE #Grundlagenforschung #Hessen