#paper! X-rays can resolve #ultrastructure in tissues non-destructively. www.nature.com/articles/s41... Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.

u-Segment3D: a universal framework for 2D to 3D cell segmentation that generalizes across cell types and imaging modalities. www.nature.com/articles/s41...

1/17 🧵 🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇 ➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC). Very proud of the team and efforts behind it. www.nature.com/articles/s41...

How does immunotherapy work, and why do some patients respond while others don’t? Book our free talk by Samra Turajlic, head of the Cancer Dynamics Lab here at the Crick, Director of @cruk-mi.bsky.social and head of the UK-wide MANIFEST programme. www.eventbrite.co.uk/e/crick-cras...

Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis. Learn more this week: https://scim.ag/4nFEGO7

Scientists point to a long list of findings that emerged out of fundamental research, the type of studies the US government is cutting, and went on to change the world. Nature lists a few of their examples. 🧪

Happy to share STORIES out now on Nature Methods STORIES learns cell fate landscapes from spatial tramscripromics data profiled at several time points, thus allowing prediction of future cell states. Led by Geert-Jan Huizing and Jules Samaran www.nature.com/articles/s41... @pasteur.fr

Today I'm announcing a new digital textbook 📖🖥️, "An Introduction to OME-Zarr for Big Bioimaging Data". ome-zarr-book.readthedocs.io

@lucianomartelotto, not on Bluesky, on a new Spatial RNA imaging method, PRISM. www.nature.com/articles/s41... Now added to #SingleCell #Spatial #Method bit.ly/scmethodstable

High-resolution imaging mass cytometry enables highly multiplexed imaging of nuclear foci and mitochondrial networks. www.nature.com/articles/s41...

🧬🩸 Cancer cells “tighten the belt” on their neighbors — Institut Pasteur, CNRS & Université Paris Cité uncover a mechanical killing strategy: tumor cells surround healthy ones and squeeze them to death via a contractile belt. Read more 👉 research.pasteur.fr/en/news/canc...

Researchers at the Crick found that virgin female mice can become aggressive towards pups when hungry, but only in certain hormonal states. It highlights the importance of understanding hormones when observing how different physical states interact in the brain. www.crick.ac.uk/news/2025-10...

👏We are pleased to announce Laura Marandino as the 2025 recipient of the ESMO José Baselga Fellowship for Clinician Scientists. This fellowship, supported by AZ, provides the resources & #mentorship for #ClinicianScientists. #ESMO25

@science.org High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer | Science www.science.org/doi/10.1126/... @lukekoblan.bsky.social @weissmanlab.bsky.social @zhuanglab.bsky.social @whiteheadinstitute.bsky.social et al.

Ultra-sensitive DNA sequencing maps mutations that precede cancer @nature.com @imartincorena.bsky.social www.nature.com/articles/d41... www.nature.com/articles/s41... www.nature.com/articles/s41... @bbglab.bsky.social @irbbarcelona.org @nlbigas.bsky.social

Nimbus predicts the likelihood of marker positivity from multiplexed image data in single cells. www.nature.com/articles/s41...

🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights. 🔗 www.biorxiv.org/content/10.1...

new out in Nature www.nature.com/articles/s41...

Global matrisome changes in obese lung are linked to fibroblastic stroma and premature aging

Come join us next year at the @embo.org meeting "The Many Faces of #Cancer evolution"! Organised by @ciriellolab.bsky.social @magnanilab.bsky.social @turajliclab.bsky.social & Céline Vaillot! In beautiful Rimini 🇮🇹 More information in the poster below ⬇️ and at meetings.embo.org/event/26-cancer-evo

CLEM-Reg automates the 3D alignment of volume correlative light and electron microscopy data. www.nature.com/articles/s41...

Super happy to see CLEM-Reg out in @natmethods.nature.com! A short thread on the algorithm behind it and how to try it out for yourself🧵(1/9) www.nature.com/articles/s41...

Systematic Growth Factor Profiling Platform for 3D Tumor Models Reveals Estradiol-Responsive Cellular Mechanisms of Immunotherapy Resistance https://www.biorxiv.org/content/10.1101/2025.09.04.674374v1

NEW content online!

Evidence that mitochondria in macrophages are destroyed by microautophagy www.nature.com/articles/s41...

new out in Nature this week www.nature.com/articles/s41...

🤔 Wondering to what extent the #ECM influences immune cell infiltration in tumors? In collaboration with @boehringerglobal.bsky.social, we applied #matrisomics to identify signatures distinguishing hot and cold #PDACs. Check out our preprint to learn what we found! www.biorxiv.org/content/10.1...

Your DNA sequence reveals a rare mutation. Will you get the disease, i.e. penetrance? A new study using machine learning predicts this across 10 common diseases, 1,600 genomic variants New @science.org science.org/doi/10.1126/...

Next up at #CBIAS2025 is @helenajambor.bsky.social‬ from the University of Applied Sciences of the Grisons. Helena researches data visualisation in the life sciences, combining their expertise with large datasets and their interest in data communication 🔗👇 helenajamborwrites.netlify.app/about

We all know that cancers -even from the same subtype- are highly heterogeneous right? In a new study we asked whether this was also the case for the three-dimensional organization of the genome in breast cancer. The answer: it’s complicated. www.cell.com/iscience/ful...

Researchers used large-scale CRISPR screening in stomach organoids to uncover how tumors respond to cancer drugs. These findings could inform more personalized treatment strategies. Learn more: spr.ly/63329fsVJF #EndCancer #OncSky

Online now: Computational framework for prioritizing candidate compounds overcoming the resistance of pancancer immunotherapy

🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals. ✅ Wet & dry lab ✅ September 2025 enrolment ✅ UK tuition fees only www.ucl.ac.uk/medical-scie...

New preprint! Deep proteome profiling for just $10/sample, all-in. → Single-step prep for ≤50 ng → 6k–8k proteins in ~10 min → No gain from more sample/time Congrats to Siqi Huang, Chao Wang & Hsien-Jung Lin! www.biorxiv.org/content/10.1...

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) www.nature.com/articles/s41...

Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...

Perfect timing on the last day of the 2025 #Collagen Gordon Research Conference! Our paper, in collaboration with @valerioizzi.bsky.social describing #MatriCom, a tool to infer ECM communication systems from scRNA-Seq datasets, is now published in @jcellsci.bsky.social! doi.org/10.1242/jcs....

In our latest feature we take a deep dive into volume electron microscopy, a powerful new method to see inside cells in 3D. Learn more about how it could reduce the time to get ultra high-quality images of biopsies to better understand kidney transplant rejection. www.crick.ac.uk/news-and-fea...

I've been interested in uncertainty visualization for a long time, yet somehow it took forever to come across this 2018 paper on ‘value-suppressed uncertainty palettes’. A neat and intuitive alternative to the clunky ‘unsuppressed’ bivariate palette approach: doi.org/10.1145/3173... 🧪 #dataviz

new out in Nature this week www.nature.com/articles/s41...

An AI model developed by Google DeepMind could help scientists make sense of the non-protein-coding part of the genome https://go.nature.com/4llASRk

📢ONLINE @natgenet.nature.com 📰Single-cell and spatial transcriptomics of stricturing #Crohn’s disease highlights a fibrosis-associated network. By Lingjia Kong, ‪@thexavierlab.bsky.social‬ and colleagues. ⬇️ www.nature.com/articles/s41...

AlphaGenome deepmind.google/discover/blo... 🧬🖥️🧪 API: github.com/google-deepm... Docs: www.alphagenomedocs.com Community: www.alphagenomecommunity.com

Now online in Cancer Discovery: AAnet Resolves a Continuum of Spatially-Localized Cell States to Unveil Intratumoral Heterogeneity - by Aarthi Venkat, Scott Youlten, Beatriz San Juan, Smita Krishnaswamy, Christine Chaffer, and colleagues doi.org/10.1158/2159...

A paper in Nature Cancer presents an autonomous artificial intelligence agent system for deployment of specialized medical oncology computational tools. The AI agent reached correct clinical conclusions in 91% of cases. go.nature.com/43J0xw0 #medsky 🧪

Microvascular obstruction is known to be a #LongCovid feature. Now a potential mechanism found for the obstruction induced by death of endothelial cells->sticky red blood cells. Which wouldn't respond to blood thinners or anti-platelet Rx www.nature.com/articles/d41... www.nature.com/articles/s41...

This Month, I'm doing 100 Push-ups a day to raise money for @cancerresearchuk.org. Now more than ever, we need to fund the research that saves lives. Every rep and every donation counts! fundraise.cancerresearchuk.org/page/matouss...

Online Now: Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception

You can now apply until the 4th of June !! #EMBOBioImage www.embl.org/about/info/c...

🚀🔬🦠 Releasing 🤖Cellpose-SAM🤖, a cellular segmentation algorithm with superhuman generalization 🦸‍♀️. Try it now on 🤗 huggingface.co/spaces/mouse... paper: www.biorxiv.org/content/10.1... w/ @computingnature.bsky.social 1/n