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Here's a spotlight article on our recent study! Tissue ultrastructure can be resolved with X-rays, which impacts not only how we can study neuronal circuits but soft tissues more generally. Kudos to Ana Diaz, @adrianawanner.bsky.social, @andreas-t-schaefer.bsky.social and all authors.

What is psychosis and how can we treat it? Crick group leader @kathaschmack.bsky.social explains how her lab is working to uncover new ways to treat psychosis by finding its biological roots. youtu.be/EUb3_5ecatU

Method of the Year 2025: In his Comment, Moritz Helmstaedter looks into the future of connectomics and the feasibility of scaling up to larger brains. www.nature.com/articles/s41...

Connectomics is Method of the Year 2025!! @natmethods.nature.com just released the news nature.com/articles/s41... In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics www.nature.com/articles/s41...

Our Method of the Year 2025 is...drumroll please...EM-based connectomics!! Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬 www.nature.com/articles/s41...

And read the associated Research Briefing here: www.nature.com/articles/s41...

An optimized X-ray nanotomography method offers an attractive alternative to volume EM for connectomics. @crick.ac.uk @psich.bsky.social psich.bsky.social @adrianawanner.bsky.social @andreas-t-schaefer.bsky.social @ucl.ac.uk @uclnpp.bsky.social www.nature.com/articles/s41...

Researchers at the Crick, @psich.bsky.social and @esrf.fr have developed a new way to look deeper into brain cell connections by using a particle accelerator and a kind of resin borrowed from the aerospace industry. www.crick.ac.uk/news/2025-11...

Scientists at the Swiss Light Source #SLS and @crick.ac.uk have succeeded in mapping a piece of brain tissue 🧠 in 3D at unprecedented resolution using X-rays – non-destructively. The breakthrough overcomes a long-standing technological barrier that had limited the use of X-rays for such studies.

Happy to share the first paper from my journey at @psich.bsky.social towards X-ray connectomics, now out in @natmethods.nature.com: www.nature.com/articles/s41...

I was glad to receive a Science Achievement Award from @crick.ac.uk! Thanks!! Cheers to all co-authors of our study showing that tissue ultrastructure can be resolved by X-rays. www.nature.com/articles/s41... And congrats as well to all the other awardees - such a pleasure to be in this lot!

Do you have 2D-to-3D image registration challenges? Let me know about them here forum.image.sc/t/toward-bet...

#paper! X-rays can resolve #ultrastructure in tissues non-destructively. www.nature.com/articles/s41... Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.

Check these positions at @crick.ac.uk! It’s an outstanding opportunity to shape the way we can map neuronal circuits - and more broadly biological tissues.

Join us *next Monday*! #CrickXrays25 X-ray #nanoimaging of biological tissues 🇬🇧🌐 @crick.ac.uk & online tinyurl.com/crickxrays25 Sponsored by @dectris.bsky.social, @webknossos.org and @biologists.bsky.social and backed by @brukercorporation.bsky.social and Histomography

#Nanoimaging symposium @crick.ac.uk! At #CrickXrays25 we'll tackle: 💫synchrotron upgrades 📈current limits in throughput, volume, resolution 🧪sample preparation for X-ray PC imaging 🧠♥️applications in neuroscience and tissue life science 🗓️13th October 2025 🇬🇧🌐 London & online tinyurl.com/crickxrays25

#preprint: We optimised the preparation of tissues for #X-ray phase contrast imaging. Drying tissue samples (instead of embedding them) brings more signal in #X-ray phase contrast images. The process largely preserves #ultrastructure. @safekhan.bsky.social @andreas-t-schaefer.bsky.social

Wouldn't it be great if we could not only image large connectomic volumes but also completely reconstruct them? And if a whole mouse brain project didn't cost billions? With the PATHFINDER preprint (www.biorxiv.org/content/10.1...), we preview a future where it doesn't have to.

#preprint: We mapped the structure and function of olfactory bulb circuits with in vivo 2-photon microscopy and synchrotron #Xray holographic nanotomography. doi.org/10.1101/2025... @yuxinzhang.bsky.social @andreas-t-schaefer.bsky.social @apacureanu.bsky.social @crick.ac.uk @esrf.fr

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