🚨 New preprint alert! We used IntAct + Ultrastructure Expansion microscopy to map actin isoforms in 3D🤯 Check out this gorgeous 3D volume of U2OS cells - revealing diverse filament networks including the elusive nuclear actin filaments! #cytoskeleton #microscopy #actin

Is it pronounced ORCID 🌸 like the flower or Orc ID 👹 like an identity card for a Middle Earth monster? Smart people disagree. Personally, I pronounce it Orc ID because I like the idea that I am a science goblin with a fixed numerical identifier. @orcid.org

Massive protests now in @wien.gv.at now against planned budged cuts of the #University sector. #unisretten. Speeches now in front of @univie.ac.at main building.

so maybe this protein is acting as a calcium sensor to let the cell keep track of its current stimulation state or past stimulus history. right now, almost any hypothesis can be on the table. in case you missed the paper you can read it here: www.cell.com/current-biol...

Another #cilia kinesin motor: kinesin-8 KIF19A localizes to ciliary tips of Drosophila mechanosensory neurons In 2012, Hirokawa lab showed KIF19A regulated ciliary length & localized to ciliary tips in mice; knockouts had hydrocephalus and female infertility phenotypes (PMID 23168168). #ciliopathy

Park, Liu, Sun, Roll-Mecak et al. present the crystal structure of an RPGR–TTLL5 co-complex, which reveals TTLL recognition paradigms for non-tubulin substrates and sheds light on disease mechanism for retinal dystrophies caused by TTLL5 and RPGR mutations. rupress.org/jcb/article/... #Cilia

Now online! Deciphering mechanical determinants of morphological evolution

🎦 See a short video summary by Sachi Inagaki: youtu.be/50JRPysrTNU

How do cells fabricate nanoscale extracellular matrix structures? Inagaki, Hayashi et al. @riken-bdr.bsky.social show that the ER network stimulates complex remodeling of the plasma membrane, thereby patterning nanoscale cuticular pore formation in insect sensilla. rupress.org/jcb/article/...

Medina, Chang et al. of the @nanigrotjahn.bsky.social lab introduce a new method based on the Surface Morphometrics pipeline to measure global and local thicknesses of organellar #membranes from cellular cryo-electron tomography data. rupress.org/jcb/article/... #CryoET

Demogorgons, Shadow Monsters and psychokinetically gifted 12-year-olds are strictly fictional creations - but what about the parallel universe at the core of Stranger Things? go.nature.com/48Mo2br

Congrats🥳 to @mike-wieczorek.bsky.social, Bin Cai, and our former lab member Jingwei Xu @xujwet.bsky.social to their multiscale imaging 🔬 story of the centriolar AC linker #teamtomo www.science.org/doi/10.1126/...

What would happen if cells would express more molecular motors ? They would break all microtubules 😱 As shown by recent great work from @kjverhey1.bsky.social rupress.org/jcb/article-...

Latest from ours: www.cell.com/cell-reports... This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾

Our new paper is out in @currentbiology.bsky.social! Using 3D reconstructions and volume measurements in Drosophila wing primordia, we show that growth can be uncoupled from cell proliferation and uncover a new time window for growth arrest. With @leopoldlab.bsky.social www.cell.com/current-biol...

Out stody Is now on National Geographic!!! www.nationalgeographic.com/animals/arti...

Very proud to share our latest preprint: postdoc/LRSF fellow Yue Rui studies the mechanisms regulating attachment of the cell wall to the plasma membrane. The Cellulose Synthase Complex and REMORINs determine the extent of attachment and root osmotic stress tolerance. www.biorxiv.org/content/10.1...

An amoeba with teeth. When building its shell, Netzelia corona selects sharp grains of quartz and positions them around its aperture with the tips pointing inward. I took a few closeups, yesterday. #ProtistsonSky #amoebae #peatlands #MEvoSky

One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics. elifesciences.org/articles/931...

Belyantseva and Liu et al. report that taperin encircles and stabilizes F-#actin at auditory hair cell #stereocilia bases and bundles F-actin. Taperin deficiency causes stereocilia disassembly, rootlet breakage at pivots, and other abnormalities culminating in deafness. rupress.org/jcb/article/...

I can say that I lived in the times of CRISPR. - @jenniferdoudna.bsky.social 's talk at @gmivienna.bsky.social 25th year anniversary jubilee at ÖAW.

#DevBio job opportunity! Development (@dev-journal.bsky.social) is looking for a new Community Manager to run our community site, the Node (@the-node.bsky.social) – a great opportunity if you love devbio, #stemcells, #scicom and community engagement. Happy to chat informally about the role. ⬇️

I’ve just updated the BioEmu notebook to include the powerful LogMD. Now, you can generate equilibrium ensembles and explore the full ensemble directly in the notebook. A huge thanks to Alexander Mathiasen for the support! 🙌 🔗 Try it on Google Colab: lnkd.in/gcuqd-fT

Kyojiro Ikeda @beingkyo.bsky.social @univie.ac.at presenting now at #DevStem2025 @viennabiocenter.bsky.social on first mechanistic & molecular regulators of #bristle biogenesis in the #Platynereis model. Also check Kyojiro's recent @naturecomms.bsky.social publication www.nature.com/articles/s41...

Are you in for a PhD project on neural #regeneration? Only 2 more weeks to apply to the @vbcscitraining.bsky.social @univie.ac.at VBC PhD programme: vbcphd.at ! Pls. see tiny.cc/RaibleLab and our recent @naturecomms.bsky.social study www.nature.com/articles/s41... for information and contact!

Take the next step in your academic career and become part of a thriving international research community! The Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences (VDS-PhaNuSpo) are offering 13 fully four-year funded PhD positions at the moment!

Incredible 4Pi and pan-expansion imaging of the Golgi 👇

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

Nature research paper: Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium https://go.nature.com/4hrHX0v

My continued biological education #Mechanobiology #RigiditySensing Stiffness Sensing by Cells "Substrate Stiffness Can Lead to Heritable Epigenetic Changes" "Cell Motility Is Faster on Soft Elastic Substrates" #PhysiolRev 2020 journals.physiology.org/doi/full/10....

Cool story on nanopatters! We had picked Osiris genes as erect wing regulated, but no clue what this was about. genomebiology.biomedcentral.com/articles/10....

Can you spot the difference? 🔬 SiR-actin labeling can be cytotoxic and affects actin dynamics - while the new XActin probes do not! Developed by @veselin-nasufovic.bsky.social and perfect for time-resolved and STED imaging without the need for genetic manipulation. www.biorxiv.org/content/10.1...

First Post! Thrilled to share our lab's first evolutionary cytoskeleton study! We uncover two distinct FtsZ paralogs in Odinarchaeota OdinFtsZ1 forms curved filaments, while OdinFtsZ2 assembles into spiral rings. A glimpse into tubulin evolution! threads👇 #Eukaryogenesis #AsgardArchaea #cytoskeleton

Huge congrats to Nadja Milivojev @vbcscitraining.bsky.social who successfully defended her @univie.ac.at PhD thesis with a brilliant presentation today. Thanks to examiners Elly Tanaka, Michael @mikebok.bsky.social and Roger Revilla, and both labs for wonderful support!

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that. www.biorxiv.org/content/10.1...

Cicadas have little, bendy micro-pillars on their wings that pierce bacterial membranes and are as effective at killing microbes as a bleach solution. It might be possible to mimic this effect for use in medical (etc.) equipment. 🪳🪲🧪 www.science.org/content/arti...

#SYStem2025 :: Vienna, March 12-14 :: #StemCell niches | Deterministic v. stochastic decisions | Germline | Stem cell model systems | #Epigenetics & imprinting | Cell biology of Stem Cells | Transitioning Stem Cells into the clinic; For oral presentations, register by Jan 15! www.sy-stem.org

📜 A cellulose synthase–like protein governs the biosynthesis of Solanum alkaloids 🧑‍🔬 Adam Jozwiak, Asaph Aharoni, et al. 📔 @science.org 🔗 www.science.org/doi/10.1126/... #️⃣ #PlantScience #PlantImmunity #PlantMetabolites

Great start into academic 2025 with an excellent @univie.ac.at MSc thesis defense by @murielmirus.bsky.social. Kudos to @beingkyo.bsky.social for great supervision, many thanks to Stephanie Ellis and Roger Revilla for joining the panel, and the entire lab for support and presents. Well done Muriel!

Mitochondria- and ER-associated actin are required for mitochondrial fusion - Nature Communications congrats @manorlaboratory.bsky.social & CO www.nature.com/articles/s41...

This #EM_Monday highlights how organelles can shape cells in 🧠! E.g. glia, with their thin processes, often wrap around neurons. But when organelles like lipid droplets (LDs) are present, they can create dents in neighboring neurons—like the one shown here, where a glial LD indents neurons' somas🧵

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology www.biorxiv.org/content/10.1...

Did you know #diatoms are motile? These tiny glass cells have no cilia or flagella and a rigid body yet can glide on surfaces using a specialised slit in the cell wall called the raphe! What is the functional morphology of the raphe? All revealed in our new preprint www.biorxiv.org/content/10.1...

Where does pattern come from inside cells? in this revised preprint, @aralbright.bsky.social Shows that regionalization of mRNA in a Stentor cell depends on dynein motors and the microtubule cytoskeleton doi.org/10.1101/2023...

Mix two motors of opposite polarity with microtubules and they will partition space ! Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns. #morphogenesis doi.org/10.1073/pnas... (1/n)

Science Magazine wrote a news article about our latest preprint, featuring @johnprensner.bsky.social @thomasmartinez.bsky.social Alan Saghatelian, Ji-Young Youn, Ami Bhatt, Jon Mudge, and more: www.science.org/content/arti... Preprint: www.biorxiv.org/content/10.1... 🔎microproteins #darkproteome

Respect/beware of His tags