Recently discovered #ggplot2 stat_sum() - a simple stat for a simple job - beautiful! #rstats

New #miRNA paper from Lai lab!! 🧬🔥 some think this field, despite recent Nobel to Ambros and Ruvkun, doesn't have much surprises left. but, do we EVEN KNOW WHAT a miRNA precursor LOOKS LIKE? we found some conserved miRNA hairpins up to 10x longer than suspected. this is mir-12, just bonkers! 1/n

🚀 Deadline approaching: apply by September 17 and become a GLOBAL POSTDOC FELLOW at the #mdcBerlin. You'll co-develop projects with two supervising labs, tackling biomedical grand challenges – with full salary, modern infrastructure, and career support. More: 👉 www.mdc-berlin.de/postdocs#t-g...#mdcBerlin👈

Interested in using MAVEs for variant classification? Read our review by Abbye E. McEwen, Malvika Tejura, @shawnfayer.bsky.social, @leastarita.bsky.social & @dougfowler.bsky.social: Multiplexed assays of variant effect for clinical variant interpretation go.nature.com/3IdCfUb rdcu.be/eFmll

🔖Last review from the lab👇 'Male meiosis at the helm: shaping genomes and sex chromosomes in emerging vertebrate models' academic.oup.com/biolreprod/a...

Long-read sequencing of single cell-derived melanoma subclones reveals divergent and parallel genomic and epigenomic evolutionary trajectories https://www.biorxiv.org/content/10.1101/2025.08.28.672865v1

Excited / nervous to share the “magnum opus” of my postdoc in Andreas Wagner’s lab! "De-novo promoters emerge more readily from random DNA than from genomic DNA" This project is the accumulation of 4 years of work, and lays the foundation for my future group. In short, we… (1/4)

A technology feature in Nature reports how scientists are seeking to decipher the role of non-coding DNA in the human genome and are helped by a suite of artificial-intelligence tools. 🧪

New paper from Bin Cao, showing that placenta-specific KO of ADAR1 is embryonic lethal.

I'm certainly a #julialang evangalist, but I've toned it down a bit - a lot of scientists don't have the time or inclination to go against the grain. Then again, when someone makes it this easy... #tidytuesday #rstats nrennie.rbind.io/blog/introdu...

Fly labs — Now is the time to show some solidarity and chip in support for this vital resource!

This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇

Absolutely textbook material - how unprocessed/intron-retained RNAs get detained in the nucleus from Yongsheng Shi lab www.biorxiv.org/content/10.1...

could there be any grander setting for a poster session than under the blue whale @amnh.org?? don't think so. congrats to our high school intern Rewan Youssef and her Lai lab mentor @neuro-david.bsky.social. she presented her research alongside 500 other NYC students. they will keep science strong!

Very happy to share the peer-reviewed version of our work on the cis-regulatory determinants of #microexon #splicing regulation by SRRM3/4, published in @natsmb.nature.com! rdcu.be/ezGqT Work led by @sobonnal.bsky.social, with Simon Bajew & @rmartinezcorral.bsky.social. @crg.eu @upf.edu

Really beautiful work led by Jessica Leismann in Joan Barau’s lab @imbmainz.bsky.social . If you like elegant mouse genetics, the transposon arms race, and a healthy dose of epigenetics, this one’s for you. www.embopress.org/doi/full/10.... @emboreports.org

Evaluating something like batch correction requires looking at the data, and picking metrics that capture what you care about. Great work @prauten.bsky.social and @uweohler.bsky.social

A Review in Nature Reviews Endocrinology discusses therapeutic targets for type 1 diabetes mellitus, including immunotherapy, and how these treatments change the future of the disease. go.nature.com/44VJ7hS 🔒

Honored to have been invited to contribute to this comprehensive review on neuropeptide signaling and its impacts on the locus coeruleus noradrenergic system 🔵🧠🧪. www.sciencedirect.com/science/arti...

@embl.org is undoubtedly one of the best place in the world to start your lab! The GB unit is collegial, supportive, collaborative and the science is just outstanding. Apply! DM me if you have questions.

The connectivity of mouse visual cortex thick tufted layer 5 pyramidal cells, also known as extratelencephalic neurons (L5-ETns), using a 1 mm3 publicly available electron microscopy dataset, part of the MICrONS Project @alleninstitute.org www.nature.com/articles/s41...

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

heads up fly folks! 120 awesome members of our community volunteered to be external mentors to fly scientists at ALL levels, from students and pds to junior faculty. now, you can sign up to get matched, just fill out the survey. please share #FlyCROSS, yet another reason 🪰 community is the BEST!

A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function go.nature.com/4mc1SmQ

Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...

Very cool story about GIANT transposons (up to 700 kb) that can transfer virulence-associated genes between diverse fungi 🧪

🚨 New paper alert 🚨 I am excited to share our new work on epigenetic enhancer priming in early mammalian development genomebiology.biomedcentral.com/articles/10.... Fantastic collaboration with Wolf Reik’s team, with key contributions from many others, led by the excellent Chris Todd. Short 🧵

Our recent overview of human stem cell models for studying neuropsychiatric disorders (including their limitations and future directions) is now openly available @annualreviews.bsky.social of Neuroscience With the great @rebeccalevymdphd.bsky.social

Xing et al. study sex chromosome evolution in two species of halfbeak fish, identifying a large sex-linked ZW region in Hyporhamphus sajori and a small sex-linked region on a different chromosome, with male heterogamety, in H. intermedius. 🔗 doi.org/10.1093/molbev/msaf151 #evobio #molbio

EVERYTHING YOU EVER WANTED TO KNOW ABOUT #PSYCHEDELICS AND THINGS YOU NEVER THOUGHT ABOUT! www.cell.com/neuron/abstr...

Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...

If you enjoyed our RNA splicing collection, this @natrevdrugdiscov.nature.com Review may be of interest: Protein isoform-centric therapeutics: expanding targets and increasing specificity go.nature.com/44HDClo

In a new #ScienceReview, researchers provide a critical evaluation of research linking glymphatic dysfunction with Alzheimer’s disease. scim.ag/4lG54a0

mRNA profiles of FGF family 22 ligands + 10 (co)receptors in♂️🐭 Heart Liver Kidney Skeletal muscle Gonadal/s.c. WAT BAT young 7-wk vs aged 12-mo -/+ #HighFatDiet Effect of HFD FGF9 ⏫in BAT, ⏬ in kidney of young, not aged🐭 Effects of #Aging ↔️FGF9 #JEndocrSoc 2025 academic.oup.com/jes/article/...

Evolution of splicing model architectures go.nature.com/4eweliE Figure from our recent Review: From computational models of the splicing code to regulatory mechanisms and therapeutic implications (free to read here: rdcu.be/dVNV4)

🥳Amazing publication from the Hornung lab, in collab. with the Carell lab, on the innate immune system: how modified RNA tricks the immune system. Big shout-out to the two first authors, Marleen Bérouti and Mirko Wagner! www.cell.com/cell/fulltex... @v-hornung.bsky.social @m-berouti.bsky.social

Please check it out! In this paper with lead author- Tess Leathers- we visualized the expression of enzymes that regulate the COX-mediated inflammation pathway during embryonic development. We are continuing to study this pathway to discover its early roles in brain and neural crest development!

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease. www.nature.com/articles/s41...

Human-like expression of the CLOCK gene in mouse neocortex enhances cognitive flexibility and neural connectivity, suggesting an evolutionary gain of function in neocortical development that may have contributed to human cognitive specialization www.nature.com/articles/s41...

A Review on changing genes, cells and networks to reprogram the brain after stroke www.nature.com/articles/s41...

By flipping an evolutionarily disabled genetic switch involved in Vitamin A metabolism, researchers in Science have enabled ear tissue regeneration in mice. Learn more: scim.ag/3TzUSnH

Heat shock proteins function as signaling molecules to mediate neuron–glia communication via extracellular vesicles during aging in C. elegans www.nature.com/articles/s41...

Excited to share our new paper in @cellreports.bsky.social that reshapes our understanding of chromosome organization's deep evolutionary roots! Our work dives into the origins of the machinery that structures our very genomes. 🔗: doi.org/10.1016/j.ce... #Genomics #Evolution #CellBiology #LECA

Nature research paper: SP140–RESIST pathway regulates interferon mRNA stability and antiviral immunity https://go.nature.com/4mRnJ42

Collaborative work between Durbin Lab at Cambridge & Svardal Lab at Antwerp 🐠 🔗 to manuscript: www.science.org/doi/10.1126/...

The Fulbright Scholarship board resigned due to political interference from the Trump administration. The State Department, led by Marco Rubio, is canceling scholarships for nearly 200 American professors and researchers based on their research topics, which include climate change, gender, and race.