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Alu repeats have played important roles in the evolution of (alternative) splicing via exonization and in other ways. In this paper, we show that they mediate interactions across exons to loop them out. Alus inserted this way in evolution render exons alternative. bit.ly/4t8Yahh 1/2

Wonderful read on microexons — their regulation, cross-species functions, disease relevance & therapeutic potential.

Thanks to all co-authors and to everyone who supported this work - check it out!

New online: Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4

A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function go.nature.com/4mc1SmQ

🐁 A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation.