Started the day by belatedly reading the excellent essay "Critically assessing atavism, an evolution-centered and deterministic hypothesis on cancer" by Bertrand Daignan-Fornier and @pradeu.bsky.social: doi.org/10.1002/bies... The latter is recruiting a postdoc: philinbiomed.cnrs.fr/jobs/postdoc...

Preprint: Plant pathogens cleave 2’cADPR to suppress TIR immune signaling Inspired by knowledge on how phages inhibit bacterial immunity, we now show that disease-causing bacteria inhibit plant immunity in a similar way. A 🧵 www.biorxiv.org/content/10.6...

ICYMI: Nuclear STING compromises replication fidelity

Reminder to register for the Unifying Ecology Gordon Conference by next Monday! Lest you miss out on this incredible line up! www.grc.org/unifying-eco... @jennsunday.bsky.social @ewaldoleitao.bsky.social #GRC #ecoevo

Sciences Po, Paris-I, Toulouse : les facs confrontées à des répressions « inédites ». www.mediapart.fr/journal/fran...

Many thanks to Markus Kunze, Jérôme Badaut, Muriel Darnaudery, Léa Peltier, Thomas Pradeu @pradeu.bsky.social Isabella Sarto-Jackson and Jan-Pieter Konsman for the great collaboration on this paper! END N=25

Fridolin Gross and @pradeu.bsky.social are advertising a two-year postdoc in conceptual, theoretical, or philosophical approaches to cancer at ImmunoConcept (CNRS & University of Bordeaux, France). Closing 30th July. Sounds amazing! philinbiomed.cnrs.fr/jobs/postdoc...

'Lower-ranked institutions exhibit higher rates than elite universities, young for-profit publishers show elevated rates vis-à-vis competitors, and academic fields differ widely in adoption. LLM adoption in academic writing is pervasive but socially stratified.' www.pnas.org/doi/10.1073/...

This is today and this is not to be missed.

Great piece and cover @science.org about how our field is uncovering the evolutionary and mechanistic connections between bacterial and eukaryotic immunity ! www.science.org/content/article/ancient-wars-between-microbes-gave-us-key-immune-defenses

Candidates for California governor discussed housing and insurance policy in the first half of an hourlong debate, then furiously attacked one another at the end.

Are all #living things capable of #cognition? Today at 5pm, Mazviita Chirimuuta, an oustanding philosopher of #neuroscience who recently received the #Lakatos Award, will give a hybrid talk that identifies the key features of non-cognitive processes. #philsci #cognitive @philinbiomed.bsky.social

CDC communication undermines trust in vaccines | Science www.science.org/doi/10.1126/...

Dismissing all members of the National Science Board will only continue the destabilization of American fundamental research and scientific workforce development. Read our statement: brnw.ch/21x1Z8n

Quelques échanges récents ici m’ont donné envie de proposer un panorama de la philosophie des sciences contemporaine. Non pour défendre une corporation, mais pour corriger une image assez datée de la discipline. Je resterai volontairement assez schématique pour ne pas alourdir un thread long. 1/n

Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.

#OTD in #Phage history: In 1873, the phage therapy pioneer Félix d’Hérelle was born!!! His amazing work at @pasteur.fr and other institutions laid the foundation in which groups like the BBH were founded You can read more about his fascinating life story here www.pasteur.fr/en/institut-...

Exclu Le Parisien : des centaines de médecins, scientifiques et personnalités publient une tribune pro-#vaccination, contre "des idéologies qui manipulent les peurs" : "C'est un bien commun de l’humanité, nous ne laisserons personne la remettre en cause."

If you are planning to attend, the registration is open. We @hpscambridge.bsky.social are pouring our hearts into this conference and it will be amazing. Even though my own submission was not accepted! #philsci #philsky #hps #metascience

NAS President Marcia McNutt claims she is being bipartisan by avoiding “topics for which there is a partisan divide.” But this is blatantly partisan. She is doing exactly what one party wants. Worse, in direct opposition to the science in these fields. 🧵1/?

Here’s the head of the National Academy of Science saying that the academies shouldn’t work on climate change or vaccines because of political partisanship, and instead focus on fields with “bipartisan” support like national defense and AI.

U.S. President Donald Trump has fired all 24 members of the National Science Board, the body that oversees the National Science Foundation. https://scim.ag/4cxQWhl

Extinction of the human species: What could cause it and how likely is it to occur?' by Professor Seán Ó hÉigeartaigh (University of Cambridge), on Wednesday 6 May at 6pm UK time. cassyni.com/events/AKmfE...

Excited to share our new findings in @science.org on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze! www.science.org/doi/10.1126/...

Very proud of this work and all the efforts from my team and collaborators on this! You can now use DGRs for in vivo targeted hypermutagenesis in E. coli. We also included some early proof of concept in Yeast thanks to @seth-shipman.bsky.social !

Happy to share our new work on how phages escape bacterial immunity. We show that a phage homing endonuclease drives segmental amplification of anti-defense genes, pointing to a versatile and rapid mode of adaptation. www.nature.com/articles/s41... #PhageSky #MicroSky

Structures of the QatBC complex from Angela Gao and Doug Wassarman in our group reveal an evolutionary link between QatABCD and Type IV CBASS and a role for protein deazguanylation in diverse anti-phage defense systems www.nature.com/articles/s41... www.science.org/doi/10.1126/...

We found that TIR domains in animal immune proteins, including the human TLR4, are enzymes that cleave NAD+ to produce the signaling molecule cADPR Read our new preprint by talented Bohdana Hurieva: “Conserved catalytic activity of immune TIR domains in animals” www.biorxiv.org/content/10.6...

Join our upcoming PhilInBioMed‑Seminar: Apr 21 | 5 - 6:30 pm (CET) | virtual on Zoom Kenneth S. Kendler (Virginia Commonwealth University, USA): “A Conversation about Major Themes in the Philosophy of Psychiatry” Further information here: philinbiomed.cnrs.fr/event/philin...

#ESR #VeilleESR Tribune de la C3N du #CNRS signée par plus de 700 scientifiques (membres du comité national, directrices et directeurs d'unités) pour alerter une nouvelle fois sur les conséquences des coupes budgétaires c3n-cn.fr/2026/04/10/b...

[Lettre ouverte du Conseil scientifique de la Fondation pour la recherche sur la biodiversité (FRB)] Présenter l’écologie scientifique comme une opinion est dangereux pour la démocratie www.fondationbiodiversite.fr/actualite/le...

#ESR #VeilleESR #Unjoursansfin #Groundhogday (2004-2026)

Some #bacteria polymerize excess carbon into polyhydroxybutyrate (PHB), a biodegradable storage polymer. This study shows that #PHB -producing bacteria kill #Celegans nematodes by disrupting pharyngeal & intestinal function @plosbiology.org 🧪 plos.io/4cFAwDz

Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.

Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge @labliston.bsky.social @sciimmunology.bsky.social @babrahaminst.bsky.social @drntombizodwa.bsky.social www.science.org/doi/10.1126/...

Increased phosphorylated tau (pTau-181) is associated with neurological post-acute sequelae of coronavirus disease in essential workers: a prospective cohort study before and after COVID-19 onset www.thelancet.com/jo... 1/9

Good RFKjr was challenged on his damaging actions cutting healthcare access, vaccine access and racist statements in congress but does anything happen because of this? www.theguardian.com/us-news/2026...

Scientists are going into politics in the US in increasing numbers. This is a brilliant and much needed trend 🧪 www.nature.com/articles/d41...

[#Parution] La #leçon de clôture de François Héran “Face à l'immigration, le savant et le politique”, @editionscdf.bsky.social, est disponible en librairie à partir d’aujourd’hui www.college-de-france.fr/fr/editions/... @lecomptoir-fmsh.bsky.social @college-de-france.fr #immigration #sociologie

Super cool papier from Félix and co ! Congrats !

Discovery of gene functions in #Mycobacterium #tuberculosis has been slow. This study tests a genome-wide barcoded #transposon library across 95 environmental conditions, providing a rich resource of new gene functions, including metabolic & resistance pathways @plosbiology.org 🧪 plos.io/4vG0mz1

French time, UTC+2

Over two billion years, a fierce battle has raged between bacteria and the viruses that infect them. The resulting evolution has shaped the way our bodies fight disease today. @vcallier.bsky.social reports: www.quantamagazine.org/the-ancient-...

Don't miss the great Ken Kendler who will speak online in our Philosophy in Biology & Medicine Seminar in just one week! Title: "A Conversation about Major Themes in the Philosophy of Psychiatry" philinbiomed.cnrs.fr/event/philin...

New from the BJPS Review of Books Deflating Mental Representation – Frances Egan Reviewed by Nico Orlandi www.thebsps.org/reviewofbook... #philsci #philsky

The capacity of vaccine induced immunological memory, a stellar open-access review by @profshanecrotty.bsky.social www.cell.com/immunity/ful...

#RESEARCHIGHLIGHT 🚨 Wang et al. investigated the functional role of tumour-associated visceral adipose tissue in regulating colorectal cancer anti-tumour immunity and immunotherapy efficacy.

New pub+project from Alan Love, @kampourakisk.bsky.social & Tobias Uller. “Improving scientific mentoring w/HPS.” Paper available soon: @royalsocietypublishing.org journal #ProceedingsB buff.ly/XY0algj Until then, check out buff.ly/8Jv3Osi & consider contributing #HPS-mentoring-in-biology